Record Information
Version1.0
Creation date2010-04-08 22:05:18 UTC
Update date2020-02-24 19:10:28 UTC
Primary IDFDB002251
Secondary Accession NumbersNot Available
Chemical Information
FooDB Name(±)-Tryptophan
Description(±)-Tryptophan, also known as HTRP or triptofano, belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. Indolyl carboxylic acids and derivatives are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring (±)-Tryptophan is a very strong basic compound (based on its pKa) (±)-Tryptophan is found, on average, in the highest concentration within a few different foods, such as red bell peppers, caseins, and dried milks and in a lower concentration in papaya, other bread, and mung beans (±)-Tryptophan has also been detected, but not quantified in, several different foods, such as dumplings, safflowers, sherries, meringues, and kumquats. This could make (±)-tryptophan a potential biomarker for the consumption of these foods.
CAS Number54-12-6
Structure
Thumb
Synonyms
SynonymSource
2-Amino-3-(1H-indol-3-yl)propanoic acidChEBI
alpha-Amino-beta-(3-indolyl)-propionic acidChEBI
alpha-Amino-beta-3-indolepropionic acidChEBI
beta-3-IndolylalanineChEBI
HTRPChEBI
TriptofanoChEBI
TrpChEBI
TryptophaneChEBI
WChEBI
2-Amino-3-(1H-indol-3-yl)propanoateGenerator
a-Amino-b-(3-indolyl)-propionateGenerator
a-Amino-b-(3-indolyl)-propionic acidGenerator
alpha-Amino-beta-(3-indolyl)-propionateGenerator
Α-amino-β-(3-indolyl)-propionateGenerator
Α-amino-β-(3-indolyl)-propionic acidGenerator
a-Amino-b-3-indolepropionateGenerator
a-Amino-b-3-indolepropionic acidGenerator
alpha-Amino-beta-3-indolepropionateGenerator
Α-amino-β-3-indolepropionateGenerator
Α-amino-β-3-indolepropionic acidGenerator
b-3-IndolylalanineGenerator
Β-3-indolylalanineGenerator
(+-)-TryptophanHMDB
(+/-)-2-amino-3-(3-indolyl)propionic acidHMDB
(+/-)-alpha-amino-3-indolepropionic acidHMDB
DL-2-Amino-3-indolepropionic acidHMDB
DL-3beta-IndolylalanineHMDB
DL-alpha-Amino-3-indolepropionic acidHMDB
DL-TryptophanHMDB
Racemic tryptophanHMDB
(+/-)-2-Amino-3-(3-indolyl)propionic acidbiospider
(+/-)-alpha-Amino-3-indolepropionic acidbiospider
DL-α-Amino-3-indolepropionic acidbiospider
Predicted Properties
PropertyValueSource
Water Solubility1.36 g/LALOGPS
logP-1.1ALOGPS
logP-1.1ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)2.54ChemAxon
pKa (Strongest Basic)9.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area79.11 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity56.2 m³·mol⁻¹ChemAxon
Polarizability21.19 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC11H12N2O2
IUPAC name2-amino-3-(1H-indol-3-yl)propanoic acid
InChI IdentifierInChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)
InChI KeyQIVBCDIJIAJPQS-UHFFFAOYSA-N
Isomeric SMILESNC(CC1=CNC2=C1C=CC=C2)C(O)=O
Average Molecular Weight204.2252
Monoisotopic Molecular Weight204.089877638
Classification
Description Belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. Indolyl carboxylic acids and derivatives are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassIndoles and derivatives
Sub ClassIndolyl carboxylic acids and derivatives
Direct ParentIndolyl carboxylic acids and derivatives
Alternative Parents
Substituents
  • Indolyl carboxylic acid derivative
  • Alpha-amino acid
  • Alpha-amino acid or derivatives
  • 3-alkylindole
  • Indole
  • Aralkylamine
  • Benzenoid
  • Substituted pyrrole
  • Heteroaromatic compound
  • Pyrrole
  • Amino acid or derivatives
  • Amino acid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Azacycle
  • Amine
  • Primary aliphatic amine
  • Hydrocarbon derivative
  • Organic oxide
  • Organic oxygen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Organopnictogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 64.69%; H 5.92%; N 13.72%; O 15.67%DFC
Melting PointMp 293°DFC
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logP-1.05HANSCH,C ET AL. (1995)
Experimental pKa7.38
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-001i-2900000000-c6c45a933a953618aa8cSpectrum
GC-MS(±)-Tryptophan, 2 TMS, GC-MS Spectrumsplash10-00lr-1940000000-7d24b93f0df6ee59c1cfSpectrum
GC-MS(±)-Tryptophan, 2 TMS, GC-MS Spectrumsplash10-0udi-0290000000-1a8228e2b523be1ae691Spectrum
GC-MS(±)-Tryptophan, non-derivatized, GC-MS Spectrumsplash10-0udi-0390000000-bf55780347500228fa0aSpectrum
GC-MS(±)-Tryptophan, non-derivatized, GC-MS Spectrumsplash10-0fsi-0930000000-a768dbcdd61c5ddfc7ffSpectrum
Predicted GC-MS(±)-Tryptophan, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-057i-5900000000-19287f7752709aae95d9Spectrum
Predicted GC-MS(±)-Tryptophan, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00e9-9560000000-6829a8b2a2096883999fSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0290000000-177c39ffff7351ae58e7Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-014i-0920000000-31f2bf06783a35cb177eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0zfr-0890000000-70571859405f22f7726dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0uxr-1960000000-4794df4619ca53da8a26Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0zfr-0790000000-71f96432b70be90e3e76Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0a4i-0900000000-678ef44eecd71f98f4bcSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-014i-1910000000-3b90b4510b3064cd8257Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0090000000-30198ffd85182eef6dbbSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0190000000-2319c76338ccc72cea91Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0690000000-2d67e3b24d52541620dfSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0390000000-32f53d15608910742122Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0gb9-1940000000-4d8b6d43d6dc47a0a53cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0090000000-672eea5be46683e01aa3Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0a4i-0900000000-b167000b756e70598ebbSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0290000000-f83d06a826ee6963c139Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0190000000-af6a41a358461c4944d5Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-014i-1930000000-fe537846c01a00076d1bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0uxr-1980000000-bc34bf853c58cd38c9ceSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0udi-0290000000-fff893c43aa27aebf582Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0a4i-0920000000-825129a9df3095f19bd0Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a59-0900000000-142753592a64d1b21225Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-0900000000-4f3eacbba35070501781Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-3490000000-de7027f417d1320c2b85Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00di-9830000000-415cd821aca8befd3e58Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-00xr-9600000000-8e10a14ed0f3f1b8fb23Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
ChemSpider ID1116
ChEMBL IDNot Available
KEGG Compound IDC00806
Pubchem Compound ID1148
Pubchem Substance IDNot Available
ChEBI ID27897
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB30396
CRC / DFC (Dictionary of Food Compounds) IDCHP14-U:CHP45-E
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDTryptophan
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Saxholt, E., et al. 'Danish food composition databank, revision 7.' Department of Nutrition, National Food Institute, Technical University of Denmark (2008).