1.0 2010-04-08 22:05:22 UTC 2025-11-18 22:37:19 UTC FDB002416 Neohesperidin dihydrochalcone Intensely sweet, 612 times more sweet than sucrose. ADI 5 mg/kg (1987). Permitted in EU at low concs. (=10 ppm) for certain applications, e.g. low-alcohol beer. Generally recognised as safe (GRAS) in the USA. Practical use limited by slow development of taste sensation and peculiar aftertaste Neohesperidin dihydrochalcone, sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.; The European Union approved NHDC's use as a sweetener in 1994. It has not been approved as a sweetener in the United States. It is sometimes said that NHDC is considered a Generally Recognized as Safe flavour enhancer by the Flavour and Extract Manufacturers' Association, which is a trade group with no legal standing. NHDC has never appeared on the FDA's GRAS listing. Neohesperidin dihydrochalcone is found in sweet orange. E959 FEMA 3811 Neohesperidin DC Neohesperidin DHC Neohesperidine dihydrochalcone NHDC NHDHC C28H36O15 612.5764 612.205420482 1-(4-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one 1-(4-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one 20702-77-6 COC1=C(O)C=C(CCC(=O)C2=C(O)C=C(OC3OC(CO)C(O)C(O)C3OC3OC(C)C(O)C(O)C3O)C=C2O)C=C1 InChI=1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3 ITVGXXMINPYUHD-UHFFFAOYSA-N belongs to the class of organic compounds known as flavones. These are flavonoids with a structure based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). Flavones Organic compounds Phenylpropanoids and polyketides Flavonoids Flavones Aromatic heteropolycyclic compounds 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids 4'-hydroxyflavonoids 5-hydroxyflavonoids 7-hydroxyflavonoids Benzene and substituted derivatives Chromones Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Organooxygen compounds Oxacyclic compounds Pyranones and derivatives Resorcinols Vinylogous acids 1-benzopyran 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid 4'-hydroxyflavonoid 5-hydroxyflavonoid 7-hydroxyflavonoid Aromatic heteropolycyclic compound Benzenoid Benzopyran Chromone Flavone Heteroaromatic compound Hydrocarbon derivative Hydroxyflavonoid Monocyclic benzene moiety Organic oxide Organic oxygen compound Organoheterocyclic compound Organooxygen compound Oxacycle Phenol Pyran Pyranone Resorcinol Vinylogous acid Flavones and Flavonols logp 0.05 ALOGPS logs -2.48 ALOGPS solubility 2.04e+00 g/l ALOGPS logp 0.75 ChemAxon pka_strongest_acidic 9.56 ChemAxon pka_strongest_basic -3.6 ChemAxon iupac 1-(4-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one ChemAxon average_mass 612.5764 ChemAxon mono_mass 612.205420482 ChemAxon smiles COC1=C(O)C=C(CCC(=O)C2=C(O)C=C(OC3OC(CO)C(O)C(O)C3OC3OC(C)C(O)C(O)C3O)C=C2O)C=C1 ChemAxon formula C28H36O15 ChemAxon inchi InChI=1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3 ChemAxon inchikey ITVGXXMINPYUHD-UHFFFAOYSA-N ChemAxon polar_surface_area 245.29 ChemAxon refractivity 143.18 ChemAxon polarizability 61.16 ChemAxon rotatable_bond_count 10 ChemAxon acceptor_count 15 ChemAxon donor_count 9 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 21223 Specdb::CMs 41982 Specdb::CMs 527983 Specdb::CMs 527984 Specdb::CMs 527985 Specdb::CMs 527986 Specdb::CMs 527987 Specdb::CMs 527988 Specdb::CMs 527989 Specdb::CMs 527990 Specdb::CMs 527991 Specdb::CMs 527992 Specdb::CMs 527993 Specdb::CMs 527994 Specdb::CMs 527995 Specdb::CMs 527996 Specdb::CMs 527997 Specdb::CMs 527998 Specdb::CMs 527999 Specdb::CMs 528000 Specdb::CMs 528001 Specdb::CMs 528002 Specdb::CMs 528003 Specdb::CMs 528004 Specdb::CMs 528005 Specdb::MsMs 313225 Specdb::MsMs 313226 Specdb::MsMs 313227 Specdb::MsMs 358669 Specdb::MsMs 358670 Specdb::MsMs 358671 Specdb::MsMs 440362 Specdb::MsMs 440363 Specdb::MsMs 440364 Specdb::MsMs 2229752 Specdb::MsMs 2232033 Specdb::MsMs 2232181 Specdb::MsMs 2234576 Specdb::MsMs 2236270 Specdb::MsMs 2237097 Specdb::MsMs 2238364 Specdb::MsMs 2239232 Specdb::MsMs 2240348 Specdb::MsMs 2241336 Specdb::MsMs 2242481 Specdb::MsMs 2243394 Specdb::MsMs 2251620 Specdb::MsMs 2777291 Specdb::MsMs 2777292 Specdb::MsMs 2777293 HMDB30542 #<Reference:0x000055ce33044438> Sweet orange Type 1 specific Citrus sinensis 2711 bland Sweetener 1341 Substance that sweeten food, beverages, medications, etc.