Showing Compound gamma-Tocopherol (FDB002431)

Record Information

Version

1.0

Creation date

2010-04-08 22:05:22 UTC

Update date

2019-11-26 02:57:26 UTC

Primary ID

FDB002431

Secondary Accession Numbers

FDB010395

Chemical Information

FooDB Name

gamma-Tocopherol

Description

Occurs in many nut and other vegetable oils such as soya and sunflower oil. It is used as antioxidant food additive. Member of Vitamin E group. Added to fats and oils to prevent rancidity. The naturally occurring tocopherol is a single steroisomer; synthetic forms are a mixture of all eight possible isomers [DFC] gamma-Tocopherol is one of the chemical compounds that is considered vitamin E. As a food additive, it has E number E308. [Wikipedia]. gamma-Tocopherol is found in many foods, some of which are common pea, shiitake, feijoa, and other bread.

CAS Number

1406-66-2

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
DL-alpha-Tocopherol	Kegg
DL-a-Tocopherol	Generator
DL-Α-tocopherol	Generator
g-Tocopherol	Generator
Γ-tocopherol	Generator
3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol	HMDB
7,8-Dimethyltocol	HMDB
7,8-Dimethyltocolo-xylotocopherol	HMDB
Methyltocols	HMDB
O-Xylotocopherol	HMDB
Tocopherol	HMDB
Tocopherols	HMDB
Vitamin e gamma	HMDB
Bioweyxin	HMDB
e-Mulsin	HMDB
Embial	HMDB
GNR-Pharma brand OF tocopherol actetate	HMDB
Organon brand OF tocopherol acetate	HMDB
Schwarzhaupt brand OF tocopherol acetate	HMDB
Snow-e muscle, energy and feritility	HMDB
Spondyvit	HMDB
Tocolion	HMDB
Tocopherol rodisma-med brand	HMDB
Tocopherol worwag brand	HMDB
Togasan vitamin e	HMDB
Unique e	HMDB
Vibolex	HMDB
Vita-e	HMDB
Vitamin e dragees	HMDB
Atarost brand OF tocopherol acetate	HMDB
Biocur brand OF tocopherol acetate	HMDB
Cambridge laboratories brand OF tocopherol actetate	HMDB
Dal e	HMDB
Detulin	HMDB
e Vitamin e	HMDB
EVI-mirale, vitamin-e	HMDB
Elex verla	HMDB
Eplonat	HMDB
Richelet brand OF tocopherol acetate	HMDB
Roche nicholas brand OF tocopherol acetate	HMDB
Rodisma med brand OF tocopherol	HMDB
Sciencex brand OF tocopherol acetate	HMDB
Steigerwald brand OF tocopherol acetate	HMDB
Strathmann brand OF tocopherol	HMDB
Tocopherol grunwalder brand	HMDB
Tocopherol stadapharm brand	HMDB
Verla brand OF tocopherol	HMDB
Vit. e stada	HMDB
VitaPlus e	HMDB
Vitamin-e evi-mirale	HMDB
Vitamine e GNR	HMDB
Vitazell	HMDB
Worwag brand OF tocopherol	HMDB
Alcala brand OF tocopherol acetate	HMDB
Bio e	HMDB
Biopto-e	HMDB
e Vicotrat	HMDB
e-Ferol	HMDB
EUNOVA vitamin e	HMDB
Equivit e	HMDB
Evion	HMDB
Internation animal health brand OF tocopherol acetate	HMDB
MIP brand OF tocopherol acetate	HMDB
Sanum-kehlbeck brand OF tocopherol actetate	HMDB
Tocopherol infirmarius-rovit brand	HMDB
Tocopherol twardy brand	HMDB
Tocovital	HMDB
Vitamin-e dragees	HMDB
Wiedemann brand OF tocopherol	HMDB
Abortosan	HMDB
Arkopharma brand OF tocopherol acetate	HMDB
Dal vita brand OF vitamin e succinate	HMDB
Eu rho brand OF tocopherol	HMDB
Eusovit	HMDB
Infirmarius-rovit brand OF tocopherol	HMDB
Richtavit e	HMDB
Riemser brand OF tocopherol	HMDB
Tocopherol ausrichter brand	HMDB
Tocopherol balkanpharma brand	HMDB
Vitagutt vitamin e	HMDB
Vitamin e natur	HMDB
Vitamin e, togasan	HMDB
Ratiopharm brand OF tocopherol	HMDB
Aliud brand OF tocopherol	HMDB
Bottger brand OF tocopherol acetate	HMDB
Dermorelle	HMDB
e Ferol	HMDB
e-Vitamin-ratiopharm	HMDB
Heyl brand OF tocopherol acetate	HMDB
Kohler brand OF tocopherol	HMDB
Lasar	HMDB
Puncto e	HMDB
Rodisma-med brand OF tocopherol	HMDB
Sanum kehlbeck brand OF tocopherol actetate	HMDB
Scot tussin brand OF tocopherol acetate	HMDB
Stadapharm brand OF tocopherol	HMDB
Tocopa	HMDB
Tocopherol bayer	HMDB
Tocopherol grace brand	HMDB
Tocopherol ratiopharm brand	HMDB
Twardy brand OF tocopherol	HMDB
Uno vit	HMDB
Uno-vit	HMDB
Veyx brand OF tocopherol	HMDB
Vit e hydrosol	HMDB
Vita e	HMDB
Vitamin e al	HMDB
Wiedemann brand OF vitamin e succinate	HMDB
Ausrichter brand OF tocopherol	HMDB
Auxina e	HMDB
Balkanpharma brand OF tocopherol	HMDB
Blackmores brand OF tocopherol	HMDB
Dal-e	HMDB
Davitamon	HMDB
e-Vicotrat	HMDB
Ecoro	HMDB
Ephynal	HMDB
Grunwalder brand OF tocopherol	HMDB
ICN brand OF tocopherol acetate	HMDB
Mucos brand OF tocopherol acetate	HMDB
Tocopherol togal brand	HMDB
Tocopherol verla brand	HMDB
Togal brand OF tocopherol	HMDB
Troyapharm brand OF tocopherol acetate	HMDB
Vita-plus e	HMDB
Vitamin e sanum	HMDB
Vitamin e MP	HMDB
Vitamin emp	HMDB
Woelm brand OF tocopherol acetate	HMDB
Bayer brand OF tocopherol acetate	HMDB
GNR Pharma brand OF tocopherol actetate	HMDB
Grace brand OF tocopherol	HMDB
Malton e	HMDB
Merck brand OF tocopherol acetate	HMDB
Mowivit vitamin e	HMDB
Tocopherol wiedemann brand	HMDB
UnoVit	HMDB
Vitamin e evi mirale	HMDB
Vitamin e suspension	HMDB
Vitamin e, mowivit	HMDB
Vitamin e, vitagutt	HMDB
Vitamin e-MP	HMDB
Adisseo brand OF tocopherol	HMDB
Antioxidans e-hevert	HMDB
Aquasol e	HMDB
AstraZeneca brand OF tocopherol acetate	HMDB
Biosan	HMDB
Dal-vita brand OF vitamin e succinate	HMDB
Dragees, vitamin-e	HMDB
e Mulsin	HMDB
Hervert brand OF tocopherol acetate	HMDB
Hydrovit e	HMDB
Infirmarius rovit brand OF tocopherol	HMDB
Jenapharm brand OF tocopherol	HMDB
Kentucky brand OF tocopherol	HMDB
Micorvit e	HMDB
Sanavitan S	HMDB
Scot-tussin brand OF tocopherol acetate	HMDB
Tocopharm	HMDB
Tocopherol kentucky brand	HMDB
Vita plus e	HMDB
VitaE	HMDB
Medphano brand OF tocopherol acetate	HMDB
VitaminE evimirale	HMDB
2,7,8-Trimethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol	biospider
3,4-dihydro-2,7,8-Trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol	HMDB
3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol, 9CI	db_source
6-Chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-	biospider
D-gamma-tocopherol	biospider
DL-α-tocopherol	Generator
E308	db_source
Gama-tocopherol	biospider
Gamma-tocopherol	biospider
O-xylotocopherol	biospider

Predicted Properties

Property	Value	Source
Water Solubility	7.4e-06 g/L	ALOGPS
logP	8.81	ALOGPS
logP	9.99	ChemAxon
logS	-7.8	ALOGPS
pKa (Strongest Acidic)	10.47	ChemAxon
pKa (Strongest Basic)	-4.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	29.46 Å²	ChemAxon
Rotatable Bond Count	12	ChemAxon
Refractivity	130.33 m³·mol⁻¹	ChemAxon
Polarizability	54.13 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Chemical Formula

C28H48O2

IUPAC name

2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol

InChI Identifier

InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3

InChI Key

QUEDXNHFTDJVIY-UHFFFAOYSA-N

Isomeric SMILES

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=CC(O)=C(C)C(C)=C2O1

Average Molecular Weight

416.6795

Monoisotopic Molecular Weight

416.36543078

Classification

Description

Belongs to the class of organic compounds known as tocopherols. These are vitamin E derivatives containing a saturated trimethyltridecyl chain attached to the carbon C6 atom of a benzopyran ring system. The differ from tocotrienols that contain an unsaturated trimethyltrideca-3,7,11-trien-1-yl chain.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Quinone and hydroquinone lipids

Direct Parent

Tocopherols

Alternative Parents

Substituents

Tocopherol
Diterpenoid
1-benzopyran
Benzopyran
Chromane
1-hydroxy-2-unsubstituted benzenoid
Alkyl aryl ether
Benzenoid
Oxacycle
Organoheterocyclic compound
Ether
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

vitamin E (GAMA-TOCOPHEROL )

Ontology

Physiological effect

Health effect:

Health condition:

Schizophrenia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Biological:

Animal

Plant:

Biological location:

Process

Naturally occurring process:

Biological process:

Biochemical process:

Chemical reaction:

Lipid peroxidation

Cellular process:

Cell signaling

Biochemical pathway:

Role

Industrial application:

Biological role:

Physico-Chemical Properties - Experimental

Property	Value	Reference
Physical state	Solid
Physical Description	Not Available
Mass Composition	C 80.71%; H 11.61%; O 7.68%	DFC
Melting Point	Mp -3°	DFC
Boiling Point	Not Available
Experimental Water Solubility	Not Available
Experimental logP	Not Available
Experimental pKa	Not Available
Isoelectric point	Not Available
Charge	Not Available
Optical Rotation	[a]25Hg546 -2.4 (C6H6)	DFC
Spectroscopic UV Data	Not Available
Density	Not Available
Refractive Index	Not Available

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	gamma-Tocopherol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0lyo-7964200000-f0d5087bb29d80c38248	Spectrum
Predicted GC-MS	gamma-Tocopherol, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00di-5644900000-85c7bfa3df1a86febfeb	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-1842900000-c0a3ade1f225f3c78ac2	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-1910000000-db436d443f9dc640b979	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0pb9-5930000000-1cbe4445929c9b90be47	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-014i-0110900000-23d01b80a965180b27d9	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-014j-0931800000-70e6ff42d0190b91ef52	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0002-0932000000-e16b76b24d1cd56f30b1	2016-08-03	View Spectrum

NMR

Not Available

External Links

ChemSpider ID

14266

ChEMBL ID

CHEMBL420898

KEGG Compound ID

Not Available

Pubchem Compound ID

14986

Pubchem Substance ID

Not Available

ChEBI ID

Not Available

Phenol-Explorer ID

Not Available

DrugBank ID

Not Available

HMDB ID

HMDB01492

CRC / DFC (Dictionary of Food Compounds) ID

CLT22-R:CLT22-R

EAFUS ID

Not Available

Dr. Duke ID

GAMMA-TOCOPHEROL

BIGG ID

2296479

KNApSAcK ID

C00007365

HET ID

Not Available

Food Biomarker Ontology

Not Available

VMH ID

Not Available

Flavornet ID

Not Available

GoodScent ID

Not Available

SuperScent ID

Not Available

Wikipedia ID

Gamma-Tocopherol

Phenol-Explorer Metabolite ID

Not Available

Duplicate IDS

Not Available

Old DFC IDS

Not Available

Associated Foods

Food	Content Range	Average	Reference
Food			Reference

Biological Effects and Interactions

Health Effects / Bioactivities

Descriptor	ID	Definition	Reference
anti atherosclerotic	38070	A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.	DUKE
anti cancer	35610	A substance that inhibits or prevents the proliferation of neoplasms.	DUKE
anti C-reactive-protein			DUKE
anti inflammatory	35472	A substance that reduces or suppresses inflammation.	DUKE
antioxidant	22586	A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324.	DUKE
anti prostaglandin	49020	A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.	DUKE
antitumor	35610	A substance that inhibits or prevents the proliferation of neoplasms.	DUKE
cardioprotective	38070	A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.	DUKE
cyclooxygenase inhibitor	35544	A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.	DUKE
hypocholesterolemic			DUKE
natriuretic			DUKE
nitric-oxide inhibitor	35222	A substance that diminishes the rate of a chemical reaction.	DUKE
protein kinase C inhibitor	37700	An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).	DUKE