Showing Compound Dillapiol (FDB002649)

Record Information

Version

1.0

Creation date

2010-04-08 22:05:28 UTC

Update date

2019-11-26 02:57:45 UTC

Primary ID

FDB002649

Secondary Accession Numbers

Not Available

Chemical Information

FooDB Name

Dillapiol

Description

Dillapiol belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms. Dillapiol is a spice and wood tasting compound. Dillapiol is found, on average, in the highest concentration within dills (Anethum graveolens) and cumins (Cuminum cyminum). Dillapiol has also been detected, but not quantified in, several different foods, such as corianders (Coriandrum sativum), fennels (Foeniculum vulgare), herbs and spices, and parsleys (Petroselinum crispum). This could make dillapiol a potential biomarker for the consumption of these foods. Based on a literature review very few articles have been published on Dillapiol.

CAS Number

484-31-1

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Synonym	Source
5-Allyl 6,7-dimethoxy 1,3-benzodioxole	MeSH
1-Allyl-2,3-dimethoxy-4,5-(methylenedioxy)benzene	MeSH
2-Methyl-5-(1-methylethenyl)-1,3-benzodioxole	MeSH
1,3-Benzodioxole, 4,5-dimethoxy-6-(2-propenyl)- (9ci)	HMDB
1-Allyl-2,3-dimethoxy-4,5-(methylenedioxy)-benzene	HMDB
1-Allyl-2,3-dimethoxy-4,5-methylenedioxybenzene	HMDB
4,5-Dimethoxy-6-(2-propenyl)-1,3-benzodioxole	HMDB
4,5-Dimethoxy-6-(2-propenyl)-1,3-benzodioxole, 9ci	HMDB
6-Allyl-4,5-dimethoxy-1,3-benzodioxole	HMDB
Apiole (dill)	HMDB
Dill apiol	HMDB
Dill apiole	HMDB
Dillapiole	HMDB
Dillapiol	KEGG
1,3-Benzodioxole, 4,5-dimethoxy-6-(2-propenyl)-	biospider
1,3-Benzodioxole, 4,5-dimethoxy-6-(2-propenyl)- (9CI)	biospider
4,5-Dimethoxy-6-(2-propenyl)-1,3-benzodioxole, 9CI	db_source
Benzene, 1-allyl-2,3-dimethoxy-4,5-(methylenedioxy)-	biospider

Predicted Properties

Property	Value	Source
Water Solubility	0.65 g/L	ALOGPS
logP	2.33	ALOGPS
logP	2.38	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Basic)	-4.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	36.92 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	59.04 m³·mol⁻¹	ChemAxon
Polarizability	22.94 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Chemical Formula

C12H14O4

IUPAC name

4,5-dimethoxy-6-(prop-2-en-1-yl)-2H-1,3-benzodioxole

InChI Identifier

InChI=1S/C12H14O4/c1-4-5-8-6-9-11(16-7-15-9)12(14-3)10(8)13-2/h4,6H,1,5,7H2,2-3H3

InChI Key

LIKYNOPXHGPMIH-UHFFFAOYSA-N

Isomeric SMILES

COC1=C(OC)C(CC=C)=CC2=C1OCO2

Average Molecular Weight

222.2372

Monoisotopic Molecular Weight

222.089208936

Classification

Description

Belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzodioxoles

Sub Class

Not Available

Direct Parent

Benzodioxoles

Alternative Parents

Substituents

Benzodioxole
Anisole
Alkyl aryl ether
Benzenoid
Oxacycle
Ether
Acetal
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

benzodioxoles (CHEBI:70453 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Biological:

Plant

Biological location:

Subcellular:

Cytoplasm

Cell and elements:

Extracellular

Physico-Chemical Properties

Physico-Chemical Properties - Experimental

Property	Value	Reference
Physical state	Not Available
Physical Description	Not Available
Mass Composition	C 64.85%; H 6.35%; O 28.80%	DFC
Melting Point	Mp 29.5°	DFC
Boiling Point	Bp0.8 100°	DFC
Experimental Water Solubility	Not Available
Experimental logP	Not Available
Experimental pKa	Not Available
Isoelectric point	Not Available
Charge	Not Available
Optical Rotation	Not Available
Spectroscopic UV Data	Not Available
Density	Not Available
Refractive Index	n25D 1.5278	DFC

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-00di-9660000000-7cd909d21ca4a4c8bb1e	2015-03-01	View Spectrum
Predicted GC-MS	Dillapiol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-052f-1930000000-759fd9f5828da82064eb	Spectrum
Predicted GC-MS	Dillapiol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-0190000000-65afe20a9d6ea8212ae4	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00dl-2490000000-a585b5b3566814b251fc	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03g3-6900000000-e4d0d60144cac96a91bb	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-0090000000-a993c42f8477ed292846	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00di-0690000000-969d0f40c3543ae56108	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0040-7900000000-72a37bef985f024191df	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-0090000000-434847f7ec0085e24b80	2021-09-21	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00di-0390000000-7be09d177fcf76fa1e71	2021-09-21	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0ldi-9520000000-f36f591d0e5c5b2747dd	2021-09-21	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-0090000000-e696c56af8179794e7ad	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00di-0970000000-d9ab44e0dc7f91b8576e	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-03fr-9700000000-dc4990fb9e6601280905	2021-09-25	View Spectrum

NMR

Type	Description		View

External Links

ChemSpider ID

ChEMBL ID

KEGG Compound ID

Pubchem Compound ID

Pubchem Substance ID

Not Available

ChEBI ID

Not Available

Phenol-Explorer ID

Not Available

DrugBank ID

Not Available

HMDB ID

HMDB30725

CRC / DFC (Dictionary of Food Compounds) ID

CMX09-T:CMX09-T

EAFUS ID

Not Available

Dr. Duke ID

DILLAPIOLE|DILLAPIOL

BIGG ID

Not Available

KNApSAcK ID

C00002737

HET ID

Not Available

Food Biomarker Ontology

Not Available

VMH ID

Not Available

Flavornet ID

484-31-1

GoodScent ID

Not Available

SuperScent ID

Not Available

Wikipedia ID

Dillapiol

Phenol-Explorer Metabolite ID

Not Available

Duplicate IDS

Not Available

Old DFC IDS

Not Available

Associated Foods

Food	Content Range	Average	Reference
Food			Reference

Biological Effects and Interactions

Health Effects / Bioactivities

Descriptor	ID	Definition	Reference
Anti bacterial	33282	An agent that inhibits the growth of or destroys bacteria, playing a crucial role in preventing and treating infections. Therapeutically, it is used to combat bacterial infections, with key medical applications including treating pneumonia, tuberculosis, and skin infections, as well as preventing surgical site infections and sepsis.	DUKE
Insecticide	24852	An agent that kills or repels insects, used to control pests and prevent disease transmission. Therapeutically, insecticides have applications in public health and veterinary medicine, key medical uses include controlling insect-borne diseases such as malaria, typhus, and Lyme disease.	DUKE
Molluscicide	33904	An agent that kills mollusks, particularly snails and slugs, playing a key role in controlling vectors of parasitic diseases. Therapeutically, it is used to prevent the spread of schistosomiasis and other snail-borne diseases, with medical applications in public health and epidemiology.	DUKE
Pesticide	25944	An agent that kills or repels pests, playing a biological role in controlling insect, weed, and fungal populations. Therapeutically, pesticides have limited applications, but some are used to treat ectoparasitic infestations, such as lice and scabies. Key medical uses include topical treatments for head lice and scabies, highlighting their role in managing parasitic infections.	DUKE
Sedative	35717	An agent that calms nervous activity, reducing anxiety and inducing relaxation. Its biological role is to slow down brain function, promoting sleep and relieving stress. Therapeutically, sedatives are used to manage insomnia, anxiety disorders, and seizures, as well as to prepare patients for medical procedures.	DUKE

Enzymes

Not Available

Pathways

Not Available

Metabolism

Not Available

Biosynthesis

Not Available

Organoleptic Properties

Flavours

Flavor	Citations
wood	Arn, H, Acree TE. “Flavornet: A database of aroma compounds based on odor potency in natural products”. Developments in Food Science 40 (1998): 27. doi:10.1016/S0167-4501(98)80029-0
spice	Arn, H, Acree TE. “Flavornet: A database of aroma compounds based on odor potency in natural products”. Developments in Food Science 40 (1998): 27. doi:10.1016/S0167-4501(98)80029-0

Files

MSDS

Not Available

References

Synthesis Reference

Not Available

General Reference

Not Available

Content Reference

— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.