Record Information
Version1.0
Creation date2010-04-08 22:05:29 UTC
Update date2019-11-26 02:57:51 UTC
Primary IDFDB002711
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameHyperin
DescriptionQuercetin 3-galactoside, also known as hyperin or hyperoside, belongs to the class of organic compounds known as flavonoid-3-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C3-position. Quercetin 3-galactoside is found, on average, in the highest concentration within a few different foods, such as common walnuts (Juglans regia), black chokeberries (Photinia melanocarpa), and sorrels (Rumex acetosa) and in a lower concentration in red raspberries (Rubus idaeus), summer grapes (Vitis aestivalis), and almonds (Prunus dulcis). Quercetin 3-galactoside has also been detected, but not quantified in, several different foods, such as pepper (spice), red tea, loquats (Eriobotrya japonica), common buckwheats (Fagopyrum esculentum), and herbs and spices. This could make quercetin 3-galactoside a potential biomarker for the consumption of these foods. Based on a literature review a significant number of articles have been published on Quercetin 3-galactoside.
CAS Number482-36-0
Structure
Thumb
Synonyms
SynonymSource
2-(3,4-Dihydroxyphenyl)-3-(beta-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-oneChEBI
HyperinChEBI
HyperosideChEBI
Quercetin 3-O-galactosideChEBI
2-(3,4-Dihydroxyphenyl)-3-(b-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-oneGenerator
2-(3,4-Dihydroxyphenyl)-3-(β-D-galactopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-oneGenerator
Quercetin galactosideMeSH
Quercetin-3-O-galactosideMeSH
3-O-b-D-Galactopyranosyloxy-3',4',5,7-tetrahydroxyflavoneHMDB
HyperozideHMDB
JyperinHMDB
Quercetin 3-beta-D-galactopyranosideHMDB
Quercetin 3-D-galactosideHMDB
Quercetin 3-O-beta-D-galactopyranosideHMDB
Quercetin 3-O-beta-D-galactosideHMDB
Quercetin 3-galactosideChEBI
Quercetin 3-O-b-D-galactopyranosideGenerator
Quercetin 3-O-β-D-galactopyranosideGenerator
3,3',4',5,7-Pentahydroxyflavone 3-O-beta-D-galactopyranosidePhytoBank
3,3',4',5,7-Pentahydroxyflavone 3-O-β-D-galactopyranosidePhytoBank
3,3’,4’,5,7-Pentahydroxyflavone 3-O-β-D-galactopyranosidePhytoBank
3-D-GalactosylquercetinPhytoBank
3-O-beta-D-Galactopyranosyl quercetinPhytoBank
3-O-β-D-Galactopyranosyl quercetinPhytoBank
3-O-beta-D-GalactopyranosylquercetinPhytoBank
3-O-β-D-GalactopyranosylquercetinPhytoBank
HyperosidPhytoBank
Quercetin 3-O-galactopyranosidePhytoBank
Quercetin 3-O-β-D-galactosidePhytoBank
Quercetin 3-O-beta-galactopyranosidePhytoBank
Quercetin 3-O-β-galactopyranosidePhytoBank
Quercetin 3-O-beta-galactosidePhytoBank
Quercetin 3-O-β-galactosidePhytoBank
Quercetin 3-beta-D-galactosidePhytoBank
Quercetin 3-β-D-galactosidePhytoBank
Quercetin 3-beta-galactosidePhytoBank
Quercetin 3-β-galactosidePhytoBank
Quercetin 3-O-β-D-galactopyranosidebiospider
Predicted Properties
PropertyValueSource
Water Solubility1.95 g/LALOGPS
logP0.47ALOGPS
logP-0.14ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)6.37ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count8ChemAxon
Polar Surface Area206.6 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity109.28 m³·mol⁻¹ChemAxon
Polarizability43.37 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC21H20O12
IUPAC name2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one
InChI IdentifierInChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1
InChI KeyOVSQVDMCBVZWGM-DTGCRPNFSA-N
Isomeric SMILESOC[C@H]1O[C@@H](OC2=C(OC3=C(C(O)=CC(O)=C3)C2=O)C2=CC(O)=C(O)C=C2)[C@H](O)[C@@H](O)[C@H]1O
Average Molecular Weight464.3763
Monoisotopic Molecular Weight464.095476104
Classification
Description Belongs to the class of organic compounds known as flavonoid-3-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C3-position.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassFlavonoids
Sub ClassFlavonoid glycosides
Direct ParentFlavonoid-3-O-glycosides
Alternative Parents
Substituents
  • Flavonoid-3-o-glycoside
  • Hydroxyflavonoid
  • 3'-hydroxyflavonoid
  • 4'-hydroxyflavonoid
  • 5-hydroxyflavonoid
  • 7-hydroxyflavonoid
  • Flavone
  • Hexose monosaccharide
  • Chromone
  • Glycosyl compound
  • O-glycosyl compound
  • Benzopyran
  • 1-benzopyran
  • Catechol
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Pyranone
  • 1-hydroxy-4-unsubstituted benzenoid
  • Monocyclic benzene moiety
  • Benzenoid
  • Pyran
  • Monosaccharide
  • Oxane
  • Vinylogous acid
  • Heteroaromatic compound
  • Secondary alcohol
  • Organoheterocyclic compound
  • Oxacycle
  • Polyol
  • Acetal
  • Hydrocarbon derivative
  • Organic oxide
  • Organic oxygen compound
  • Alcohol
  • Primary alcohol
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 54.32%; H 4.34%; O 41.34%DFC
Melting PointMp 232-233° dec.DFC
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical Rotation[a]20D -83 (c, 0.2 in Py)DFC
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSHyperin, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0uea-8903800000-499ac85a438f6221151eSpectrum
Predicted GC-MSHyperin, 3 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-014r-3620009000-aa92fb234d45c04fb4a1Spectrum
Predicted GC-MSHyperin, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-03di-0000900000-d60d8b7b555f72b770e8Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-03di-0001900000-f2659f2ecc8cfe825e94Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0udi-0009200000-fb8341fdb16a9e23a75eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0udi-0019000000-1a226fba24f56b619964Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0uk9-0097000000-5067646f23e49b711552Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0w29-0179700000-5040715c1b88dc41ba6aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-03di-0003900002-b3b20b949d3387148921Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0udi-0059000000-901297fb44ccb903acfaSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-03di-0000900000-84736db1d76deb6da60cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0w29-0179400000-aa2a652149ab343a1341Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0w29-0189500000-7ff049ba7cc9caedea63Spectrum
MS/MSLC-MS/MS Spectrum - , negativesplash10-0udi-0139300000-b99c9ec27bda7ca0248aSpectrum
MS/MSLC-MS/MS Spectrum - 40V, Negativesplash10-0udi-0019000000-6c4a0f0151f89b993af7Spectrum
MS/MSLC-MS/MS Spectrum - 50V, Negativesplash10-0uk9-0096000000-2a8faa231ffe4833d3e5Spectrum
MS/MSLC-MS/MS Spectrum - 30V, Negativesplash10-0udi-0009200000-abf468a3d736431e673cSpectrum
MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-03di-0001900000-a884073b5df03fc34d44Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-03di-0000900000-04fd0a90f823358ed680Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-03di-0003900000-4db0525ae401808d7debSpectrum
MS/MSLC-MS/MS Spectrum - 50V, Negativesplash10-0uk9-0097000000-5067646f23e49b711552Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-0udi-0009200000-c91c4c55166de049afb9Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Negativesplash10-0uk9-0194000000-552918a6ca743829d9c0Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Negativesplash10-0udi-0019000000-1a226fba24f56b619964Spectrum
MS/MSLC-MS/MS Spectrum - 30V, Negativesplash10-0udi-0009200000-fb8341fdb16a9e23a75eSpectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-03di-0000900000-d60d8b7b555f72b770e8Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-03di-0001900000-f2659f2ecc8cfe825e94Spectrum
NMRNot Available
ChemSpider ID4444962
ChEMBL IDCHEMBL251254
KEGG Compound IDC10073
Pubchem Compound ID5281643
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer ID292
DrugBank IDNot Available
HMDB IDHMDB30775
CRC / DFC (Dictionary of Food Compounds) IDCNF10-I:CNF10-I
EAFUS IDNot Available
Dr. Duke IDHYPERIN|HYPEROSIDE|QUERCETIN-3-O-GALACTOSIDE|3-O-(BETA-D-GALACTOPYRANOSYL)-QUERCETIN
BIGG IDNot Available
KNApSAcK IDC00005372
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDHyperoside
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / Bioactivities
DescriptorIDDefinitionReference
aldose reductase inhibitor48550 An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).DUKE
analgesic35480 An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.DUKE
anti aging52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
anti bacterial33282 A substance that kills or slows the growth of bacteria.DUKE
anti cancer35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
anti capillary-fragilityDUKE
anti dermatitic50177 A drug used to treat or prevent skin disorders or for the routine care of skin.DUKE
anti elastase23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
anti flu22587 A substance that destroys or inhibits replication of viruses.DUKE
anti hepatotoxic62868 Any compound that is able to prevent damage to the liver.DUKE
anti inflammatory35472 A substance that reduces or suppresses inflammation.DUKE
anti ischemic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
anti nociceptive35470 A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.DUKE
antioxidant22586 A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324.DUKE
anti radicularDUKE
anti tussive52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
anti viral22587 A substance that destroys or inhibits replication of viruses.DUKE
anti wrinkleDUKE
calcium antagonist48706 Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.DUKE
cAMP inhibitor35222 A substance that diminishes the rate of a chemical reaction.DUKE
cancer preventive35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
capillarifortificantDUKE
capillarigenicDUKE
cyclooxygenase activatorDUKE
diuretic35498 An agent that promotes the excretion of urine through its effects on kidney function.DUKE
hepatoprotective62868 Any compound that is able to prevent damage to the liver.DUKE
hypotensiveDUKE
pesticide25944 Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.DUKE
tissue thromboplastin inhibitor50427 A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.DUKE
xanthine oxidase inhibitor35634 An EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor that interferes with the action of xanthine oxidase (EC 1.17.3.2).DUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070.
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.