| Description | A minor component of many animal lipids
Although GLA is an n?6 fatty acid, a type of acid which is generally pro-inflammatory, it has anti-inflammatory properties. (See discussion at Essential fatty acid interactions: The paradox of dietary GLA.); An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed) -- Pubchem; From GLA, the body forms dihomo-?-linolenic acid (DGLA). This is one of the body's three sources of eicosanoids (along with AA and EPA.) DGLA is the precursor of the prostaglandin PGH1, which in turn forms PGE1 and the thromboxane TXA1. PGE1 has a role in regulation of immune system function and is used as the medicine alprostadil. TXA1 modulates the pro-inflammatory properties of the thromboxane TXA2.; GLA is categorized as an n?6 (also called ??6 or omega-6) fatty acid, meaning that the first double bond on the methyl end (designated with n or ?) is the sixth bond. In physiological literature, GLA is designated as 18:3 (n?6). Chemically, GLA is a carboxylic acid with an 18-carbon chain and three cis double bonds. It is an isomer of ?-linolenic acid, which is the n?3 fatty acid found in flax seed.; The human body produces GLA from linoleic acid (LA). This reaction is catalyzed by ?6-desaturase (D6D), an enzyme which allows the creation of a double bond on the sixth carbon counting from the carboxyl terminus. LA is consumed sufficiently in most diets, from such abundant sources as cooking oils and meats. However, a lack of GLA can occur when there is a reduction of the efficiency of the D6D conversion (for instance, as people grow older or when there are specific dietary deficiencies) or in disease states where there is excessive consumption of GLA metabolites.; ?-Linolenic acid (gamma-linolenic acid or GLA, sometimes called gamoleic acid) is a fatty acid found primarily in vegetable oils. It is sold as a dietary supplement for treating problems with inflammation and auto-immune diseases. The efficacy of such use is disputed. |
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| Synonyms | | Synonym | Source |
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| Gamolenate | Generator | | (6,9,12)-linolenate | biospider | | (6,9,12)-linolenic acid | biospider | | (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid | biospider | | (6Z,9Z,12Z)-Octadecatrienoate | biospider | | (6Z,9Z,12Z)-Octadecatrienoic acid | biospider | | (Z,Z,Z)-6,9,12-Octadecatrienoate | biospider | | (Z,Z,Z)-6,9,12-Octadecatrienoic acid | biospider | | «gamma»-linolenic acid | biospider | | 18:3 (N-6) | ChEBI | | 6-cis,9-cis,12-cis-Octadecatrienoate | Generator | | 6-cis,9-cis,12-cis-Octadecatrienoic acid | biospider | | 6,9,12-all-cis-Octadecatrienoate | biospider | | 6,9,12-all-cis-Octadecatrienoic acid | biospider | | 6,9,12-Octadecatrienoate | biospider | | 6,9,12-Octadecatrienoic acid | biospider | | 6,9,12-Octadecatrienoic acid, (6Z,9Z,12Z)- | biospider | | 6,9,12-Octadecatrienoic acid, (Z,Z,Z)- | biospider | | 6(Z),9(Z),12(Z)-Octadecatrienoate | biospider | | 6(Z),9(Z),12(Z)-Octadecatrienoic acid | biospider | | 6Z,9Z,12Z-octadecatrienoate | biospider | | 6Z,9Z,12Z-octadecatrienoic acid | biospider | | Acido gamolenico | biospider | | Acidum gamolenicum | biospider | | all-cis-6,9,12-octadecatrienoate | biospider | | all-cis-6,9,12-octadecatrienoic acid | biospider | | C18:3 (N-6) | ChEBI | | C18:3, N-6,9,12 all-cis | ChEBI | | cis-6, cis-9, cis-12-octadecatrienoic acid | biospider | | cis-6,cis-9,cis-12-Octadecatrienoic acid | biospider | | cis-Delta(6,9,12)-octadecatrienoate | biospider | | cis-Delta(6,9,12)-octadecatrienoic acid | biospider | | cis-δ(6,9,12)-octadecatrienoate | Generator | | cis-δ(6,9,12)-octadecatrienoic acid | Generator | | cis,cis,cis-6,9,12-Octadecatrienoic acid | biospider | | Efamast | biospider | | Efemast | db_source | | Efomase | db_source | | Epogam | db_source | | g-Linolenate | Generator | | g-Linolenic acid | db_source | | g-Linolensaeure | Generator | | Gamma-linolenate | biospider | | Gamma-linolenic acid | biospider | | gamma-Linolensaeure | ChEBI | | Gamma-llnolenic acid | biospider | | Gammalinolenic acid | db_source | | Gammolin | db_source | | Gamoleate | Generator | | Gamoleic acid | ChEBI | | Gamolenic acid | biospider | | Gamolenic acid (inn) | biospider | | Gamolenic acid [inn:ban] | biospider | | Gamolenic acid, BAN, INN | db_source | | GLA | db_source | | Ligla | biospider | | Octadeca-6,9,12-triensaeure | ChEBI | | Unigam | db_source | | Viacutan | biospider | | γ-linolenate | Generator | | γ-linolenic acid | Generator | | γ-linolensaeure | Generator |
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