1.0 2010-04-08 22:05:58 UTC 2025-11-18 22:54:00 UTC FDB003812 Phosphatase Phosphatase, also known as 4-nitrophenylphosphate or dipotassium nitrophenylphosphate, is a member of the class of compounds known as phenyl phosphates. Phenyl phosphates are aromatic organooxygen compounds containing a phosphate group, which is O-esterified with a phenyl group. Phosphatase can be found in a number of food items such as french plantain, fenugreek, pineapple, and horseradish, which makes phosphatase a potential biomarker for the consumption of these food products. A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research . C6H16NNa2O12P 371.144 371.020550843 disodium hexahydrate 4-nitrophenyl phosphate disodium hexahydrate p-nitrophenyl phosphate O.O.O.O.O.O.[Na+].[Na+].[O-][N+](=O)C1=CC=C(OP([O-])([O-])=O)C=C1 InChI=1S/C6H6NO6P.2Na.6H2O/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12;;;;;;;;/h1-4H,(H2,10,11,12);;;6*1H2/q;2*+1;;;;;;/p-2 KAKKHKRHCKCAGH-UHFFFAOYSA-L belongs to the class of organic compounds known as phenyl phosphates. These are aromatic organooxygen compounds containing a phosphate group, which is O-esterified with a phenyl group. Phenyl phosphates Organic compounds Organic acids and derivatives Organic phosphoric acids and derivatives Phosphate esters Aromatic homomonocyclic compounds Hydrocarbon derivatives Nitroaromatic compounds Nitrobenzenes Organic oxides Organic oxoazanium compounds Organic sodium salts Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Phenoxy compounds Propargyl-type 1,3-dipolar organic compounds Allyl-type 1,3-dipolar organic compound Aromatic homomonocyclic compound Benzenoid C-nitro compound Hydrocarbon derivative Monocyclic benzene moiety Nitroaromatic compound Nitrobenzene Organic 1,3-dipolar compound Organic alkali metal salt Organic nitro compound Organic nitrogen compound Organic oxide Organic oxoazanium Organic oxygen compound Organic salt Organic sodium salt Organonitrogen compound Organooxygen compound Organopnictogen compound Phenoxy compound Phenyl phosphate Propargyl-type 1,3-dipolar organic compound logp 0.96 ChemAxon pka_strongest_acidic 1.78 ChemAxon iupac disodium hexahydrate 4-nitrophenyl phosphate ChemAxon average_mass 371.144 ChemAxon mono_mass 371.020550843 ChemAxon smiles O.O.O.O.O.O.[Na+].[Na+].[O-][N+](=O)C1=CC=C(OP([O-])([O-])=O)C=C1 ChemAxon formula C6H16NNa2O12P ChemAxon inchi InChI=1S/C6H6NO6P.2Na.6H2O/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12;;;;;;;;/h1-4H,(H2,10,11,12);;;6*1H2/q;2*+1;;;;;;/p-2 ChemAxon inchikey KAKKHKRHCKCAGH-UHFFFAOYSA-L ChemAxon polar_surface_area 118.24 ChemAxon refractivity 43.99 ChemAxon polarizability 16.08 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 5 ChemAxon donor_count 0 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon European chestnut Type 1 specific Castanea sativa 21020 Fenugreek Type 1 specific Trigonella foenum-graecum 78534 French plantain Type 1 specific Musa X paradisiaca 89151 Horseradish Type 1 specific Armoracia rusticana 3704 Jerusalem artichoke Type 1 specific Helianthus tuberosus 4233 Lentils Type 1 generic Lens culinaris 3864 Pineapple Type 1 specific Ananas comosus 4615