1.0 2010-04-08 22:06:05 UTC 2019-11-26 02:59:48 UTC FDB004090 Atropine Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure. Atropine is found in burdock. (&plusmn;)-atropine (&plusmn;)-hyoscyamine (+-)-atropine (+-)-hyoscyamine (+,-)-tropyl tropate (+,-)-Tropyl tropic acid (+/-)-atropine (+/-)-hyoscyamine (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate (3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropic acid [(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate [(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoic acid 1-&alpha;-H,5-&alpha;-H-Tropan-3-&alpha;-ol (.+/-.)-tropate 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) 1&alpha;H,5&alpha;H-Tropan-3&alpha;-ol (&plusmn;)-tropate 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester) 2-Phenylhydracrylic acid 3-&alpha;-tropanyl ester 2-Phenylhydracrylic acid 3-alpha-tropanyl ester 51-55-8 (FREE BASE) 5908-99-6 (SULFATE(2:1), MONOHYDRATE) 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoic acid 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropic acid Anaspaz Atnaa Atropen Atropen (TN) Atropin Atropin-flexiolen Atropina Atropine Atropine (usp) Atropine [ban] Atropine Ont 1% Atropine sulfate Atropine sulfate ansyr plastic syringe Atropinol Atropinum Atropisol Atropt Belladenal Bellergal-s Butibel Cytospaz DL-hyoscyamine DL-Tropanyl 2-hydroxy-1-phenylpropionate DL-tropyl tropate DL-tropyltropate DL-Tropyltropic acid Donnagel Donnatal Eyesules Hycodan Hyoscyamine Hyoscyamine sulfate Isopto Atropine 1% Isopto-atropine Lomotil Lonox Minims Minims Atropine Sulphate 1% Neo-diophen Protamine + atropine Protamine and atropine tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate Tropic acid, 3-&alpha;-tropanyl ester Tropic acid, 3-alpha-tropanyl ester Tropic acid, ester with tropine Tropine (+/-)-tropate Tropine tropate Tropine tropic acid Tropine, tropate (ester) Troyl tropate Urised C17H23NO3 289.3694 289.167793607 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate ()-hyoscyamine 51-55-8 CN1C2CCC1CC(C2)OC(=O)C(CO)C1=CC=CC=C1 InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3 RKUNBYITZUJHSG-UHFFFAOYSA-N belongs to the class of organic compounds known as tropane alkaloids. These are organic compounds containing the nitrogenous bicyclic alkaloid parent N-Methyl-8-azabicyclo[3.2.1]octane. Tropane alkaloids Organic compounds Alkaloids and derivatives Tropane alkaloids Aromatic heteropolycyclic compounds Amino acids and derivatives Azacyclic compounds Benzene and substituted derivatives Beta hydroxy acids and derivatives Carbonyl compounds Carboxylic acid esters Hydrocarbon derivatives Monocarboxylic acids and derivatives N-alkylpyrrolidines Organic oxides Organopnictogen compounds Piperidines Primary alcohols Trialkylamines Alcohol Amine Amino acid or derivatives Aromatic heteropolycyclic compound Azacycle Benzenoid Beta-hydroxy acid Carbonyl group Carboxylic acid derivative Carboxylic acid ester Hydrocarbon derivative Hydroxy acid Monocarboxylic acid or derivatives Monocyclic benzene moiety N-alkylpyrrolidine Organic nitrogen compound Organic oxide Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Piperidine Primary alcohol Pyrrolidine Tertiary aliphatic amine Tertiary amine Tropane alkaloid Solid logp 2.19 ALOGPS logs -2.06 ALOGPS solubility 2.52e+00 g/l ALOGPS melting_point 118.5 oC logp 1.57 ChemAxon pka_strongest_acidic 15.15 ChemAxon pka_strongest_basic 9.39 ChemAxon iupac 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate ChemAxon average_mass 289.3694 ChemAxon mono_mass 289.167793607 ChemAxon smiles CN1C2CCC1CC(C2)OC(=O)C(CO)C1=CC=CC=C1 ChemAxon formula C17H23NO3 ChemAxon inchi InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3 ChemAxon inchikey RKUNBYITZUJHSG-UHFFFAOYSA-N ChemAxon polar_surface_area 49.77 ChemAxon refractivity 80.82 ChemAxon polarizability 31.97 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 105866 Specdb::CMs 117988 Specdb::MsMs 68496 Specdb::MsMs 68497 Specdb::MsMs 68498 Specdb::MsMs 126540 Specdb::MsMs 126541 Specdb::MsMs 126542 Specdb::MsMs 2226207 Specdb::MsMs 2228561 Specdb::MsMs 2230909 Specdb::MsMs 2233429 Specdb::MsMs 2235527 Specdb::MsMs 2236536 Specdb::MsMs 2244830 Specdb::MsMs 2245309 Specdb::MsMs 2246922 Specdb::MsMs 2247341 Specdb::MsMs 2249070 Specdb::MsMs 2249346 Specdb::MsMs 2251034 Specdb::MsMs 2251355 Specdb::MsMs 2254385 Specdb::MsMs 2256161 Specdb::MsMs 3388561 Specdb::MsMs 3388562 Specdb::MsMs 3388563 HMDB14712 16684 #<Reference:0x000055ce32449cc8> #<Reference:0x000055ce32449ac0> #<Reference:0x000055ce32449908> #<Reference:0x000055ce32449750> #<Reference:0x000055ce32449598> Burdock Type 1 specific Arctium lappa 4217 3.0 3.0 3.0 mg/100 g Allergenic 43 A chemical compound which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy. Analgesic 56 An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. Anesthetic 62 Anhydrotic 65 Anti cholinergic 183 Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. Anti emetic 253 A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. Anti emphysemic 254 Any substance introduced into a living organism with therapeutic or diagnostic purpose. Anti enuretic 263 Anti iritic 375 Anti peristaltic 517 Anti polio 538 A substance that destroys or inhibits replication of viruses. Anti sialogogue 613 Anti ulcer 676 One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. Anti vertigo 688 Any substance introduced into a living organism with therapeutic or diagnostic purpose. Anti-anoxic 119 Any substance introduced into a living organism with therapeutic or diagnostic purpose. Anti-arrhythmic 129 A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. Anti-asthmatic 134 A drug used to treat asthma. Anti-bradycardic 151 A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. Anti-herpetic 329 A substance that destroys or inhibits replication of viruses. Anti-muscarinic 450 A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. Anti-Parkinsonian 509 A drug used in the treatment of Parkinson's disease. Anti-perspirant 522 Anti-pertussic 523 A substance that kills or slows the growth of bacteria. Anti-spasmodic 619 Any substance introduced into a living organism with therapeutic or diagnostic purpose. Anti-uveitic 684 Anti-viral 689 A substance that destroys or inhibits replication of viruses. Antidote 236 Any protective agent counteracting or neutralizing the action of poisons. Bronchodilator 736 An agent that causes an increase in the expansion of a bronchus or bronchial tubes. Central nervous system depressant 812 A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system. Central nervous system stimulant 816 A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system. Choleretic 801 Hyperpyrexic 1006 Insecticide 1040 Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. Mydriatic 1129 Agent that dilates the pupil. Used in eye diseases and to facilitate eye examination. It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high doses and may precipitate glaucoma. Myorelaxant 1134 Neurotoxic 1160 A poison that interferes with the functions of the nervous system. Paralytic 1196 Pesticide 1210 Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests. Psychotomimetic 1269 A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system. Tachycardic 1345 A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. Transdermal 1374 Tumorigenic 1388 A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities. Vasodilator 1413 A drug used to cause dilation of the blood vessels.