1.0 2010-04-08 22:06:40 UTC 2025-11-18 22:59:10 UTC FDB005416 Guanidine Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.; Guanidine is a crystalline compound of strong alkalinity formed by the oxidation of guanine. It is used in the manufacture of plastics and explosives. It is found in urine as a normal product of protein metabolism. The molecule was first synthesized in 1861 by the oxidative degradation of an aromatic natural product, guanine, isolated from Peruvian guano. Despite the provocative simplicity of the molecule, the crystal structure was first described 148 years later.; Guanidine is a polyamine that can function as a strong organic base existing primarily as guanidium ions at physiological pH. With a pKa of 12.5, guanidine is protonated, with a charge of +1 in physiological conditions. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed). Guanidine is a crystalline compound of strong alkalinity formed by the oxidation of guanine. It is used in the manufacture of plastics and explosives. -- Wikipedia; Guanidines are a group of organic compounds sharing a common functional group with the general structure (R1R2N)(R3R4N)C=N-R5. The central bond within this group is that of an imine; the other recognizable motif within this group is an aminal. Examples of guanidines are arginine, triazabicyclodecene and saxitoxin. other derivatives could include guanidine hydroxide, the active ingredient in some non-lye relaxers. Guanidinium salts are well known for their denaturing action on proteins. Guanidinium chloride is one of the most effective denaturants. In 6 M GndHCl all proteins with an ordered structure lose their structure, and most of them become randomly coiled, that is, they do not contain any residual structure. (4-Aminobutyl) guanidine (NH2)2C=NH 1184-68-5 (unspecified sulfate) 1763-07-1 (unspecified phosphate) 50-01-1 (mono-hydrochloride) Aminoformamidine Aminomethanamidine Bisguanidinium sulfate Carbamamidine Carbamidine GAI GU Guanidin Guanidine hydrochloride Guanidine, hydrochloride Guanidine, sulfate (2:1) Guanidinium sulfate H2N-C(=NH)-NH2 Imidourea Iminourea NSC7296 (SULFATE, 2:1) CH5N3 59.0705 59.048347175 guanidine guanidine 50-01-1 NC(N)=N InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4) ZRALSGWEFCBTJO-UHFFFAOYSA-N belongs to the class of organic compounds known as guanidines. Guanidines are compounds containing a guanidine moiety, with the general structure (R1R2N)(R3R4N)C=N-R5. Guanidines Organic compounds Organic nitrogen compounds Organonitrogen compounds Guanidines Aliphatic acyclic compounds Carboximidamides Hydrocarbon derivatives Imines Organopnictogen compounds Aliphatic acyclic compound Carboximidamide Guanidine Hydrocarbon derivative Imine Organopnictogen compound a small molecule carboxamidine guanidines one-carbon compound Solid logp -1.92 ALOGPS logs -0.71 ALOGPS solubility 1.15e+01 g/l ALOGPS melting_point 182.3 oC logp -1.2 ChemAxon pka_strongest_basic 12.55 ChemAxon iupac guanidine ChemAxon average_mass 59.0705 ChemAxon mono_mass 59.048347175 ChemAxon smiles NC(N)=N ChemAxon formula CH5N3 ChemAxon inchi InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4) ChemAxon inchikey ZRALSGWEFCBTJO-UHFFFAOYSA-N ChemAxon polar_surface_area 75.89 ChemAxon refractivity 25.86 ChemAxon polarizability 5.57 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 3 ChemAxon donor_count 3 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::MsIr 1358 Specdb::MsIr 1359 Specdb::MsIr 1360 Specdb::CMs 942 Specdb::CMs 13460 Specdb::CMs 31353 Specdb::CMs 170810 Specdb::MsMs 1690 Specdb::MsMs 1691 Specdb::MsMs 1692 Specdb::MsMs 10190 Specdb::MsMs 10191 Specdb::MsMs 10192 Specdb::MsMs 16862 Specdb::MsMs 16863 Specdb::MsMs 16864 Specdb::MsMs 2298894 Specdb::MsMs 2298895 Specdb::MsMs 2298896 Specdb::MsMs 2639512 Specdb::MsMs 2639513 Specdb::MsMs 2639514 HMDB01842 24435 GAI #<Reference:0x000055ce32119670> #<Reference:0x000055ce321194b8> #<Reference:0x000055ce32119300> #<Reference:0x000055ce32119148> #<Reference:0x000055ce32118f90> #<Reference:0x000055ce32118d60> #<Reference:0x000055ce32118ae0> #<Reference:0x000055ce32118928> #<Reference:0x000055ce32118770> #<Reference:0x000055ce321185b8> #<Reference:0x000055ce32118400> #<Reference:0x000055ce32118248> #<Reference:0x000055ce32117f50> #<Reference:0x000055ce32117d98> #<Reference:0x000055ce32117be0> #<Reference:0x000055ce32117a28> #<Reference:0x000055ce32117870> #<Reference:0x000055ce321176b8> #<Reference:0x000055ce32117500> #<Reference:0x000055ce32117348> Anatidae Type 1 specific Anatidae 8830 Apple Type 1 specific Malus pumila 283210 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Corn Type 1 specific Zea mays 4577 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Loquat Type 1 specific Eriobotrya japonica 32224 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rice Type 1 specific Oryza sativa 4530 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Soy bean Type 1 specific Glycine max 3847 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 Arginine decarboxylase Q96A70 ADC Disks large homolog 4 P78352 DLG4 Ribonuclease pancreatic P07998 RNASE1 Anti myasthenic 454 Any substance introduced into a living organism with therapeutic or diagnostic purpose. Convulsant 832 Hepatotoxic 984 A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals. Hypertensive 1007 Hypoglycemic 1017 A drug which lowers the blood glucose level. Myostimulant 1135