1.0 2010-04-08 22:07:27 UTC 2025-11-18 23:03:56 UTC FDB007119 Lormetazepam Lormetazepam, also known as methyllorazepam or (+-)-lorazepam, is a member of the class of compounds known as 1,4-benzodiazepines. 1,4-benzodiazepines are organic compounds containing a benzene ring fused to a 1,4-azepine. Lormetazepam is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Lormetazepam can be found in potato, which makes lormetazepam a potential biomarker for the consumption of this food product. Lormetazepam is a non-carcinogenic (not listed by IARC) potentially toxic compound. Lormetazepam is a drug which is used for the treatment of short-term insomnia [l927. The Dutch, British, and French system called the System of Objectified Judgement Analysis for assessing whether drugs should be included in drug formularies based on clinical efficacy, adverse effects, pharmacokinetic properties, toxicity, and drug interactions was used to assess lormetazepam. A Dutch analysis using the system found that lormetazepam could be suitable to be included in drug prescribing formularies, although zolpidem, zopiclone, and temazepam had higher scores and thus can be seen as relatively favorable . The primary manifestation of overdosage ranges from drowsiness to coma and symptoms may include ataxia, hypotension, hypotonia, respiratory depression which may lead to death [L927]. (+-)-lorazepam Ergocalm Loramet Loramet (TN) Lorazepam Loretam Lormetazepam (jan/usan/inn) Lormetazepam [usan:inn:ban:jan] Lormetazepamum Methyllorazepam N-methyllorazepam Noctamid O-chlorooxazepam O-chloroxazepam C16H12Cl2N2O2 335.185 334.027583052 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one lormetazepam 848-75-9 CN1C2=C(C=C(Cl)C=C2)C(=NC(O)C1=O)C1=CC=CC=C1Cl InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3 FJIKWRGCXUCUIG-UHFFFAOYSA-N belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine. 1,4-benzodiazepines Organic compounds Organoheterocyclic compounds Benzodiazepines 1,4-benzodiazepines Aromatic heteropolycyclic compounds Alkanolamines Alpha amino acids and derivatives Aryl chlorides Azacyclic compounds Carbonyl compounds Chlorobenzenes Hydrocarbon derivatives Ketimines Lactams Organic oxides Organochlorides Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Tertiary carboxylic acid amides 1,4-benzodiazepine Alkanolamine Alpha-amino acid or derivatives Aromatic heteropolycyclic compound Aryl chloride Aryl halide Azacycle Benzenoid Carbonyl group Carboxamide group Carboxylic acid derivative Chlorobenzene Halobenzene Hydrocarbon derivative Imine Ketimine Lactam Monocyclic benzene moiety Organic 1,3-dipolar compound Organic nitrogen compound Organic oxide Organic oxygen compound Organochloride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Tertiary carboxylic acid amide 1,4-benzodiazepinone organochlorine compound logp 2.92 ALOGPS logs -4.31 ALOGPS solubility 1.64e-02 g/l ALOGPS melting_point 206 oC logp 3.39 ChemAxon pka_strongest_acidic 10.68 ChemAxon pka_strongest_basic -2.2 ChemAxon iupac 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one ChemAxon average_mass 335.185 ChemAxon mono_mass 334.027583052 ChemAxon smiles CN1C2=C(C=C(Cl)C=C2)C(=NC(O)C1=O)C1=CC=CC=C1Cl ChemAxon formula C16H12Cl2N2O2 ChemAxon inchi InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3 ChemAxon inchikey FJIKWRGCXUCUIG-UHFFFAOYSA-N ChemAxon polar_surface_area 52.9 ChemAxon refractivity 85.82 ChemAxon polarizability 32.21 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::MsMs 49233 Specdb::MsMs 49234 Specdb::MsMs 49235 Specdb::MsMs 152181 Specdb::MsMs 152182 Specdb::MsMs 152183 Specdb::MsMs 2658532 Specdb::MsMs 2658533 Specdb::MsMs 2658534 Specdb::MsMs 3050243 Specdb::MsMs 3050244 Specdb::MsMs 3050245 Specdb::CMs 10769 Specdb::CMs 27722 Specdb::CMs 47614 Specdb::CMs 102283 Specdb::CMs 130892 Specdb::CMs 138626 Specdb::EiMs 44 HMDB0041919 52993 Potato Type 1 specific Solanum tuberosum 4113 Sedative 1311 A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.