1.0 2010-04-08 22:09:09 UTC 2025-11-18 23:19:41 UTC FDB010505 N-(2-Hydroxybenzoyl)glycine Constituent of milk Salicyluric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:; acyl-CoA + glycine < -- > CoA + N-acylglycine; The induction of the salicyluric acid formation is one of the saturable pathways of salicylate elimination.; The formation of the methyl ester of salicyluric acid is observed during the quantitation of salicyluric acid and other salicylate metabolites in urine by high-pressure liquid chromatography. This methyl ester formation causes artificially low values for salicyluric acid and high values for salicylic acid.; (PMID: 6101164, 6857178). N-(2-Hydroxybenzoyl)glycine is found in milk and milk products. ((2-hydroxybenzoyl)amino)acetic acid (2-hydroxybenzamido)acetic acid (2-Hydroxybenzoyl)glycine [(2-Hydroxybenzoyl)amino]acetate [(2-Hydroxybenzoyl)amino]acetic acid 2-Hydroxybenzamidoacetic acid 2-hydroxybenzoylaminoacetate 2-hydroxybenzoylaminoacetic acid 2-Hydroxybenzoylglycine 2-Hydroxyhippurate 2-Hydroxyhippuric acid Glycine, N-(2-hydroxybenzoyl)- Glycine, N-(2-hydroxybenzoyl)- (9CI) Glycine, n-salicyloyl- Hippuric acid, o-hydroxy- N-(2-Hydroxybenzoyl)-glycine N-o-hydroxybenzoylglycine N-salicyloylglycine O-hydroxy-hippurate O-hydroxy-hippuric acid O-Hydroxyhippate O-Hydroxyhippic acid O-hydroxyhippurate O-hydroxyhippuric acid o-Hydroxyhippuric acid, 8CI Ortho-hydroxyhippurate Ortho-hydroxyhippuric acid Salicylglycine Salicyloylaminoacetic acid Salicyloylglycine Salicylurate Salicyluric acid C9H9NO4 195.1721 195.053157781 2-[(2-hydroxyphenyl)formamido]acetic acid salicyluric acid 487-54-7 OC(=O)CNC(=O)C1=CC=CC=C1O InChI=1S/C9H9NO4/c11-7-4-2-1-3-6(7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13) ONJSZLXSECQROL-UHFFFAOYSA-N belongs to the class of organic compounds known as hippuric acids. Hippuric acids are compounds containing hippuric acid, which consists of a of a benzoyl group linked to the N-terminal of a glycine. Hippuric acids Organic compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Aromatic homomonocyclic compounds 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Benzoyl derivatives Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Monocarboxylic acids and derivatives N-acyl-alpha amino acids Organic oxides Organonitrogen compounds Organopnictogen compounds Salicylamides Secondary carboxylic acid amides Vinylogous acids 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid Alpha-amino acid or derivatives Aromatic homomonocyclic compound Benzoyl Carbonyl group Carboxamide group Carboxylic acid Carboxylic acid derivative Hippuric acid Hydrocarbon derivative Monocarboxylic acid or derivatives N-acyl-alpha amino acid or derivatives N-acyl-alpha-amino acid Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenol Salicylamide Salicylic acid or derivatives Secondary carboxylic acid amide Vinylogous acid N-acyl-amino acid N-acylglycine Solid logp 0.51 ALOGPS logs -1.68 ALOGPS solubility 4.04e+00 g/l ALOGPS melting_point Mp 170-172° logp 0.87 ChemAxon pka_strongest_acidic 3.27 ChemAxon pka_strongest_basic -1.9 ChemAxon iupac 2-[(2-hydroxyphenyl)formamido]acetic acid ChemAxon average_mass 195.1721 ChemAxon mono_mass 195.053157781 ChemAxon smiles OC(=O)CNC(=O)C1=CC=CC=C1O ChemAxon formula C9H9NO4 ChemAxon inchi InChI=1S/C9H9NO4/c11-7-4-2-1-3-6(7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13) ChemAxon inchikey ONJSZLXSECQROL-UHFFFAOYSA-N ChemAxon polar_surface_area 86.63 ChemAxon refractivity 48.1 ChemAxon polarizability 18.4 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 4 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1504 Specdb::MsIr 899 Specdb::MsIr 900 Specdb::MsIr 901 Specdb::CMs 1677 Specdb::CMs 1773 Specdb::CMs 2926 Specdb::CMs 31243 Specdb::CMs 31244 Specdb::CMs 32055 Specdb::CMs 32056 Specdb::CMs 37795 Specdb::CMs 174819 Specdb::CMs 1079237 Specdb::CMs 1079239 Specdb::CMs 1079241 Specdb::CMs 1079242 Specdb::CMs 1079244 Specdb::CMs 1079245 Specdb::CMs 1079247 Specdb::CMs 1079249 Specdb::CMs 1079251 Specdb::CMs 1079253 Specdb::CMs 1079254 Specdb::MsMs 1184 Specdb::MsMs 1185 Specdb::MsMs 1186 Specdb::MsMs 4710 Specdb::MsMs 4711 Specdb::MsMs 4712 Specdb::MsMs 4713 Specdb::MsMs 4714 Specdb::MsMs 179112 Specdb::MsMs 179113 Specdb::MsMs 179114 Specdb::MsMs 181437 Specdb::MsMs 181438 Specdb::MsMs 181439 Specdb::MsMs 437826 Specdb::MsMs 437827 Specdb::MsMs 437828 Specdb::MsMs 437829 Specdb::MsMs 437830 Specdb::MsMs 438669 Specdb::MsMs 2236282 Specdb::MsMs 2237086 Specdb::MsMs 2239223 Specdb::MsMs 2240355 Specdb::MsMs 2241330 Specdb::NmrOneD 1562 HMDB00840 9008 #<Reference:0x000055ce317177d0> #<Reference:0x000055ce31717618> #<Reference:0x000055ce31717460> #<Reference:0x000055ce317172a8> #<Reference:0x000055ce317170f0> #<Reference:0x000055ce31716f10> #<Reference:0x000055ce31716cb8> #<Reference:0x000055ce31716b00> #<Reference:0x000055ce31716948> #<Reference:0x000055ce317166c8> #<Reference:0x000055ce317164c0> #<Reference:0x000055ce317162e0> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Milk (Cow) Type 2 specific Milk and milk products Unknown generic Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 Glycine N-acyltransferase Q6IB77 GLYAT Glycine N-acyltransferase-like protein 1 Q969I3 GLYATL1 Glycine N-acyltransferase-like protein 2 Q8WU03 GLYATL2 Glycine N-acyltransferase-like protein 3 Q5SZD4 GLYATL3