1.0 2010-04-08 22:09:11 UTC 2025-11-18 23:20:28 UTC FDB010566 Phthalic acid Phthalic acid is an aromatic dicarboxylic acid, with formula C6H4(COOH)2. Phthalic acid is used mainly in the form of the anhydride to produce other chemicals such as dyes, perfumes, saccharin, phthalates and many other useful products. Phthalic acid, when found in tissues or biofluids arises from exposure to these phthalate products. Phthalate is an environmental chemical of heightened public concern because reports of its potential risk to male reproductive health (PMID 16804814), being significantly associated with reduced sperm concentration to pesticide concentration in men's urine (PMID 16804812). Within the reproductive tract, the male is exquisitely vulnerable to the effects of anti-androgens during development due the reliance on the synthesis and action of androgens for the masculinization of the male reproductive tract. The ability of phthalates to suppress androgen synthesis during development and to induce testicular dysgenesis together with cryptorchidism and hypospadias has raised considerable concern. (PMID 15016950) [HMDB]. 1,2-Benzenedicarboxylate 1,2-Benzenedicarboxylic acid Alizarinate Alizarinic acid M 2 Naphthalinate Naphthalinic acid Naphthalinic acid? O-Benzenedicarboxylate O-Benzenedicarboxylic acid O-Carboxybenzoate O-Carboxybenzoic acid O-Dicarboxybenzene ortho-Phthalate ortho-Phthalic acid Phthalate Phthalic acid, 8CI Phthalinate Phthalinic acid Sunftal 20 C8H6O4 166.1308 166.02660868 benzene-1,2-dicarboxylic acid phthalic acid 88-99-3 OC(=O)C1=CC=CC=C1C(O)=O InChI=1S/C8H6O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H,9,10)(H,11,12) XNGIFLGASWRNHJ-UHFFFAOYSA-N belongs to the class of organic compounds known as benzoic acids. These are organic Compounds containing a benzene ring which bears at least one carboxyl group. Benzoic acids Organic compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Aromatic homomonocyclic compounds Benzoyl derivatives Carboxylic acids Dicarboxylic acids and derivatives Hydrocarbon derivatives Organic oxides Organooxygen compounds Aromatic homomonocyclic compound Benzoic acid Benzoyl Carboxylic acid Carboxylic acid derivative Dicarboxylic acid or derivatives Hydrocarbon derivative Organic oxide Organic oxygen compound Organooxygen compound benzenedicarboxylic acid Solid logp 1.22 ALOGPS logs -1.73 ALOGPS solubility 3.12e+00 g/l ALOGPS logp 1.29 ChemAxon pka_strongest_acidic 2.94 ChemAxon iupac benzene-1,2-dicarboxylic acid ChemAxon average_mass 166.1308 ChemAxon mono_mass 166.02660868 ChemAxon smiles OC(=O)C1=CC=CC=C1C(O)=O ChemAxon formula C8H6O4 ChemAxon inchi InChI=1S/C8H6O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H,9,10)(H,11,12) ChemAxon inchikey XNGIFLGASWRNHJ-UHFFFAOYSA-N ChemAxon polar_surface_area 74.6 ChemAxon refractivity 40.57 ChemAxon polarizability 14.94 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1794 Specdb::MsIr 1613 Specdb::MsIr 1614 Specdb::MsIr 1615 Specdb::NmrOneD 1854 Specdb::NmrOneD 10082 Specdb::NmrOneD 10083 Specdb::NmrOneD 10084 Specdb::NmrOneD 10085 Specdb::NmrOneD 10086 Specdb::NmrOneD 10087 Specdb::NmrOneD 10088 Specdb::NmrOneD 10089 Specdb::NmrOneD 10090 Specdb::NmrOneD 10091 Specdb::NmrOneD 10092 Specdb::NmrOneD 10093 Specdb::NmrOneD 10094 Specdb::NmrOneD 10095 Specdb::NmrOneD 10096 Specdb::NmrOneD 10097 Specdb::NmrOneD 10098 Specdb::NmrOneD 10099 Specdb::NmrOneD 10100 Specdb::NmrOneD 10101 Specdb::CMs 807 Specdb::CMs 7573 Specdb::CMs 29702 Specdb::CMs 30143 Specdb::CMs 30668 Specdb::CMs 32148 Specdb::CMs 38272 Specdb::CMs 136953 Specdb::CMs 144687 Specdb::MsMs 2004 Specdb::MsMs 2005 Specdb::MsMs 2006 Specdb::MsMs 5725 Specdb::MsMs 5726 Specdb::MsMs 5727 Specdb::MsMs 5728 Specdb::MsMs 5729 Specdb::MsMs 254598 Specdb::MsMs 254599 Specdb::MsMs 254600 Specdb::MsMs 274539 Specdb::MsMs 274540 Specdb::MsMs 274541 Specdb::MsMs 438345 Specdb::MsMs 438346 Specdb::MsMs 438347 Specdb::MsMs 438348 Specdb::MsMs 438349 Specdb::MsMs 2226709 Specdb::MsMs 2227991 Specdb::MsMs 2249714 Specdb::MsMs 2252632 Specdb::MsMs 2253870 Specdb::MsMs 2254699 HMDB02107 PHT #<Reference:0x000055ce324b4938> #<Reference:0x000055ce324b4780> #<Reference:0x000055ce324b45c8> #<Reference:0x000055ce324b4410> #<Reference:0x000055ce324b4258> #<Reference:0x000055ce324b40a0> Beer Type 2 specific 0.02 0.02 0.02 mg/100 g Red raspberry Type 1 specific Rubus idaeus 32247