1.0 2010-04-08 22:09:16 UTC 2019-11-26 03:04:03 UTC FDB010731 N2-Succinoylarginine Constituent of the shoots of pear trees Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. N2-Succinoylarginine is found in pomes. 1, 4-Dimethanesulfonoxybutane 1, 4-Dimethylsulfonoxybutane 1,4-Bis(methanesulfonoxy)butane 1,4-Bis(methanesulfonyloxy)butane 1,4-Bis[methanesulfonoxy]butane 1,4-Butanedi yl dimethanesulfonate 1,4-Butanediol dimethanesulfonate 1,4-Butanediol dimethanesulphonate 1,4-Butanediol dimethylsulfonate 1,4-Butanediol, dimethanesulfonate 1,4-Butanediol, dimethanesulphonate 1,4-Butanediyl dimethanesulfonate 1,4-Di(methylsulfonoxy)butane 1,4-Dimesyloxybutane 1,4-Dimethane sulfonyl oxybutane 1,4-Dimethanesulfonoxybutane 1,4-Dimethanesulfonoxylbutane 1,4-Dimethanesulfonyloxybutane 1,4-Dimethanesulphonyloxybutane 1,4-Dimethylsulfonoxybutane 1,4-Dimethylsulfonyloxybutane 4-((Methylsulfonyl)oxy)butyl methanesulfonate 4-methylsulfonyloxybutyl methanesulfonate Alkylating agent: crosslinks guanine residues Busulfan BUSULFAN (1,4-BUTANEDIOL, DIMETHANESULFONATE) Busulfan (JP15/USP/INN) Busulfan [inn:jan] Busulfan glaxosmithkline brand Busulfan orphan brand Busulfan wellcome Busulfan wellcome brand Busulfano Busulfanum Busulfex Busulphan Busulphane butane-1,4-diyl dimethanesulfonate Butanedioldimethanesulfonate Buzulfan Citosulfan Glaxo wellcome brand of busulfan Glaxosmithkline brand of busulfan Glyzophrol Leucosulfan Mablin Methanesulfonic acid, tetram ethylene ester Methanesulfonic acid, tetramethylene ester Mielevcin Mielosan Mielucin Milecitan Mileran Misulban Mitostan Myeleukon Myeloleukon Myelosan Myelosanum Mylecytan Myleran Myleran (TN) Mylerlan n-Butane-1,3-di(methylsulfonate) N2-Succinoylarginine NSC-750sulphabutin Orphan brand of busulfan Sulfabutin Sulfabutin (van) Sulphabutin Tetramethylene bis(methanesulfonate) Tetramethylene bis[methanesulfonate] Tetramethylene dimethane sulfonate Tetramethylenester kyseliny methansulfonove Wellcome brand of busulfan Wellcome, busulfan C10H18N4O5 274.2737 274.127719706 5-carbamimidamido-2-[(3-carboxy-1-hydroxypropylidene)amino]pentanoic acid 5-carbamimidamido-2-[(3-carboxy-1-hydroxypropylidene)amino]pentanoic acid 2478-02-6 NC(=N)NCCCC(N=C(O)CCC(O)=O)C(O)=O InChI=1S/C10H18N4O5/c11-10(12)13-5-1-2-6(9(18)19)14-7(15)3-4-8(16)17/h6H,1-5H2,(H,14,15)(H,16,17)(H,18,19)(H4,11,12,13) UMOXFSXIFQOWTD-UHFFFAOYSA-N belongs to the class of organic compounds known as n-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. N-acyl-alpha amino acids Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aliphatic acyclic compounds Carbonyl compounds Carboximidamides Carboxylic acids Dicarboxylic acids and derivatives Fatty acids and conjugates Guanidines Hydrocarbon derivatives N-acyl amines Organic oxides Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Secondary carboxylic acid amides Aliphatic acyclic compound Carbonyl group Carboxamide group Carboximidamide Carboxylic acid Dicarboxylic acid or derivatives Fatty acid Fatty acyl Fatty amide Guanidine Hydrocarbon derivative N-acyl-alpha-amino acid N-acyl-amine Organic 1,3-dipolar compound Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Secondary carboxylic acid amide logp -1.58 ALOGPS logs -2.97 ALOGPS solubility 2.97e-01 g/l ALOGPS logp -3 ChemAxon pka_strongest_acidic 3.32 ChemAxon pka_strongest_basic 12.16 ChemAxon iupac 5-carbamimidamido-2-[(3-carboxy-1-hydroxypropylidene)amino]pentanoic acid ChemAxon average_mass 274.2737 ChemAxon mono_mass 274.127719706 ChemAxon smiles NC(=N)NCCCC(N=C(O)CCC(O)=O)C(O)=O ChemAxon formula C10H18N4O5 ChemAxon inchi InChI=1S/C10H18N4O5/c11-10(12)13-5-1-2-6(9(18)19)14-7(15)3-4-8(16)17/h6H,1-5H2,(H,14,15)(H,16,17)(H,18,19)(H4,11,12,13) ChemAxon inchikey UMOXFSXIFQOWTD-UHFFFAOYSA-N ChemAxon polar_surface_area 169.09 ChemAxon refractivity 74.78 ChemAxon polarizability 27.08 ChemAxon rotatable_bond_count 9 ChemAxon acceptor_count 9 ChemAxon donor_count 6 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 20377 Specdb::CMs 42950 Specdb::CMs 151300 Specdb::MsMs 97128 Specdb::MsMs 97129 Specdb::MsMs 97130 Specdb::MsMs 161784 Specdb::MsMs 161785 Specdb::MsMs 161786 Specdb::MsMs 2679370 Specdb::MsMs 2679371 Specdb::MsMs 2679372 Specdb::MsMs 3026091 Specdb::MsMs 3026092 Specdb::MsMs 3026093 Specdb::NmrOneD 115018 Specdb::NmrOneD 115019 Specdb::NmrOneD 115020 Specdb::NmrOneD 115021 Specdb::NmrOneD 115022 Specdb::NmrOneD 115023 Specdb::NmrOneD 115024 Specdb::NmrOneD 115025 Specdb::NmrOneD 115026 Specdb::NmrOneD 115027 Specdb::NmrOneD 115028 Specdb::NmrOneD 115029 Specdb::NmrOneD 115030 Specdb::NmrOneD 115031 Specdb::NmrOneD 115032 Specdb::NmrOneD 115033 Specdb::NmrOneD 115034 Specdb::NmrOneD 115035 Specdb::NmrOneD 115036 Specdb::NmrOneD 115037 HMDB32764 28901 #<Reference:0x000055ce318e06e8> Pomes Unknown generic