1.0 2010-04-08 22:09:41 UTC 2025-11-18 23:28:46 UTC FDB011524 Epiestradiol 17a-estradiol is found in the estrogen patch. The estrogen patch is a delivery system for estradiol used as hormone replacement therapy to treat the symptoms of menopause, such as hot flashes and vaginal dryness, and to prevent osteoporosis. Originally marketed as Vivelle (Novartis), it was discontinued in 2003 and reintroduced in a smaller form as Vivelle-Dot. Although the estrogen is given transdermally rather than in the standard oral tablets, the estrogen patch carries similar risks and benefits as more conventional forms of estrogen-only hormone replacement therapy. (17alpha)-estra-1,3,5(10)-triene-3,17-diol α-estradiol 1,3,5-Estratriene-3,17α-diol 1,3,5-Estratriene-3,17a-diol 1,3,5(10)-Estratriene-3,17alpha-diol 13b-Methyl-1,3,5(10)-gonatriene-3,17a-diol 17-alpha-Estradiol 17-Epiestradiol 17α-Estradiol 17α-Oestradiol 17a-Estradiol 17a-Oestradiol 17alpha estradiol 17alpha-Estradiol 17α-estradiol 3, 17-Dihydroxyestratriene 3, 17α-Dihydroxyestra-1,3,5(10)-triene 3, 17α-Dihydroxyoestra-1,3,5(10)-triene 3,17-Dihydroxyestratriene 3,17α-Dihydroxyestra-1,3,5(10)-triene 3,17α-Dihydroxyoestra-1,3,5(10)-triene 3,17a-Dihydroxyestra-1,3,5(10)-triene 3,17a-Dihydroxyoestra-1,3,5(10)-triene 3,17alpha-Dihydroxy-1,3,5(10)-estratriene 5A-Estran-3A,17B-diol A-estradiol Alfatradiol Alfatradiol (inn) Alfatradiol, INN Alpha-estradiol b-Estradiol (obsol., misleading) Epiestradiol Epiestrol Estra-1,3,5(10)-triene-3, 17α-diol Estra-1,3,5(10)-triene-3,17-diol Estra-1,3,5(10)-triene-3,17-diol, (17α)- Estra-1,3,5(10)-triene-3,17α-diol Estra-1,3,5(10)-triene-3,17a-diol estra-1,3,5(10)-triene-3,17alpha-diol Estra-1,3,5(10)trien-3,17a-diol Estra-1,3,5(10)trien-3,17alpha-diol Estra-1,3,5(10)trien-3,17α-diol Estradiol Estradiol-17a estradiol-17alpha Estradiol-17α Estradiol, 17α- Oestra-1,3,5(10)-triene-3, 17α-diol Oestra-1,3,5(10)-triene-3,17α-diol Oestra-1,3,5(10)-triene-3,17a-diol Oestradiol-17α α-estradiol C18H24O2 272.382 272.177630012 15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol 15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol 57-91-0 CC12CCC3C(CCC4=C3C=CC(O)=C4)C1CCC2O InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3 VOXZDWNPVJITMN-UHFFFAOYSA-N belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane. Estrogens and derivatives Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Estrane steroids Aromatic homopolycyclic compounds 1-hydroxy-2-unsubstituted benzenoids 17-hydroxysteroids 3-hydroxysteroids Cyclic alcohols and derivatives Hydrocarbon derivatives Phenanthrenes and derivatives Secondary alcohols Tetralins 1-hydroxy-2-unsubstituted benzenoid 17-hydroxysteroid 3-hydroxysteroid Alcohol Aromatic homopolycyclic compound Benzenoid Cyclic alcohol Estrogen-skeleton Hydrocarbon derivative Hydroxysteroid Organic oxygen compound Organooxygen compound Phenanthrene Secondary alcohol Tetralin a steroid Solid logp 3.57 ALOGPS logs -4.11 ALOGPS solubility 2.13e-02 g/l ALOGPS melting_point Mp 223° logp 3.75 ChemAxon pka_strongest_acidic 10.33 ChemAxon pka_strongest_basic -0.88 ChemAxon iupac 15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol ChemAxon average_mass 272.382 ChemAxon mono_mass 272.177630012 ChemAxon smiles CC12CCC3C(CCC4=C3C=CC(O)=C4)C1CCC2O ChemAxon formula C18H24O2 ChemAxon inchi InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3 ChemAxon inchikey VOXZDWNPVJITMN-UHFFFAOYSA-N ChemAxon polar_surface_area 40.46 ChemAxon refractivity 79.9 ChemAxon polarizability 31.86 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 2 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::MsMs 3394312 Specdb::MsMs 3394313 Specdb::MsMs 3394314 Specdb::MsMs 3394315 Specdb::MsMs 3394316 Specdb::MsMs 3394317 Specdb::CMs 113972 Specdb::CMs 127897 Specdb::CMs 808195 Specdb::CMs 808196 Specdb::CMs 808197 Specdb::CMs 808198 Specdb::CMs 808199 Specdb::CMs 808200 HMDB00429 17160 #<Reference:0x000055ce31680380> #<Reference:0x000055ce31680128> #<Reference:0x000055ce3167be98> Apricot Type 1 specific Prunus armeniaca 36596 Milk (Cow) Type 2 specific 0.000124 0.000145 0.000111 uM Pomegranate Type 1 specific Punica granatum 22663