Record Information
Version1.0
Creation date2010-04-08 22:09:52 UTC
Update date2019-11-26 03:05:36 UTC
Primary IDFDB011860
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameHomofureanol
DescriptionHomofureanol, also known as HEMF or ehmf CPD, belongs to the class of organic compounds known as furanones. Furanones are compounds containing a furan ring bearing a ketone group. Homofureanol is an extremely weak basic (essentially neutral) compound (based on its pKa). Homofureanol is a sweet, butterscotch, and candy tasting compound. Homofureanol has been detected, but not quantified in, several different foods, such as angelica, dates, towel gourds, alpine sweetvetchs, and common grapes. This could make homofureanol a potential biomarker for the consumption of these foods.
CAS Number27538-10-9
Structure
Thumb
Synonyms
SynonymSource
4-Hydroxy-2-ethyl-5-methyl-3(2H)-furanoneChEBI
HomofuraneolChEBI
2-Ethyl-4-hydroxy-5-methyl-3(2H)-furanoneHMDB
2-Ethyl-4-hydroxy-5-methyl-3(2H)-furanone (homofuraneol)HMDB
2-Ethyl-4-hydroxy-5-methylfuran-3(2H)-oneHMDB
4-Hydroxy-2- or 5-ethyl-5- and 2-methyl-3(2H)-furanoneHMDB
Ethyl 4-hydroxy-5-methyl-3(2H)-furanone (homofuraneol)HMDB
HEMFHMDB
4-HEMFHMDB
4-Hydroxy-5-ethyl-2-methyl-3(2H)-furanoneHMDB
5-Ethyl-4-hydroxy-2-methyl-3(2H)-furanoneHMDB
EHMF CPDHMDB
2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone (homofuraneol)biospider
3(2H)-Furanone, 2-ethyl-4-hydroxy-5-methyl-biospider
4-hydroxy-2- or 5-ethyl-5- and 2-methyl-3(2H)-furanonebiospider
ethyl 4-hydroxy-5-methyl-3(2H)-furanone (homofuraneol)biospider
Homofureanoldb_source
Predicted Properties
PropertyValueSource
Water Solubility236 g/LALOGPS
logP0.11ALOGPS
logP0.73ChemAxon
logS0.22ALOGPS
pKa (Strongest Acidic)7.54ChemAxon
pKa (Strongest Basic)-4.3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity37.82 m³·mol⁻¹ChemAxon
Polarizability14.51 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC7H10O3
IUPAC name2-ethyl-4-hydroxy-5-methyl-2,3-dihydrofuran-3-one
InChI IdentifierInChI=1S/C7H10O3/c1-3-5-7(9)6(8)4(2)10-5/h5,8H,3H2,1-2H3
InChI KeyGWCRPYGYVRXVLI-UHFFFAOYSA-N
Isomeric SMILESCCC1OC(C)=C(O)C1=O
Average Molecular Weight142.1525
Monoisotopic Molecular Weight142.062994186
Classification
Description belongs to the class of organic compounds known as furanones. Furanones are compounds containing a furan ring bearing a ketone group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDihydrofurans
Sub ClassFuranones
Direct ParentFuranones
Alternative Parents
Substituents
  • 3-furanone
  • Vinylogous ester
  • Cyclic ketone
  • Ketone
  • Oxacycle
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External DescriptorsNot Available
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Biological role:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 59.14%; H 7.09%; O 33.76%DFC
Melting PointNot Available
Boiling PointBp0.3 85-90°DFC
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-056r-9100000000-e77441a2926b81d6c1e6JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positivesplash10-004i-8900000000-19d917e9df06c53f68cfJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0006-2900000000-661926735086b21235e4JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0006-6900000000-b6df9b77aa2ba2efebc7JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-9000000000-1c3e8534a205fdd72c67JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0006-2900000000-bf10665a914b166457f4JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0006-2900000000-a2a2d562eaad775f5009JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0aou-9000000000-86b5eedb782b1fcc76efJSpectraViewer
ChemSpider ID31277
ChEMBL IDNot Available
KEGG Compound IDNot Available
Pubchem Compound ID33931
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB33736
CRC / DFC (Dictionary of Food Compounds) IDHBF43-R:HBF43-R
EAFUS ID1231
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet ID27538-10-9
GoodScent IDrw1491201
SuperScent ID33931
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
Flavours
FlavorCitations
caramel
  1. Arn, H, Acree TE. “Flavornet: A database of aroma compounds based on odor potency in natural products”. Developments in Food Science 40 (1998): 27. doi:10.1016/S0167-4501(98)80029-0
  2. Dunkel, M. et al. SuperScent – a database of flavors and scents. Nucleic Acids Research 2008, doi:10.1093/nar/gkn695
  3. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
sweet
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
candy
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
butterscotch
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference