1.0 2010-04-08 22:09:55 UTC 2025-11-18 23:32:32 UTC FDB011964 Demethoxycurcumin Isolated from Curcuma zedoaria (zedoary), Curcuma longa (turmeric), Curcuma xanthorrhiza (Java turmeric). Demethoxycurcumin is found in many foods, some of which are beverages, herbs and spices, turmeric, and root vegetables. (1e,6e)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione (1e,6e)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-hepta-1,6-diene-3,5-dione 1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, 9CI 4-hydroxycinnamoyl(feroyl)methane 4-Hydroxycinnamoyl(feruloyl)methane Bhcfm CurcuminII Demethoxy-curcumin Demethoxycurcumin Feruloyl-p-hydroxycinnnamoylmethane Monodemethoxycurcumin p-Hydroxycinnamoylferuloylmethane C20H18O5 338.3539 338.115423686 (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione 22608-11-3 COC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC=C(O)C=C2)=CC=C1O InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+ HJTVQHVGMGKONQ-LUZURFALSA-N belongs to the class of organic compounds known as curcuminoids. These are aromatic compounds containing a curcumin moiety, which is composed of two aryl buten-2-one (feruloyl) chromophores joined by a methylene group. Curcuminoids Organic compounds Phenylpropanoids and polyketides Diarylheptanoids Linear diarylheptanoids Aromatic homomonocyclic compounds 1-hydroxy-2-unsubstituted benzenoids Acryloyl compounds Alkyl aryl ethers Anisoles Beta-diketones Enones Hydrocarbon derivatives Hydroxycinnamic acids and derivatives Ketones Methoxybenzenes Methoxyphenols Organic oxides Phenoxy compounds Styrenes 1,3-dicarbonyl compound 1,3-diketone 1-hydroxy-2-unsubstituted benzenoid Acryloyl-group Alkyl aryl ether Alpha,beta-unsaturated ketone Anisole Aromatic homomonocyclic compound Benzenoid Carbonyl group Desmethoxycurcumin Enone Ether Hydrocarbon derivative Hydroxycinnamic acid or derivatives Ketone Methoxybenzene Methoxyphenol Monocyclic benzene moiety Organic oxide Organic oxygen compound Organooxygen compound Phenol Phenol ether Phenoxy compound Styrene beta-diketone diarylheptanoid enone polyphenol logp 3.54 ALOGPS logs -4.70 ALOGPS solubility 6.73e-03 g/l ALOGPS melting_point Mp 168° logp 4.28 ChemAxon pka_strongest_acidic 8.84 ChemAxon pka_strongest_basic -4.5 ChemAxon iupac (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione ChemAxon average_mass 338.3539 ChemAxon mono_mass 338.115423686 ChemAxon smiles COC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC=C(O)C=C2)=CC=C1O ChemAxon formula C20H18O5 ChemAxon inchi InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+ ChemAxon inchikey HJTVQHVGMGKONQ-LUZURFALSA-N ChemAxon polar_surface_area 83.83 ChemAxon refractivity 97.35 ChemAxon polarizability 35.35 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 11172 Specdb::CMs 43512 Specdb::CMs 146439 Specdb::MsMs 76503 Specdb::MsMs 76504 Specdb::MsMs 76505 Specdb::MsMs 136350 Specdb::MsMs 136351 Specdb::MsMs 136352 Specdb::MsMs 2226658 Specdb::MsMs 2228077 Specdb::MsMs 2228989 Specdb::MsMs 2230441 Specdb::MsMs 2231460 Specdb::MsMs 2232756 Specdb::MsMs 2233861 Specdb::MsMs 2235067 Specdb::MsMs 2258675 Specdb::MsMs 2259907 Specdb::MsMs 3041914 Specdb::MsMs 3041915 Specdb::MsMs 3041916 Specdb::MsMs 3098311 Specdb::MsMs 3098312 Specdb::MsMs 3098313 HMDB33801 #<Reference:0x000055ce2ec20720> #<Reference:0x000055ce2ec20450> #<Reference:0x000055ce2ec03d00> #<Reference:0x000055ce2ec03af8> #<Reference:0x000055ce2ec03698> #<Reference:0x000055ce2ec03468> #<Reference:0x000055ce2ec03288> Beverages Unknown generic Herbs and Spices Unknown generic Root vegetables Unknown generic Turmeric Type 1 specific Curcuma longa 136217 1982.5 1982.5 1982.5 mg/100 g Anti aflatoxin 92 A substance that diminishes the rate of a chemical reaction. Anti amyloid-beta 109 Anti leishmanic 388 A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. Anti lipoperoxidant 407 Anti-Alzheimeran 105 Any substance introduced into a living organism with therapeutic or diagnostic purpose. Anti-angiogenic 115 An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. Anti-inflammatory 370 A substance that reduces or suppresses inflammation. Anti-mutagenic 451 Anti-nitrosating 481 Anti-papillomic 507 A substance that destroys or inhibits replication of viruses. Antitumor promoter 673 A substance that inhibits or prevents the proliferation of neoplasms. DNA-protective 887 Nematicide 1141 A substance used to destroy pests of the phylum Nematoda (roundworms). Nitric-oxide scavenger 1168 Plasmodicide 1233 Quinone-reductase inducer 1277 Sortase-A inhibitor 1319 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Topoisomerase-I inhibitor 1368 A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. Topoisomerase-II inhibitor 1366 A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (topoisomerase II), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.