Record Information
Version1.0
Creation date2010-04-08 22:10:01 UTC
Update date2019-11-26 03:06:18 UTC
Primary IDFDB012162
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameCodeine
DescriptionOpium alkaloid (Papaver somniferum) (content ca. 1%) An opioid analgesic related to morphine but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.; Codeine (INN) or methylmorphine is an opiate used for its analgesic, antitussive and antidiarrheal properties. Codeine is found in many foods, some of which are small-leaf linden, european plum, apple, and chinese water chestnut.
CAS Number76-57-3
Structure
Thumb
Synonyms
SynonymSource
(-)-CodeineChEBI
(1S,13R,14S,17R)-10-Methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10,15-tetraen-14-olChEBI
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-olChEBI
7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-olChEBI
CodeinChEBI
CodeinaChEBI
Codeine anhydrousChEBI
CodiceptChEBI
CoduceptChEBI
L-CodeineChEBI
MethylmorphineChEBI
Morphine 3-methyl etherChEBI
Morphine monomethyl etherChEBI
Morphine-3-methyl etherChEBI
O(3)-MethylmorphineChEBI
(5a,6a)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-olGenerator
(5Α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-olGenerator
7,8-Didehydro-4,5a-epoxy-3-methoxy-17-methylmorphinan-6a-olGenerator
7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-olGenerator
Norcodeine, N-methylHMDB
Norcodine, N-methylHMDB
O3-MethylmorphineHMDB
Codeine phosphateMeSH, HMDB
IsocodeineMeSH, HMDB
N-MethylmorphineMeSH, HMDB
ArdinexMeSH, HMDB
N MethylmorphineMeSH, HMDB
(-)-codeinebiospider
7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol, 9CIdb_source
Actacodebiospider
Calcidrinebiospider
Kodeindb_source
Morphine-3-methyl esterbiospider
morphine-3-methyl etherbiospider
N-methyl norcodinebiospider
N-methylmorphinebiospider
N-methylnorcodeinebiospider
Novahistine DHbiospider
Tussipandb_source
Predicted Properties
PropertyValueSource
Water Solubility0.58 g/LALOGPS
logP1.2ALOGPS
logP1.34ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)13.78ChemAxon
pKa (Strongest Basic)9.19ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area41.93 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity84.6 m³·mol⁻¹ChemAxon
Polarizability31.95 ųChemAxon
Number of Rings5ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC18H21NO3
IUPAC name(1S,5R,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-tetraen-14-ol
InChI IdentifierInChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1
InChI KeyOROGSEYTTFOCAN-DNJOTXNNSA-N
Isomeric SMILES[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2O
Average Molecular Weight299.3642
Monoisotopic Molecular Weight299.152143543
Classification
Description Belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassMorphinans
Sub ClassNot Available
Direct ParentMorphinans
Alternative Parents
Substituents
  • Morphinan
  • Phenanthrene
  • Tetralin
  • Coumaran
  • Anisole
  • Aralkylamine
  • Alkyl aryl ether
  • Benzenoid
  • Piperidine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Source:

Route of exposure:

Biological location:

Role

Environmental role:

Biological role:

Industrial application:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionC 72.22%; H 7.07%; N 4.68%; O 16.03%DFC
Melting PointMp 155°DFC
Boiling PointNot Available
Experimental Water Solubility9 mg/mL at 20 oCYALKOWSKY,SH & DANNENFELSER,RM (1992)
Experimental logP1.19AVDEEF,A ET AL. (1996)
Experimental pKa8.21
Isoelectric pointNot Available
ChargeNot Available
Optical Rotation[a]D -137.8 (EtOH)DFC
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-01ot-3950000000-e80ecb11646b4da6aa92Spectrum
Predicted GC-MSCodeine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00lr-3090000000-38668348c3e45e16a9e7Spectrum
Predicted GC-MSCodeine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0ab9-9135000000-5476697a08758d9606baSpectrum
Predicted GC-MSCodeine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSCodeine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL Thermo Scientific) 60V, Positivesplash10-0uxr-0973000000-87d07ddd2ed24b9598d7Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0udi-0009000000-d68b67071bf467a42afaSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0udi-0009000000-a298cedb776a11677cf7Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0udi-0459000000-1a92521b38ba51a7fa81Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0gc1-0940000000-68cae285315cfe9c7d0eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0uxs-0910000000-b0c288c76c616e1a54d3Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0159-0390000000-ac30542a576060b3373cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0udi-0009000000-870de7833257cd342810Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0udi-0009000000-8ece718ed46e5e439112Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0udi-0139000000-7880499a47dbd2f41229Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0uxr-0973000000-87d07ddd2ed24b9598d7Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-015a-0920000000-4f676c9e2b42320493afSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0uxr-0910000000-e67964930533268605cdSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0udi-0009000000-99b083bf48ae39e3cec6Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0udi-0009000000-efebfbff05a4cb72fe32Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0udi-0139000000-be0f9b6eaa028b54ad6cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0uxr-0973000000-89bc81638a52beefd890Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-015a-0920000000-7eccc8e19d8d88b18128Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , positivesplash10-0uxr-0910000000-5809a9ed32210bcfa231Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0029000000-426a3155887524f062f8Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-1098000000-e16cf5105c8be7f2dd00Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-4090000000-7d22a9e9b2e7b780b7b6Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0002-0090000000-d34a35c4caed20d97ad0Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0002-0090000000-16ee1c88e7d182e8ebf4Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-003f-1290000000-b1e3ca03a80d7ea7edabSpectrum
NMR
TypeDescriptionView
ChemSpider ID4447447
ChEMBL IDNot Available
KEGG Compound IDC06174
Pubchem Compound ID163159
Pubchem Substance IDNot Available
ChEBI ID16714
Phenol-Explorer IDNot Available
DrugBank IDDB00318
HMDB IDHMDB04995
CRC / DFC (Dictionary of Food Compounds) IDHDV94-X:HDV94-X
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDC00001837
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDCodeine
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
Enzymes
NameGene NameUniProt ID
UDP-glucuronosyltransferase 2B28UGT2B28Q9BY64
UDP-glucuronosyltransferase 2B4UGT2B4P06133
UDP-glucuronosyltransferase 1-4UGT1A4P22310
UDP-glucuronosyltransferase 2B10UGT2B10P36537
UDP-glucuronosyltransferase 2B7UGT2B7P16662
UDP-glucuronosyltransferase 2B15UGT2B15P54855
UDP-glucuronosyltransferase 2A1UGT2A1Q9Y4X1
UDP-glucuronosyltransferase 1-1UGT1A1P22309
UDP-glucuronosyltransferase 1-9UGT1A9O60656
UDP-glucuronosyltransferase 1-8UGT1A8Q9HAW9
UDP-glucuronosyltransferase 1-3UGT1A3P35503
UDP-glucuronosyltransferase 1-10UGT1A10Q9HAW8
UDP-glucuronosyltransferase 2B17UGT2B17O75795
UDP-glucuronosyltransferase 1-6UGT1A6P19224
UDP-glucuronosyltransferase 1-5UGT1A5P35504
UDP-glucuronosyltransferase 2B11UGT2B11O75310
UDP-glucuronosyltransferase 1-7UGT1A7Q9HAW7
UDP-glucuronosyltransferase 2A3UGT2A3Q6UWM9
Cytochrome P450, family 1, subfamily A, polypeptide 1CYP1A1A0N0X8
Cytochrome P450 2D6CYP2D6Q6NWU0
Pathways
NameSMPDB LinkKEGG Link
Codeine PathwaySMP00405 Not Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSshow
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.