<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2010-04-08 22:10:08 UTC</creation_date>
  <update_date>2019-11-26 03:06:40 UTC</update_date>
  <accession>FDB012390</accession>
  <name>5'-Guanylic acid</name>
  <description>Widely distributed in plants and animals, occurs in the hydrolysates of RNA

Guanosine 5'-monophosphate. A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.</description>
  <synonyms>
    <synonym>1sgx</synonym>
    <synonym>2fxv</synonym>
    <synonym>5'-GMP</synonym>
    <synonym>5'-Guanylic acid (8CI,9CI)</synonym>
    <synonym>5'-Guanylic acid, homopolymer</synonym>
    <synonym>CPG</synonym>
    <synonym>e 626</synonym>
    <synonym>E626</synonym>
    <synonym>GMP</synonym>
    <synonym>GNP</synonym>
    <synonym>Guanidine monoate</synonym>
    <synonym>Guanidine monophosphate</synonym>
    <synonym>Guanine polynucleotides</synonym>
    <synonym>guanine riboside-5-phosphoric acid</synonym>
    <synonym>Guanosine 5'-(dihydrogen phosphate)</synonym>
    <synonym>Guanosine 5'-ate</synonym>
    <synonym>Guanosine 5'-ic acid</synonym>
    <synonym>Guanosine 5'-monoate</synonym>
    <synonym>Guanosine 5'-monoic acid</synonym>
    <synonym>Guanosine 5'-monophosphate</synonym>
    <synonym>Guanosine 5'-monophosphoric acid</synonym>
    <synonym>Guanosine 5'-orate</synonym>
    <synonym>Guanosine 5'-oric acid</synonym>
    <synonym>Guanosine 5'-phosphate</synonym>
    <synonym>Guanosine 5'-phosphorate</synonym>
    <synonym>Guanosine 5'-phosphoric acid</synonym>
    <synonym>Guanosine monoate</synonym>
    <synonym>Guanosine monoic acid</synonym>
    <synonym>Guanosine monophosphate</synonym>
    <synonym>Guanosine-5'-ate</synonym>
    <synonym>Guanosine-5'-monoate</synonym>
    <synonym>Guanosine-5'-monoic acid</synonym>
    <synonym>guanosine-5'-monophosphate</synonym>
    <synonym>guanosine-5'-phosphate</synonym>
    <synonym>Guanosine-ate</synonym>
    <synonym>Guanosine-monophosphate</synonym>
    <synonym>Guanosine-phosphate</synonym>
    <synonym>Guanylate</synonym>
    <synonym>Guanylic acid</synonym>
    <synonym>Poly g</synonym>
    <synonym>Polyguanylic acids</synonym>
    <synonym>Xylo-GMP</synonym>
  </synonyms>
  <chemical_formula>C10H14N5O8P</chemical_formula>
  <average_molecular_weight>363.2206</average_molecular_weight>
  <monisotopic_moleculate_weight>363.057998961</monisotopic_moleculate_weight>
  <iupac_name>{[3,4-dihydroxy-5-(6-hydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid</iupac_name>
  <traditional_iupac>[3,4-dihydroxy-5-(6-hydroxy-2-imino-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic acid</traditional_iupac>
  <cas_registry_number>85-32-5</cas_registry_number>
  <smiles>OC1C(COP(O)(O)=O)OC(C1O)N1C=NC2=C1NC(=N)N=C2O</smiles>
  <inchi>InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)</inchi>
  <inchikey>RQFCJASXJCIDSX-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <description> belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.</description>
    <direct_parent>Purine ribonucleoside monophosphates</direct_parent>
    <kingdom>Organic compounds</kingdom>
    <super_class>Nucleosides, nucleotides, and analogues</super_class>
    <class>Purine nucleotides</class>
    <sub_class>Purine ribonucleotides</sub_class>
    <molecular_framework>Aromatic heteropolycyclic compounds</molecular_framework>
    <alternative_parents>
      <alternative_parent>1,2-diols</alternative_parent>
      <alternative_parent>6-oxopurines</alternative_parent>
      <alternative_parent>Aminopyrimidines and derivatives</alternative_parent>
      <alternative_parent>Azacyclic compounds</alternative_parent>
      <alternative_parent>Glycosylamines</alternative_parent>
      <alternative_parent>Heteroaromatic compounds</alternative_parent>
      <alternative_parent>Hydrocarbon derivatives</alternative_parent>
      <alternative_parent>Hypoxanthines</alternative_parent>
      <alternative_parent>Monoalkyl phosphates</alternative_parent>
      <alternative_parent>Monosaccharide phosphates</alternative_parent>
      <alternative_parent>N-substituted imidazoles</alternative_parent>
      <alternative_parent>Organic oxides</alternative_parent>
      <alternative_parent>Organopnictogen compounds</alternative_parent>
      <alternative_parent>Oxacyclic compounds</alternative_parent>
      <alternative_parent>Pentose phosphates</alternative_parent>
      <alternative_parent>Primary amines</alternative_parent>
      <alternative_parent>Pyrimidones</alternative_parent>
      <alternative_parent>Secondary alcohols</alternative_parent>
      <alternative_parent>Tetrahydrofurans</alternative_parent>
      <alternative_parent>Vinylogous amides</alternative_parent>
    </alternative_parents>
    <substituents>
      <substituent>1,2-diol</substituent>
      <substituent>6-oxopurine</substituent>
      <substituent>Alcohol</substituent>
      <substituent>Alkyl phosphate</substituent>
      <substituent>Amine</substituent>
      <substituent>Aminopyrimidine</substituent>
      <substituent>Aromatic heteropolycyclic compound</substituent>
      <substituent>Azacycle</substituent>
      <substituent>Azole</substituent>
      <substituent>Glycosyl compound</substituent>
      <substituent>Heteroaromatic compound</substituent>
      <substituent>Hydrocarbon derivative</substituent>
      <substituent>Hypoxanthine</substituent>
      <substituent>Imidazole</substituent>
      <substituent>Imidazopyrimidine</substituent>
      <substituent>Monoalkyl phosphate</substituent>
      <substituent>Monosaccharide</substituent>
      <substituent>Monosaccharide phosphate</substituent>
      <substituent>N-glycosyl compound</substituent>
      <substituent>N-substituted imidazole</substituent>
      <substituent>Organic nitrogen compound</substituent>
      <substituent>Organic oxide</substituent>
      <substituent>Organic oxygen compound</substituent>
      <substituent>Organic phosphoric acid derivative</substituent>
      <substituent>Organoheterocyclic compound</substituent>
      <substituent>Organonitrogen compound</substituent>
      <substituent>Organooxygen compound</substituent>
      <substituent>Organopnictogen compound</substituent>
      <substituent>Oxacycle</substituent>
      <substituent>Pentose monosaccharide</substituent>
      <substituent>Pentose phosphate</substituent>
      <substituent>Pentose-5-phosphate</substituent>
      <substituent>Phosphoric acid ester</substituent>
      <substituent>Primary amine</substituent>
      <substituent>Purine</substituent>
      <substituent>Purine ribonucleoside monophosphate</substituent>
      <substituent>Pyrimidine</substituent>
      <substituent>Pyrimidone</substituent>
      <substituent>Secondary alcohol</substituent>
      <substituent>Tetrahydrofuran</substituent>
      <substituent>Vinylogous amide</substituent>
    </substituents>
    <external_descriptors>
    </external_descriptors>
  </taxonomy>
  <state>Solid</state>
  <predicted_properties>
    <property>
      <kind>logp</kind>
      <value>-1.92</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>logs</kind>
      <value>-2.14</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>solubility</kind>
      <value>2.63e+00 g/l</value>
      <source>ALOGPS</source>
    </property>
  </predicted_properties>
  <experimental_properties>
    <property>
      <kind>melting_point</kind>
      <value>Mp 190-200° dec.</value>
    </property>
  </experimental_properties>
  <property>
    <kind>logp</kind>
    <value>-3.7</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>pka_strongest_acidic</kind>
    <value>1.22</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>pka_strongest_basic</kind>
    <value>2.97</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>iupac</kind>
    <value>{[3,4-dihydroxy-5-(6-hydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>average_mass</kind>
    <value>363.2206</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>mono_mass</kind>
    <value>363.057998961</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>smiles</kind>
    <value>OC1C(COP(O)(O)=O)OC(C1O)N1C=NC2=C1NC(=N)N=C2O</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>formula</kind>
    <value>C10H14N5O8P</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>inchi</kind>
    <value>InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>inchikey</kind>
    <value>RQFCJASXJCIDSX-UHFFFAOYSA-N</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>polar_surface_area</kind>
    <value>202.74</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>refractivity</kind>
    <value>86.08</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>polarizability</kind>
    <value>31.11</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>rotatable_bond_count</kind>
    <value>4</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>acceptor_count</kind>
    <value>11</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>donor_count</kind>
    <value>7</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>physiological_charge</kind>
    <value>-2</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>formal_charge</kind>
    <value>0</value>
    <source>ChemAxon</source>
  </property>
  <pathways>
    <pathway>
      <name>Glutamate Metabolism</name>
      <smpdb_id>SMP00072</smpdb_id>
      <kegg_map_id>map00250</kegg_map_id>
    </pathway>
    <pathway>
      <name>Purine Metabolism</name>
      <smpdb_id>SMP00050</smpdb_id>
      <kegg_map_id>map00230</kegg_map_id>
    </pathway>
    <pathway>
      <name>Transcription/Translation</name>
      <smpdb_id>SMP00019</smpdb_id>
      <kegg_map_id></kegg_map_id>
    </pathway>
  </pathways>
  <spectra>
    <spectrum>
      <type>Specdb::NmrOneD</type>
      <spectrum_id>4711</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::MsMs</type>
      <spectrum_id>26792</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::MsMs</type>
      <spectrum_id>26793</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::MsMs</type>
      <spectrum_id>26794</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::MsMs</type>
      <spectrum_id>33350</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::MsMs</type>
      <spectrum_id>33351</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::MsMs</type>
      <spectrum_id>33352</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>112537</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>126045</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970859</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970860</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970861</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970862</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970863</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970864</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970865</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970866</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970867</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970868</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970869</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970870</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970871</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970872</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970873</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970874</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970875</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970876</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970877</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970878</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970879</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970880</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>970881</spectrum_id>
    </spectrum>
  </spectra>
  <hmdb_id>HMDB01397</hmdb_id>
  <pubchem_compound_id/>
  <chemspider_id/>
  <kegg_id/>
  <chebi_id>17345</chebi_id>
  <biocyc_id/>
  <het_id>5GP</het_id>
  <wikipidia/>
  <vmh_id/>
  <fbonto_id/>
  <foodb_id/>
  <general_references>
    <reference>#&lt;Reference:0x000055ce318e6a48&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e6868&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e66b0&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e64f8&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e6318&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e6138&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e5f80&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e5dc8&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e5c10&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e5a58&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e58a0&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e56e8&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e5508&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e5350&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e5198&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e4fe0&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e4e28&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e4c48&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e4a68&gt;</reference>
    <reference>#&lt;Reference:0x000055ce318e48b0&gt;</reference>
  </general_references>
  <foods>
    <food>
      <name>Milk (Cow)</name>
      <food_type>Type 2</food_type>
      <category>specific</category>
      <name_scientific></name_scientific>
      <ncbi_taxonomy_id/>
      <average_value>5.05</average_value>
      <max_value>8.3</max_value>
      <min_value>1.8</min_value>
      <unit>uM</unit>
    </food>
  </foods>
  <flavors>
    <flavor>
      <name>odorless</name>
    </flavor>
  </flavors>
  <enzymes>
    <enzyme>
      <name>Adenine phosphoribosyltransferase</name>
      <uniprot_id>P07741</uniprot_id>
      <uniprot_name/>
      <gene_name>APRT</gene_name>
    </enzyme>
    <enzyme>
      <name>Bifunctional purine biosynthesis protein PURH</name>
      <uniprot_id>P31939</uniprot_id>
      <uniprot_name/>
      <gene_name>ATIC</gene_name>
    </enzyme>
    <enzyme>
      <name>Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B</name>
      <uniprot_id>Q01064</uniprot_id>
      <uniprot_name/>
      <gene_name>PDE1B</gene_name>
    </enzyme>
    <enzyme>
      <name>cGMP-inhibited 3',5'-cyclic phosphodiesterase B</name>
      <uniprot_id>Q13370</uniprot_id>
      <uniprot_name/>
      <gene_name>PDE3B</gene_name>
    </enzyme>
    <enzyme>
      <name>Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'</name>
      <uniprot_id>P51160</uniprot_id>
      <uniprot_name/>
      <gene_name>PDE6C</gene_name>
    </enzyme>
    <enzyme>
      <name>Cytosolic 5'-nucleotidase 3</name>
      <uniprot_id>Q9H0P0</uniprot_id>
      <uniprot_name/>
      <gene_name>NT5C3</gene_name>
    </enzyme>
    <enzyme>
      <name>Disks large homolog 4</name>
      <uniprot_id>P78352</uniprot_id>
      <uniprot_name/>
      <gene_name>DLG4</gene_name>
    </enzyme>
    <enzyme>
      <name>ENTPD4 protein</name>
      <uniprot_id>Q8NE73</uniprot_id>
      <uniprot_name/>
      <gene_name>ENTPD4</gene_name>
    </enzyme>
    <enzyme>
      <name>GMP reductase 1</name>
      <uniprot_id>P36959</uniprot_id>
      <uniprot_name/>
      <gene_name>GMPR</gene_name>
    </enzyme>
    <enzyme>
      <name>GMP reductase 2</name>
      <uniprot_id>Q9P2T1</uniprot_id>
      <uniprot_name/>
      <gene_name>GMPR2</gene_name>
    </enzyme>
    <enzyme>
      <name>Guanine nucleotide-binding protein G(q) subunit alpha</name>
      <uniprot_id>P50148</uniprot_id>
      <uniprot_name/>
      <gene_name>GNAQ</gene_name>
    </enzyme>
    <enzyme>
      <name>Guanine nucleotide-binding protein G(s) subunit alpha isoforms short</name>
      <uniprot_id>P63092</uniprot_id>
      <uniprot_name/>
      <gene_name>GNAS</gene_name>
    </enzyme>
    <enzyme>
      <name>Guanine nucleotide-binding protein G(t) subunit alpha-1</name>
      <uniprot_id>P11488</uniprot_id>
      <uniprot_name/>
      <gene_name>GNAT1</gene_name>
    </enzyme>
    <enzyme>
      <name>Guanine nucleotide-binding protein subunit alpha-11</name>
      <uniprot_id>P29992</uniprot_id>
      <uniprot_name/>
      <gene_name>GNA11</gene_name>
    </enzyme>
    <enzyme>
      <name>Guanylate kinase</name>
      <uniprot_id>Q16774</uniprot_id>
      <uniprot_name/>
      <gene_name>GUK1</gene_name>
    </enzyme>
    <enzyme>
      <name>Lysophosphatidic acid receptor 2</name>
      <uniprot_id>Q9HBW0</uniprot_id>
      <uniprot_name/>
      <gene_name>LPAR2</gene_name>
    </enzyme>
    <enzyme>
      <name>Protein RCC2</name>
      <uniprot_id>Q9P258</uniprot_id>
      <uniprot_name/>
      <gene_name>RCC2</gene_name>
    </enzyme>
    <enzyme>
      <name>Protein very KIND</name>
      <uniprot_id>Q76NI1</uniprot_id>
      <uniprot_name/>
      <gene_name>KNDC1</gene_name>
    </enzyme>
    <enzyme>
      <name>Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma</name>
      <uniprot_id>Q13956</uniprot_id>
      <uniprot_name/>
      <gene_name>PDE6H</gene_name>
    </enzyme>
    <enzyme>
      <name>Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta</name>
      <uniprot_id>O43924</uniprot_id>
      <uniprot_name/>
      <gene_name>PDE6D</gene_name>
    </enzyme>
    <enzyme>
      <name>Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma</name>
      <uniprot_id>P18545</uniprot_id>
      <uniprot_name/>
      <gene_name>PDE6G</gene_name>
    </enzyme>
    <enzyme>
      <name>Rho guanine nucleotide exchange factor 1</name>
      <uniprot_id>Q92888</uniprot_id>
      <uniprot_name/>
      <gene_name>ARHGEF1</gene_name>
    </enzyme>
    <enzyme>
      <name>Rho-related GTP-binding protein RhoU</name>
      <uniprot_id>Q7L0Q8</uniprot_id>
      <uniprot_name/>
      <gene_name>RHOU</gene_name>
    </enzyme>
    <enzyme>
      <name>Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha</name>
      <uniprot_id>P16499</uniprot_id>
      <uniprot_name/>
      <gene_name>PDE6A</gene_name>
    </enzyme>
    <enzyme>
      <name>Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta</name>
      <uniprot_id>P35913</uniprot_id>
      <uniprot_name/>
      <gene_name>PDE6B</gene_name>
    </enzyme>
    <enzyme>
      <name>Vinexin</name>
      <uniprot_id>O60504</uniprot_id>
      <uniprot_name/>
      <gene_name>SORBS3</gene_name>
    </enzyme>
  </enzymes>
  <health_effects>
  </health_effects>
</compound>
