1.0 2010-04-08 22:10:15 UTC 2025-11-18 23:38:01 UTC FDB012577 Fraxidin Fraxidin, also known as 8-hydroxy-6,7-dimethoxy-2h-1-benzopyran-2-one, is a member of the class of compounds known as hydroxycoumarins. Hydroxycoumarins are coumarins that contain one or more hydroxyl groups attached to the coumarin skeleton. Fraxidin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Fraxidin can be found in durian and watermelon, which makes fraxidin a potential biomarker for the consumption of these food products. 2H-1-Benzopyran-2-one, 8-hydroxy-6,7-dimethoxy- 8-Hydroxy-6,7-dimethoxy-2-benzopyrone 8-Hydroxy-6,7-dimethoxy-2H-1-benzopyran-2-one 8-Hydroxy-6,7-dimethoxycoumarin Fraxidin C11H10O5 222.1941 222.05282343 8-hydroxy-6,7-dimethoxy-2H-chromen-2-one 8-hydroxy-6,7-dimethoxychromen-2-one 525-21-3 COC1=C(OC)C(O)=C2OC(=O)C=CC2=C1 InChI=1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)9(13)11(7)15-2/h3-5,13H,1-2H3 QNFBKOHHLAWWTC-UHFFFAOYSA-N belongs to the class of organic compounds known as hydroxycoumarins. These are coumarins that contain one or more hydroxyl groups attached to the coumarin skeleton. Hydroxycoumarins Organic compounds Phenylpropanoids and polyketides Coumarins and derivatives Hydroxycoumarins Aromatic heteropolycyclic compounds 1-benzopyrans 1-hydroxy-4-unsubstituted benzenoids Alkyl aryl ethers Anisoles Heteroaromatic compounds Hydrocarbon derivatives Lactones Organic oxides Oxacyclic compounds Pyranones and derivatives 1-benzopyran 1-hydroxy-4-unsubstituted benzenoid Alkyl aryl ether Anisole Aromatic heteropolycyclic compound Benzenoid Benzopyran Ether Heteroaromatic compound Hydrocarbon derivative Hydroxycoumarin Lactone Organic oxide Organic oxygen compound Organoheterocyclic compound Organooxygen compound Oxacycle Pyran Pyranone hydroxycoumarin logp 1.83 ALOGPS logs -2.15 ALOGPS solubility 1.58e+00 g/l ALOGPS melting_point Mp 196-197° logp 1.81 ChemAxon pka_strongest_acidic 10.73 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac 8-hydroxy-6,7-dimethoxy-2H-chromen-2-one ChemAxon average_mass 222.1941 ChemAxon mono_mass 222.05282343 ChemAxon smiles COC1=C(OC)C(O)=C2OC(=O)C=CC2=C1 ChemAxon formula C11H10O5 ChemAxon inchi InChI=1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)9(13)11(7)15-2/h3-5,13H,1-2H3 ChemAxon inchikey QNFBKOHHLAWWTC-UHFFFAOYSA-N ChemAxon polar_surface_area 64.99 ChemAxon refractivity 56.46 ChemAxon polarizability 21.2 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::MsMs 100476 Specdb::MsMs 100477 Specdb::MsMs 100478 Specdb::MsMs 165813 Specdb::MsMs 165814 Specdb::MsMs 165815 Specdb::MsMs 2386187 Specdb::MsMs 2386188 Specdb::MsMs 2386189 Specdb::MsMs 2576877 Specdb::MsMs 2576878 Specdb::MsMs 2576879 Specdb::CMs 54433 Specdb::CMs 66879 Specdb::CMs 170389 Durian Type 1 specific Durio zibethinus 66656 Watermelon Type 1 specific Citrullus lanatus 3654