1.02010-04-08 22:10:17 UTC2020-09-17 15:30:15 UTCFDB012644PiperidinePiperidine, named after the genus Piper, which is Latin for pepper, has the molecular formula (CH2)5NH. It is a heterocyclic amine which consists of a six-membered ring containing five methylene units and one nitrogen atom. Piperidine is a strong basic compound. It is a colorless fuming liquid with an ammoniacal and pepper-like odor. It is found in black pepper fruit, oil and seed (Piper nigrum), barley seeds, celery plant, bell pepper and tobacco ( http://www.thegoodscentscompany.com/data/rw1009201.html#tooccur). Piperidine was obtained from the plants Psilocaulon absimile (Aizoaceae) and in Petrosimonia monandra ( https://en.wikipedia.org/wiki/Piperidine#cite_note-17). Piperidine is metabolized by microbes and is potentially used as an anti-bacterial agent controlling bacterial populations within rhizomes (http//doi.org/10.1101/499731). Piperidine is a widely used building block and chemical reagent in the synthesis of organic compounds, including pharmaceuticals such as vasodilators and antipsychotic medications (PMID: 25255204). Piperidine is a widely used secondary amine and used to convert ketones to enamines. Enamines derived from piperidine can be used in the Stork enamine alkylation reaction. Piperidine is used as a solvent and as a base. The same is true for certain derivatives: N-formylpiperidine is a polar aprotic solvent with better hydrocarbon solubility than other amide solvents, and 2,2,6,6-tetramethylpiperidine is highly sterically hindered base, useful because of its low nucleophilicity and high solubility in organic solvents.AzacyclohexaneAzinaneCyclopentimineCypentilFEMA 2908hexahydro-PyridineHexahydropyridineHexazanePentamethyleneaminePentamethyleneiminePentamethyleniminePerhydropyridinePIPPiperidinPiperidine [UN2401] [Corrosive]Piperidine on rasta resinPyridine, hexahydro-C5H11N85.147585.089149357piperidinepiperidine110-89-4C1CCNCC1InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2NQRYJNQNLNOLGT-UHFFFAOYSA-N belongs to the class of organic compounds known as piperidines. Piperidines are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms.PiperidinesOrganic compoundsOrganoheterocyclic compoundsPiperidinesAliphatic heteromonocyclic compoundsAzacyclic compoundsDialkylaminesHydrocarbon derivativesOrganopnictogen compoundsAliphatic heteromonocyclic compoundAmineAzacycleHydrocarbon derivativeOrganic nitrogen compoundOrganonitrogen compoundOrganopnictogen compoundPiperidineSecondary aliphatic amineSecondary amineazacycloalkanepiperidinessaturated organic heteromonocyclic parentsecondary amineLiquidlogp0.97logs0.16solubility1.24e+02 g/lmelting_pointMp -9°logp0.66pka_strongest_basic10.4iupacpiperidineaverage_mass85.1475mono_mass85.089149357smilesC1CCNCC1formulaC5H11NinchiInChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2inchikeyNQRYJNQNLNOLGT-UHFFFAOYSA-Npolar_surface_area12.03refractivity26.84polarizability10.43rotatable_bond_count0acceptor_count1donor_count1physiological_charge1formal_charge0Specdb::EiMs1659Specdb::MsIr6550Specdb::MsIr6551Specdb::MsIr6552Specdb::NmrOneD3795Specdb::NmrOneD4057Specdb::NmrOneD318631Specdb::NmrOneD318632Specdb::NmrOneD318633Specdb::NmrOneD318634Specdb::NmrOneD318635Specdb::NmrOneD318636Specdb::NmrOneD318637Specdb::NmrOneD318638Specdb::NmrOneD318639Specdb::NmrOneD318640Specdb::NmrOneD318641Specdb::NmrOneD318642Specdb::NmrOneD318643Specdb::NmrOneD318644Specdb::NmrOneD318645Specdb::NmrOneD318646Specdb::NmrOneD318647Specdb::NmrOneD318648Specdb::NmrOneD318649Specdb::NmrOneD318650Specdb::CMs2564Specdb::CMs26853Specdb::CMs28071Specdb::CMs29387Specdb::CMs101608Specdb::CMs101609Specdb::CMs101610Specdb::CMs135753Specdb::CMs143487Specdb::MsMs86916Specdb::MsMs86917Specdb::MsMs86918Specdb::MsMs149319Specdb::MsMs149320Specdb::MsMs149321Specdb::MsMs446724Specdb::MsMs446725Specdb::MsMs446726Specdb::MsMs446727Specdb::MsMs446728Specdb::MsMs448055Specdb::MsMs448267Specdb::MsMs448268Specdb::MsMs448269Specdb::MsMs448270Specdb::MsMs448271Specdb::MsMs448272Specdb::MsMs448273Specdb::MsMs448274Specdb::MsMs448275Specdb::MsMs448276Specdb::MsMs448277Specdb::MsMs448278Specdb::MsMs448279HMDB3430118049PIP#<Reference:0x00005556760c7d90>#<Reference:0x00005556760c7ae8>#<Reference:0x00005556760c77a0>#<Reference:0x00005556760c7570>#<Reference:0x00005556760c7228>#<Reference:0x00005556760c6ee0>BarleyType 1specificHordeum vulgare45130.10.10.1mg/100 gGrape wineType 2specific0.00.00.0mg/100 gGreen bell pepperType 1specificCapsicum annuum40720.520.520.52mg/100 gHerbs and SpicesUnknowngenericMilk (Cow)Type 2specificOrange bell pepperType 1specificCapsicum annuum40720.520.520.52mg/100 gPepperType 1specificCapsicum annuum40720.520.520.52mg/100 gPepper (Spice)Type 1specificPiper nigrum13216Red bell pepperType 1specificCapsicum annuum40720.520.520.52mg/100 gSoy beanType 1specificGlycine max3847Sweet bayType 1specificLaurus nobilis85223Wild celeryType 1specificApium graveolens4045Yellow bell pepperType 1specificCapsicum annuum40720.520.520.52mg/100 ganimalbitterfloralheavysweetanti enzymatic264central nervous system depressant812A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.diaphoretic879flavor936A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell.hepatotropic985insectifuge1041Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.perfumery1206A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell.pesticide1210Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.spinoconvulsant1325urate-solvent1393