1.0 2010-04-08 22:10:18 UTC 2019-11-26 03:07:24 UTC FDB012694 Thermophillin Isolated from Acorus calamus (sweet flag) Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance. Thermophillin is found in herbs and spices and root vegetables. 1,1'-Dithiobis(N,N-diethylthio-formamide 1,1'-Dithiobis(N,N-diethylthio)-formamide 1,1'-dithiobis(N,N-diethylthioformamide) 1,1'-Dithiobis[N,N-diethylthioformamide] 1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetraethane 2,5-Dimethoxy-1,4-benzoquinone Abstenisil Abstensil Abstensyl (argentina) Abstinil Abstinyl Accel tet Accel tet-r Alcophobin Alk-aubs Allphar brand of disulfiram Altana pharma brand of disulfiram Antab use Antabus Antabuse Antabuse (TN) Antadix Antaenyl Antaethan Antaethyl Antaetil Antalcol Antetan Antethyl Antetil Anteyl Anthethyl Anti-ethyl Antiaethan Anticol Antietanol Antiethanol Antietil Antikol Antivitium Antivitium (spain) Artu brand of disulfiram Aversan Averzan Bis-(diethylthiocarbamoyl)disulfide Bis((diethylamino)thioxomethyl) disulfide Bis((diethylamino)thioxomethyl)disulfide Bis((diethylamino)thioxomethyl)disulphide Bis(diethylthiocarbamoyl) disulfide Bis(diethylthiocarbamoyl)disulphide Bis(diethylthiocarbamyl) disulfide Bis(n,n-diethylthiocarbamoyl) disulfide Bis(n,n-diethylthiocarbamoyl)disulphide Bis[(diethylamino)thioxomethyl] disulfide Bohm brand of disulfiram Bonibal Contralin Contrapot Cronetal Dicupral Diethylcarbamothioylsulfanyl diethylaminomethanedithioate Disetil Disulfamide Disulfan Disulfide, bis(diethylthiocarbamoyl) Disulfide, tetraethylthiuram Disulfiram Disulfiram (JP15/USP/INN) Disulfiram (tetraethylthiuram disulfide) Disulfiram [inn:ban:jan] Disulfirame Disulfirame [dcit] Disulfiramo Disulfiramum Disulfirm Disulfuram Disulphuram Dumex brand of disulfiram Dupont fungicide 4472 Ekagom dtet Ekagom teds Ekagom tetds Ephorran Espenal Esperal Eta bus Etabus Ethyl thiram Ethyl thiudad Ethyl thiurad Ethyl tuads Ethyl tuex Ethyldithiourame Ethyldithiurame Exhoran Exhorran Formamide, 1,1'-dithiobis(N,N-diethylthio- Formamide, 1,1'-dithiobis(N,N-diethylthio)- HOCA Krotenal N,n,n',n'-tetraethylthiuram disulfide N,n,n',n'-tetraethylthiuram disulphide Nocbin Nocceler Nocceler tet Nocceler tet-g Noxal Noxal (van) Odyssey brand of disulfiram Orphan brand of disulfiram Refusal Refusal [netherlands] Ro-sulfiram Ro-Sulfram-500 (USA) Robac tet Sanceler tet Sanceler tet-g Sanofi synthelabo brand of disulfiram Soxinol tet Stopaethyl Stopethyl Stopety Stopetyl TATD Tenurid Tenutex Tet raethylthiuram TETD Tetidis Tetradin Tetradine Tetraethyl-thioperoxydicarbonic diamide Tetraethyl-thioperoxydicarbonic diamide (((H2N)C(S))2S2) Tetraethyl-thioperoxydicarbonic diamide ((H2N)C(S))2S2 Tetraethyl-thioperoxydicarbonic diamide ([(H2N)C(S)]2S2) Tetraethyl-thiuram disulfide Tetraethylthioperoxydicarbonic diamide Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2 Tetraethylthioperoxydicarbonothioic diamide Tetraethylthiram disulfide Tetraethylthiram disulphide Tetraethylthiuram Tetraethylthiuram disulfide Tetraethylthiuram disulphide Tetraethylthiuram sulfide Tetraethylthiuran disulfide Tetraethylthiurium disulfide Tetraetil Teturam Teturamin Thermophillin Thermophyllin Thiocid Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl- Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl- Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl- Thioperoxydicarbonic diamide, tetraethyl- Thiosan Thioscabin Thireranide Thiuram disulfide, tetraethyl- Thiuram e Thiuranide Tillram Tiuram TTD TTS TTS [alcohol deterrent] Tuads, ethyl C8H8O4 168.1467 168.042258744 2,5-dimethoxycyclohexa-2,5-diene-1,4-dione 2,5-dimethoxycyclohexa-2,5-diene-1,4-dione 3117-03-1 COC1=CC(=O)C(OC)=CC1=O InChI=1S/C8H8O4/c1-11-7-3-6(10)8(12-2)4-5(7)9/h3-4H,1-2H3 RMMPZDDLWLALLJ-UHFFFAOYSA-N belongs to the class of organic compounds known as p-benzoquinones. These are benzoquinones where the two C=O groups are attached at the 1- and 4-positions, respectively. P-benzoquinones Organic compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Aliphatic homomonocyclic compounds Hydrocarbon derivatives Organic oxides Vinylogous esters Aliphatic homomonocyclic compound Hydrocarbon derivative Organic oxide P-benzoquinone Vinylogous ester logp 0.27 ALOGPS logs -1.39 ALOGPS solubility 6.89e+00 g/l ALOGPS melting_point Mp 250 dec. (300° dec.) logp 0.21 ChemAxon pka_strongest_basic -4.6 ChemAxon iupac 2,5-dimethoxycyclohexa-2,5-diene-1,4-dione ChemAxon average_mass 168.1467 ChemAxon mono_mass 168.042258744 ChemAxon smiles COC1=CC(=O)C(OC)=CC1=O ChemAxon formula C8H8O4 ChemAxon inchi InChI=1S/C8H8O4/c1-11-7-3-6(10)8(12-2)4-5(7)9/h3-4H,1-2H3 ChemAxon inchikey RMMPZDDLWLALLJ-UHFFFAOYSA-N ChemAxon polar_surface_area 52.6 ChemAxon refractivity 44.47 ChemAxon polarizability 15.65 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::MsIr 6565 Specdb::MsIr 6566 Specdb::CMs 15309 Specdb::CMs 135832 Specdb::CMs 143566 Specdb::MsMs 64287 Specdb::MsMs 64288 Specdb::MsMs 64289 Specdb::MsMs 121401 Specdb::MsMs 121402 Specdb::MsMs 121403 Specdb::MsMs 2278847 Specdb::MsMs 2278848 Specdb::MsMs 2278849 Specdb::MsMs 3089827 Specdb::MsMs 3089828 Specdb::MsMs 3089829 Specdb::NmrOneD 125818 Specdb::NmrOneD 125819 Specdb::NmrOneD 125820 Specdb::NmrOneD 125821 Specdb::NmrOneD 125822 Specdb::NmrOneD 125823 Specdb::NmrOneD 125824 Specdb::NmrOneD 125825 Specdb::NmrOneD 125826 Specdb::NmrOneD 125827 Specdb::NmrOneD 125828 Specdb::NmrOneD 125829 Specdb::NmrOneD 125830 Specdb::NmrOneD 125831 Specdb::NmrOneD 125832 Specdb::NmrOneD 125833 Specdb::NmrOneD 125834 Specdb::NmrOneD 125835 Specdb::NmrOneD 125836 Specdb::NmrOneD 125837 HMDB34335 4659 #<Reference:0x000055ce31bf54c8> #<Reference:0x000055ce31bf5310> #<Reference:0x000055ce31bf5158> #<Reference:0x000055ce31bf4fa0> #<Reference:0x000055ce31bf4de8> #<Reference:0x000055ce31bf4c30> #<Reference:0x000055ce31bf4a78> #<Reference:0x000055ce31bf48c0> #<Reference:0x000055ce31bf4708> #<Reference:0x000055ce31bf44d8> #<Reference:0x000055ce31bf4320> #<Reference:0x000055ce31bf4168> #<Reference:0x000055ce31bf7570> #<Reference:0x000055ce31bf3e20> #<Reference:0x000055ce31bf3c68> #<Reference:0x000055ce31bf3ab0> Herbs and Spices Unknown generic Root vegetables Unknown generic