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Showing Compound Hordenine (FDB012750)

Record Information
Version1.0
Creation date2010-04-08 22:10:20 UTC
Update date2020-09-17 15:29:59 UTC
Primary IDFDB012750
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameHordenine
DescriptionHordenine belongs to the class of organic compounds known as phenethylamines. Phenethylamines are compounds containing a phenethylamine moiety, which consists of a phenyl group substituted at the second position by an ethan-1-amine. Hordenine, a strong basic compound, is a colorless solid that is soluble in organic solvents. Hordenine is biosynthesized by the stepwise N-methylation of tyramine, which is first converted to N-methyltyramine by tyramine N-methyltransferase and then is methylated to hordenine (PMID: 24257763). Hordenine exists in all living organisms, ranging from plants to humans. It is found in highest concentrations with barley (Hordeum species), from which its name is derived. Several varieties of plants in the family Cactacea (cacti) produce hordenine which, as a potent phenylethylamine alkaloid, has antibacterial and antibiotic properties (PMID: 30609368; PMID: 30128579). Hordenine has been found in several different foods, such as cereals and cereal products, corns, oats, sweet oranges, and tamarinds making it a potential biomarker for the consumption of these foods. People consuming beer brewed from barley will have higher levels of hordenine. However, hordenine in urine interferes with tests for morphine, heroin and other opioid drugs (PMID: 1618458). Hordenine is widely sold as an ingredient of nutritional supplements, with the claims that it is a stimulant of the central nervous system and can promote weight loss by enhancing metabolism.
CAS Number539-15-1
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
SynonymSource
4-[2-(Dimethylamino)ethyl]phenolChEBI
N,N-Dimethyl-2-(4-hydroxyphenyl)ethylamineChEBI
N,N-Dimethyl-4-hydroxy-beta-phenethylamineChEBI
N,N-DimethyltyramineChEBI
p-(2-Dimethylaminoethyl)phenolChEBI
N,N-Dimethyl-4-hydroxy-b-phenethylamineGenerator
N,N-Dimethyl-4-hydroxy-β-phenethylamineGenerator
Hordenine hydrochlorideHMDB
Hordenine sulfate (2:1)HMDB
Hordenine sulfate (1:1)HMDB
4-(2-Dimethylaminoethyl)phenolHMDB
AnhalinHMDB
AnhalineHMDB
CactineHMDB
EremursineHMDB
HordeninHMDB
HordetinHMDB
N,N-Dimethyl-p-hydroxyphenethylamineHMDB
OrdeninaHMDB
OrdenineHMDB
p-Hydroxy-N,N-dimethylphenethylamineHMDB
p-[2-(Dimethylamino)ethyl]phenolHMDB
PeyocactineHMDB
3595-05-9 (unspecified sulfate)biospider
4-(2-Dimethylaminoethyl)phenol, 9CIdb_source
4-Hydroxy-N,N-dimethylphenethylaminedb_source
N-Dimethyltyraminedb_source
N,N-Dimethyl-4-hydroxy-β-phenethylaminebiospider
N,n-dimethyl-p-hydroxyphenethylaminebiospider
N,n-dimethyltyraminebiospider
P-hydroxy-n,n-dimethylphenethylaminebiospider
Phenol, 4-[2-(dimethylamino)ethyl]-biospider
Phenol, p-[2-(dimethylamino)ethyl]-biospider
Predicted Properties
PropertyValueSource
Water Solubility29.7 g/LALOGPS
logP1.76ALOGPS
logP1.63ChemAxon
logS-0.75ALOGPS
pKa (Strongest Acidic)10.31ChemAxon
pKa (Strongest Basic)9.19ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area23.47 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity51.34 m³·mol⁻¹ChemAxon
Polarizability19.35 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC10H15NO
IUPAC name4-[2-(dimethylamino)ethyl]phenol
InChI IdentifierInChI=1S/C10H15NO/c1-11(2)8-7-9-3-5-10(12)6-4-9/h3-6,12H,7-8H2,1-2H3
InChI KeyKUBCEEMXQZUPDQ-UHFFFAOYSA-N
Isomeric SMILESCN(C)CCC1=CC=C(O)C=C1
Average Molecular Weight165.2322
Monoisotopic Molecular Weight165.115364107
Classification
Description Belongs to the class of organic compounds known as phenethylamines. Phenethylamines are compounds containing a phenethylamine moiety, which consists of a phenyl group substituted at the second position by an ethan-1-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenethylamines
Direct ParentPhenethylamines
Alternative Parents
Substituents
  • Phenethylamine
  • 1-hydroxy-2-unsubstituted benzenoid
  • Aralkylamine
  • Phenol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Role

Industrial application:

Physico-Chemical Properties
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionC 72.69%; H 9.15%; N 8.48%; O 9.68%DFC
Melting PointMp 118°DFC
Boiling PointBp11 173-174°DFC
Experimental Water Solubility7 mg/mLMERCK INDEX (1996)
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSHordenine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0a4i-9500000000-acdc91b4203b177fc754Spectrum
Predicted GC-MSHordenine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0a4i-9310000000-734c4e2c455b97372774Spectrum
Predicted GC-MSHordenine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSHordenine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - QqQ , positivesplash10-0uvo-9900000000-130b6ae804451c70f74f2020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 10V, positivesplash10-00xr-0900000000-25885270de2c1836c33b2020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 30V, positivesplash10-0096-9500000000-8b84d5e79a70fa3d426a2020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 50V, positivesplash10-00dl-8900000000-31b039648b094d1219b12020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 6V, positivesplash10-00xr-0900000000-25885270de2c1836c33b2020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 3V, positivesplash10-014i-0900000000-af85ba014415bf9af0252020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 4V, positivesplash10-014i-0900000000-35709636b966d858c1472020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 6V, positivesplash10-014i-0900000000-cb918f599a55448f67b12020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 8V, positivesplash10-014i-0900000000-2c71ef92063a1e597ef92020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 9V, positivesplash10-01b9-0900000000-4a5dab8033ea67d49fed2020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 11V, positivesplash10-00xr-0900000000-ceea75c15d32fbdad6b12020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 13V, positivesplash10-00di-0900000000-0786df40672ae99b47022020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 14V, positivesplash10-00di-0900000000-739407a14a5e392c93bb2020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 16V, positivesplash10-00di-0900000000-ea6d249aa8c9a27346032020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 18V, positivesplash10-00di-0900000000-95ea20554b9c70cfdb042020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 19V, positivesplash10-00di-0900000000-840ccb1e804c5f2bd8592020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 21V, positivesplash10-00di-1900000000-b5bd97221f7577432dff2020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 23V, positivesplash10-00di-1900000000-4e1722b74214bbe8fb5d2020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 24V, positivesplash10-00di-2900000000-ace89f936dcba1a150152020-07-21View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-0900000000-2975a2eab163805d17702016-08-01View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-01b9-1900000000-6dd6cd15bdc875928e112016-08-01View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0zor-9500000000-e30fbba1f375c20ecde32016-08-01View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-0900000000-6597696b538689d6d14c2016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-03di-1900000000-59c23eff8e4369d6798a2016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-052f-9600000000-a54caf3eb3d7672f69bc2016-08-03View Spectrum
NMRNot Available
ChemSpider ID61609
ChEMBL IDCHEMBL505789
KEGG Compound IDC06199
Pubchem Compound ID68313
Pubchem Substance IDNot Available
ChEBI ID5764
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB04366
CRC / DFC (Dictionary of Food Compounds) IDHKP28-Z:HKP28-Z
EAFUS IDNot Available
Dr. Duke IDHORDENINE
BIGG IDNot Available
KNApSAcK IDC00001417
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDHordenine
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / Bioactivities
DescriptorIDDefinitionReference
Anti-asthmatic49167 An agent that relieves bronchospasm and inflammation, commonly used to manage asthma symptoms, chronic obstructive pulmonary disease (COPD), and other respiratory disorders, improving lung function and overall respiratory health.DUKE
Anti-diarrheic55323 An agent that reduces the frequency and severity of diarrhea, commonly used to manage gastrointestinal disorders, such as irritable bowel syndrome, and to treat infectious diarrhea, by slowing bowel movements and increasing water absorption.DUKE
Anti feedantA substance that inhibits normal feeding behavior, found in certain plants, deterring insects and animals from consuming them. Its therapeutic applications include pest control, while key medical uses involve managing insect-borne diseases and reducing crop damage.DUKE
Broncho elaxant52217 An agent that relaxes airway smooth muscles, reducing bronchospasm and increasing airflow. Therapeutically, it's used to treat respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD), providing relief from wheezing, coughing, and shortness of breath.DUKE
Cardiotonic38070 An agent that strengthens heart muscle contractions, enhancing cardiac output. It plays a biological role in regulating heart function and is therapeutically used to treat heart failure, improving symptoms and exercise tolerance. Key medical uses include managing cardiomyopathy, atrial fibrillation, and congestive heart failure.DUKE
Hepatoprotective62868 An agent that protects the liver from damage, promoting liver health and function. It plays a biological role in reducing oxidative stress and inflammation, and has therapeutic applications in managing liver diseases, such as hepatitis and cirrhosis, and key medical uses in treating drug-induced liver injury and toxicities.DUKE
Pesticide25944 An agent that kills or repels pests, playing a biological role in controlling insect, weed, and fungal populations. Therapeutically, pesticides have limited applications, but some are used to treat ectoparasitic infestations, such as lice and scabies. Key medical uses include topical treatments for head lice and scabies, highlighting their role in managing parasitic infections.DUKE
Vasoconstrictor50514 An agent that narrows blood vessels, reducing blood flow. It plays a biological role in regulating blood pressure and is therapeutically used to treat conditions like hypotension, nasal congestion, and bleeding. Key medical uses include managing shock, reducing bleeding during surgery, and relieving migraine headaches.DUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.