Record Information
Version1.0
Creation date2010-04-08 22:10:20 UTC
Update date2020-09-17 15:29:59 UTC
Primary IDFDB012750
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameHordenine
DescriptionHordenine belongs to the class of organic compounds known as phenethylamines. Phenethylamines are compounds containing a phenethylamine moiety, which consists of a phenyl group substituted at the second position by an ethan-1-amine. Hordenine, a strong basic compound, is a colorless solid that is soluble in organic solvents. Hordenine is biosynthesized by the stepwise N-methylation of tyramine, which is first converted to N-methyltyramine by tyramine N-methyltransferase and then is methylated to hordenine (PMID: 24257763). Hordenine exists in all living organisms, ranging from plants to humans. It is found in highest concentrations with barley (Hordeum species), from which its name is derived. Several varieties of plants in the family Cactacea (cacti) produce hordenine which, as a potent phenylethylamine alkaloid, has antibacterial and antibiotic properties (PMID: 30609368; PMID: 30128579). Hordenine has been found in several different foods, such as cereals and cereal products, corns, oats, sweet oranges, and tamarinds making it a potential biomarker for the consumption of these foods. People consuming beer brewed from barley will have higher levels of hordenine. However, hordenine in urine interferes with tests for morphine, heroin and other opioid drugs (PMID: 1618458). Hordenine is widely sold as an ingredient of nutritional supplements, with the claims that it is a stimulant of the central nervous system and can promote weight loss by enhancing metabolism.
CAS Number539-15-1
Structure
Thumb
Synonyms
SynonymSource
4-[2-(Dimethylamino)ethyl]phenolChEBI
N,N-Dimethyl-2-(4-hydroxyphenyl)ethylamineChEBI
N,N-Dimethyl-4-hydroxy-beta-phenethylamineChEBI
N,N-DimethyltyramineChEBI
p-(2-Dimethylaminoethyl)phenolChEBI
N,N-Dimethyl-4-hydroxy-b-phenethylamineGenerator
N,N-Dimethyl-4-hydroxy-β-phenethylamineGenerator
Hordenine hydrochlorideHMDB
Hordenine sulfate (2:1)HMDB
Hordenine sulfate (1:1)HMDB
4-(2-Dimethylaminoethyl)phenolHMDB
AnhalinHMDB
AnhalineHMDB
CactineHMDB
EremursineHMDB
HordeninHMDB
HordetinHMDB
N,N-Dimethyl-p-hydroxyphenethylamineHMDB
OrdeninaHMDB
OrdenineHMDB
p-Hydroxy-N,N-dimethylphenethylamineHMDB
p-[2-(Dimethylamino)ethyl]phenolHMDB
PeyocactineHMDB
3595-05-9 (unspecified sulfate)biospider
4-(2-Dimethylaminoethyl)phenol, 9CIdb_source
4-Hydroxy-N,N-dimethylphenethylaminedb_source
N-Dimethyltyraminedb_source
N,N-Dimethyl-4-hydroxy-β-phenethylaminebiospider
N,n-dimethyl-p-hydroxyphenethylaminebiospider
N,n-dimethyltyraminebiospider
P-hydroxy-n,n-dimethylphenethylaminebiospider
Phenol, 4-[2-(dimethylamino)ethyl]-biospider
Phenol, p-[2-(dimethylamino)ethyl]-biospider
Predicted Properties
PropertyValueSource
Water Solubility29.7 g/LALOGPS
logP1.76ALOGPS
logP1.63ChemAxon
logS-0.75ALOGPS
pKa (Strongest Acidic)10.31ChemAxon
pKa (Strongest Basic)9.19ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area23.47 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity51.34 m³·mol⁻¹ChemAxon
Polarizability19.35 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC10H15NO
IUPAC name4-[2-(dimethylamino)ethyl]phenol
InChI IdentifierInChI=1S/C10H15NO/c1-11(2)8-7-9-3-5-10(12)6-4-9/h3-6,12H,7-8H2,1-2H3
InChI KeyKUBCEEMXQZUPDQ-UHFFFAOYSA-N
Isomeric SMILESCN(C)CCC1=CC=C(O)C=C1
Average Molecular Weight165.2322
Monoisotopic Molecular Weight165.115364107
Classification
Description Belongs to the class of organic compounds known as phenethylamines. Phenethylamines are compounds containing a phenethylamine moiety, which consists of a phenyl group substituted at the second position by an ethan-1-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenethylamines
Direct ParentPhenethylamines
Alternative Parents
Substituents
  • Phenethylamine
  • 1-hydroxy-2-unsubstituted benzenoid
  • Aralkylamine
  • Phenol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Role

Industrial application:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionC 72.69%; H 9.15%; N 8.48%; O 9.68%DFC
Melting PointMp 118°DFC
Boiling PointBp11 173-174°DFC
Experimental Water Solubility7 mg/mLMERCK INDEX (1996)
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSHordenine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0a4i-9500000000-acdc91b4203b177fc754Spectrum
Predicted GC-MSHordenine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0a4i-9310000000-734c4e2c455b97372774Spectrum
Predicted GC-MSHordenine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSHordenine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - QqQ , positivesplash10-0uvo-9900000000-130b6ae804451c70f74fSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 10V, positivesplash10-00xr-0900000000-25885270de2c1836c33bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 30V, positivesplash10-0096-9500000000-8b84d5e79a70fa3d426aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 50V, positivesplash10-00dl-8900000000-31b039648b094d1219b1Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 6V, positivesplash10-00xr-0900000000-25885270de2c1836c33bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 3V, positivesplash10-014i-0900000000-af85ba014415bf9af025Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 4V, positivesplash10-014i-0900000000-35709636b966d858c147Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 6V, positivesplash10-014i-0900000000-cb918f599a55448f67b1Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 8V, positivesplash10-014i-0900000000-2c71ef92063a1e597ef9Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 9V, positivesplash10-01b9-0900000000-4a5dab8033ea67d49fedSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 11V, positivesplash10-00xr-0900000000-ceea75c15d32fbdad6b1Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 13V, positivesplash10-00di-0900000000-0786df40672ae99b4702Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 14V, positivesplash10-00di-0900000000-739407a14a5e392c93bbSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 16V, positivesplash10-00di-0900000000-ea6d249aa8c9a2734603Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 18V, positivesplash10-00di-0900000000-95ea20554b9c70cfdb04Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 19V, positivesplash10-00di-0900000000-840ccb1e804c5f2bd859Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 21V, positivesplash10-00di-1900000000-b5bd97221f7577432dffSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 23V, positivesplash10-00di-1900000000-4e1722b74214bbe8fb5dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 24V, positivesplash10-00di-2900000000-ace89f936dcba1a15015Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-0900000000-2975a2eab163805d1770Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-01b9-1900000000-6dd6cd15bdc875928e11Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0zor-9500000000-e30fbba1f375c20ecde3Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-0900000000-6597696b538689d6d14cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-03di-1900000000-59c23eff8e4369d6798aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-052f-9600000000-a54caf3eb3d7672f69bcSpectrum
NMRNot Available
ChemSpider ID61609
ChEMBL IDCHEMBL505789
KEGG Compound IDC06199
Pubchem Compound ID68313
Pubchem Substance IDNot Available
ChEBI ID5764
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB04366
CRC / DFC (Dictionary of Food Compounds) IDHKP28-Z:HKP28-Z
EAFUS IDNot Available
Dr. Duke IDHORDENINE
BIGG IDNot Available
KNApSAcK IDC00001417
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDHordenine
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / Bioactivities
DescriptorIDDefinitionReference
anti asthmatic49167 A drug used to treat asthma.DUKE
anti diarrheic55323 Any drug found useful in the symptomatic treatment of diarrhoea.DUKE
anti feedantDUKE
broncho elaxant52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
cardiotonic38070 A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.DUKE
hepatoprotective62868 Any compound that is able to prevent damage to the liver.DUKE
pesticide25944 Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.DUKE
vasoconstrictor50514 Drug used to cause constriction of the blood vessels.DUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.