Record Information
Version1.0
Creation date2010-04-08 22:10:22 UTC
Update date2020-09-17 15:29:56 UTC
Primary IDFDB012802
Secondary Accession NumbersNot Available
Chemical Information
FooDB Nametrans-Ferulic acid
DescriptionFerulic acid, also known as (e)-ferulate or trans-ferulate, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing a cinnamic acid where the benzene ring is hydroxylated. Ferulic acid is a moderately weak acid (based on its pKa). Ferulic acid is a highly abundant phenolic phytochemical which is present in plant cell walls. In humans it can be readily absorbed by the small intestine and excreted through the urine. It is one of the most abundant phenolic acids in plants, varying from 5 g/kg in wheat bran to 9 g/kg in sugar-beet pulp and 50 g/kg in corn kernels. It occurs primarily in seeds and leaves both in its free form (albeit rarely) and covalently linked to lignin and other biopolymers. It is usually found as ester cross-links with polysaccharides in the cell wall, such as arabinoxylans in grasses, pectin in spinach and sugar beet, and xyloglucans in bamboo. It also can cross-link with a variety of plant proteins. Due to its phenolic nucleus and an extended side chain conjugation (carbohydrates and proteins), ferulic acid readily forms a resonance-stabilized phenoxy radical which accounts for its potent antioxidant potential. Food supplementation with curcumin and ferulic acid is considered a nutritional approach to reducing oxidative damage and amyloid pathology in Alzheimer’s disease (PMID: 17127365, 1398220, 15453708, 9878519). Ferulic acid can be produced by a number of microbes including Pseudomonas and Saccharomyces (PMID: 8395165). It possesses antioxidant, anti-aging and anti-inflammatory properties. It protects the skin from damage by UV light and is used in skin care, sun care, hair care and color cosmetics.
CAS Number537-98-4
Structure
Thumb
Synonyms
SynonymSource
(e)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acidChEBI
(e)-4'-Hydroxy-3'-methoxycinnamic acidChEBI
(e)-4-Hydroxy-3-methoxycinnamic acidChEBI
(e)-Ferulic acidChEBI
3-(4-Hydroxy-3-methoxyphenyl)propenoic acidChEBI
3-Methoxy-4-hydroxy-trans-cinnamic acidChEBI
4-Hydroxy-3-methoxycinnamic acidChEBI
trans-4-Hydroxy-3-methoxycinnamic acidChEBI
3-Methoxy-4-hydroxy-trans-cinnamateKegg
4-Hydroxy-3-methoxycinnamateKegg
(e)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoateGenerator
(e)-4'-Hydroxy-3'-methoxycinnamateGenerator
(e)-4-Hydroxy-3-methoxycinnamateGenerator
(e)-FerulateGenerator
3-(4-Hydroxy-3-methoxyphenyl)propenoateGenerator
trans-4-Hydroxy-3-methoxycinnamateGenerator
trans-FerulateGenerator
FerulateGenerator
8,8'-Diferulic acidHMDB
Ferulic acid, (e)-isomerHMDB
Ferulic acid, monosodium saltHMDB
Sodium ferulateHMDB
Ferulic acid, (Z)-isomerHMDB
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoateHMDB
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acidHMDB
(e)-4-Hydroxy-3-methoxy-cinnamateHMDB
(e)-4-Hydroxy-3-methoxy-cinnamic acidHMDB
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-acrylic acidHMDB
(2E)-3-(4-Hydroxy-3-methoxyphenyl)prop-2-enoic acidHMDB
(e)-3-(4-Hydroxy-3-methoxyphenyl)acrylic acidHMDB
Fumalic acidHMDB
3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acidHMDB
3-Methoxy-4-hydroxycinnamic acidHMDB
4'-Hydroxy-3'-methoxycinnamic acidHMDB
Coniferic acidHMDB
Ferulaic acidHMDB
4’-Hydroxy-3’-methoxycinnamic acidPhytoBank
(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acidbiospider
(E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoatebiospider
(E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acidbiospider
(E)-4-Hydroxy-3-methoxy-cinnamatebiospider
(E)-4-Hydroxy-3-methoxy-cinnamic acidbiospider
(E)-4-Hydroxy-3-methoxycinnamatebiospider
(E)-4-Hydroxy-3-methoxycinnamic acidbiospider
(E)-4'-Hydroxy-3'-methoxycinnamic acidbiospider
(E)-Ferulatebiospider
(E)-Ferulic acidbiospider
2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (E)-biospider
4-Hydroxy-3-methoxy-(E)-cinnamic acidbiospider
trans-Ferulic acidbiospider
Predicted Properties
PropertyValueSource
Water Solubility0.91 g/LALOGPS
logP1.58ALOGPS
logP1.67ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)3.77ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area66.76 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity51.5 m³·mol⁻¹ChemAxon
Polarizability19.18 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC10H10O4
IUPAC name(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
InChI IdentifierInChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+
InChI KeyKSEBMYQBYZTDHS-HWKANZROSA-N
Isomeric SMILESCOC1=C(O)C=CC(\C=C\C(O)=O)=C1
Average Molecular Weight194.184
Monoisotopic Molecular Weight194.057908808
Classification
Description Belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCinnamic acids and derivatives
Sub ClassHydroxycinnamic acids and derivatives
Direct ParentHydroxycinnamic acids
Alternative Parents
Substituents
  • Cinnamic acid
  • Coumaric acid or derivatives
  • Hydroxycinnamic acid
  • Methoxyphenol
  • Phenoxy compound
  • Anisole
  • Methoxybenzene
  • Styrene
  • Phenol ether
  • 1-hydroxy-2-unsubstituted benzenoid
  • Alkyl aryl ether
  • Phenol
  • Monocyclic benzene moiety
  • Benzenoid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Ether
  • Organic oxygen compound
  • Carbonyl group
  • Organic oxide
  • Organooxygen compound
  • Hydrocarbon derivative
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Foods
  • Cocoa and cocoa products
  • Grains:

    Nuts and legumes:

    Fruits and vegetables:

    Fats and oils:

    Beverages:

    Physico-Chemical Properties - Experimental
    Physico-Chemical Properties - Experimental
    PropertyValueReference
    Physical stateSolid
    Physical DescriptionNot Available
    Mass CompositionC 61.85%; H 5.19%; O 32.96%DFC
    Melting PointMp 174°DFC
    Boiling PointNot Available
    Experimental Water SolubilityNot Available
    Experimental logP1.51HANSCH,C ET AL. (1995)
    Experimental pKa4.7
    Isoelectric pointNot Available
    ChargeNot Available
    Optical RotationNot Available
    Spectroscopic UV Data322 () (EtOH) (Berdy)DFC
    DensityNot Available
    Refractive IndexNot Available
    Spectra
    Spectra
    EI-MS/GC-MS
    TypeDescriptionSplash KeyView
    EI-MSMass Spectrum (Electron Ionization)splash10-0006-5900000000-8c81de6c352294475072Spectrum
    EI-MSMass Spectrum (Electron Ionization)splash10-0a4i-9800000000-24fa3ff739ff064312abSpectrum
    EI-MSMass Spectrum (Electron Ionization)splash10-0a4i-8900000000-5b42adf83e422cffefb6Spectrum
    GC-MStrans-Ferulic acid, 2 TMS, GC-MS Spectrumsplash10-05g4-1978000000-1097d5b300514a0489dfSpectrum
    GC-MStrans-Ferulic acid, 2 TMS, GC-MS Spectrumsplash10-00kv-2964000000-3d20d62c97c33247cfcfSpectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-00ku-1965000000-ebee2a916fe97f0270a1Spectrum
    GC-MStrans-Ferulic acid, 2 TMS, GC-MS Spectrumsplash10-00di-9654000000-b3f1759076cffd2ac235Spectrum
    GC-MStrans-Ferulic acid, 2 TMS, GC-MS Spectrumsplash10-000m-3975000000-5a41c311d78f7219474cSpectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-0006-1900000000-5dffac87fe7c815de4ceSpectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-0006-2900000000-8db541bacfe47b9e0c8bSpectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-0006-2900000000-a338415bd30d4e62e664Spectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-05g4-1978000000-1097d5b300514a0489dfSpectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-00kv-2964000000-3d20d62c97c33247cfcfSpectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-00ku-1965000000-ebee2a916fe97f0270a1Spectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-00di-9654000000-b3f1759076cffd2ac235Spectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-000m-3975000000-5a41c311d78f7219474cSpectrum
    GC-MStrans-Ferulic acid, non-derivatized, GC-MS Spectrumsplash10-00kv-1954000000-9dae07505bd18466be87Spectrum
    Predicted GC-MStrans-Ferulic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-002e-0900000000-d76b7991f2d90cb58bd5Spectrum
    Predicted GC-MStrans-Ferulic acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00di-6094000000-b805979df23a0d890d7cSpectrum
    MS/MS
    TypeDescriptionSplash KeyView
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-0006-0900000000-c173873ef0d975be6c34Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-001i-0900000000-0b9174ecaba08b2f01b9Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-001i-1900000000-eff77e27aef254928643Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-001r-9700000000-18946fad05ffb1f78a7dSpectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-001r-9300000000-e2221a73d3d078bf6e03Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-001i-0900000000-a7cded21e6010eb8bce2Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-0006-0900000000-c173873ef0d975be6c34Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-001i-0900000000-0b9174ecaba08b2f01b9Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-001i-1900000000-eff77e27aef254928643Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-001r-9700000000-18946fad05ffb1f78a7dSpectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-001r-9300000000-e2221a73d3d078bf6e03Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-001i-0900000000-a7cded21e6010eb8bce2Spectrum
    MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-002b-0900000000-cdced9ddbcdaedf2f1b9Spectrum
    MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-002b-0900000000-df06f7f58486ac25c21bSpectrum
    MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-004i-0900000000-d193da7a6efffdab2dbbSpectrum
    MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-00kr-7900000000-b5b8d28b28c8067c3932Spectrum
    MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-002r-9000000000-d3616a5367a7a2a9b3c6Spectrum
    MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-52) , Positivesplash10-0006-1900000000-5dffac87fe7c815de4ceSpectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0002-0900000000-653c9a454414dd8b8b50Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positivesplash10-002b-0900000000-62b2ee8bf9571be3d97fSpectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0002-0900000000-653c9a454414dd8b8b50Spectrum
    MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-002b-0900000000-62b2ee8bf9571be3d97fSpectrum
    MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-000j-0900000000-1ef88466d8544694f557Spectrum
    MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-000j-0900000000-bb82c87030f6232d5663Spectrum
    MS/MSLC-MS/MS Spectrum - , positivesplash10-002b-2921111101-6d1aa599f0f132a3695dSpectrum
    NMR
    TypeDescriptionView
    1D NMR1H NMR SpectrumSpectrum
    1D NMR1H NMR SpectrumSpectrum
    1D NMR13C NMR SpectrumSpectrum
    1D NMR1H NMR SpectrumSpectrum
    1D NMR13C NMR SpectrumSpectrum
    2D NMR[1H,13C] 2D NMR SpectrumSpectrum
    ChemSpider ID393368
    ChEMBL IDCHEMBL32749
    KEGG Compound IDC01494
    Pubchem Compound ID445858
    Pubchem Substance IDNot Available
    ChEBI IDNot Available
    Phenol-Explorer ID499
    DrugBank IDDB07767
    HMDB IDHMDB00954
    CRC / DFC (Dictionary of Food Compounds) IDHLG59-X:HLG60-R
    EAFUS IDNot Available
    Dr. Duke IDTRANS-FERULIC-ACID
    BIGG IDNot Available
    KNApSAcK IDNot Available
    HET IDFER
    Food Biomarker OntologyNot Available
    VMH IDNot Available
    Flavornet IDNot Available
    GoodScent IDNot Available
    SuperScent IDNot Available
    Wikipedia IDNot Available
    Phenol-Explorer Metabolite IDNot Available
    Duplicate IDSNot Available
    Old DFC IDSNot Available
    Associated Foods
    FoodContent Range AverageReference
    FoodReference
    Biological Effects and Interactions
    Health Effects / Bioactivities
    DescriptorIDDefinitionReference
    antioxidant22586 A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324.DUKE
    cancer preventive35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
    inhibitor35222 A substance that diminishes the rate of a chemical reaction.CHEBI
    EnzymesNot Available
    PathwaysNot Available
    MetabolismNot Available
    BiosynthesisNot Available
    Organoleptic Properties
    FlavoursNot Available
    Files
    MSDSshow
    References
    Synthesis ReferenceNot Available
    General ReferenceNot Available
    Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).