1.02010-04-08 22:10:28 UTC2019-11-26 03:07:50 UTCFDB012993Pristanic acidComponent of butterfat and sheep perinephric fat
Pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) is a terpenoid acid present at micromolar concentrations in the plasma of healthy individuals. It is also found in the lipids from many sources such as freshwater sponges, krill, earthworms, whales, human milk fat, bovine depot fat, butterfat or Californian petroleum. It is usually present in combination with phytanic acid. In humans, pristanic acid is obtained from two sources: either directly from the diet or as the alpha oxidation product of phytanic acid. At physiological concentrations pristanic acid is a natural ligand for PPARalpha. In liver, pristanic acid is degraded by peroxisomal beta oxidation to propionyl-CoA. Together with phytanic acid, pristanic acid accumulates in several inherited disorders such as Zellweger syndrome.; Pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) is a terpenoid acid present at micromolar concentrations in the blood plasma of healthy individuals. It is also found in the lipids from many sources such as freshwater sponges, krill, earthworms, whales, human milk fat, bovine depot fat, butterfat or Californian petroleum. It is usually present in combination with phytanic acid. In humans, pristanic acid is obtained from two sources: either directly from the diet or as the alpha oxidation product of phytanic acid. At physiological concentrations pristanic acid is a natural ligand for PPAR?. In liver, pristanic acid is degraded by peroxisomal beta oxidation to propionyl-CoA. Together with phytanic acid, pristanic acid accumulates in several inherited disorders such as Zellweger syndrome.; Pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) is a terpenoid acid present at micromolar concentrations in the plasma of healthy individuals. It is also found in the lipids from many sources such as freshwater sponges, krill, earthworms, whales, human milk fat, bovine depot fat, butterfat or Californian petroleum. It is usually present in combination with phytanic acid. In humans, pristanic acid is obtained from two sources: either directly from the diet or as the alpha oxidation product of phytanic acid. At physiological concentrations pristanic acid is a natural ligand for PPARalpha. In liver, pristanic acid is degraded by peroxisomal beta oxidation to propionyl-CoA. Together with phytanic acid, pristanic acid accumulates in several inherited disorders such as Zellweger syndrome.; Pristanic acid is a branched chain fatty acid that arises from the breakdown of phytanic acid. It is present at micromolar concentrations in the plasma of healthy individuals. Pristanic acid is normally degraded by peroxisomal beta-oxidation. In patients affected with generalized peroxisomal disorders, degradation of both phytanic acid and pristanic acid is impaired owing to absence of functional peroxisomes. Pristanic acid has been found to activate the peroxisome proliferator-activated receptor {alpha} (PPAR{alpha}) in a concentration dependent manner.(2S,6R,10R)-2,6,10,14-tetramethylpentadecanoate(2S,6R,10R)-2,6,10,14-tetramethylpentadecanoic acid(2S,6R,10R)-pristanic acid(2S)-Pristanic acid(2S)-pristanic acid;2,6,10,14-Tetramethyl-pentadecansaeure2,6,10,14-Tetramethylpentadecanoate2,6,10,14-Tetramethylpentadecanoic acid2,6,10,14-Tetramethylpentadecylate2,6,10,14-Tetramethylpentadecylic acidAcide pristaniqueAcido pristanicoPristanate:(2S,6R,10R)-pristanatePristanic acidPristaninsaeureC19H38O2298.511298.2871804642,6,10,14-tetramethylpentadecanoic acidpristanic acid1189-37-3CC(C)CCCC(C)CCCC(C)CCCC(C)C(O)=OInChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)PAHGJZDQXIOYTH-UHFFFAOYSA-N belongs to the class of organic compounds known as acyclic diterpenoids. These are diterpenoids (compounds made of four consecutive isoprene units) that do not contain a cycle.Acyclic diterpenoidsOrganic compoundsLipids and lipid-like moleculesPrenol lipidsDiterpenoidsAliphatic acyclic compoundsCarbonyl compoundsCarboxylic acidsHydrocarbon derivativesLong-chain fatty acidsMethyl-branched fatty acidsMonocarboxylic acids and derivativesOrganic oxidesAcyclic diterpenoidAliphatic acyclic compoundBranched fatty acidCarbonyl groupCarboxylic acidCarboxylic acid derivativeFatty acidFatty acylHydrocarbon derivativeLong-chain fatty acidMethyl-branched fatty acidMonocarboxylic acid or derivativesOrganic oxideOrganic oxygen compoundOrganooxygen compoundAcyclic diterpenoidsbranched-chain saturated fatty acidlong-chain fatty acidmethyl-branched fatty acidSolidlogp6.90logs-6.34solubility1.36e-04 g/llogp7.22pka_strongest_acidic5iupac2,6,10,14-tetramethylpentadecanoic acidaverage_mass298.511mono_mass298.287180464smilesCC(C)CCCC(C)CCCC(C)CCCC(C)C(O)=OformulaC19H38O2inchiInChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)inchikeyPAHGJZDQXIOYTH-UHFFFAOYSA-Npolar_surface_area37.3refractivity90.7polarizability38.82rotatable_bond_count13acceptor_count2donor_count1physiological_charge-1formal_charge0Oxidation of Branched Chain Fatty AcidsSMP00030Phytanic Acid Peroxisomal OxidationSMP00450Specdb::CMs5831Specdb::CMs37770Specdb::CMs167387Specdb::CMs1076663Specdb::NmrOneD303771Specdb::NmrOneD303772Specdb::NmrOneD303773Specdb::NmrOneD303774Specdb::NmrOneD303775Specdb::NmrOneD303776Specdb::NmrOneD303777Specdb::NmrOneD303778Specdb::NmrOneD303779Specdb::NmrOneD303780Specdb::NmrOneD303781Specdb::NmrOneD303782Specdb::NmrOneD303783Specdb::NmrOneD303784Specdb::NmrOneD303785Specdb::NmrOneD303786Specdb::NmrOneD303787Specdb::NmrOneD303788Specdb::NmrOneD303789Specdb::NmrOneD303790Specdb::MsMs1132Specdb::MsMs1133Specdb::MsMs1134Specdb::MsMs240772Specdb::MsMs240773Specdb::MsMs240774Specdb::MsMs242827Specdb::MsMs242828Specdb::MsMs242829Specdb::MsMs2718435Specdb::MsMs2718436Specdb::MsMs2718437Specdb::MsMs2964336Specdb::MsMs2964337Specdb::MsMs2964338HMDB0079551340#<Reference:0x00005556749722f8>#<Reference:0x0000555674972140>#<Reference:0x0000555674971f88>#<Reference:0x0000555674971dd0>#<Reference:0x0000555674971c18>#<Reference:0x0000555674971a60>#<Reference:0x00005556749718a8>#<Reference:0x00005556749716f0>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Fats and oilsUnknowngenericGreylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Milk and milk productsUnknowngenericMountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823