| Synonyms | | Synonym | Source |
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| 3beta-Hydroxyolean-12-en-28-Oic acid | ChEBI | | Astrantiagenin C | ChEBI | | Caryophyllin | ChEBI | | Giganteumgenin C | ChEBI | | Oleanic acid | ChEBI | | Virgaureagenin b | ChEBI | | Oleanolate | Kegg | | 3b-Hydroxyolean-12-en-28-Oate | Generator | | 3b-Hydroxyolean-12-en-28-Oic acid | Generator | | 3beta-Hydroxyolean-12-en-28-Oate | Generator | | 3Β-hydroxyolean-12-en-28-Oate | Generator | | 3Β-hydroxyolean-12-en-28-Oic acid | Generator | | Oleanate | Generator | | (3-beta)-3-Hydroxyolean-12-en-28-oate | HMDB | | (3-beta)-3-Hydroxyolean-12-en-28-oic acid | HMDB | | (3.beta.)-3-beta-hydroxy-olean-12-en-28-oate | HMDB | | (3.beta.)-3-beta-hydroxy-olean-12-en-28-oic acid | HMDB | | (3.beta.)-3-hydroxy-olean-12-en-28-oate | HMDB | | (3.beta.)-3-hydroxy-olean-12-en-28-oic acid | HMDB | | (4AS,5S,6as,6BR,8R,8ar,10S,12ar,12BR,14BS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid | HMDB | | 3-beta-Hydroxyolean-12-en-28-oate | HMDB | | 3-beta-Hydroxyolean-12-en-28-oic acid | HMDB | | 3.beta.-hydroxy-olean-12-en-28-oate | HMDB | | 3.beta.-hydroxy-olean-12-en-28-oic acid | HMDB | | 3beta-Hydroxy-olean-12-en-28-oate | HMDB | | 3beta-Hydroxy-olean-12-en-28-oic acid | HMDB | | Oleanane triterpenes | MeSH, HMDB | | Triterpenes, oleanane | MeSH, HMDB | | Oleanol | MeSH, HMDB | | Hederins | MeSH, HMDB | | (3beta)-3-Hydroxyolean-12-en-28-oic acid | PhytoBank | | (3β)-3-Hydroxyolean-12-en-28-oic acid | PhytoBank | | (+)-Oleanolic acid | PhytoBank | | Gledigenin 1 | PhytoBank | | Oleonolic acid | PhytoBank | | OA | PhytoBank | | (3.beta.)-3-beta-hydroxy-olean-12-en-28-Oate | HMDB | | (3.beta.)-3-beta-hydroxy-olean-12-en-28-Oic acid | HMDB | | (3.beta.)-3-hydroxy-olean-12-en-28-Oate | HMDB | | (3.beta.)-3-hydroxy-olean-12-en-28-Oic acid | HMDB | | (4AS,5S,6as,6br,8R,8ar,10S,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid | HMDB | | 3.beta.-hydroxy-olean-12-en-28-Oate | HMDB | | 3.beta.-hydroxy-olean-12-en-28-Oic acid | HMDB | | 3beta-Hydroxy-olean-12-en-28-Oate | HMDB | | 3beta-Hydroxy-olean-12-en-28-Oic acid | HMDB | | 3β-hydroxyolean-12-en-28-Oate | Generator | | 3β-hydroxyolean-12-en-28-Oic acid | Generator | | Olean-12-en-28-oic acid, 3-beta-hydroxy- (8CI) | biospider | | Olean-12-en-28-oic acid, 3-hydroxy-, (3-beta)- | biospider | | Olean-12-en-28-oic acid, 3-hydroxy-, (3β)- | biospider | | Olean-12-en-28-oic acid, 3β-hydroxy- | biospider | | Olean-12-en-28-oic acid, 3beta-hydroxy- (8CI) | biospider | | Oleanolic acid | db_source | | Virgaureagenin B | db_source |
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| Health Effects / Bioactivities | | Descriptor | ID | Definition | Reference |
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| Abortifacient | 50691 | An agent that induces abortion, disrupting pregnancy by blocking progesterone or causing uterine contractions. Therapeutically, it's used to terminate early pregnancies, manage ectopic pregnancies, or treat miscarriages. Key medical uses include medical abortion, pregnancy termination, and menstrual regulation. | DUKE | | Anti-allergic | 50857 | An agent that reduces or blocks allergic reactions, commonly used to manage symptoms of allergies, such as itching, sneezing, and inflammation, by inhibiting the release of histamine and other chemical mediators, providing relief in conditions like hay fever, asthma, and skin allergies. | DUKE | | Anti-arrhythmic | 38070 | An agent that regulates heart rhythm, correcting irregular heartbeat patterns. Therapeutically, it restores normal cardiac function, commonly used to manage arrhythmias, prevent sudden cardiac death, and treat conditions like atrial fibrillation and ventricular tachycardia. | DUKE | | Anti-atherosclerotic | 38070 | An agent that prevents or slows the formation of atherosclerosis, a condition characterized by plaque buildup in arteries. It reduces inflammation, improves lipid profiles, and inhibits platelet aggregation, commonly used to manage cardiovascular diseases, such as coronary artery disease, and prevent heart attacks and strokes. | DUKE | | Anti bacterial | 33282 | An agent that inhibits the growth of or destroys bacteria, playing a crucial role in preventing and treating infections. Therapeutically, it is used to combat bacterial infections, with key medical applications including treating pneumonia, tuberculosis, and skin infections, as well as preventing surgical site infections and sepsis. | DUKE | | Anti carcinomic | 35610 | An agent that inhibits the growth and proliferation of cancer cells, playing a crucial role in cancer prevention and treatment. Therapeutically, it is used to manage and treat various types of cancer, reducing tumor size and slowing disease progression, with key medical uses in oncology and chemotherapy. | DUKE | | Anti cariogenic | 52217 | An agent that prevents tooth decay, reducing bacterial acid production and plaque formation. Its biological role is to inhibit the growth of cariogenic bacteria, and its therapeutic applications include preventing dental caries and managing tooth decay. Key medical uses include toothpaste, mouthwashes, and dental varnishes to maintain oral health. | DUKE | | Anti complement | | A substance that neutralizes complement action by preventing its union with an antibody, regulating immune response. Its therapeutic applications include managing autoimmune diseases, transplant rejection, and inflammatory disorders, with key medical uses in treating conditions like rheumatoid arthritis and lupus. | DUKE | | Anti-edemic | | An agent that relieves or prevents edema, reducing abnormal fluid accumulation in tissues or the circulatory system, commonly used to treat conditions such as swelling, inflammation, and water retention. | DUKE | | Anti-fertility | | An agent that inhibits reproduction, playing a biological role in population control. Therapeutically, it's used as a contraceptive, with key medical applications in family planning and birth control, preventing unwanted pregnancies and managing reproductive health. | DUKE | | Anti-gingivitic | 52217 | An agent that reduces gingivitis symptoms, commonly used in managing plaque, inflammation, and gum disease, promoting oral health by preventing bacterial growth and infection. | DUKE | | Anti hepatotoxic | 62868 | An agent that protects the liver from damage, reducing toxicity and promoting liver health. It plays a biological role in preventing liver injury and supporting liver function. Therapeutically, it is used to treat liver diseases, such as hepatitis and cirrhosis, and to counteract liver-damaging effects of certain medications and toxins. | DUKE | | Anti HIV | 22587 | An agent that prevents the replication of the Human Immunodeficiency Virus (HIV), used to treat and manage HIV infection and Acquired Immunodeficiency Syndrome (AIDS), reducing viral load and slowing disease progression. | DUKE | | Anti hyperlipidemic | 52217 | An agent that reduces lipid levels in the blood, playing a crucial role in preventing cardiovascular disease. Therapeutically, it is used to manage hyperlipidemia, lowering cholesterol and triglyceride levels, and is commonly used to prevent atherosclerosis, heart attacks, and strokes. | DUKE | | Anti-inflammatory | 35472 | An agent that reduces inflammation, playing a biological role in suppressing immune responses and therapeutic applications in managing pain, swelling, and redness. Key medical uses include treating arthritis, allergies, and autoimmune disorders, as well as relieving symptoms of conditions such as asthma and dermatitis. | DUKE | | Anti-ischemic | 52217 | An agent that reduces or prevents tissue damage from inadequate blood flow, commonly used to manage angina, heart attacks, and strokes by improving oxygen delivery and reducing cardiac workload. | DUKE | | Anti leukemic | 35610 | An agent that targets and inhibits the growth of leukemia cells, playing a crucial role in cancer treatment. Therapeutically, it is used to induce remission, manage symptoms, and improve survival rates in patients with leukemia. Key medical uses include treating acute and chronic leukemia, lymphoma, and other hematological malignancies. | DUKE | | Anti leukotriene | 35222 | An agent that blocks the action of leukotrienes, reducing inflammation and bronchoconstriction. Therapeutically, it is used to treat asthma, allergic rhinitis, and other respiratory disorders by inhibiting the biological role of leukotrienes in mediating inflammatory responses. | DUKE | | Anti-malarial | 33281 | An agent that prevents or treats malaria, a disease caused by Plasmodium parasites. It works by targeting the parasite's life cycle, reducing symptoms and preventing transmission. Therapeutically, anti-malarials are used to treat and prevent malaria, as well as to manage related conditions such as babesiosis and toxoplasmosis. | DUKE | | Anti nephritic | 52217 | An agent that reduces kidney inflammation, commonly used to manage nephritis and other kidney disorders, helping to prevent kidney damage and promote renal health. | DUKE | | Anti-oxidant | 22586 | An agent that neutralizes free radicals, reducing oxidative stress and cell damage. Its biological role involves protecting cells from harm, and it has therapeutic applications in managing chronic diseases, such as cancer, diabetes, and neurodegenerative disorders, with key medical uses including anti-aging, anti-inflammatory, and cardio protective effects. | DUKE | | Anti periodontic | | An agent that prevents or treats periodontal disease, reducing inflammation and infection in the gums and supporting tissues of the teeth, commonly used in managing periodontitis, gingivitis, and promoting oral health. | DUKE | | Anti peroxidant | | An agent that prevents oxygen atom and peroxide formation, reducing oxidative stress and cell damage. It plays a biological role in protecting cells from free radicals. Therapeutically, it's used to manage conditions like cancer, Alzheimer's, and atherosclerosis, with key medical applications in neuroprotection, cardiovascular health, and anti-aging. | DUKE | | Anti prostaglandin-E2 | 49023 | An agent that inhibits prostaglandin E2, reducing inflammation and pain. Therapeutically, it's used to manage conditions like arthritis, dysmenorrhea, and colorectal cancer, by blocking PGE2's role in pain modulation, inflammation, and tumor growth. | DUKE | | Anti-plaque | | An agent that removes or prevents the formation of dental plaque, a biofilm of bacteria, to prevent tooth decay and gum disease, commonly used in oral care products and therapeutic applications for periodontal health. | DUKE | | Anti plasmodial | 33281 | An agent that inhibits the growth of Plasmodium parasites, reducing malaria symptoms. Therapeutically, it's used to treat and prevent malaria, with key medical applications including prophylaxis and treatment of malaria infections. | DUKE | | Anti sarcomic | 35610 | An agent that targets sarcomas, a type of cancer that arises from connective tissue. It plays a biological role in inhibiting tumor growth and proliferation. Therapeutically, it is used to manage soft tissue sarcomas, with key medical applications in oncology, particularly in treating rare and aggressive sarcoma subtypes. | DUKE | | Anti septic | 33281 | An agent that prevents or reduces the growth of microorganisms, such as bacteria, fungi, or viruses, to promote wound healing and prevent infection. Therapeutically, anti septics are used to treat minor cuts, scrapes, and burns, and are commonly applied topically to reduce the risk of infection and promote tissue repair. Key medical uses include wound care, surgical site preparation, and skin infection management. | DUKE | | Anti TGF-beta | 35222 | An agent that inhibits the activity of Transforming Growth Factor-beta, reducing fibrosis and inflammation. It has therapeutic applications in treating cancer, fibrotic diseases, and autoimmune disorders, with key medical uses including oncology and pulmonary fibrosis management. | DUKE | | Antitumor | 35610 | An agent that inhibits tumor growth and proliferation, playing a crucial role in cancer treatment. Therapeutically, antitumors are used to manage various types of cancer, including chemotherapy, targeted therapy, and immunotherapy, helping to reduce tumor size, prevent metastasis, and improve patient outcomes. | DUKE | | Anti ulcer | 49201 | An agent that reduces stomach acid and protects the mucous lining, preventing ulcer formation. It is used to treat conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome, promoting healing and relieving symptoms. | DUKE | | Anti-viral | 22587 | An agent that inhibits the replication of viruses, playing a crucial role in preventing and treating viral infections. Therapeutically, anti-virals are used to manage diseases such as HIV, herpes, and influenza, reducing symptoms and slowing disease progression. Key medical uses include treating viral hepatitis, respiratory syncytial virus, and COVID-19. | DUKE | | Aromatase inhibitor | 50790 | An agent that blocks the activity of aromatase, an enzyme converting androgens to estrogens, reducing estrogen levels. Therapeutically, it's used to treat hormone-sensitive breast cancer, endometriosis, and infertility, by decreasing estrogen-dependent growth and symptoms. | DUKE | | Beta-blocker | | An agent that blocks the effects of epinephrine (adrenaline), lowering blood pressure and heart rate. Therapeutically, it reduces cardiovascular stress, commonly used to manage hypertension, angina, heart failure, and certain arrhythmias. | DUKE | | Beta-glucuronidase inhibitor | 23924 | An agent that blocks the activity of beta-glucuronidase, an enzyme that breaks down glucuronides. It reduces the toxicity of certain drugs and is used to manage conditions like cancer, inflammatory bowel disease, and irinotecan-induced diarrhea, improving treatment outcomes and reducing side effects. | DUKE | | Cancer preventive | 35610 | An agent that inhibits the development and progression of cancer, reducing tumor formation and growth. It plays a biological role in blocking carcinogenic pathways, and has therapeutic applications in chemoprevention. Key medical uses include reducing the risk of cancer in high-risk individuals and preventing cancer recurrence. | DUKE | | Cardioprotective | 38070 | An agent that protects the heart from damage, reducing the risk of cardiovascular disease. It plays a biological role in mitigating cardiac stress and injury, with therapeutic applications in preventing heart attacks, strokes, and arrhythmias, and key medical uses in treating hypertension, heart failure, and coronary artery disease. | DUKE | | Cardiotonic | 38070 | An agent that strengthens heart muscle contractions, enhancing cardiac output. It plays a biological role in regulating heart function and is therapeutically used to treat heart failure, improving symptoms and exercise tolerance. Key medical uses include managing cardiomyopathy, atrial fibrillation, and congestive heart failure. | DUKE | | Cyclooxygenase-2 inhibitor | 50629 | An agent that blocks the activity of cyclooxygenase-2 (COX-2), reducing inflammation and pain. Therapeutically, it is used to manage conditions such as arthritis, menstrual cramps, and other inflammatory disorders, providing relief from symptoms with reduced gastrointestinal side effects compared to non-selective NSAIDs. | DUKE | | Cyclooxygenase inhibitor | 35544 | An agent that blocks the activity of cyclooxygenase enzymes, reducing inflammation and pain. Therapeutically, it is used to treat conditions such as arthritis, headaches, and menstrual cramps, by decreasing prostaglandin production, a key mediator of inflammation. | DUKE | | Diuretic | 35498 | An agent that increases urine production, helping remove excess fluids and salts from the body. It plays a key biological role in regulating fluid balance and blood pressure. Therapeutically, diuretics are used to treat conditions such as hypertension, edema, and heart failure, helping reduce swelling and lower blood pressure. | DUKE | | Elastase inhibitor | 23924 | An agent that blocks the activity of elastase, an enzyme that breaks down elastin, reducing tissue damage and inflammation. Therapeutically, it's used to manage conditions like chronic obstructive pulmonary disease (COPD), cystic fibrosis, and emphysema, protecting lung tissue and improving respiratory function. | DUKE | | Hepatoprotective | 62868 | An agent that protects the liver from damage, promoting liver health and function. It plays a biological role in reducing oxidative stress and inflammation, and has therapeutic applications in managing liver diseases, such as hepatitis and cirrhosis, and key medical uses in treating drug-induced liver injury and toxicities. | DUKE | | Hypolipemic | | An agent that lowers lipid levels, treating hyperlipidemias by reducing cholesterol and triglyceride levels, with therapeutic applications in managing cardiovascular disease, atherosclerosis, and stroke prevention. | DUKE | | Hypotensive | | An agent that lowers blood pressure, playing a biological role in regulating cardiovascular function. Therapeutically, it's used to manage hypertension, heart failure, and angina, with key medical applications in preventing stroke, kidney disease, and cardiac complications. | DUKE | | Immunomodulator | 50846 | An agent that regulates the immune system, modifying its response to maintain balance. Therapeutically, it's used to treat autoimmune diseases, prevent transplant rejection, and manage chronic inflammatory conditions, such as rheumatoid arthritis and multiple sclerosis. | DUKE | | Leucocytogenic | | An agent that stimulates the formation of leucocytes (white blood cells), playing a biological role in immune system regulation. Therapeutically, it is used to treat conditions associated with low white blood cell count, such as leukemia and infections, and to support recovery after chemotherapy or bone marrow transplantation. | DUKE | | NF-kappa-B inhibitor | 35222 | An agent that blocks the activity of NF-kappa-B, a protein complex involved in inflammation and immune responses, reducing inflammation and cell proliferation. Therapeutically, it is used to treat conditions such as cancer, autoimmune disorders, and inflammatory diseases, including rheumatoid arthritis and asthma. | DUKE | | Phagocytotic | | An agent that engulfs and internalizes solid particles or cells through phagocytosis, playing a key role in immune defense. Therapeutically, it aids in removing pathogens and debris, with medical applications in treating infections and inflammatory disorders. | DUKE | | Piscicide | | A substance poisonous to fish, used to eliminate dominant or invasive fish species, and combat parasitic fish, allowing for population control and management of aquatic ecosystems. | DUKE | | Prostaglandin synthesis inhibitor | 35222 | An agent that blocks the production of prostaglandins, reducing inflammation and pain. Therapeutically, it's used to treat conditions like arthritis, menstrual cramps, and fever, commonly found in nonsteroidal anti-inflammatory drugs (NSAIDs). | DUKE | | Sedative | 35717 | An agent that calms nervous activity, reducing anxiety and inducing relaxation. Its biological role is to slow down brain function, promoting sleep and relieving stress. Therapeutically, sedatives are used to manage insomnia, anxiety disorders, and seizures, as well as to prepare patients for medical procedures. | DUKE | | Utero tonic | 52217 | An agent that stimulates and strengthens the uterine muscles, aiding in childbirth and reducing postpartum bleeding. Therapeutically, it is used to induce labor, manage uterine atony, and treat menstrual disorders, promoting overall reproductive health. | DUKE | | Vasopressor | | An agent that causes constriction of blood vessels, increasing blood pressure. It plays a biological role in regulating blood pressure and fluid balance. Therapeutically, vasopressors are used to treat hypotension, shock, and bleeding, and have key medical applications in surgery, trauma, and critical care. | DUKE |
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