1.0 2010-04-08 22:10:45 UTC 2019-11-26 03:08:31 UTC FDB013511 4-Hydroxyproline Constituent of proteins [DFC]. 4-hydroxyproline is a biomarker for the consumption of processed meat . 4-Hydroxyproline is found in many foods, some of which are parsnip, ginger, chinese cinnamon, and garlic. (2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylate (2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylic acid (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid (2S,4R)-trans-4-Hydroxyproline (4R)-4-Hydroxy-L-proline 4-Hydroxy-2-pyrrolidinecarboxylic acid 4-Hydroxy-L-proline 4-Hydroxyproline 4-L-Hydroxyproline delta-Hydroxyproline Hydroxiproline Hydroxy-L-proline Hydroxy-proline Hydroxyproline Hypro L-4-Hydroxyproline L-Hydroxyproline L-threo-4-Hydroxyproline L-trans-4-Hydroxyproline LS-hydroxyproline Oxaceprol trans-4-Hydroxy-L-proline trans-4-Hydroxyproline trans-Hydroxyproline trans-L-Hydroxyproline δ-hydroxyproline C5H9NO3 131.1299 131.058243159 4-hydroxypyrrolidine-2-carboxylic acid 4-hydroxyproline 51-35-4 OC1CNC(C1)C(O)=O InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9) PMMYEEVYMWASQN-UHFFFAOYSA-N belongs to the class of organic compounds known as proline and derivatives. Proline and derivatives are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Proline and derivatives Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aliphatic heteromonocyclic compounds 1,2-aminoalcohols Alpha amino acids Amino acids Azacyclic compounds Carbonyl compounds Carboxylic acids Dialkylamines Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Pyrrolidine carboxylic acids Secondary alcohols 1,2-aminoalcohol Alcohol Aliphatic heteromonocyclic compound Alpha-amino acid Amine Amino acid Azacycle Carbonyl group Carboxylic acid Hydrocarbon derivative Monocarboxylic acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Proline or derivatives Pyrrolidine Pyrrolidine carboxylic acid Pyrrolidine carboxylic acid or derivatives Secondary alcohol Secondary aliphatic amine Secondary amine monohydroxyproline Solid logp -3.31 ALOGPS logs 0.57 ALOGPS solubility 4.92e+02 g/l ALOGPS melting_point Mp 274° logp -3.7 ChemAxon pka_strongest_acidic 1.64 ChemAxon pka_strongest_basic 10.62 ChemAxon iupac 4-hydroxypyrrolidine-2-carboxylic acid ChemAxon average_mass 131.1299 ChemAxon mono_mass 131.058243159 ChemAxon smiles OC1CNC(C1)C(O)=O ChemAxon formula C5H9NO3 ChemAxon inchi InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9) ChemAxon inchikey PMMYEEVYMWASQN-UHFFFAOYSA-N ChemAxon polar_surface_area 69.56 ChemAxon refractivity 29.38 ChemAxon polarizability 12.33 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 4 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::EiMs 1150 Specdb::NmrOneD 2419 Specdb::NmrOneD 3109 Specdb::CMs 1133 Specdb::CMs 1210 Specdb::CMs 11272 Specdb::CMs 31654 Specdb::CMs 31655 Specdb::CMs 44911 Specdb::MsMs 12383 Specdb::MsMs 12384 Specdb::MsMs 12385 Specdb::MsMs 19055 Specdb::MsMs 19056 Specdb::MsMs 19057 Specdb::MsMs 440117 HMDB00725 18240 HYP #<Reference:0x000055ce328807d8> #<Reference:0x000055ce32880620> #<Reference:0x000055ce32880440> #<Reference:0x000055ce32880260> #<Reference:0x000055ce32880080> #<Reference:0x000055ce3286bce8> #<Reference:0x000055ce3286ba40> #<Reference:0x000055ce3286b658> #<Reference:0x000055ce3286b360> #<Reference:0x000055ce3286b0e0> #<Reference:0x000055ce3286abe0> #<Reference:0x000055ce3286a8c0> #<Reference:0x000055ce3286a578> #<Reference:0x000055ce3286a190> #<Reference:0x000055ce32869e70> #<Reference:0x000055ce32869b28> #<Reference:0x000055ce328696a0> #<Reference:0x000055ce32869448> #<Reference:0x000055ce328691a0> #<Reference:0x000055ce32868e30> #<Reference:0x000055ce32868ac0> #<Reference:0x000055ce328687a0> #<Reference:0x000055ce328684d0> #<Reference:0x000055ce32868318> #<Reference:0x000055ce32868160> #<Reference:0x000055ce32867d50> Anatidae Type 1 specific Anatidae 8830 Atlantic halibut Type 1 specific Hippoglossus hippoglossus 8267 0.11 0.11 0.11 mg/100 g Atlantic salmon Type 1 specific Salmo salar 8030 42.0 42.0 42.0 mg/100 g Baby food Type 2 specific 7.2 20.0 0.0 mg/100 g Bagel Type 2 specific 0.0 0.0 0.0 mg/100 g Baked beans Type 2 specific 0.0 0.0 0.0 mg/100 g Barley Type 1 specific Hordeum vulgare 4513 7.07109 7.072179775 7.07 mg/100 g Bean Type 1 specific 0.0 0.0 0.0 mg/100 g Beefalo Type 1 specific Bos taurus X Bison bison 297284 Beer Type 2 specific 5.5 5.5 5.5 mg/100 g Bison Type 1 specific Bison bison 9901 0.233 0.233 0.233 mg/100 g Borage Type 1 specific Borago officinalis 13363 Breakfast cereal Type 2 specific 0.0 0.0 0.0 mg/100 g Broccoli Type 1 specific Brassica oleracea var. italica 36774 0.6 0.6 0.6 mg/100 g Buffalo Type 1 specific Bubalus bubalis 89462 Cake Type 2 specific 0.0 0.0 0.0 mg/100 g Carob Type 1 specific Ceratonia siliqua 20340 47.0 47.0 47.0 mg/100 g Carrot Type 1 specific Daucus carota ssp. sativus 79200 0.28 0.28 0.28 mg/100 g Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 205.848287 566.0 16.0 mg/100 g Cheese Type 2 specific 7.5 30.0 0.0 mg/100 g Chicken Type 1 specific Gallus gallus 9031 Chinese cinnamon Type 1 specific Cinnamomum aromaticum 119260 0.0 0.0 0.0 mg/100 g Chocolate Type 2 specific 0.0 0.0 0.0 mg/100 g Cinnamon Type 1 specific Cinnamomum 13428 0.0 0.0 0.0 mg/100 g Cloves Type 1 specific Syzygium aromaticum 219868 0.0 0.0 0.0 mg/100 g Coconut Type 1 specific Cocos nucifera 13894 0.0 0.0 0.0 mg/100 g Cold cut Type 2 specific 47.0 94.0 0.0 mg/100 g Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Common bean Type 1 specific Phaseolus vulgaris 3885 0.0 0.0 0.0 mg/100 g Common oregano Type 1 specific Origanum vulgare 39352 0.0 0.0 0.0 mg/100 g Corn Type 1 specific Zea mays 4577 0.0 0.0 0.0 mg/100 g Corn chip Type 2 specific 0.0 0.0 0.0 mg/100 g Cow milk, pasteurized, vitamin A + D added, 0% fat Type 2 specific 0.0 0.0 0.0 mg/100 g Cow milk, pasteurized, vitamin A + D added, 2% fat Type 2 specific 0.0 0.0 0.0 mg/100 g Cucumber Type 1 specific Cucumis sativus 3659 0.08 0.08 0.08 mg/100 g Deer Type 1 specific Cervidae 9850 424.833333 519.0 313.0 mg/100 g Dill Type 1 specific Anethum graveolens 40922 1.37 1.37 1.37 mg/100 g Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 112.479638 678.0 0.0 mg/100 g Edible shell Type 2 specific 0.0 0.0 0.0 mg/100 g Egg roll Type 2 specific 0.0 0.0 0.0 mg/100 g Egg yolk Type 1 0.0 0.0 0.0 mg/100 g Eggplant Type 1 specific Solanum melongena 4111 0.4 0.4 0.4 mg/100 g Eggs Unknown generic 0.0 0.0 0.0 mg/100 g Elk Type 1 specific Cervus canadensis 1574408 0.204 0.204 0.204 mg/100 g Emu Type 1 specific Dromaius novaehollandiae 8790 0.149 0.149 0.149 mg/100 g European rabbit Type 1 specific Oryctolagus 9984 Flaxseed Type 1 specific Linum usitatissimum 4006 87.5225 175.0 0.045 mg/100 g Garden onion Type 1 specific Allium cepa 4679 0.1 0.1 0.1 mg/100 g Garlic Type 1 specific Allium sativum 4682 0.0 0.0 0.0 mg/100 g Ginger Type 1 specific Zingiber officinale 94328 0.0 0.0 0.0 mg/100 g Green bean Type 1 specific Phaseolus vulgaris 3885 0.57 0.57 0.57 mg/100 g Green bell pepper Type 1 specific Capsicum annuum 4072 2.9 2.9 2.9 mg/100 g Green zucchini Type 1 specific Cucurbita pepo var. cylindrica 1.65 1.65 1.65 mg/100 g Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Hamburger Type 2 specific 175.0 200.0 150.0 mg/100 g Hippoglossus (Common halibut) Type 1 specific Hippoglossus 8266 145.0 183.0 107.0 mg/100 g Horse Type 1 specific Equus caballus 9796 Italian oregano Type 1 specific Origanum X majoricum 1384207 0.0 0.0 0.0 mg/100 g Japanese pumpkin Type 1 specific Cucurbita maxima 3661 0.14 0.14 0.14 mg/100 g Lasagna Type 2 specific 0.0 0.0 0.0 mg/100 g Mallard duck Type 1 specific Anas platyrhynchos 8839 Meatloaf Type 2 specific 90.0 90.0 90.0 mg/100 g Mexican oregano Type 1 specific Lippia graveolens 0.0 0.0 0.0 mg/100 g Milk (Cow) Type 2 specific 3.030769 5.1 0.0 mg/100 g Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Nanking cherry Type 1 specific Prunus tomentosa 105667 15.5 15.5 15.5 mg/100 g Nutritional drink Type 2 specific 0.0 0.0 0.0 mg/100 g Oat Type 1 specific Avena sativa 4498 11.96 11.96 11.96 mg/100 g Opium poppy Type 1 specific Papaver somniferum 3469 0.0 0.0 0.0 mg/100 g Orange bell pepper Type 1 specific Capsicum annuum 4072 1.33 1.33 1.33 mg/100 g Ostrich Type 1 specific Struthio camelus 8801 0.38175 0.392 0.361 mg/100 g Other bread Type 2 specific 0.0 0.0 0.0 mg/100 g Other candy Type 2 specific 0.0 0.0 0.0 mg/100 g Other dish Type 2 specific 70.0 86.0 48.0 mg/100 g Other pasta dish Type 2 specific 4.0 4.0 4.0 mg/100 g Other sandwich Type 2 specific 80.0 80.0 80.0 mg/100 g Other snack food Type 2 specific 0.0 0.0 0.0 mg/100 g Other soy product Type 2 specific 0.0 0.0 0.0 mg/100 g Parsley Type 1 specific Petroselinum crispum 4043 0.0 0.0 0.0 mg/100 g Parsnip Type 1 specific Pastinaca sativa 4041 0.518566 0.52 0.517132394 mg/100 g Pasta Type 2 specific 0.0 0.0 0.0 mg/100 g Pastry Type 2 specific 0.0 0.0 0.0 mg/100 g Peanut Type 1 specific Arachis hypogaea 3818 40.0 40.0 40.0 mg/100 g Pepper Type 1 specific Capsicum annuum 4072 0.0 0.0 0.0 mg/100 g Pepper (Spice) Type 1 specific Piper nigrum 13216 0.0 0.0 0.0 mg/100 g Pheasant Type 1 specific Phasianus colchicus 9054 Pie crust Type 2 specific 0.0 0.0 0.0 mg/100 g Pizza Type 2 specific 3.666667 12.0 0.0 mg/100 g Popcorn Type 2 specific 0.0 0.0 0.0 mg/100 g Potato Type 1 specific Solanum tuberosum 4113 0.046 0.23 0.0 mg/100 g Pudding Type 2 specific 0.0 0.0 0.0 mg/100 g Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Red beetroot Type 1 specific Beta vulgaris var. rubra 0.2 0.2 0.2 mg/100 g Red bell pepper Type 1 specific Capsicum annuum 4072 0.770568 0.771136421 0.77 mg/100 g Red raspberry Type 1 specific Rubus idaeus 32247 0.501656 0.501656308 0.501656308 mg/100 g Rock ptarmigan Type 1 specific Lagopus muta 64668 Romaine lettuce Type 1 specific Lactuca sativa L. var. longifolia 0.2 0.2 0.2 mg/100 g Rye Type 1 specific Secale cereale 4550 9.975 14.09 5.86 mg/100 g Saskatoon berry Type 1 specific Amelanchier alnifolia 32219 3.3 3.3 3.3 mg/100 g Sauce Type 2 specific 36.0 36.0 36.0 mg/100 g Sausage Type 2 specific 217.529412 382.0 0.0 mg/100 g Sesame Type 1 specific Sesamum orientale 4182 0.0 0.0 0.0 mg/100 g Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Snack bar Type 2 specific 30.0 90.0 0.0 mg/100 g Soy bean Type 1 specific Glycine max 3847 0.0 0.0 0.0 mg/100 g Spinach Type 1 specific Spinacia oleracea 3562 0.47 0.47 0.47 mg/100 g Squab Type 1 specific Columba 8931 Sunburst squash (pattypan squash) Type 1 specific Cucurbita pepo var. clypeata 1.16 1.16 1.16 mg/100 g Sweet basil Type 1 specific Ocimum basilicum 39350 0.0 0.0 0.0 mg/100 g Sweet custard Type 2 specific 0.0 0.0 0.0 mg/100 g Sweet orange Type 1 specific Citrus sinensis 2711 Swiss chard Type 1 specific Beta vulgaris ssp. cicla 1527200 1.981803 1.983606236 1.98 mg/100 g Taco shell Type 2 0.0 0.0 0.0 mg/100 g Tortilla chip Type 2 specific 0.0 0.0 0.0 mg/100 g Turkey Type 1 specific Meleagris gallopavo 9103 0.031 0.062 0.0 mg/100 g Turmeric Type 1 specific Curcuma longa 136217 0.0 0.0 0.0 mg/100 g Turnip Type 1 specific Brassica rapa var. rapa 51350 0.68 0.68 0.68 mg/100 g Unclassified food or beverage Type 2 specific 0.0 0.0 0.0 mg/100 g Velvet duck Type 1 specific Melanitta fusca 371864 Watermelon Type 1 specific Citrullus lanatus 3654 Wheat Type 1 specific Triticum 4564 30.829079 30.83 30.82815865 mg/100 g White bread Type 1 0.0 0.0 0.0 mg/100 g White cabbage Type 1 specific Brassica oleracea L. var. capitata L. f. alba DC. 0.44 0.44 0.44 mg/100 g White mustard Type 1 specific Sinapis alba 3728 0.0 0.0 0.0 mg/100 g Wild boar Type 1 specific Sus scrofa 9823 Wild carrot Type 1 specific Daucus carota 4039 Wild leek Type 1 specific Allium ampeloprasum 4681 Yellow bell pepper Type 1 specific Capsicum annuum 4072 0.88 0.88 0.88 mg/100 g Yellow wax bean Type 1 specific Phaseolus vulgaris 3885 0.8 0.8 0.8 mg/100 g Yellow zucchini Type 1 specific Cucurbita pepo var. cylindrica 0.22 0.33 0.11 mg/100 g Dipeptidyl peptidase 4 P27487 DPP4 Egl nine homolog 1 Q9GZT9 EGLN1 Egl nine homolog 2 Q96KS0 EGLN2 Egl nine homolog 3 Q9H6Z9 EGLN3 Prolyl 4-hydroxylase subunit alpha-1 P13674 P4HA1 Prolyl 4-hydroxylase subunit alpha-2 O15460 P4HA2 Prolyl 4-hydroxylase subunit alpha-3 Q7Z4N8 P4HA3 Transmembrane prolyl 4-hydroxylase Q9NXG6 P4HTM Vulnerary 1430 A drug used in treating and healing of wounds.