1.0 2010-04-08 22:10:55 UTC 2019-11-26 03:09:04 UTC FDB013798 beta-Boswellic acid Constituent of frankincense (Boswellia subspecies) and olibanum oil Boswellic acid (BA) is an active component of Boswellia serrata (also known as Salai guggul). Extensive research in the past 30 years identified the active component of this resin as BA (a pentacyclic triterpenic acid) and its derivatives (acetyl-beta-boswellic acid, 11-keto-beta-boswellic acid and acetyl-11-keto-beta-boswellic acid). In animal models of inflammation, BA has been shown to be an effective adjuvant mitigating bovine serum albumin-induced arthritis and osteoarthritis. The anti-arthritic potential of BA is a result of its anti-inflammatory activity, mediated through inhibition of NF-kB, COX-2 and 5-LOX. ((PMID: 17475558, 3429205). beta-Boswellic acid is found in herbs and spices. (3alpha,4beta)-3-Hydroxy-urs-12-en-23-Oate (3alpha,4beta)-3-Hydroxy-urs-12-en-23-Oic acid 3-Hydroxy-12-ursen-24-oic acid b-Boswellate b-Boswellic acid beta-Boswellate beta-Boswellic acid Boswellate Boswellic acid β-boswellate β-boswellic acid C30H48O3 456.7003 456.360345402 3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid 3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid 631-69-6 CC1CCC2(C)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C5CCC34C)C(O)=O)C2C1C InChI=1S/C30H48O3/c1-18-10-13-26(3)16-17-28(5)20(24(26)19(18)2)8-9-21-27(4)14-12-23(31)30(7,25(32)33)22(27)11-15-29(21,28)6/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33) NBGQZFQREPIKMG-UHFFFAOYSA-N belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units. Triterpenoids Organic compounds Lipids and lipid-like molecules Prenol lipids Triterpenoids Aliphatic homopolycyclic compounds Beta hydroxy acids and derivatives Carbonyl compounds Carboxylic acids Cyclic alcohols and derivatives Hydrocarbon derivatives Hydroxysteroids Monocarboxylic acids and derivatives Organic oxides Secondary alcohols 15-hydroxysteroid Alcohol Aliphatic homopolycyclic compound Beta-hydroxy acid Carbonyl group Carboxylic acid Carboxylic acid derivative Cyclic alcohol Hydrocarbon derivative Hydroxy acid Hydroxysteroid Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Secondary alcohol Steroid Triterpenoid Solid logp 6.46 ALOGPS logs -5.97 ALOGPS solubility 4.94e-04 g/l ALOGPS melting_point Mp 238-240° (228-232°) logp 6.58 ChemAxon pka_strongest_acidic 4.57 ChemAxon pka_strongest_basic -3 ChemAxon iupac 3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid ChemAxon average_mass 456.7003 ChemAxon mono_mass 456.360345402 ChemAxon smiles CC1CCC2(C)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C5CCC34C)C(O)=O)C2C1C ChemAxon formula C30H48O3 ChemAxon inchi InChI=1S/C30H48O3/c1-18-10-13-26(3)16-17-28(5)20(24(26)19(18)2)8-9-21-27(4)14-12-23(31)30(7,25(32)33)22(27)11-15-29(21,28)6/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33) ChemAxon inchikey NBGQZFQREPIKMG-UHFFFAOYSA-N ChemAxon polar_surface_area 57.53 ChemAxon refractivity 133.7 ChemAxon polarizability 55.17 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::MsMs 70011 Specdb::MsMs 70012 Specdb::MsMs 70013 Specdb::MsMs 128433 Specdb::MsMs 128434 Specdb::MsMs 128435 Specdb::MsMs 3417692 Specdb::MsMs 3417693 Specdb::MsMs 3417694 Specdb::MsMs 3417695 Specdb::MsMs 3417696 Specdb::MsMs 3417697 Specdb::CMs 107932 Specdb::CMs 120400 Specdb::CMs 122636 Specdb::CMs 123444 Specdb::CMs 129935 Specdb::CMs 851805 Specdb::CMs 851806 HMDB02388 #<Reference:0x000055ce31845670> #<Reference:0x000055ce31845440> Herbs and Spices Unknown generic