Record Information
Version1.0
Creation date2010-04-08 22:11:11 UTC
Update date2020-09-17 15:32:55 UTC
Primary IDFDB014280
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameLuteolin 7-glucoside
DescriptionLuteolin-7-O-glucoside, also known as 7-O-glucoluteolin or cinaroside, belongs to the class of organic compounds known as flavonoid O-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position. glucoside. Because of the conjugation of glucose, Luteolin 7-O-glucoside is a moderately water-soluble compound. Luteolin 7-O-glucoside is found, on average, in a few different plants, spices and foods, such as Mexican oregano, anises, and wild celeries and in a lower concentration in lentils, and wild carrots. common buckwheats, corns, globe artichokes, roman camomiles, and orange mints.
CAS Number5373-11-5
Structure
Thumb
Synonyms
SynonymSource
2-(3,4-Dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranosideChEBI
2-(3,4-Dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzopyran-4-oneChEBI
7-GlucoluteolinChEBI
7-GlucosylluteolinChEBI
7-O-beta-D-Glucosyl-5,7,3',4'-tetrahydroxyflavoneChEBI
CinarosideChEBI
CynarosideChEBI
Luteolin 7-monoglucosideChEBI
Luteolin 7-O-glucopyranosideChEBI
Luteolin 7-O-glucosideChEBI
Luteolin-7-glucosideChEBI
LuteolosideChEBI
2-(3,4-Dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl b-D-glucopyranosideGenerator
2-(3,4-Dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl β-D-glucopyranosideGenerator
2-(3,4-Dihydroxyphenyl)-7-(b-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzopyran-4-oneGenerator
2-(3,4-Dihydroxyphenyl)-7-(β-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzopyran-4-oneGenerator
7-O-b-D-Glucosyl-5,7,3',4'-tetrahydroxyflavoneGenerator
7-O-Β-D-glucosyl-5,7,3',4'-tetrahydroxyflavoneGenerator
DaphneflavonolosideHMDB
FlavopurposideHMDB
GlucoluteolinHMDB
Luteolin 7-O-beta-D-glucosideHMDB
Luteolin 7-glucosideChEBI
Luteolin 7-O-b-D-glucosideGenerator
Luteolin 7-O-β-D-glucosideGenerator
NephrocizinMeSH
Luteolin-7-O-monoglucosideMeSH
Luteolin-7-O-beta-D-glucopyranosideMeSH
Luteolin-7-beta-D-glucosideMeSH
3',4',5,7-Tetrahydroxyflavone 7-beta-D-glucopyranosidePhytoBank
3',4',5,7-Tetrahydroxyflavone 7-β-D-glucopyranosidePhytoBank
3’,4’,5,7-Tetrahydroxyflavone 7-β-D-glucopyranosidePhytoBank
3',4',5-Trihydroxyflavone 7-O-beta-D-glucopyranosidePhytoBank
3',4',5-Trihydroxyflavone 7-O-β-D-glucopyranosidePhytoBank
3’,4’,5-Trihydroxyflavone 7-O-β-D-glucopyranosidePhytoBank
7-(beta-D-Glucosyloxy)-3',4',5-trihydroxyflavonePhytoBank
7-(β-D-Glucosyloxy)-3',4',5-trihydroxyflavonePhytoBank
7-(β-D-Glucosyloxy)-3’,4’,5-trihydroxyflavonePhytoBank
7-O-beta-D-GlucosylluteolinPhytoBank
7-O-β-D-GlucosylluteolinPhytoBank
Luteolin 7-O-beta-D-glucopyranosidePhytoBank
Luteolin 7-O-β-D-glucopyranosidePhytoBank
Luteolin 7-O-beta-glucopyranosidePhytoBank
Luteolin 7-O-β-glucopyranosidePhytoBank
Luteolin 7-O-beta-glucosidePhytoBank
Luteolin 7-O-β-glucosidePhytoBank
Luteolin 7-beta-D-glucosidePhytoBank
Luteolin 7-β-D-glucosidePhytoBank
7-O-β-D-glucosyl-5,7,3',4'-tetrahydroxyflavoneGenerator
Predicted Properties
PropertyValueSource
Water Solubility1.08 g/LALOGPS
logP0.58ALOGPS
logP0.14ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)7.3ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area186.37 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity107.04 m³·mol⁻¹ChemAxon
Polarizability42.98 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC21H20O11
IUPAC name2-(3,4-dihydroxyphenyl)-5-hydroxy-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one
InChI IdentifierInChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/m1/s1
InChI KeyPEFNSGRTCBGNAN-QNDFHXLGSA-N
Isomeric SMILESOC[C@H]1O[C@@H](OC2=CC3=C(C(O)=C2)C(=O)C=C(O3)C2=CC=C(O)C(O)=C2)[C@H](O)[C@@H](O)[C@@H]1O
Average Molecular Weight448.3769
Monoisotopic Molecular Weight448.100561482
Classification
Description belongs to the class of organic compounds known as flavonoid-7-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassFlavonoids
Sub ClassFlavonoid glycosides
Direct ParentFlavonoid-7-O-glycosides
Alternative Parents
Substituents
  • Flavonoid-7-o-glycoside
  • 3'-hydroxyflavonoid
  • 4'-hydroxyflavonoid
  • 5-hydroxyflavonoid
  • Flavone
  • Hydroxyflavonoid
  • Phenolic glycoside
  • Hexose monosaccharide
  • Chromone
  • Glycosyl compound
  • O-glycosyl compound
  • Benzopyran
  • 1-benzopyran
  • Catechol
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Pyranone
  • Pyran
  • Oxane
  • Monocyclic benzene moiety
  • Benzenoid
  • Monosaccharide
  • Heteroaromatic compound
  • Vinylogous acid
  • Secondary alcohol
  • Organoheterocyclic compound
  • Oxacycle
  • Polyol
  • Acetal
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organooxygen compound
  • Alcohol
  • Primary alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Biological role:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 56.25%; H 4.50%; O 39.25%DFC
Melting PointMp 256-258° (254°)DFC
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV Data398 (e 21000) (MeOH-NaOH) (Berdy)DFC
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-001r-8934600000-7e7c6044b90fb9c11463JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (3 TMS) - 70eV, Positivesplash10-0f72-4730119000-f82ba729f371b8abdbdaJSpectraViewer
LC-MS/MSLC-MS/MS Spectrum - ESI-TOF 10V, Negativesplash10-0002-0010900030-c10d893db863fa97d0a8JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - ESI-TOF 10V, Negativesplash10-0002-0010900030-c10d893db863fa97d0a8JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - DI-ESI-qTof , Positivesplash10-000i-0090000000-f076599705f9f223d360JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - DI-ESI-qTof , Negativesplash10-000i-0090100000-fe6850abbcec4fe56dd9JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0012-0190500000-bcf45c556204b1713d58JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0002-0030900020-65868b413ea8969c4672JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0019-0090000000-0908e4e690a4acb6edfcJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0002-0000900000-f15806fb1fd62f75af54JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-001a-0190400000-862638c136c541fb742bJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , negativesplash10-000i-0091000000-f63c0d3cebcf6fc2e507JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - , negativesplash10-0002-0040900000-e3f9043e8fac7872cb66JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-000i-0090000000-1ff8e42522b8a1f6961aJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-000i-0090100000-cb0df3f467ea51e6ab18JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-000j-0090600000-8f1dad507334d836e2a8JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-000i-0190000000-e3aa1461dda1c7043d2dJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITTOF , positivesplash10-000i-0090000000-31bb8bd03bfd2eff538bJSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Linear Ion Trap , positivesplash10-000i-0091100000-ea4c2b653cea6f474766JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-000i-0090000000-8392154e4309f46037d5JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000j-0190600000-49dfd37238ba14bc6c11JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00kr-0190000000-8733c538660a8dd11d05JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-014i-1390000000-ceeece13914238abed46JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-000b-1261900000-e1ec4112e692ec8fbbd6JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-000i-1190100000-bcbf2a30e128889e8047JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-00ku-2190000000-954ea2eef82d3bedfb36JSpectraViewer
ChemSpider ID4444241
ChEMBL IDCHEMBL233929
KEGG Compound IDC03951
Pubchem Compound ID5280637
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer ID245
DrugBank IDNot Available
HMDB IDHMDB35588
CRC / DFC (Dictionary of Food Compounds) IDHQG45-Z:JPC55-X
EAFUS IDNot Available
Dr. Duke IDCINAROSIDE|CYANAROSIDE|LUTEOLIN-7-BETA-D-GLUCOPYRANOSIDE|LUTEOLIN-7-BETA-D-GLUCOSIDE|LUTEOLIN-7-O-BETA-GLUCOSIDE|LUTEOLIN-7-GLUCOSIDE|CYNAROSIDE|LUTEOLIN-7-O-GLUCOSIDE|LUTEOLIN-7-O-BETA-D-GLUCOSIDE
BIGG IDNot Available
KNApSAcK IDC00004266
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDLuteolin_7-glucoside
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / Bioactivities
DescriptorIDDefinitionReference
aldose reductase inhibitor48550 An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).DUKE
anti complementaryDUKE
anti dermatic50177 A drug used to treat or prevent skin disorders or for the routine care of skin.DUKE
anti herpetic22587 A substance that destroys or inhibits replication of viruses.DUKE
anti hyperthyroid52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
anti inflammatory35472 A substance that reduces or suppresses inflammation.DUKE
antioxidant22586 A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324.DUKE
anti viral22587 A substance that destroys or inhibits replication of viruses.DUKE
calcium antagonist48706 Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.DUKE
cancer preventive35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
cholagogueDUKE
deiodinase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
hypocholesterolemicDUKE
Insectiphile24852 Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.DUKE
pesticide25944 Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.DUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070.
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.