| Record Information |
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| Version | 1.0 |
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| Creation date | 2010-04-08 22:12:46 UTC |
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| Update date | 2019-11-26 03:14:01 UTC |
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| Primary ID | FDB016983 |
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| Secondary Accession Numbers | Not Available |
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| Chemical Information |
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| FooDB Name | Ficin |
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| Description | Chillproofing agent for beer, meat tenderiser, dough conditioner, rennet substitute, processing aid for precooked cereals. GRAS approved
Ficain (or ficin) is an enzyme which is derived from figs latex. It is of a family of proteases known as the cysteine endopeptidases, a group that also includes papain derived from papaya latex, bromelase (bromelain) extracted from pineapple stem, calpain, caspases, cathespisin B, and chymopapain.; It is one of the most commonly used for differentiating many blood group antigens: eg destroy M, N, S, Duffy a and Duffy b and enhance some other antigens. Ficin is found in many foods, some of which are alcoholic beverages, fig, animal foods, and cereals and cereal products. |
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| CAS Number | 9001-33-6 |
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| Structure | |
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| Synonyms | | Synonym | Source |
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| Ficus protease | HMDB | | Higueroxyl delabarre | HMDB | | Ficain | MeSH | | Ficin | MeSH |
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| Predicted Properties | |
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| Chemical Formula | CH2FI2N |
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| IUPAC name | fluoro[(imino-λ³-iodanyl)methylidene]-λ³-iodane |
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| InChI Identifier | InChI=1S/CH2FI2N/c2-3-1-4-5/h1,5H |
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| InChI Key | POTUGHMKJGOKRI-UHFFFAOYSA-N |
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| Isomeric SMILES | F[I]=C[I]=N |
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| Average Molecular Weight | 300.8406 |
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| Monoisotopic Molecular Weight | 300.826064114 |
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| Classification |
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| Description | Belongs to the class of organic compounds known as organoiodides. Organoiodides are compounds containing a chemical bond between a carbon atom and an iodine atom. |
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| Kingdom | Organic compounds |
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| Super Class | Organohalogen compounds |
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| Class | Organoiodides |
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| Sub Class | Not Available |
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| Direct Parent | Organoiodides |
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| Alternative Parents | |
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| Substituents | - Organic nitrogen compound
- Hydrocarbon derivative
- Organoiodide
- Aliphatic acyclic compound
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| Molecular Framework | Aliphatic acyclic compounds |
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| External Descriptors | Not Available |
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| Ontology |
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| Disposition | Route of exposure: Source: Biological location: |
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| Role | Biological role: |
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| Physico-Chemical Properties |
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| Physico-Chemical Properties - Experimental | | Property | Value | Reference |
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| Physical state | Not Available | |
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| Physical Description | Not Available | |
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| Mass Composition | Not Available | |
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| Melting Point | Not Available | |
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| Boiling Point | Not Available | |
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| Experimental Water Solubility | Not Available | |
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| Experimental logP | Not Available | |
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| Experimental pKa | Not Available | |
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| Isoelectric point | Not Available | |
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| Charge | Not Available | |
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| Optical Rotation | Not Available | |
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| Spectroscopic UV Data | Not Available | |
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| Density | Not Available | |
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| Refractive Index | Not Available | |
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| Spectra |
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| Spectra | |
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| EI-MS/GC-MS | | Type | Description | Splash Key | View |
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| Predicted GC-MS | Ficin, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive | splash10-000x-0972000000-9aa51648157ae2b55568 | Spectrum | | Predicted GC-MS | Ficin, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum |
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| MS/MS | | Type | Description | Splash Key | View |
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| Predicted MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0a4i-0009000000-40be04079cb18de3bc15 | 2016-08-02 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0a4i-0429000000-95038b947b50a758abf4 | 2016-08-02 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-08fu-0913000000-0b4d5dc9d9296a13e7b5 | 2016-08-02 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0udi-0917000000-8363f386a9c753e0a827 | 2016-08-03 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0udi-0904000000-feb8f7d8fba3fbdf0f29 | 2016-08-03 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a4i-0911000000-a740d602a8689a23ada9 | 2016-08-03 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0002-0390000000-a2a868c32272914ce116 | 2021-09-24 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0006-0900000000-c602b1afd75233712e57 | 2021-09-24 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0006-0900000000-c602b1afd75233712e57 | 2021-09-24 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0udi-0009000000-ffab7e66dc1bb28a116a | 2021-09-24 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0udr-0159000000-9ac668165e994e4045c8 | 2021-09-24 | View Spectrum | | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0a4i-0900000000-3624c6ca61565a1d211a | 2021-09-24 | View Spectrum |
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| NMR | Not Available |
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| External Links |
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| ChemSpider ID | 21172771 |
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| ChEMBL ID | Not Available |
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| KEGG Compound ID | Not Available |
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| Pubchem Compound ID | Not Available |
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| Pubchem Substance ID | Not Available |
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| ChEBI ID | Not Available |
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| Phenol-Explorer ID | Not Available |
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| DrugBank ID | Not Available |
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| HMDB ID | HMDB37833 |
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| CRC / DFC (Dictionary of Food Compounds) ID | KVT16-U:KVT16-U |
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| EAFUS ID | 1390 |
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| Dr. Duke ID | FICIN |
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| BIGG ID | Not Available |
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| KNApSAcK ID | Not Available |
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| HET ID | Not Available |
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| Food Biomarker Ontology | Not Available |
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| VMH ID | Not Available |
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| Flavornet ID | Not Available |
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| GoodScent ID | Not Available |
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| SuperScent ID | Not Available |
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| Wikipedia ID | Ficin |
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| Phenol-Explorer Metabolite ID | Not Available |
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| Duplicate IDS | Not Available |
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| Old DFC IDS | Not Available |
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| Associated Foods |
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| Food | Content Range | Average | Reference |
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| Food | | | Reference |
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| Biological Effects and Interactions |
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| Health Effects / Bioactivities | | Descriptor | ID | Definition | Reference |
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| Anti-inflammatory | 35472 | An agent that reduces inflammation, playing a biological role in suppressing immune responses and therapeutic applications in managing pain, swelling, and redness. Key medical uses include treating arthritis, allergies, and autoimmune disorders, as well as relieving symptoms of conditions such as asthma and dermatitis. | DUKE | | Dermatitigenic | | An agent that causes inflammation of the skin (dermatitis), triggering allergic reactions and immune responses. Its biological role involves activating immune cells, leading to skin irritation. Therapeutically, it is used to test skin sensitivity and develop treatments for dermatitis. Key medical uses include diagnosing skin allergies and researching dermatitis treatments. | DUKE | | Irritant | | An agent that causes slight inflammation or discomfort, stimulating a biological response. Therapeutically, it can be used to increase blood flow or stimulate healing. Key medical uses include treating wounds, skin conditions, and respiratory issues, such as congestion, by inducing a mild inflammatory response to promote recovery. | DUKE | | Pesticide | 25944 | An agent that kills or repels pests, playing a biological role in controlling insect, weed, and fungal populations. Therapeutically, pesticides have limited applications, but some are used to treat ectoparasitic infestations, such as lice and scabies. Key medical uses include topical treatments for head lice and scabies, highlighting their role in managing parasitic infections. | DUKE | | Proteolytic | | An agent that catalyzes proteolysis, breaking down proteins into smaller polypeptides or amino acids, playing a biological role in protein regulation and turnover. It has therapeutic applications in wound healing, cancer treatment, and inflammatory disease management, with key medical uses including digestive enzyme supplementation and oncology therapy. | DUKE | | Pruritogenic | | An agent that induces pruritus, or itching, playing a role in inflammatory and allergic responses. Therapeutically, understanding pruritogenic mechanisms helps develop treatments for itch-related disorders, with key medical uses in managing conditions like atopic dermatitis, psoriasis, and uremic pruritus. | DUKE | | Trichuricide | | An agent that kills parasitic whipworms of the genus Trichuris, used to treat trichuriasis, a parasitic infection affecting the large intestine, and other related gastrointestinal disorders. | DUKE | | Vermifuge | 25944 | An agent that expels or destroys intestinal parasites, such as worms, by paralyzing or killing them, commonly used to treat parasitic infections like hookworm, roundworm, and tapeworm infestations. | DUKE |
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| Enzymes | Not Available |
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| Pathways | Not Available |
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| Metabolism | Not Available |
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| Biosynthesis | Not Available |
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| Organoleptic Properties |
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| Flavours | Not Available |
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| Files |
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| MSDS | show |
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| References |
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| Synthesis Reference | Not Available |
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| General Reference | Not Available |
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| Content Reference | — Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
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