1.0 2011-04-08 19:39:10 UTC 2025-11-19 02:39:40 UTC FDB021794 25,26-Dihydroxyvitamin D3 25,26-(OH)2D3 is a renal microsomal 25-OH-D3 metabolite, whose plasma concentration increases during vitamin D excess concomitantly with an increase in the concentration of lactone. This observation considered with the related structural features of 25,26-(OH)2D3 and lactone (both are oxidized at (C-26) suggested that 25,26(OH)2D3, a metabolite of unknown function, could be a precursor to lactone. In fact, it has been reported that functionalization of C-26 and subsequent lactone formation occurs exclusively in kidney. However, rigorous examination has unambiguously excluded 25S,26-(OH)2D3, the naturally occurring form as a significant lactone precursor. (PMID: 6286629) [HMDB] 25,26-Dihydroxycholecalciferol 9,10-Secocholesta-5,7,10(19)-triene-3b,25,26-triol C27H44O3 416.6365 416.329045274 6-[(4Z)-4-{2-[(1E)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyl-octahydro-1H-inden-1-yl]-2-methylheptane-1,2-diol 6-[(4Z)-4-{2-[(1E)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyl-hexahydro-1H-inden-1-yl]-2-methylheptane-1,2-diol 29261-12-9 CC(CCCC(C)(O)CO)C1CCC2\C(CCCC12C)=C/C=C1\CC(O)CCC1=C InChI=1S/C27H44O3/c1-19-9-12-23(29)17-22(19)11-10-21-8-6-16-27(4)24(13-14-25(21)27)20(2)7-5-15-26(3,30)18-28/h10-11,20,23-25,28-30H,1,5-9,12-18H2,2-4H3/b21-10-,22-11+ QOWCBCXATJITSI-PANSPLHPSA-N belongs to the class of organic compounds known as vitamin d and derivatives. Vitamin D and derivatives are compounds containing a secosteroid backbone, usually secoergostane or secocholestane. Vitamin D and derivatives Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Vitamin D and derivatives Aliphatic homopolycyclic compounds Cyclic alcohols and derivatives Fatty alcohols Hydrocarbon derivatives Primary alcohols Secondary alcohols Tertiary alcohols Triterpenoids Alcohol Aliphatic homopolycyclic compound Cyclic alcohol Fatty acyl Fatty alcohol Hydrocarbon derivative Organic oxygen compound Organooxygen compound Primary alcohol Secondary alcohol Tertiary alcohol Triterpenoid Solid logp 5.54 ALOGPS logs -4.71 ALOGPS solubility 8.13e-03 g/l ALOGPS logp 4.61 ChemAxon pka_strongest_acidic 14.04 ChemAxon pka_strongest_basic -1.3 ChemAxon iupac 6-[(4Z)-4-{2-[(1E)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyl-octahydro-1H-inden-1-yl]-2-methylheptane-1,2-diol ChemAxon average_mass 416.6365 ChemAxon mono_mass 416.329045274 ChemAxon smiles CC(CCCC(C)(O)CO)C1CCC2\C(CCCC12C)=C/C=C1\CC(O)CCC1=C ChemAxon formula C27H44O3 ChemAxon inchi InChI=1S/C27H44O3/c1-19-9-12-23(29)17-22(19)11-10-21-8-6-16-27(4)24(13-14-25(21)27)20(2)7-5-15-26(3,30)18-28/h10-11,20,23-25,28-30H,1,5-9,12-18H2,2-4H3/b21-10-,22-11+ ChemAxon inchikey QOWCBCXATJITSI-PANSPLHPSA-N ChemAxon polar_surface_area 60.69 ChemAxon refractivity 126.6 ChemAxon polarizability 51.24 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 3 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon HMDB01420 #<Reference:0x000055ce3213b798> #<Reference:0x000055ce3213b5e0>