1.0 2011-04-11 17:01:43 UTC 2025-11-19 02:39:46 UTC FDB021813 Adenosine triphosphate Adenosine triphosphate (ATP) is a nucleotide consisting of a purine base (adenine) attached to the first carbon atom of ribose (a pentose sugar). Three phosphate groups are esterified at the fifth carbon atom of the ribose. ATP is incorporated into nucleic acids by polymerases in the processes of DNA replication and transcription. ATP contributes to cellular energy charge and participates in overall energy balance, maintaining cellular homeostasis. ATP can act as an extracellular signaling molecule via interactions with specific purinergic receptors to mediate a wide variety of processes as diverse as neurotransmission, inflammation, apoptosis, and bone remodelling. Extracellular ATP and its metabolite adenosine have also been shown to exert a variety of effects on nearly every cell type in human skin, and ATP seems to play a direct role in triggering skin inflammatory, regenerative, and fibrotic responses to mechanical injury, an indirect role in melanocyte proliferation and apoptosis, and a complex role in Langerhans cell-directed adaptive immunity. During exercise, intracellular homeostasis depends on the matching of adenosine triphosphate (ATP) supply and ATP demand. Metabolites play a useful role in communicating the extent of ATP demand to the metabolic supply pathways Effects as different as proliferation or differentiation, chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular ATP. The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. (PMID: 15490415, 15129319, 14707763, 14696970, 11157473) [HMDB] 5'-(Tetrahydrogen triate) adenosine 5'-ATP Adenosine 5'-triate Adenosine 5'-triic acid Adenosine 5'-triorate Adenosine 5'-trioric acid Adenosine triate Adenosine triic acid ADENOSINE-5'-triATE ADENOSINE-5'-triic acid Adenylpyroorate Adenylpyrooric acid Adephos Adetol Adynol Atipi ATP Atriphos Cardenosine Fosfobion Glucobasin H4ATP Myotriphos Obion Striadyne Triaden Triadenyl Trioric acid adenosine ester C10H16N5O13P3 507.181 506.995745159 ({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid adenosine triphosphate 56-65-5 NC1=C2N=CN(C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O)C2=NC=N1 InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20) ZKHQWZAMYRWXGA-UHFFFAOYSA-N belongs to the class of organic compounds known as purine ribonucleoside polyphosphates. These are purine ribobucleotides with polyphosphate (with 4 or more phosphate) group linked to the ribose moiety. Purine ribonucleoside polyphosphates Organic compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleotides Aromatic heteropolycyclic compounds 6-aminopurines Aminopyrimidines and derivatives Azacyclic compounds Dialkyl phosphates Glycosylamines Heteroaromatic compounds Hydrocarbon derivatives Imidolactams Monosaccharide phosphates N-substituted imidazoles Organic oxides Organopnictogen compounds Oxacyclic compounds Pentose phosphates Primary amines Purine nucleotide sugars Purine ribonucleoside monophosphates Secondary alcohols Tetrahydrofurans 6-aminopurine Alcohol Alkyl phosphate Amine Aminopyrimidine Aromatic heteropolycyclic compound Azacycle Azole Dialkyl phosphate Glycosyl compound Heteroaromatic compound Hydrocarbon derivative Imidazole Imidazopyrimidine Imidolactam Monosaccharide Monosaccharide phosphate N-glycosyl compound N-substituted imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organic phosphoric acid derivative Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Pentose monosaccharide Pentose phosphate Pentose-5-phosphate Phosphoric acid ester Primary amine Purine Purine nucleotide sugar Purine ribonucleoside monophosphate Purine ribonucleoside polyphosphate Pyrimidine Secondary alcohol Tetrahydrofuran Solid logp -0.84 ALOGPS logs -2.05 ALOGPS solubility 4.49e+00 g/l ALOGPS logp -5.8 ChemAxon pka_strongest_acidic 0.9 ChemAxon pka_strongest_basic 4.01 ChemAxon iupac ({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid ChemAxon average_mass 507.181 ChemAxon mono_mass 506.995745159 ChemAxon smiles NC1=C2N=CN(C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O)C2=NC=N1 ChemAxon formula C10H16N5O13P3 ChemAxon inchi InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20) ChemAxon inchikey ZKHQWZAMYRWXGA-UHFFFAOYSA-N ChemAxon polar_surface_area 279.13 ChemAxon refractivity 95.81 ChemAxon polarizability 38.86 ChemAxon rotatable_bond_count 8 ChemAxon acceptor_count 14 ChemAxon donor_count 7 ChemAxon physiological_charge -3 ChemAxon formal_charge 0 ChemAxon Amino Sugar Metabolism SMP00045 map00520 Ammonia Recycling SMP00009 map00910 Citric Acid Cycle SMP00057 map00020 DNA Replication Fork SMP00477 Ethanol Degradation SMP00449 Folate Metabolism SMP00053 map00670 Gluconeogenesis SMP00128 map00010 Glycerolipid Metabolism SMP00039 map00561 Glycine and Serine Metabolism SMP00004 map00260 Glycolysis SMP00040 map00010 Histidine Metabolism SMP00044 map00340 Inositol Phosphate Metabolism SMP00462 map00562 Lactose Degradation SMP00457 Lactose Synthesis SMP00444 Methionine Metabolism SMP00033 map00270 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids SMP00482 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids SMP00481 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids SMP00480 Mitochondrial Electron Transport Chain SMP00355 map00190 Phosphatidylinositol Phosphate Metabolism SMP00463 map00562 Phytanic Acid Peroxisomal Oxidation SMP00450 Purine Metabolism SMP00050 map00230 Spermidine and Spermine Biosynthesis SMP00445 Threonine and 2-Oxobutanoate Degradation SMP00452 Transcription/Translation SMP00019 Transfer of Acetyl Groups into Mitochondria SMP00466 Trehalose Degradation SMP00467 Urea Cycle SMP00059 map00330 Specdb::CMs 975680 Specdb::CMs 975681 Specdb::CMs 975682 Specdb::CMs 975683 Specdb::CMs 975684 Specdb::CMs 975685 Specdb::CMs 975686 Specdb::CMs 975687 Specdb::CMs 975688 Specdb::CMs 975689 Specdb::CMs 975690 Specdb::CMs 975691 Specdb::CMs 975692 Specdb::CMs 975693 Specdb::CMs 975694 Specdb::CMs 975695 Specdb::CMs 975696 Specdb::CMs 975697 Specdb::CMs 975698 Specdb::CMs 975699 Specdb::CMs 975700 Specdb::CMs 975701 Specdb::CMs 975702 Specdb::CMs 975703 Specdb::CMs 975704 HMDB00538 ATP #<Reference:0x00007f093c06b548> #<Reference:0x00007f093c06afa8> #<Reference:0x00007f093c06ad00> #<Reference:0x00007f093c06a9e0> #<Reference:0x00007f093c06a6e8> #<Reference:0x00007f093c06a3f0> #<Reference:0x00007f093c06a0f8> #<Reference:0x00007f093c069e50> #<Reference:0x00007f093c069bf8> #<Reference:0x00007f093c069a40> #<Reference:0x00007f093c069888> #<Reference:0x00007f093c0696d0> #<Reference:0x00007f093c069518> #<Reference:0x00007f093c069360> #<Reference:0x00007f093c0691a8> Beer Type 2 specific 5.55555 19.0 0.0019 mg/100 g Milk (Cow) Type 2 specific 0.233333 0.25 0.225 uM [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Q15118 PDK1 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial Q15120 PDK3 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH 3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1 5-oxoprolinase O14841 OPLAH 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 P16118 PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Q16875 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Q16877 PFKFB4 Acetoacetyl-CoA synthetase Q86V21 AACS Acetyl-coenzyme A synthetase 2-like, mitochondrial Q9NUB1 ACSS1 Acetyl-coenzyme A synthetase, cytoplasmic Q9NR19 ACSS2 Acyl-CoA synthetase family member 4 Q4L235 AASDH Adenylate kinase 2, mitochondrial P54819 AK2 Adenylate kinase 7 Q96M32 AK7 Adenylate kinase isoenzyme 1 P00568 AK1 Adenylate kinase isoenzyme 4, mitochondrial P27144 AK4 Adenylyltransferase and sulfurtransferase MOCS3 O95396 MOCS3 Alanine--tRNA ligase, cytoplasmic P49588 AARS Alanine--tRNA ligase, mitochondrial Q5JTZ9 AARS2 ALK tyrosine kinase receptor Q9UM73 ALK Alpha-type platelet-derived growth factor receptor P16234 PDGFRA AP2-associated protein kinase 1 Q2M2I8 AAK1 Arginine--tRNA ligase, cytoplasmic P54136 RARS Argininosuccinate synthase P00966 ASS1 Asparagine synthetase [glutamine-hydrolyzing] P08243 ASNS Asparagine--tRNA ligase, cytoplasmic O43776 NARS Aspartate--tRNA ligase, cytoplasmic P14868 DARS Aspartate--tRNA ligase, mitochondrial Q6PI48 DARS2 ATP synthase lipid-binding protein, mitochondrial P48201 ATP5G3 ATP synthase protein 8 P03928 MT-ATP8 ATP synthase subunit alpha, mitochondrial P25705 ATP5A1 ATP synthase subunit b, mitochondrial P24539 ATP5F1 ATP synthase subunit beta, mitochondrial P06576 ATP5B ATP synthase subunit d, mitochondrial O75947 ATP5H ATP synthase subunit delta, mitochondrial P30049 ATP5D ATP synthase subunit e, mitochondrial P56385 ATP5I ATP synthase subunit epsilon, mitochondrial P56381 ATP5E ATP synthase subunit f, mitochondrial P56134 ATP5J2 ATP synthase subunit gamma, mitochondrial P36542 ATP5C1 ATP synthase subunit O, mitochondrial P48047 ATP5O ATP synthase-coupling factor 6, mitochondrial P18859 ATP5J ATP-citrate synthase P53396 ACLY ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F A4D1K0 ATP6V1F ATPase, H+ transporting, lysosomal accessory protein 1 (ATPase, H+ transporting, lysosomal accessory protein 1, isoform CRA_d) (cDNA FLJ78461, highly similar to Homo sapiens ATPase, H+ transporting, lysosomal accessory protein 1 (ATP6AP1), mRNA) (Fragment Q15904 ATP6AP1 Aurora/Ipl1-related kinase 3 transcript variant 1 Q9UQB9 AURKC AXL receptor tyrosine kinase P30530 AXL Baculoviral IAP repeat-containing protein 6 Q9NR09 BIRC6 BDNF/NT-3 growth factors receptor Q16620 NTRK2 Beta-adrenergic receptor kinase 1 P25098 ADRBK1 Beta-adrenergic receptor kinase 2 P35626 ADRBK2 Beta-type platelet-derived growth factor receptor P09619 PDGFRB Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 O43252 PAPSS1 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 O95340 PAPSS2 Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) Q3LXA3 DAK Bifunctional coenzyme A synthase Q13057 COASY Bifunctional glutamate/proline--tRNA ligase P07814 EPRS Bifunctional polynucleotide phosphatase/kinase Q96T60 PNKP Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase Q9Y223 GNE Bile acyl-CoA synthetase Q9Y2P5 SLC27A5 Biotin--protein ligase P50747 HLCS C-1-tetrahydrofolate synthase, cytoplasmic P11586 MTHFD1 Calcium/calmodulin-dependent protein kinase (CaM kinase) II beta A4D2J9 CAMK2B Calcium/calmodulin-dependent protein kinase I, isoform CRA_a B0YIY3 CAMK1 Calcium/calmodulin-dependent protein kinase ID Q5SQQ7 CAMK1D Calcium/calmodulin-dependent protein kinase type II subunit delta Q13557 CAMK2D Cancer-related nucleoside-triphosphatase Q9BSD7 NTPCR Carbamoyl-phosphate synthase [ammonia], mitochondrial P31327 CPS1 Casein kinase 2 beta polypeptide P67870 CSNK2B Casein kinase I isoform delta P48730 CSNK1D Casein kinase I isoform epsilon P49674 CSNK1E Casein kinase I isoform gamma-2 P78368 CSNK1G2 Casein kinase I isoform gamma-3 Q9Y6M4 CSNK1G3 Casein kinase II subunit alpha P68400 CSNK2A1 Casein kinase II subunit alpha' P19784 CSNK2A2 CCR4-NOT transcription complex subunit 4 O95628 CNOT4 Cell division cycle 7-related protein kinase O00311 CDC7 Cell division protein kinase 10 Q15131 CDK10 Cell division protein kinase 12 Q9NYV4 CDK12 Cell division protein kinase 13 Q14004 CDK13 Cell division protein kinase 17 Q00537 CDK17 Cell division protein kinase 18 Q07002 CDK18 Cell division protein kinase 19 Q9BWU1 CDK19 Cell division protein kinase 20 Q8IZL9 CDK20 Cell division protein kinase 3 Q00526 CDK3 Cell division protein kinase 4 P11802 CDK4 Cell division protein kinase 5 Q00535 CDK5 Cell division protein kinase 7 P50613 CDK7 Cell division protein kinase 9 P50750 CDK9 cGMP-dependent protein kinase 1 Q13976 PRKG1 cGMP-dependent protein kinase 2 Q13237 PRKG2 Choline kinase alpha P35790 CHKA Choline/ethanolamine kinase Q9Y259 CHKB Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial Q96EY8 MMAB Creatine kinase B-type P12277 CKB Creatine kinase M-type P06732 CKM Creatine kinase S-type, mitochondrial P17540 CKMT2 Creatine kinase U-type, mitochondrial P12532 CKMT1A CSNK1A1 protein Q6PJ06 CSNK1A1 CTP synthase 2 Q9NRF8 CTPS2 Cyclin-dependent kinase 6 A4D1G0 CDK6 Cyclin-dependent kinase-like 1 Q00532 CDKL1 Cyclin-dependent kinase-like 2 Q92772 CDKL2 Cyclin-dependent kinase-like 3 Q8IVW4 CDKL3 Cyclin-dependent kinase-like 4 Q5MAI5 CDKL4 Cyclin-dependent kinase-like 5 O76039 CDKL5 Cyclin-G-associated kinase O14976 GAK Cysteine--tRNA ligase, cytoplasmic P49589 CARS Delta-1-pyrroline-5-carboxylate synthase P54886 ALDH18A1 Deoxycytidine kinase P27707 DCK Deoxyguanosine kinase, mitochondrial Q16854 DGUOK Diacylglycerol kinase, epsilon 64kDa A1L4Q0 DGKE Diphosphomevalonate decarboxylase P53602 MVD Discoidin domain-containing receptor 2 Q16832 DDR2 DNA ligase 1 P18858 LIG1 DNA ligase 4 P49917 LIG4 DNA-dependent protein kinase catalytic subunit P78527 PRKDC DNA-directed RNA polymerase Q7Z3R8 DKFZp686D10173 DNA-directed RNA polymerase I subunit RPA1 O95602 POLR1A DNA-directed RNA polymerase I subunit RPA2 Q9H9Y6 POLR1B DNA-directed RNA polymerase I subunit RPA49 Q9GZS1 POLR1E DNA-directed RNA polymerase III subunit RPC1 O14802 POLR3A DNA-directed RNA polymerase III subunit RPC2 Q9NW08 POLR3B DNA-directed RNA polymerase III subunit RPC4 P05423 POLR3D DNA-directed RNA polymerase III subunit RPC7 O15318 POLR3G DNA-directed RNA polymerase III subunit RPC7-like Q9BT43 POLR3GL DNA-directed RNA polymerase III subunit RPC8 Q9Y535 POLR3H DNA-directed RNA polymerase, mitochondrial O00411 POLRMT DNA-directed RNA polymerases I and III subunit RPAC2 Q9Y2S0 POLR1D Dual serine/threonine and tyrosine protein kinase Q6XUX3 DSTYK Dual specificity mitogen-activated protein kinase kinase 2 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 3 P46734 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 4 P45985 MAP2K4 Dual specificity protein kinase CLK1 P49759 CLK1 Dual specificity protein kinase CLK2 P49760 CLK2 Dual specificity protein kinase CLK4 Q9HAZ1 CLK4 Dual specificity tyrosine-phosphorylation-regulated kinase 1A Q13627 DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1B Q9Y463 DYRK1B E3 ubiquitin ligase SMURF1 Q9HCE7 SMURF1 E3 ubiquitin-protein ligase AMFR Q9UKV5 AMFR E3 ubiquitin-protein ligase CCNB1IP1 Q9NPC3 CCNB1IP1 E3 ubiquitin-protein ligase CHFR Q96EP1 CHFR E3 ubiquitin-protein ligase DZIP3 Q86Y13 DZIP3 E3 ubiquitin-protein ligase FANCL Q9NW38 FANCL E3 ubiquitin-protein ligase HUWE1 Q7Z6Z7 HUWE1 E3 ubiquitin-protein ligase LNX Q8TBB1 LNX1 E3 ubiquitin-protein ligase LRSAM1 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase MARCH1 Q8TCQ1 MARCH1 E3 ubiquitin-protein ligase MARCH2 Q9P0N8 MARCH2 E3 ubiquitin-protein ligase MARCH3 Q86UD3 MARCH3 E3 ubiquitin-protein ligase MARCH4 Q9P2E8 MARCH4 E3 ubiquitin-protein ligase MARCH5 Q9NX47 MARCH5 E3 ubiquitin-protein ligase MARCH7 Q9H992 MARCH7 E3 ubiquitin-protein ligase MARCH8 Q5T0T0 MARCH8 E3 ubiquitin-protein ligase MARCH9 Q86YJ5 MARCH9 E3 ubiquitin-protein ligase MGRN1 O60291 MGRN1 E3 ubiquitin-protein ligase MIB1 Q86YT6 MIB1 E3 ubiquitin-protein ligase NEDD4 P46934 NEDD4 E3 ubiquitin-protein ligase NEDD4-like Q96PU5 NEDD4L E3 ubiquitin-protein ligase RAD18 Q9NS91 RAD18 E3 ubiquitin-protein ligase RFWD3 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RING2 Q99496 RNF2 E3 ubiquitin-protein ligase RNF128 Q8TEB7 RNF128 E3 ubiquitin-protein ligase RNF138 Q8WVD3 RNF138 E3 ubiquitin-protein ligase RNF144B Q7Z419 RNF144B E3 ubiquitin-protein ligase RNF5 Q99942 RNF5 E3 ubiquitin-protein ligase RNF8 O76064 RNF8 E3 ubiquitin-protein ligase SIAH1 Q8IUQ4 SIAH1 E3 ubiquitin-protein ligase SIAH2 O43255 SIAH2 E3 ubiquitin-protein ligase SMURF2 Q9HAU4 SMURF2 E3 ubiquitin-protein ligase synoviolin Q86TM6 SYVN1 E3 ubiquitin-protein ligase Topors Q9NS56 TOPORS E3 ubiquitin-protein ligase TRIM11 Q96F44 TRIM11 E3 ubiquitin-protein ligase TRIM32 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM33 Q9UPN9 TRIM33 E3 ubiquitin-protein ligase TRIM63 Q969Q1 TRIM63 E3 ubiquitin-protein ligase UBR1 Q8IWV7 UBR1 E3 ubiquitin-protein ligase UBR2 Q8IWV8 UBR2 E3 ubiquitin-protein ligase UBR4 Q5T4S7 UBR4 E3 ubiquitin-protein ligase UBR5 O95071 UBR5 E3 ubiquitin-protein ligase ZNRF1 Q8ND25 ZNRF1 E3 ubiquitin-protein ligase ZNRF2 Q8NHG8 ZNRF2 EPH receptor A8 P29322 EPHA8 Ephrin type-A receptor 1 P21709 EPHA1 Ephrin type-A receptor 10 Q5JZY3 EPHA10 Ephrin type-A receptor 2 P29317 EPHA2 Ephrin type-A receptor 3 P29320 EPHA3 Ephrin type-A receptor 4 P54764 EPHA4 Ephrin type-A receptor 5 P54756 EPHA5 Ephrin type-A receptor 7 Q15375 EPHA7 Ephrin type-B receptor 1 P54762 EPHB1 Ephrin type-B receptor 2 P29323 EPHB2 Ephrin type-B receptor 3 P54753 EPHB3 Ephrin type-B receptor 4 P54760 EPHB4 Ephrin type-B receptor 6 O15197 EPHB6 Epidermal growth factor receptor P00533 EGFR Epithelial discoidin domain-containing receptor 1 Q08345 DDR1 Ethanolamine kinase 1 Q9HBU6 ETNK1 Ethanolamine kinase 2 Q9NVF9 ETNK2 Eukaryotic translation initiation factor 2-alpha kinase 3 Q9NZJ5 EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 4 Q9P2K8 EIF2AK4 FARSLA protein Q6IBR2 FARSLA Fibroblast growth factor receptor 2 P21802 FGFR2 Fibroblast growth factor receptor 3 P22607 FGFR3 Fibroblast growth factor receptor 4 P22455 FGFR4 FL cytokine receptor P36888 FLT3 Focal adhesion kinase 1 Q05397 PTK2 Folylpolyglutamate synthase, mitochondrial Q05932 FPGS G protein-coupled receptor kinase 7 Q8WTQ7 GRK7 Galactokinase P51570 GALK1 Galactosyl transferase-associated protein Q29SN7 GTAP Glucokinase P35557 GCK Glutamate--cysteine ligase catalytic subunit P48506 GCLC Glutamine synthetase P15104 GLUL Glutamine--tRNA ligase P47897 QARS Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Q9H0R6 QRSL1 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial O75879 PET112 Glutathione synthetase P48637 GSS Glycerate kinase Q8IVS8 GLYCTK Glycerol kinase P32189 GK Glycerol kinase 2 Q14410 GK2 Glycine--tRNA ligase P41250 GARS Glycogen synthase kinase-3 alpha P49840 GSK3A Glycogen synthase kinase-3 beta P49841 GSK3B Guanylate kinase Q16774 GUK1 HCG1641087 A0ZT99 TSSK2 Heat shock 70 kDa protein 1A/1B P08107 HSPA1A Hexokinase-1 P19367 HK1 Hexokinase-2 P52789 HK2 Hexokinase-3 P52790 HK3 Histidine--tRNA ligase, cytoplasmic P12081 HARS HNP95 Q96T88 hNp95 Homeodomain-interacting protein kinase 1 Q86Z02 HIPK1 Homeodomain-interacting protein kinase 2 Q9H2X6 HIPK2 Homeodomain-interacting protein kinase 3 Q9H422 HIPK3 Hormonally up-regulated neu tumor-associated kinase P57058 HUNK Inhibitor of nuclear factor kappa-B kinase subunit alpha O15111 CHUK Inhibitor of nuclear factor kappa-B kinase subunit beta O14920 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit epsilon Q14164 IKBKE Inositol hexakisphosphate kinase 3 Q5TAQ4 IHPK3 Inositol polyphosphate multikinase Q8NFU5 IPMK Inositol-pentakisphosphate 2-kinase Q9H8X2 IPPK Inositol-trisphosphate 3-kinase A P23677 ITPKA Insulin receptor P06213 INSR Insulin receptor-related protein P14616 INSRR Insulin-like growth factor 1 receptor P08069 IGF1R Integrin-linked protein kinase Q13418 ILK Interleukin-1 receptor associated kinase-4 Q69FE3 IRAK4 Interleukin-1 receptor-associated kinase-like 2 O43187 IRAK2 Isoleucine--tRNA ligase, cytoplasmic P41252 IARS Isoleucine--tRNA ligase, mitochondrial Q9NSE4 IARS2 Katanin p60 ATPase-containing subunit A1 O75449 KATNA1 Ketohexokinase P50053 KHK L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Q9NRN7 AASDHPPT L-fucose kinase Q8N0W3 FUK Leucine--tRNA ligase, cytoplasmic Q9P2J5 LARS Leucine-rich repeat serine/threonine-protein kinase 2 Q5S007 LRRK2 LIM domain kinase 2 P53671 LIMK2 Long-chain-fatty-acid--CoA ligase ACSBG1 Q96GR2 ACSBG1 Long-chain-fatty-acid--CoA ligase ACSBG2 Q5FVE4 ACSBG2 Lymphokine-activated killer T-cell-originated protein kinase Q96KB5 PBK LYN protein Q6NUK7 LYN Lysine--tRNA ligase Q15046 KARS Macrophage colony-stimulating factor 1 receptor P07333 CSF1R Macrophage-stimulating protein receptor Q04912 MST1R MAP kinase-activated protein kinase 2 P49137 MAPKAPK2 MAP kinase-activated protein kinase 3 Q16644 MAPKAPK3 MAP/microtubule affinity-regulating kinase 3 P27448 MARK3 MAP/microtubule affinity-regulating kinase 4 Q96L34 MARK4 MAPK/MAK/MRK overlapping kinase Q9UQ07 RAGE Mast/stem cell growth factor receptor P10721 KIT Maternal embryonic leucine zipper kinase Q14680 MELK Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a) O60337 MARCH6 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Q99640 PKMYT1 Met proto-oncogene (Hepatocyte growth factor receptor) P08581 MET Methionine--tRNA ligase, cytoplasmic P56192 MARS Methionine--tRNA ligase, mitochondrial Q96GW9 MARS2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Q9HCC0 MCCC2 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial Q96RQ3 MCCC1 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Q7Z650 MTHFD2 Mevalonate kinase Q03426 MVK Microtubule-associated serine/threonine-protein kinase-like Q96GX5 MASTL Midline-1 O15344 MID1 Mitogen-activated protein kinase 15 Q8TD08 MAPK15 Mitogen-activated protein kinase 4 A1A4C4 MAPK4 Mitogen-activated protein kinase kinase 1 A4QPA9 MAP2K1 Mitogen-activated protein kinase kinase kinase 14 Q99558 MAP3K14 Mitotic checkpoint serine/threonine-protein kinase BUB1 O43683 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta O60566 BUB1B Mixed lineage kinase domain-like protein Q8NB16 MLKL Monofunctional C1-tetrahydrofolate synthase, mitochondrial Q6UB35 MTHFD1L Multifunctional protein ADE2 P22234 PAICS Multiple substrate lipid kinase, isoform CRA_a A4D1U5 FLJ10842 Muscle, skeletal receptor tyrosine-protein kinase O15146 MUSK Myosin light chain kinase 2, skeletal/cardiac muscle Q9H1R3 MYLK2 Myosin light chain kinase family member 4 Q86YV6 MYLK4 Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a) Q8WY64 MYLIP Myosin-IIIa Q8NEV4 MYO3A Myosin-IIIb Q8WXR4 MYO3B N-acetyl-D-glucosamine kinase Q9UJ70 NAGK N-acetylgalactosamine kinase Q01415 GALK2 N-acylglucosamine 2-epimerase P51606 RENBP NEDD4-like E3 ubiquitin-protein ligase WWP2 O00308 WWP2 NEDD8-conjugating enzyme Ubc12 P61081 UBE2M NEDD8-conjugating enzyme UBE2F Q969M7 UBE2F Neurotrophic tyrosine kinase, receptor, type 3 Q96CY4 NTRK3 Non-receptor tyrosine-protein kinase TNK1 Q13470 TNK1 Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2 Pantothenate kinase 1 Q8TE04 PANK1 Pantothenate kinase 3 Q9H999 PANK3 Pantothenate kinase 4 Q9NVE7 PANK4 PASK protein Q96RG2 PASK PFTAIRE protein kinase 1 (PFTAIRE protein kinase 1, isoform CRA_c) (cDNA FLJ75582, highly similar to Homo sapiens PFTAIRE protein kinase 1 (PFTK1), mRNA) O94921 PFTK1 Phenylalanine--tRNA ligase alpha subunit Q9Y285 FARSA Phenylalanine--tRNA ligase beta subunit Q9NSD9 FARSB Phenylalanine--tRNA ligase, mitochondrial O95363 FARS2 Phosphatidylinositol 4-kinase alpha P42356 PI4KA Phosphatidylinositol 4-kinase, catalytic, beta polypeptide Q9UBF8 PIK4CB Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma O75747 PIK3C2G Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma O60331 PIP5K1C Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform P42336 PIK3CA Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform P42338 PIK3CB Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform O00329 PIK3CD Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PIK3CG Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha P48426 PIP4K2A Phosphatidylinositol-5-phosphate 4-kinase type-2 beta P78356 PIP4K2B Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Q8TBX8 PIP4K2C Phosphoglycerate kinase 1 P00558 PGK1 Phosphoglycerate kinase 2 P07205 PGK2 Phosphoinositide-3-kinase, class 2, beta polypeptide A2RUF7 PIK3C2B Phosphomevalonate kinase Q15126 PMVK Phosphopantothenate--cysteine ligase Q9HAB8 PPCS Phosphoribosylformylglycinamidine synthase O15067 PFAS Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform Q16816 PHKG1 Phosphorylase b kinase gamma catalytic chain, testis/liver isoform P15735 PHKG2 POLR1C protein Q96HT3 POLR1C Poly(A) polymerase alpha P51003 PAPOLA Poly(A) polymerase beta (Testis specific) A4D1Z6 PAPOLB Poly(A) polymerase gamma Q9BWT3 PAPOLG Potassium-transporting ATPase alpha chain 1 P20648 ATP4A Potassium-transporting ATPase alpha chain 2 P54707 ATP12A Potassium-transporting ATPase subunit beta P51164 ATP4B Praja 1 A2A322 PJA1 Pre-mRNA-processing factor 19 Q9UMS4 PRPF19 Probable arginine--tRNA ligase, mitochondrial Q5T160 RARS2 Probable asparagine--tRNA ligase, mitochondrial Q96I59 NARS2 Probable E3 ubiquitin-protein ligase MARCH10 Q8NA82 MARCH10 Probable E3 ubiquitin-protein ligase MYCBP2 O75592 MYCBP2 Probable E3 ubiquitin-protein ligase TRIP12 Q14669 TRIP12 Probable gluconokinase Q5T6J7 IDNK Probable glutamate--tRNA ligase, mitochondrial Q5JPH6 EARS2 Probable histidine--tRNA ligase, mitochondrial P49590 HARS2 Probable leucine--tRNA ligase, mitochondrial Q15031 LARS2 Probable phospholipid-transporting ATPase IIB O43861 ATP9B Probable proline--tRNA ligase, mitochondrial Q7L3T8 PARS2 Probable threonine--tRNA ligase 2, cytoplasmic A2RTX5 TARSL2 Propionyl-CoA carboxylase alpha chain, mitochondrial P05165 PCCA Propionyl-CoA carboxylase beta chain, mitochondrial P05166 PCCB Protein kinase Q9H4D1 dik Protein kinase, cAMP-dependent, catalytic, beta, isoform CRA_a B2RB89 PRKACB Protein-tyrosine kinase 6 Q13882 PTK6 Proto-oncogene serine/threonine-protein kinase mos P00540 MOS Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET Proto-oncogene tyrosine-protein kinase ROS P08922 ROS1 Proto-oncogene tyrosine-protein kinase Src P12931 SRC Proto-oncogene tyrosine-protein kinase Yes P07947 YES1 Putative glycerol kinase 3 Q14409 GK3P Putative glycerol kinase 5 Q6ZS86 GK5 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 O60231 DHX16 Putative ubiquitin-conjugating enzyme E2 N-like Q5JXB2 UBE2NL Putative uncharacterized protein ATP6V1E1 P36543 ATP6V1E1 Putative uncharacterized protein BMP2K Q4W5H2 BMP2K Putative uncharacterized protein DKFZp547K1617 (Casein kinase 1, gamma 1) (HCG2004507, isoform CRA_a) Q9HCP0 DKFZp547K1617 Putative uncharacterized protein DKFZp686I0955 Q5HYC3 DKFZp686I0955 Putative uncharacterized protein IP6K1 Q92551 IP6K1 Putative uncharacterized protein RPS6KA1 A6NND1 RPS6KA1 Putative uncharacterized protein VRK3 Q8IV63 VRK3 Putative uncharacterized protein WNK2 A8MQ23 WNK2 Pyruvate dehydrogenase kinase, isoenzyme 4 A4D1H4 PDK4 RAC-beta serine/threonine-protein kinase P31751 AKT2 RAC-gamma serine/threonine-protein kinase Q9Y243 AKT3 Receptor tyrosine-protein kinase erbB-2 P04626 ERBB2 Receptor tyrosine-protein kinase erbB-3 P21860 ERBB3 Receptor tyrosine-protein kinase erbB-4 Q15303 ERBB4 Receptor-interacting serine/threonine-protein kinase 1 Q13546 RIPK1 Receptor-interacting serine/threonine-protein kinase 2 O43353 RIPK2 Receptor-interacting serine/threonine-protein kinase 3 Q9Y572 RIPK3 RFWD2 protein Q05CT6 RFWD2 Rhodopsin kinase Q15835 GRK1 Ribokinase Q9H477 RBKS Ribonucleoside-diphosphate reductase large subunit P23921 RRM1 Ribosomal protein S6 kinase beta-1 P23443 RPS6KB1 Ribosomal protein S6 kinase beta-2 Q9UBS0 RPS6KB2 Ring finger protein 20 Q5VTR2 RNF20 RNA 3'-terminal phosphate cyclase O00442 RTCA ROR1 protein Q01973 ROR1 RuvB-like 2 Q9Y230 RUVBL2 Sedoheptulokinase Q9UHJ6 SHPK Selenide, water dikinase 1 P49903 SEPHS1 Selenide, water dikinase 2 Q99611 SEPHS2 Serine--tRNA ligase, cytoplasmic P49591 SARS Serine--tRNA ligase, mitochondrial Q9NP81 SARS2 Serine-protein kinase ATM Q13315 ATM Serine/threonine kinase 24 (STE20 homolog, yeast) Q5U0E6 STK24 Serine/threonine-protein kinase 10 O94804 STK10 Serine/threonine-protein kinase 16 O75716 STK16 Serine/threonine-protein kinase 17A Q9UEE5 STK17A Serine/threonine-protein kinase 17B O94768 STK17B Serine/threonine-protein kinase 35 Q8TDR2 STK35 Serine/threonine-protein kinase 6 O14965 AURKA Serine/threonine-protein kinase Chk1 O14757 CHEK1 Serine/threonine-protein kinase DCLK2 Q8N568 DCLK2 Serine/threonine-protein kinase H1 P11801 PSKH1 Serine/threonine-protein kinase H2 Q96QS6 PSKH2 Serine/threonine-protein kinase LMTK2 Q8IWU2 LMTK2 Serine/threonine-protein kinase MAK P20794 MAK Serine/threonine-protein kinase N1 Q16512 PKN1 Serine/threonine-protein kinase N2 Q16513 PKN2 Serine/threonine-protein kinase N3 Q6P5Z2 PKN3 Serine/threonine-protein kinase pim-2 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-3 Q86V86 PIM3 Serine/threonine-protein kinase PLK1 P53350 PLK1 Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2 Serine/threonine-protein kinase PLK4 O00444 PLK4 Serine/threonine-protein kinase PRP4 homolog Q13523 PRPF4B Serine/threonine-protein kinase RIO1 Q9BRS2 RIOK1 Serine/threonine-protein kinase RIO2 Q9BVS4 RIOK2 Serine/threonine-protein kinase SBK1 Q52WX2 SBK1 Serine/threonine-protein kinase Sgk2 Q9HBY8 SGK2 Serine/threonine-protein kinase TAO3 Q9H2K8 TAOK3 Serine/threonine-protein kinase ULK1 O75385 ULK1 Serine/threonine-protein kinase ULK2 Q8IYT8 ULK2 Serine/threonine-protein kinase ULK3 Q6PHR2 ULK3 Serine/threonine-protein kinase VRK1 Q99986 VRK1 Serine/threonine-protein kinase VRK2 Q86Y07 VRK2 Serum paraoxonase/lactonase 3 Q15166 PON3 SFRS protein kinase 3 Q9UPE1 SRPK3 Sodium/potassium-transporting ATPase subunit beta-2 P14415 ATP1B2 Sodium/potassium-transporting ATPase subunit beta-3 P54709 ATP1B3 Sphingosine kinase 1 Q96GK1 SPHK1 Spliceosome RNA helicase DDX39B Q13838 DDX39B STE20-like serine/threonine-protein kinase Q9H2G2 SLK STE20/SPS1-related proline-alanine-rich protein kinase Q9UEW8 STK39 STIP1 homology and U-box containing protein 1 (STIP1 homology and U- box containing protein 1, isoform CRA_c) Q9UNE7 STUB1 SUMO-activating enzyme subunit 1 Q9UBE0 SAE1 SUMO-activating enzyme subunit 2 Q9UBT2 UBA2 SUMO-conjugating enzyme UBC9 P63279 UBE2I T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3, isoform CRA_c) Q13488 TCIRG1 TAO kinase 1 (TAO kinase 1, isoform CRA_a) Q7L7X3 TAOK1 TAOK2 protein A0PJ48 TAOK2 Tau-tubulin kinase 2 Q6IQ55 TTBK2 Testis-specific serine kinase 1 A0ZT98 TSSK1 Thiamin pyrophosphokinase 1 Q9H3S4 TPK1 Threonine--tRNA ligase, cytoplasmic P26639 TARS Threonine--tRNA ligase, mitochondrial Q9BW92 TARS2 Thymidine kinase 2, mitochondrial O00142 TK2 Thymidine kinase, cytosolic P04183 TK1 Thymidylate kinase P23919 DTYMK TP53-regulating kinase Q96S44 TP53RK TRAF2 and NCK interacting kinase (TRAF2 and NCK interacting kinase, isoform CRA_g) Q9UKE5 TNIK Trifunctional purine biosynthetic protein adenosine-3 P22102 GART Tripartite motif-containing protein 5 Q9C035 TRIM5 Tryptophan--tRNA ligase, cytoplasmic P23381 WARS Tryptophan--tRNA ligase, mitochondrial Q9UGM6 WARS2 Tyrosine--tRNA ligase, cytoplasmic P54577 YARS Tyrosine--tRNA ligase, mitochondrial Q9Y2Z4 YARS2 Tyrosine-protein kinase Blk P51451 BLK Tyrosine-protein kinase Fer P16591 FER Tyrosine-protein kinase Fes/Fps P07332 FES Tyrosine-protein kinase Fgr P09769 FGR Tyrosine-protein kinase FRK P42685 FRK Tyrosine-protein kinase HCK P08631 HCK Tyrosine-protein kinase JAK1 P23458 JAK1 Tyrosine-protein kinase JAK2 O60674 JAK2 Tyrosine-protein kinase JAK3 P52333 JAK3 Tyrosine-protein kinase Lck P06239 LCK Tyrosine-protein kinase Mer Q12866 MERTK Tyrosine-protein kinase receptor Tie-1 P35590 TIE1 Tyrosine-protein kinase receptor TYRO3 Q06418 TYRO3 Tyrosine-protein kinase RYK P34925 RYK Tyrosine-protein kinase Srms Q9H3Y6 SRMS Tyrosine-protein kinase STYK1 Q6J9G0 STYK1 Tyrosine-protein kinase transmembrane receptor ROR2 Q01974 ROR2 Tyrosine-protein kinase TXK P42681 TXK Tyrosine-protein kinase ZAP-70 P43403 ZAP70 Tyrosine-protein kinase-like 7 Q13308 PTK7 U4/U6 small nuclear ribonucleoprotein Prp4 O43172 PRPF4 Ubiquitin carrier protein A4D1L5 UBE2H Ubiquitin conjugation factor E4 A Q14139 UBE4A Ubiquitin conjugation factor E4 B O95155 UBE4B Ubiquitin-conjugating enzyme E2 A P49459 UBE2A Ubiquitin-conjugating enzyme E2 B P63146 UBE2B Ubiquitin-conjugating enzyme E2 C O00762 UBE2C Ubiquitin-conjugating enzyme E2 D2 P62837 UBE2D2 Ubiquitin-conjugating enzyme E2 D3 P61077 UBE2D3 Ubiquitin-conjugating enzyme E2 D4 Q9Y2X8 UBE2D4 Ubiquitin-conjugating enzyme E2 E1 P51965 UBE2E1 Ubiquitin-conjugating enzyme E2 E2 Q96LR5 UBE2E2 Ubiquitin-conjugating enzyme E2 G1 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 J1 Q9Y385 UBE2J1 Ubiquitin-conjugating enzyme E2 J2 Q8N2K1 UBE2J2 Ubiquitin-conjugating enzyme E2 L3 P68036 UBE2L3 Ubiquitin-conjugating enzyme E2 N P61088 UBE2N Ubiquitin-conjugating enzyme E2 O Q9C0C9 UBE2O Ubiquitin-conjugating enzyme E2 Q2 Q8WVN8 UBE2Q2 Ubiquitin-conjugating enzyme E2 R2 Q712K3 UBE2R2 Ubiquitin-conjugating enzyme E2 S Q16763 UBE2S Ubiquitin-conjugating enzyme E2 U Q5VVX9 UBE2U Ubiquitin-conjugating enzyme E2 W Q96B02 UBE2W Ubiquitin-conjugating enzyme E2 Z Q9H832 UBE2Z Ubiquitin-like modifier-activating enzyme 1 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 6 A0AVT1 UBA6 Ubiquitin-like modifier-activating enzyme 7 P41226 UBA7 Ubiquitin-protein ligase E3A Q05086 UBE3A Ubiquitin-protein ligase E3B Q7Z3V4 UBE3B Ubiquitin-protein ligase E3C Q15386 UBE3C Ubiquitin/ISG15-conjugating enzyme E2 L6 O14933 UBE2L6 UMP-CMP kinase 2, mitochondrial Q5EBM0 CMPK2 Uridine-cytidine kinase-like 1 Q9NWZ5 UCKL1 V-akt murine thymoma viral oncogene homolog 1 B0LPE5 AKT1 V-ATPase subunit E 2 Q96A05 ATP6V1E2 V-type proton ATPase 116 kDa subunit a isoform 2 Q9Y487 ATP6V0A2 V-type proton ATPase 16 kDa proteolipid subunit P27449 ATP6V0C V-type proton ATPase catalytic subunit A P38606 ATP6V1A V-type proton ATPase subunit B, brain isoform P21281 ATP6V1B2 V-type proton ATPase subunit C 1 P21283 ATP6V1C1 V-type proton ATPase subunit C 2 Q8NEY4 ATP6V1C2 V-type proton ATPase subunit D Q9Y5K8 ATP6V1D V-type proton ATPase subunit d 1 P61421 ATP6V0D1 V-type proton ATPase subunit d 2 Q8N8Y2 ATP6V0D2 V-type proton ATPase subunit e 1 O15342 ATP6V0E1 V-type proton ATPase subunit e 2 Q8NHE4 ATP6V0E2 V-type proton ATPase subunit G 1 O75348 ATP6V1G1 V-type proton ATPase subunit G 2 O95670 ATP6V1G2 V-type proton ATPase subunit G 3 Q96LB4 ATP6V1G3 V-type proton ATPase subunit H Q9UI12 ATP6V1H Valine--tRNA ligase P26640 VARS Valine--tRNA ligase, mitochondrial Q5ST30 VARS2 Vascular endothelial growth factor receptor 1 P17948 FLT1 Vascular endothelial growth factor receptor 2 P35968 KDR Vascular endothelial growth factor receptor 3 P35916 FLT4 Very long-chain acyl-CoA synthetase O14975 SLC27A2 WNK lysine deficient protein kinase 4 B0LPI0 WNK4 Xylulose kinase O75191 XYLB Zinc ribbon domain containing 1 Q2L6J2 ZNRD1