1.0 2011-09-21 00:04:36 UTC 2015-10-09 22:29:17 UTC FDB021888 Cortisol Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.; As an oral or injectable drug, cortisol is also known as hydrocortisone. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis.; Cortisol or Hydrocortisone is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress. It increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Its synthetic counterpart (hydrocortisone) is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortisol is synthesized from pregnenolone. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning, and lower levels in the evening, several hours after the onset of sleep.; Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation. [HMDB] 11-beta-Hydrocortisone 11-beta-Hydroxycortisone 11-Hydrocortisone 11a-Hydroxycorticosterone 11alpha-Hydroxycorticosterone 11b-Hydrocortisone 11b-Hydroxycortisone 11b,17,21-Trihydroxyprogesterone 11beta-Hydrocortisone 11beta-Hydroxycortisone 11beta,17,21-Trihydroxyprogesterone 17-Hydroxycorticosterone 17a-Hydroxycorticosterone 17alpha-Hydroxycorticosterone 4-Pregnene-11alpha,21-triol 3,20-dione 4-Pregnene-11b,17a,21-triol-3,20-dione Acticort Aeroseb HC Aeroseb-HC Ala-Cort Ala-Scalp Alacort Algicirtis alphaderm Amberin Anflam Anti-inflammatory hormone Aquacort Aquanil HC Barseb HC Basan-Corti CaldeCORT Spray Cetacort Chronocort Clear aid Cleiton Cobadex Compound F Cor-Tar-Quin Cort-Dome Cort-Quin Cortanal Cortenema Cortesal Corticreme Cortifan Cortifoam Cortiment Cortisol alcohol Cortisolonum Cortisporin Cortisporin Otico Cortispray Cortizol Cortolotion Cortonema Cortoxide Cremesone Cremicort-H Cutisol Delacort Derm-Aid Dermil Dermolate Dihydrocostisone Dioderm Dome-cort Domolene-HC Drotic Ef corlin Efcorbin Efcortelan Efcortelin Eldercort Epicort Epiderm H Esiderm H Evacort Ficortril Fiocortril Foille Insetti Genacort Gyno-Cortisone H-Cort HC Heb Cort Heb-Cort Hidalone Hidro-Colisona Hidrocortisona Hycort Hycortol Hycortole Hydracort Hydrasson Hydro-Adreson Hydro-colisona Hydrocort Hydrocortal Hydrocorticosterone Hydrocortisone Hydrocortisone alcohol Hydrocortisone base Hydrocortisone free alcohol Hydrocortisonum Hydrocortistab Hydrocortisyl Hydrocortone Hydroskin Hydroxycortisone Hysone Hytisone Hytone Hytone lotion Idrocortisone Incortin-H Incortin-hydrogen Kendall's compound F Komed HC Kyypakkaus Lacticare HC Lacticare-HC Lactisona Lubricort Maintasone Medicort Meusicort Mildison Milliderm Neo-Cort-Dome Neosporin-H Ear Nutracort Nystaform-HC Optef Otalgine Otic-Neo-Cort-Dome Otobiotic Otocort Otosone-F Pediotic Suspension Penecort Permicort Polcort H Preparation H Hydrocortisone Cream Prepcort Prestwick_265 Prevex HC Proctocort Proctofoam Protocort Racet Rectoid Reichstein's substance M Remederm HC Sanatison Scalpicin Capilar Schericur Scheroson F Sigmacort Signef Stiefcorcil Synacort Systral Hydrocort Tarcortin Timocort Topicort Transderma H Traumaide Uniderm Vioform-Hydrocortisone VoSol HC Vytone Zenoxone C21H30O5 362.4599 362.20932407 (1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one (1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one 50-23-7 [H][C@@]12CC[C@@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21+/m0/s1 JYGXADMDTFJGBT-CZFMHFDVSA-N belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. 21-hydroxysteroids Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids Aliphatic homopolycyclic compounds 11-beta-hydroxysteroids 17-hydroxysteroids 20-oxosteroids 3-oxo delta-4-steroids Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclohexenones Delta-4-steroids Gluco/mineralocorticoids, progestogins and derivatives Hydrocarbon derivatives Organic oxides Primary alcohols Secondary alcohols Tertiary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 17-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-4-steroid 3-oxosteroid Alcohol Aliphatic homopolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Tertiary alcohol Solid logp 1.79 ALOGPS logs -3.26 ALOGPS solubility 1.99e-01 g/l ALOGPS logp 1.28 ChemAxon pka_strongest_acidic 12.58 ChemAxon pka_strongest_basic -2.8 ChemAxon iupac (1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one ChemAxon average_mass 362.4599 ChemAxon mono_mass 362.20932407 ChemAxon smiles [H][C@@]12CC[C@@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C ChemAxon formula C21H30O5 ChemAxon inchi InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21+/m0/s1 ChemAxon inchikey JYGXADMDTFJGBT-CZFMHFDVSA-N ChemAxon polar_surface_area 94.83 ChemAxon refractivity 97.4 ChemAxon polarizability 39.63 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Steroidogenesis SMP00130 map00140 Specdb::MsMs 291532 Specdb::MsMs 291533 Specdb::MsMs 291534 Specdb::MsMs 331471 Specdb::MsMs 331472 Specdb::MsMs 331473 Specdb::CMs 11575 Specdb::CMs 37275 HMDB00063 #<Reference:0x000055ce31d7ece0> #<Reference:0x000055ce31d7eb28> #<Reference:0x000055ce31d7e970> #<Reference:0x000055ce31d7e7b8> #<Reference:0x000055ce31d7e600> #<Reference:0x000055ce31d7e448> #<Reference:0x000055ce31d7e290> #<Reference:0x000055ce31d7e0d8> #<Reference:0x000055ce31d7df20> #<Reference:0x000055ce31d7dd68> #<Reference:0x000055ce31d7dbb0> #<Reference:0x000055ce31d7d9f8> #<Reference:0x000055ce31d7d840> #<Reference:0x000055ce31d7d688> #<Reference:0x000055ce31d7d4d0> #<Reference:0x000055ce31d7d318> #<Reference:0x000055ce31d7d160> #<Reference:0x000055ce31d7cfa8> #<Reference:0x000055ce31d7cdf0> #<Reference:0x000055ce31d7cc38> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 bitter Corticosteroid 11-beta-dehydrogenase isozyme 1 P28845 HSD11B1 Cytochrome P450 21-hydroxylase Q16874 P450-CYP21B Cytochrome P450, family 21, subfamily A, polypeptide 2 Q08AG9 CYP21A2