1.02011-09-21 00:04:53 UTC2015-10-09 22:29:13 UTCFDB021902Inosine triphosphateInosine triphosphate (ITP) is an intermediate in the purine metabolism pathway. Relatively high levels of ITP in red cells are found in individuals as result of deficiency of inosine triphosphatase (EC 3.1.3.56, ITPase) ITPase is a cytosolic nucleoside triphosphate pyrophosphohydrolase specific for ITP catalysis to inosine monophosphate (IMP) and deoxy-inosine triphosphate (dITP) to deoxy-inosine monophosphate. ITPase deficiency is not associated with any defined pathology other than the characteristic and abnormal accumulation of ITP in red blood cells. Nevertheless, ITPase deficiency may have pharmacogenomic implications, and the abnormal metabolism of 6-mercaptopurine in ITPase-deficient patients may lead to thiopurine drug toxicity. ITPase's function is not clearly understood but possible roles for ITPase could be to prevent the accumulation of rogue nucleotides which would be otherwise incorporated into DNA and RNA, or compete with nucleotides such as GTP in signalling processes. (PMID : 170291, 1204209, 17113761, 17924837) [HMDB]2'-Inosine-5'-triate2'-Inosine-5'-triic acid2'-inosine-5'-triphosphate5-ITP5'-ITPInosine 5Inosine 5-triphopshateInosine 5'-(tetrahydrogen triate)inosine 5'-(tetrahydrogen triphosphate)Inosine 5'-triateInosine 5'-triic acidInosine 5'-triphosphateInosine 5(tetrahydrogen triate)Inosine 5(tetrahydrogen triphosphate)Inosine triateInosine triic acidInosine triphosphateInosine triphosphic acidInosine tripolyateInosine tripolyic acidInosine tripolyphosphateITPITTO(5')-(Tetrahydroxytrioryl)inosineC10H15N4O14P3508.1658507.979760744({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxypurin-9-yl)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid132-06-9O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CN=C2OInChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1HAEJPQIATWHALX-KQYNXXCUSA-N belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety.Purine ribonucleoside triphosphatesOrganic compoundsNucleosides, nucleotides, and analoguesPurine nucleotidesPurine ribonucleotidesAromatic heteropolycyclic compounds1,2-diols6-oxopurinesAzacyclic compoundsGlycosylaminesHeteroaromatic compoundsHydrocarbon derivativesHypoxanthinesMonoalkyl phosphatesMonosaccharide phosphatesN-substituted imidazolesOrganic oxidesOrganonitrogen compoundsOrganopnictogen compoundsOxacyclic compoundsPentose phosphatesPurine ribonucleoside monophosphatesPyrimidonesSecondary alcoholsTetrahydrofuransVinylogous amides1,2-diol6-oxopurineAlcoholAlkyl phosphateAromatic heteropolycyclic compoundAzacycleAzoleGlycosyl compoundHeteroaromatic compoundHydrocarbon derivativeHypoxanthineImidazoleImidazopyrimidineMonoalkyl phosphateMonosaccharideMonosaccharide phosphateN-glycosyl compoundN-substituted imidazoleOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganic phosphoric acid derivativeOrganoheterocyclic compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundOxacyclePentose phosphatePentose-5-phosphatePhosphoric acid esterPurinePurine ribonucleoside monophosphatePurine ribonucleoside triphosphatePyrimidinePyrimidoneSecondary alcoholTetrahydrofuranVinylogous amideinosine phosphatepurine ribonucleoside 5'-triphosphateSolidlogp-0.67logs-2.03solubility4.78e+00 g/llogp-2.7pka_strongest_acidic0.91pka_strongest_basic-0.5iupac({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidaverage_mass508.1658mono_mass507.979760744smilesO[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CN=C2OformulaC10H15N4O14P3inchiInChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1inchikeyHAEJPQIATWHALX-KQYNXXCUSA-Npolar_surface_area273.34refractivity93.09polarizability38.09rotatable_bond_count8acceptor_count14donor_count7physiological_charge-3formal_charge0Purine MetabolismSMP00050map00230Specdb::NmrTwoD988Specdb::NmrTwoD1194Specdb::NmrOneD1160Specdb::NmrOneD4912Specdb::NmrOneD4913Specdb::CMs15817Specdb::CMs37345Specdb::CMs1053663Specdb::CMs1053664Specdb::CMs1053665Specdb::CMs1053666Specdb::CMs1053668Specdb::CMs1053670Specdb::CMs1053672Specdb::CMs1053674Specdb::CMs1053676Specdb::CMs1053678Specdb::CMs1053680Specdb::CMs1053682Specdb::CMs1053684Specdb::CMs1053686Specdb::CMs1053688Specdb::CMs1053690Specdb::CMs1053692Specdb::CMs1053694Specdb::CMs1053696Specdb::CMs1053698Specdb::CMs1053700Specdb::CMs1053701Specdb::CMs1053703Specdb::MsMs298Specdb::MsMs299Specdb::MsMs300Specdb::MsMs180135Specdb::MsMs180136Specdb::MsMs180137Specdb::MsMs182469Specdb::MsMs182470Specdb::MsMs182471Specdb::MsMs2228080Specdb::MsMs2231456Specdb::MsMs2232759Specdb::MsMs2233859Specdb::MsMs2234461Specdb::MsMs2234478Specdb::MsMs2235071Specdb::MsMs2253195Specdb::MsMs2253285Specdb::MsMs2255260Specdb::MsMs2255291Specdb::MsMs2257225Specdb::MsMs2257369Specdb::MsMs2259175Specdb::MsMs2259375Specdb::MsMs2824546HMDB0018916039ITT#<Reference:0x00005556748139e8>#<Reference:0x00005556748137e0>#<Reference:0x00005556748134e8>#<Reference:0x0000555674813308>#<Reference:0x0000555674812a70>#<Reference:0x0000555674812890>#<Reference:0x0000555674812638>#<Reference:0x0000555674812200>#<Reference:0x0000555674811fd0>#<Reference:0x0000555674811da0>#<Reference:0x00005556748119b8>#<Reference:0x0000555674811800>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823GlucokinaseP35557GCKHexokinase-2P52789HK2Hexokinase-3P52790HK3Uridine-cytidine kinase-like 1Q9NWZ5UCKL1