Showing Compound Phosphoribosyl pyrophosphate (FDB021928)

Record Information

Version

1.0

Creation date

2011-09-21 00:05:22 UTC

Update date

2025-11-19 02:40:25 UTC

Primary ID

FDB021928

Secondary Accession Numbers

Not Available

Chemical Information

FooDB Name

Phosphoribosyl pyrophosphate

Description

Phosphoribosyl pyrophosphate, also known as PRPP or prib-PP, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. Phosphoribosyl pyrophosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Phosphoribosyl pyrophosphate exists in all living species, ranging from bacteria to humans. Within humans, phosphoribosyl pyrophosphate participates in a number of enzymatic reactions. In particular, guanine and phosphoribosyl pyrophosphate can be biosynthesized from guanosine monophosphate; which is catalyzed by the enzyme adenine phosphoribosyltransferase. In addition, guanine and phosphoribosyl pyrophosphate can be biosynthesized from guanosine monophosphate through its interaction with the enzyme hypoxanthine-guanine phosphoribosyltransferase. In humans, phosphoribosyl pyrophosphate is involved in the metabolic disorder called the gout or kelley-seegmiller syndrome pathway. A derivative of alpha-D-ribose having a phosphate group at the 5-position and a diphosphate at the 1-position.

CAS Number

7540-64-9

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Synonym	Source
5-Phospho-alpha-D-ribose 1-diphosphate	ChEBI
5-Phosphoribosyl 1-pyrophosphate	ChEBI
5-Phosphoribosyl diphosphate	ChEBI
alpha-D-Ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)	ChEBI
ALPHA-PHOSPHORIBOSYLPYROphosphORIC ACID	ChEBI
Phosphoribosylpyrophosphate	ChEBI
PRib-PP	ChEBI
PRPP	ChEBI
5-Phospho-a-D-ribose 1-diphosphate	Generator
5-Phospho-a-D-ribose 1-diphosphoric acid	Generator
5-Phospho-alpha-D-ribose 1-diphosphoric acid	Generator
5-Phospho-α-D-ribose 1-diphosphate	Generator
5-Phospho-α-D-ribose 1-diphosphoric acid	Generator
5-Phosphoribosyl 1-pyrophosphoric acid	Generator
5-Phosphoribosyl diphosphoric acid	Generator
a-D-Ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)	Generator
a-D-Ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid)	Generator
alpha-D-Ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid)	Generator
Α-D-ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)	Generator
Α-D-ribofuranose 5-(dihydrogen phosphoric acid) 1-(trihydrogen diphosphoric acid)	Generator
a-PHOSPHORIBOSYLPYROphosphate	Generator
a-PHOSPHORIBOSYLPYROphosphoric acid	Generator
alpha-PHOSPHORIBOSYLPYROphosphate	Generator
Α-phosphoribosylpyrophosphate	Generator
Α-phosphoribosylpyrophosphoric acid	Generator
Phosphoribosylpyrophosphoric acid	Generator
Phosphoribosyl pyrophosphoric acid	Generator
5-Phospho-a-D-ribose-1-diphosphate	HMDB
5-Phospho-a-D-ribosyl pyrophosphate	HMDB
5-Phospho-alpha-D-ribose-1-diphosphate	HMDB
5-Phospho-alpha-D-ribosyl pyrophosphate	HMDB
5-Phosphoribose 1-pyrophosphate	HMDB
5-Phosphoribosyl 1-diphosphate	HMDB
5-Phosphoribosyl a-1-pyrophosphate	HMDB
5-Phosphoribosyl-1-pyrophosphate	HMDB
5-Phosphorylribose 1-a-diphosphate	HMDB
5-Phosphorylribose 1-alpha-diphosphate	HMDB
5-Phosphorylribose 1-pyrophosphate	HMDB
5-Phosphorylribosyl 1-pyrophosphate	HMDB
a-D-5-(Dihydrogen phosphate) 1-(trihydrogen pyrophosphate) ribofuranose	HMDB
a-D-5-Phosphoribosyl 1-pyrophosphate	HMDB
a-D-Ribofuranose 5-phosphate 1-pyrophosphate	HMDB
a-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)	HMDB
alpha-D-5-(Dihydrogen phosphate) 1-(trihydrogen pyrophosphate) ribofuranose	HMDB
alpha-D-5-Phosphoribosyl 1-pyrophosphate	HMDB
alpha-D-Ribofuranose 5-phosphate 1-pyrophosphate	HMDB
alpha-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)	HMDB
Phosphoribosyl-1-pyrophosphate	HMDB
Phosphoribosyl-pyrophosphate	HMDB
Phosphoribosylpyrophosphorate	HMDB
PP-Ribose-p	HMDB
Pyrophosphate, phosphoribosyl	HMDB
5-Phospho-α-D-ribose-1-diphosphate	HMDB
5-Phospho-α-D-ribosyl pyrophosphate	HMDB
5-Phosphoribosyl alpha-1-pyrophosphate	HMDB
5-Phosphoribosyl pyrophosphate	HMDB
5-Phosphoribosyl α-1-pyrophosphate	HMDB
5-Phosphorylribose 1-α-diphosphate	HMDB
Α-D-5-phosphoribosyl 1-pyrophosphate	HMDB
Phosphoribosyl pyrophosphate	HMDB
5-O-a-D-Ribose 1-diate	Generator
5-O-a-D-Ribose 1-diic acid	Generator
5-O-a-D-Ribose-1-diate	HMDB
5-O-a-D-Ribosyl pyroate	HMDB
5-O-alpha-D-Ribose 1-diate	ChEBI
5-O-alpha-D-Ribose 1-diic acid	Generator
5-O-alpha-D-Ribose-1-diate	HMDB
5-O-alpha-D-Ribosyl pyroate	HMDB
5-O-alpha-D-Riobse 1-diate	HMDB
5-O-alpha-delta-Ribose 1-diate	HMDB
5-O-alpha-delta-Ribose-1-diate	HMDB
5-O-alpha-delta-Ribosyl pyroate	HMDB
5-O-α-D-ribose 1-diate	Generator
5-O-α-D-ribose 1-diic acid	Generator
5-Oribose 1-pyroate	HMDB
5-Oribosyl 1-diate	HMDB
5-Oribosyl 1-pyroate	ChEBI
5-Oribosyl 1-pyroic acid	Generator
5-Oribosyl a-1-pyroate	HMDB
5-Oribosyl diate	ChEBI
5-Oribosyl diic acid	Generator
5-Oribosyl-1-pyroate	HMDB
5-Orylribose 1-a-diate	HMDB
5-Orylribose 1-alpha-diate	HMDB
5-Orylribose 1-pyroate	HMDB
5-Orylribosyl 1-pyroate	HMDB
5-phospho-alpha-D-riobse 1-diphosphate	hmdb
5-Phospho-alpha-delta-ribose 1-diphosphate	hmdb
5-Phospho-alpha-delta-ribose-1-diphosphate	hmdb
5-Phospho-alpha-delta-ribosyl pyrophosphate	hmdb
a-D-5-(Dihydrogen ate) 1-(trihydrogen pyroate) ribofuranose	HMDB
a-D-5-(dihydrogen phosphate) 1-(trihydrogen pyrophosphate) Ribofuranose	hmdb
a-D-5-Oribosyl 1-pyroate	HMDB
a-D-Ribofuranose 5-(dihydrogen ate) 1-(trihydrogen diate)	Generator
a-D-Ribofuranose 5-(dihydrogen ic acid) 1-(trihydrogen diic acid)	Generator
a-D-Ribofuranose 5-ate 1-pyroate	HMDB
a-D-Ribofuranose, 5-(dihydrogen ate) 1-(trihydrogen diate)	HMDB
a-ORIBOSYLPYROate	Generator
a-ORIBOSYLPYROic acid	Generator
alpha-D-5-(Dihydrogen ate) 1-(trihydrogen pyroate) ribofuranose	HMDB
alpha-D-5-(dihydrogen phosphate) 1-(trihydrogen pyrophosphate) Ribofuranose	hmdb
alpha-D-5-Oribosyl 1-pyroate	HMDB
alpha-D-Ribofuranose 5-(dihydrogen ate) 1-(trihydrogen diate)	ChEBI
alpha-D-Ribofuranose 5-(dihydrogen ic acid) 1-(trihydrogen diic acid)	Generator
alpha-D-Ribofuranose 5-ate 1-pyroate	HMDB
alpha-D-Ribofuranose, 5-(dihydrogen ate) 1-(trihydrogen diate)	HMDB
alpha-delta-5-(Dihydrogen ate) 1-(trihydrogen pyroate) ribofuranose	HMDB
alpha-delta-5-(dihydrogen phosphate) 1-(trihydrogen pyrophosphate) Ribofuranose	hmdb
alpha-delta-5-Oribosyl 1-pyroate	HMDB
alpha-delta-5-Phosphoribosyl 1-pyrophosphate	hmdb
alpha-delta-Ribofuranose 5-ate 1-pyroate	HMDB
alpha-delta-Ribofuranose 5-phosphate 1-pyrophosphate	hmdb
alpha-ORIBOSYLPYROate	Generator
alpha-ORIBOSYLPYROic acid	Generator
ALPHA-ORIBOSYLPYROORIC ACID	ChEBI
Oribosyl pyroate	ChEBI
Oribosyl pyroic acid	Generator
Oribosyl-1-pyroate	HMDB
Oribosyl-pyroate	HMDB
Oribosylpyroate	ChEBI
Oribosylpyroic acid	Generator
Oribosylpyroorate	HMDB
Oribosylpyrooric acid	HMDB
Phosphoribosyl pyrophosphic acid	hmdb
PP-Ribose-P	hmdb
α-D-ribofuranose 5-(dihydrogen ate) 1-(trihydrogen diate)	Generator
α-D-ribofuranose 5-(dihydrogen ic acid) 1-(trihydrogen diic acid)	Generator
α-oribosylpyroate	Generator
α-oribosylpyroic acid	Generator

Predicted Properties

Property	Value	Source
Water Solubility	11.6 g/L	ALOGPS
logP	-0.74	ALOGPS
logP	-3	ChemAxon
logS	-1.5	ALOGPS
pKa (Strongest Acidic)	1.09	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	-4	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	229.74 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	62.58 m³·mol⁻¹	ChemAxon
Polarizability	27.46 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Chemical Formula

C5H13O14P3

IUPAC name

[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid

InChI Identifier

InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1

InChI Key

PQGCEDQWHSBAJP-TXICZTDVSA-N

Isomeric SMILES

O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O

Average Molecular Weight

390.0696

Monoisotopic Molecular Weight

389.95181466

Classification

Description

Belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Pentose phosphates

Alternative Parents

Substituents

Pentose phosphate
Pentose-5-phosphate
Monosaccharide phosphate
Organic pyrophosphate
Monoalkyl phosphate
Organic phosphoric acid derivative
Phosphoric acid ester
Alkyl phosphate
Tetrahydrofuran
1,2-diol
Secondary alcohol
Organoheterocyclic compound
Oxacycle
Alcohol
Hydrocarbon derivative
Organic oxide
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

5-O-phosphono-D-ribofuranosyl diphosphate (CHEBI:17111 )

Ontology

Disposition

Source:

Endogenous

Biological location:

Cell and elements:

Cell:

Fibroblast

Subcellular:

Cytoplasm

Biofluid and excreta:

Blood

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physico-Chemical Properties

Physico-Chemical Properties - Experimental

Property	Value	Reference
Physical state	Solid
Physical Description	Not Available
Mass Composition	Not Available
Melting Point	Not Available
Boiling Point	Not Available
Experimental Water Solubility	Not Available
Experimental logP	Not Available
Experimental pKa	Not Available
Isoelectric point	Not Available
Charge	Not Available
Optical Rotation	Not Available
Spectroscopic UV Data	Not Available
Density	Not Available
Refractive Index	Not Available

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Phosphoribosyl pyrophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004j-7902000000-513a0a03122b76d768d9	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004i-6952010000-eac4b7259ac1081ff665	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_10, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_11, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TMS_2_12, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TBDMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Phosphoribosyl pyrophosphate, TBDMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Orbitrap 5V, negative	splash10-000i-0009000000-4d49c2b254fa550d7fc4	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 8V, negative	splash10-000i-0129000000-1d706d02a4abbeb42ed5	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 11V, negative	splash10-004u-0987000000-ea0ae1567abd90f10399	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 14V, negative	splash10-004l-0961000000-703b20987f54fa234a79	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 19V, negative	splash10-004i-1930000000-0b45299b5f0eae24d372	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 24V, negative	splash10-004i-2910000000-9ce95a1b1c6b6ca5768d	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 28V, negative	splash10-004i-6900000000-98e568c985ce119eab97	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 32V, negative	splash10-004i-9600000000-4d4d3c26cf4221488cb8	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 38V, negative	splash10-004i-9300000000-ae7ce84c85a837e48257	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 45V, negative	splash10-004i-9100000000-535b36bb64043a2b5e66	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 54V, negative	splash10-004i-9000000000-b83900fdd755592d555a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 27V, negative	splash10-0006-0190000000-535b5f43d315fbc182ad	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 27V, negative	splash10-004i-9000000000-46d4cee1b5ac630ba9b8	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 27V, negative	splash10-0a4i-0900000000-8f51c8c38a697fb3a6f0	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 27V, negative	splash10-006x-0930000000-6eebf2cc9471f692be90	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 27V, negative	splash10-01t9-7900000000-a94c6a883f36818a0855	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 27V, positive	splash10-00di-0089000000-73b944f3bcd8c2e5fa58	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 27V, positive	splash10-0udi-0079300000-a94093288821d386ab6a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 6V, positive	splash10-0a4i-0001900000-04d2c9666f93d8bb3ec0	2020-07-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-01tc-2934000000-e0fcfd13254fd3781439	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03dm-6593000000-b295e74d43b0dc625e47	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-01r2-7920000000-a021603f22f19c083511	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-000i-0509000000-54231bd8f000ab2dd4a0	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9301000000-447b996f7510c6ae354b	2015-09-15	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9000000000-54f70df2270a3e4f67d2	2015-09-15	View Spectrum

NMR

Not Available

External Links

ChemSpider ID

7062

ChEMBL ID

Not Available

KEGG Compound ID

C00119

Pubchem Compound ID

7339

Pubchem Substance ID

Not Available

ChEBI ID

17111

Phenol-Explorer ID

Not Available

DrugBank ID

DB01632

HMDB ID

HMDB00280

CRC / DFC (Dictionary of Food Compounds) ID

Not Available

EAFUS ID

Not Available

Dr. Duke ID

Not Available

BIGG ID

33926

KNApSAcK ID

C00007296

HET ID

PRP

Food Biomarker Ontology

Not Available

VMH ID

Not Available

Flavornet ID

Not Available

GoodScent ID

Not Available

SuperScent ID

Not Available

Wikipedia ID

Phosphoribosyl pyrophosphate

Phenol-Explorer Metabolite ID

Not Available

Duplicate IDS

Not Available

Old DFC IDS

Not Available

Associated Foods

Food	Content Range	Average	Reference
Food			Reference

Biological Effects and Interactions

Health Effects / Bioactivities

Not Available

Enzymes

Name	Gene Name	UniProt ID
Adenine phosphoribosyltransferase	APRT	P07741
Uracil phosphoribosyltransferase homolog	UPRT	Q96BW1
Uridine 5'-monophosphate synthase	UMPS	P11172

Pathways

Name	SMPDB Link	KEGG Link
Pentose Phosphate Pathway	SMP00031	map00030
Purine Metabolism	SMP00050	map00230
Pyrimidine Metabolism	SMP00046	map00240
Metabolism and Physiological Effects of Uridine	SMP0124871	Not Available