1.0 2011-09-21 00:06:36 UTC 2015-10-09 22:32:15 UTC FDB021989 2-Amino-3-phosphonopropionic acid 2-Amino-3-phosphonopropionic acid (AP-3)is a normal human metabolite found in diverse tissues, such as liver, intestine and spleen. (PMID 2627760) AP-3 is a metabotropic glutamate receptor agonist (PMID 8836635) shown to block the amyloid precursor protein (APP) release evoked by glutamate receptor stimulation in neurons of the cortex and hippocampus; APP accumulation is believed to produce the damage in Alzheimer disease (PMID 7644542) [HMDB] 1-amino-3-(Ohydroxy)propan-2-one 1-Amino-3-(phosphohydroxy)propan-2-one 1-amino-Propan-2-one-3-ate 1-amino-propan-2-one-3-phosphate 2-amino-3-Onopropanoate 2-amino-3-Onopropanoic acid 2-amino-3-Onopropionate 2-amino-3-Onopropionic acid 2-Amino-3-phosphonopropanoate 2-Amino-3-phosphonopropanoic acid 2-Amino-3-phosphonopropionate 2-Amino-3-phosphonopropionic acid 3-amino-2-Oxopropyl ate 3-Amino-2-oxopropyl phosphate D-Alanyl-ate D-Alanyl-phosphate Glyphosate Onoalanine Phosphonoalanine C3H8NO5P 169.0731 169.014008883 2-amino-3-phosphonopropanoic acid phosphonoalanine 5652-28-8 NC(CP(O)(O)=O)C(O)=O InChI=1S/C3H8NO5P/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9) LBTABPSJONFLPO-UHFFFAOYSA-N belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Alpha amino acids Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aliphatic acyclic compounds Amino acids Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Monoalkylamines Monocarboxylic acids and derivatives Organic oxides Organic phosphonic acids Organophosphorus compounds Organopnictogen compounds Aliphatic acyclic compound Alpha-amino acid Amine Amino acid Carbonyl group Carboxylic acid Hydrocarbon derivative Monocarboxylic acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organophosphonic acid Organophosphonic acid derivative Organophosphorus compound Organopnictogen compound Primary aliphatic amine Primary amine alanine derivative non-proteinogenic alpha-amino acid Solid logp -2.49 ALOGPS logs -0.69 ALOGPS solubility 3.47e+01 g/l ALOGPS logp -3.8 ChemAxon pka_strongest_acidic 1.4 ChemAxon pka_strongest_basic 9.83 ChemAxon iupac 2-amino-3-phosphonopropanoic acid ChemAxon average_mass 169.0731 ChemAxon mono_mass 169.014008883 ChemAxon smiles NC(CP(O)(O)=O)C(O)=O ChemAxon formula C3H8NO5P ChemAxon inchi InChI=1S/C3H8NO5P/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9) ChemAxon inchikey LBTABPSJONFLPO-UHFFFAOYSA-N ChemAxon polar_surface_area 120.85 ChemAxon refractivity 31.08 ChemAxon polarizability 12.85 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 6 ChemAxon donor_count 4 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1290 Specdb::CMs 1436 Specdb::CMs 2682 Specdb::CMs 31135 Specdb::CMs 37473 Specdb::CMs 134693 Specdb::CMs 142427 Specdb::CMs 1059787 Specdb::CMs 1059788 Specdb::CMs 1059790 Specdb::CMs 1059792 Specdb::CMs 1059794 Specdb::MsIr 457 Specdb::MsIr 458 Specdb::MsIr 459 Specdb::NmrOneD 1348 Specdb::NmrOneD 5136 Specdb::NmrOneD 5137 Specdb::NmrOneD 6642 Specdb::NmrOneD 6643 Specdb::NmrOneD 6644 Specdb::NmrOneD 6645 Specdb::NmrOneD 6646 Specdb::NmrOneD 6647 Specdb::NmrOneD 6648 Specdb::NmrOneD 6649 Specdb::NmrOneD 6650 Specdb::NmrOneD 6651 Specdb::NmrOneD 6652 Specdb::NmrOneD 6653 Specdb::NmrOneD 6654 Specdb::NmrOneD 6655 Specdb::NmrOneD 6656 Specdb::NmrOneD 6657 Specdb::NmrOneD 6658 Specdb::NmrOneD 6659 Specdb::NmrOneD 6660 Specdb::NmrOneD 6661 Specdb::NmrOneD 166587 Specdb::MsMs 585 Specdb::MsMs 586 Specdb::MsMs 587 Specdb::MsMs 4036 Specdb::MsMs 4037 Specdb::MsMs 4038 Specdb::MsMs 4039 Specdb::MsMs 4040 Specdb::MsMs 4041 Specdb::MsMs 4042 Specdb::MsMs 4043 Specdb::MsMs 4044 Specdb::MsMs 4045 Specdb::MsMs 182700 Specdb::MsMs 182701 Specdb::MsMs 182702 Specdb::MsMs 183048 Specdb::MsMs 183049 Specdb::MsMs 183050 Specdb::MsMs 437231 Specdb::MsMs 437232 Specdb::MsMs 437233 Specdb::MsMs 437234 Specdb::MsMs 437235 Specdb::MsMs 445701 HMDB00370 #<Reference:0x000055ce33616b40> #<Reference:0x000055ce33616988> #<Reference:0x000055ce33616780> #<Reference:0x000055ce336165c8> #<Reference:0x000055ce33616410> #<Reference:0x000055ce33616208> #<Reference:0x000055ce33616028> #<Reference:0x000055ce33615e20> #<Reference:0x000055ce33615c18> #<Reference:0x000055ce336159c0> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823