Record Information
Version1.0
Creation date2011-09-21 00:08:52 UTC
Update date2015-07-21 06:56:59 UTC
Primary IDFDB022127
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameChondroitin sulfate
DescriptionChondroitin sulfate (CS) is a linear heteropolysaccharide consisting of repeating disaccharide units of glucuronic acid and galactosamine, which is commonly sulfated at C-4 and/or C-6 of galactosamine. chondroitin sulfate (CS) is a glycosaminoglycan (GAG) covalently linked to proteins forming proteoglycans (PGs). GAGs are all anionic linear heteropolysaccharide chains of repeating disaccharide units. According to the monosaccharide types and the glycosidic bonds between them, GAGs are divided into (1) hyaluronan, (2) CS and dermatan sulfate (DS), (3) heparan sulfate and heparin, and (4) keratan sulfate. CS was isolated from cartilage in 1884, but the nature of its monosaccharides and structure was first described in 1925. On the basis of the structure of chondroitin sulfate, at least five enzyme activities could be predicted, including three transferases (EC 2.4.1.79, the initiating GalNAc transferase, EC 2.4.1.175, polymerizing GalNAc and EC 2.4.1.17, GlcA transferase) and two sulfotransferases (EC 2.8.2.5, GalNAc 4-sulfotransferase and EC 2.8.2.17, GalNAc 6-sulfotransferase). Additional enzymes exist for epimerization of GlcA, sulfation of the uronic acids, and other patterns of sulfation found in unusual species of chondroitin. chondroitin sulfate assembly can occur on virtually all proteoglycans, depending on the cell in which the core protein is expressed. chondroitin sulfates from different sources vary in the location of sulfate groups. Separation of the products reveals that many types of chondroitin sulfate exist in nature but many chains are hybrid structures containing more than one type of disaccharide. Animal cells also degrade chondroitin sulfate in lysosomes using a series of exoglycolytic activities. (PMID: 167797850) [HMDB]
CAS Number9007-28-7
Structure
Thumb
Synonyms
SynonymSource
Chondroitin sulfuric acidGenerator
Chondroitin sulphateGenerator
Chondroitin sulphuric acidGenerator
ChondritinsulfateHMDB
ChondritinsulphateHMDB
Chondroitin 6-sulfateHMDB
Chondroitin 6-sulphateHMDB
Chondroitin polysulfateHMDB
Chondroitin polysulphateHMDB
Chondroitin sodium sulfate ex sharkHMDB
Chondroitin sulfate CHMDB
Chondroitin sulfate from swineHMDB
Chondroitin sulphate CHMDB
Chondroitin sulphate from swineHMDB
ChondroitinsulfurateHMDB
Chondroitinsulfuric acidHMDB
Chondroitinsulfuric acidsHMDB
BlutalHMDB
Chondroitin 4 sulfate, aluminum saltHMDB
Chondroitin 4-sulfate, aluminum saltHMDB
Chondroitin 6 sulfate, potassium saltHMDB
Chondroitin 6 sulfate, sodium saltHMDB
Chondroitin sulfate aHMDB
Sulfate, sodium chondroitinHMDB
Chondroitin 4-sulfate, potassium saltHMDB
Chondroitin 6-sulfate, potassium saltHMDB
Chondroitin sulfate 4 sulfate, sodium saltHMDB
Chondroitin sulfate, calcium saltHMDB
Chondroitin sulfate, iron (+3) saltHMDB
Chondroitin sulfate, iron saltHMDB
Chondroitin sulfate, potassium saltHMDB
Sulfate, chondroitinHMDB
TranslagenHMDB
Chondroitin 4-sulfateHMDB
Chondroitin 6 sulfateHMDB
Chondroitin sulfate, sodiumHMDB
Chondroitin sulfate, sodium saltHMDB
ChonsuridHMDB
Sulfates, chondroitinHMDB
Chondroitin 4 sulfateHMDB
Chondroitin 4 sulfate, potassium saltHMDB
Chondroitin 6-sulfate, sodium saltHMDB
Chondroitin sulfate 4-sulfate, sodium saltHMDB
Chondroitin sulfate, zinc saltHMDB
Chondroitin sulfatesHMDB
Sodium chondroitin sulfateHMDB
(2S,3S,4S,5R,6R)-6-{[(2R,3R,4R,5R,6R)-2,5-dihydroxy-3-[(1-hydroxyethylidene)amino]-6-(sulfooxy)oxan-4-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylateHMDB
(2S,3S,4S,5R,6R)-6-{[(2R,3R,4R,5R,6R)-2,5-dihydroxy-3-[(1-hydroxyethylidene)amino]-6-(sulphooxy)oxan-4-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylateHMDB
(2S,3S,4S,5R,6R)-6-{[(2R,3R,4R,5R,6R)-2,5-dihydroxy-3-[(1-hydroxyethylidene)amino]-6-(sulphooxy)oxan-4-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acidHMDB
Chondroitin sulfateMeSH
Chondroitin Sodium Sulfate Ex Sharkhmdb
Chondroitin sulfic acidhmdb
Predicted Properties
PropertyValueSource
Water Solubility57.1 g/LALOGPS
logP-1.2ALOGPS
logP-6.2ChemAxon
logS-0.91ALOGPS
pKa (Strongest Acidic)-1.9ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count8ChemAxon
Polar Surface Area258.84 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity84.36 m³·mol⁻¹ChemAxon
Polarizability38.83 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC13H21NO15S
IUPAC name(2S,3S,4S,5R,6R)-6-{[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-(sulfooxy)oxan-4-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid
InChI IdentifierInChI=1S/C13H21NO15S/c1-2(15)14-3-8(7(19)13(28-11(3)22)29-30(23,24)25)26-12-6(18)4(16)5(17)9(27-12)10(20)21/h3-9,11-13,16-19,22H,1H3,(H,14,15)(H,20,21)(H,23,24,25)/t3-,4+,5+,6-,7-,8-,9+,11-,12-,13-/m1/s1
InChI KeyKXKPYJOVDUMHGS-OSRGNVMNSA-N
Isomeric SMILESCC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O
Average Molecular Weight463.369
Monoisotopic Molecular Weight463.063189697
Classification
Description Belongs to the class of organic compounds known as o-glucuronides. These are glucuronides in which the aglycone is linked to the carbohydrate unit through an O-glycosidic bond.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentO-glucuronides
Alternative Parents
Substituents
  • 1-o-glucuronide
  • O-glucuronide
  • Disaccharide
  • Glycosyl compound
  • O-glycosyl compound
  • Beta-hydroxy acid
  • Hydroxy acid
  • Oxane
  • Pyran
  • Sulfuric acid monoester
  • Sulfate-ester
  • Alkyl sulfate
  • Sulfuric acid ester
  • Acetamide
  • Organic sulfuric acid or derivatives
  • Carboxamide group
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Hemiacetal
  • Oxacycle
  • Monocarboxylic acid or derivatives
  • Acetal
  • Carboxylic acid
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Polyol
  • Hydrocarbon derivative
  • Carbonyl group
  • Organic oxide
  • Organopnictogen compound
  • Organic nitrogen compound
  • Organonitrogen compound
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External DescriptorsNot Available
Ontology
Disposition

Source:

Biological location:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSChondroitin sulfate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0092-9226600000-e2926cb2b441d0248b48Spectrum
Predicted GC-MSChondroitin sulfate, 3 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-044i-3432219000-e93cc29262ee63b4076eSpectrum
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0072-3070900000-6cd9ea60eef6ed5da8c8Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0072-4190100000-6ea91dbda6c60562111bSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-01oy-8970100000-1b323176cc14d43c8b60Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0bt9-1679500000-d14d4a02aa564400ce03Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0ldr-6795500000-cd3b52d1aebf380af91fSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0pb9-9520000000-ab046b753ab8b0981c85Spectrum
NMRNot Available
ChemSpider ID23152
ChEMBL IDNot Available
KEGG Compound IDC00607
Pubchem Compound ID24766
Pubchem Substance IDNot Available
ChEBI ID37397
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB00580
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDChondroitin sulfate
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
Enzymes
NameGene NameUniProt ID
UDP-glucuronosyltransferase 2B4UGT2B4P06133
UDP-glucuronosyltransferase 1-4UGT1A4P22310
UDP-glucuronosyltransferase 2B7UGT2B7P16662
UDP-glucuronosyltransferase 1-1UGT1A1P22309
UDP-glucuronosyltransferase 1-9UGT1A9O60656
UDP-glucuronosyltransferase 1-6UGT1A6P19224
Neurocan core proteinNCANO14594
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSshow
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference