1.0 2011-09-21 00:08:56 UTC 2015-07-21 06:56:59 UTC FDB022131 Glutarylglycine Glutarylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine Glutarylglycine is involved in lysine metabolism. An elevated level of glutarylglycine occurs in patients with glutaric acidemia type II, which is an autosomal recessive inborn error of metabolism due to a mitochondrial respiratory electron chain transport defect. (http://www.pediatricneuro.com/alfonso/pg75.htm) [HMDB] 5-[(carboxymethyl)amino]-5-oxo-Pentanoate 5-[(carboxymethyl)amino]-5-oxo-Pentanoic acid Glutarylglycine N-(carboxymethyl)-Glutaramic acid C7H11NO5 189.1659 189.063722467 4-[(carboxymethyl)carbamoyl]butanoic acid 4-(carboxymethylcarbamoyl)butanoic acid 17686-38-3 OC(=O)CCCC(=O)NCC(O)=O InChI=1S/C7H11NO5/c9-5(8-4-7(12)13)2-1-3-6(10)11/h1-4H2,(H,8,9)(H,10,11)(H,12,13) NBLKTRLPZFCMJG-UHFFFAOYSA-N belongs to the class of organic compounds known as n-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. N-acyl-alpha amino acids Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aliphatic acyclic compounds Carbonyl compounds Carboxylic acids Dicarboxylic acids and derivatives Fatty acids and conjugates Hydrocarbon derivatives N-acyl amines Organic oxides Organonitrogen compounds Organopnictogen compounds Secondary carboxylic acid amides Aliphatic acyclic compound Carbonyl group Carboxamide group Carboxylic acid Dicarboxylic acid or derivatives Fatty acid Fatty acyl Fatty amide Hydrocarbon derivative N-acyl-alpha-amino acid N-acyl-amine Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Secondary carboxylic acid amide Solid logp -0.82 ALOGPS logs -1.18 ALOGPS solubility 1.24e+01 g/l ALOGPS logp -1.1 ChemAxon pka_strongest_acidic 3.47 ChemAxon pka_strongest_basic -1.9 ChemAxon iupac 4-[(carboxymethyl)carbamoyl]butanoic acid ChemAxon average_mass 189.1659 ChemAxon mono_mass 189.063722467 ChemAxon smiles OC(=O)CCCC(=O)NCC(O)=O ChemAxon formula C7H11NO5 ChemAxon inchi InChI=1S/C7H11NO5/c9-5(8-4-7(12)13)2-1-3-6(10)11/h1-4H2,(H,8,9)(H,10,11)(H,12,13) ChemAxon inchikey NBLKTRLPZFCMJG-UHFFFAOYSA-N ChemAxon polar_surface_area 103.7 ChemAxon refractivity 40.94 ChemAxon polarizability 17.68 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1377 Specdb::MsIr 655 Specdb::MsIr 656 Specdb::MsIr 657 Specdb::CMs 14247 Specdb::CMs 37640 Specdb::CMs 151968 Specdb::CMs 1069262 Specdb::CMs 1069264 Specdb::CMs 1069265 Specdb::CMs 1069267 Specdb::CMs 1069269 Specdb::CMs 1069271 Specdb::CMs 1069273 Specdb::CMs 1069275 Specdb::CMs 1069277 Specdb::CMs 1069278 Specdb::CMs 1069280 Specdb::MsMs 813 Specdb::MsMs 814 Specdb::MsMs 815 Specdb::MsMs 297427 Specdb::MsMs 297428 Specdb::MsMs 297429 Specdb::MsMs 338959 Specdb::MsMs 338960 Specdb::MsMs 338961 Specdb::MsMs 2422878 Specdb::MsMs 2422879 Specdb::MsMs 2422880 Specdb::MsMs 2513066 Specdb::MsMs 2513067 Specdb::MsMs 2513068 Specdb::NmrOneD 1432 Specdb::NmrOneD 144490 Specdb::NmrOneD 144491 Specdb::NmrOneD 144492 Specdb::NmrOneD 144493 Specdb::NmrOneD 144494 Specdb::NmrOneD 144495 Specdb::NmrOneD 144496 Specdb::NmrOneD 144497 Specdb::NmrOneD 144498 Specdb::NmrOneD 144499 Specdb::NmrOneD 144500 Specdb::NmrOneD 144501 Specdb::NmrOneD 144502 Specdb::NmrOneD 144503 Specdb::NmrOneD 144504 Specdb::NmrOneD 144505 Specdb::NmrOneD 144506 Specdb::NmrOneD 144507 Specdb::NmrOneD 144508 Specdb::NmrOneD 144509 HMDB00590 #<Reference:0x000055ce320aaf40> #<Reference:0x000055ce320aad88> #<Reference:0x000055ce320aabd0> #<Reference:0x000055ce320aaa18> #<Reference:0x000055ce320aa860> #<Reference:0x000055ce320aa6a8> #<Reference:0x000055ce320aa4f0> #<Reference:0x000055ce320aa338> #<Reference:0x000055ce320aa180> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 Glycine N-acyltransferase Q6IB77 GLYAT Glycine N-acyltransferase-like protein 1 Q969I3 GLYATL1 Glycine N-acyltransferase-like protein 2 Q8WU03 GLYATL2 Glycine N-acyltransferase-like protein 3 Q5SZD4 GLYATL3