Showing Compound N-Glycoloylganglioside GM2 (FDB022233)

Record Information

Version

1.0

Creation date

2011-09-21 00:10:38 UTC

Update date

2017-03-11 23:00:18 UTC

Primary ID

FDB022233

Secondary Accession Numbers

Not Available

Chemical Information

FooDB Name

N-Glycoloylganglioside GM2

Description

A glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside AII carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues. [HMDB]

CAS Number

104443-57-4

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
Ganglioside aii	HMDB
N-Glycoloyl-ganglioside GM2	HMDB
N-Glycoloyl-GM2	HMDB
NeuGc-GM2	HMDB
N-[(2S,3S)-3-Hydroxy-1-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}nonadecan-2-yl]octadecanimidate	HMDB
Ganglioside AII	hmdb
N-glycoloyl-Ganglioside GM2	hmdb

Predicted Properties

Property	Value	Source
Water Solubility	0.00051 g/L	ALOGPS
logP	8.25	ALOGPS
logP	10.63	ChemAxon
logS	-6.2	ALOGPS
pKa (Strongest Acidic)	12.19	ChemAxon
pKa (Strongest Basic)	-1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	148.71 Å²	ChemAxon
Rotatable Bond Count	37	ChemAxon
Refractivity	211.03 m³·mol⁻¹	ChemAxon
Polarizability	95.72 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Chemical Formula

C43H85NO8

IUPAC name

N-[(2S,3S)-3-hydroxy-1-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}nonadecan-2-yl]octadecanamide

InChI Identifier

InChI=1S/C43H85NO8/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-39(47)44-36(35-51-43-42(50)41(49)40(48)38(34-45)52-43)37(46)32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h36-38,40-43,45-46,48-50H,3-35H2,1-2H3,(H,44,47)/t36-,37-,38+,40+,41-,42+,43+/m0/s1

InChI Key

SYMIJCRAJBNLEL-YPQBUIQASA-N

Isomeric SMILES

CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@@H](O)CCCCCCCCCCCCCCCC

Average Molecular Weight

744.1369

Monoisotopic Molecular Weight

743.627518701

Classification

Description

Belongs to the class of organic compounds known as glycosphingolipids. These are sphingolipids containing a saccharide moiety glycosidically attached to the sphingoid base. Although saccharide moieties are mostly O-glycosidically linked to the ceramide moiety, other sphingolipids with glycosidic bonds of other types (e.G. S-,C-, or N-type) has been reported.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Sphingolipids

Sub Class

Glycosphingolipids

Direct Parent

Glycosphingolipids

Alternative Parents

Substituents

Glycosphingolipid
Fatty acyl glycoside
Fatty acyl glycoside of mono- or disaccharide
Alkyl glycoside
Hexose monosaccharide
Glycosyl compound
O-glycosyl compound
Fatty amide
Fatty acyl
Monosaccharide
N-acyl-amine
Oxane
Carboxamide group
Secondary carboxylic acid amide
Secondary alcohol
Organoheterocyclic compound
Oxacycle
Acetal
Carboxylic acid derivative
Polyol
Organonitrogen compound
Organopnictogen compound
Organic nitrogen compound
Hydrocarbon derivative
Alcohol
Organic oxygen compound
Carbonyl group
Organic oxide
Organooxygen compound
Primary alcohol
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Ontology

Physiological effect

Organoleptic effect:

Touch:

Smooth

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Biological location:

Organ and components:

Brain

Cell and elements:

Extracellular

Cell:

Nerve cell

Subcellular:

Process

Naturally occurring process:

Biological process:

Chemical reaction:

Lipid peroxidation

Biochemical pathway:

Lipid metabolism pathway

Biochemical process:

Cellular process:

Cell signaling

Role

Industrial application:

Food and nutrition:

Biological role:

Molecular messenger:

Signaling molecule

Physico-Chemical Properties

Physico-Chemical Properties - Experimental

Property	Value	Reference
Physical state	Solid
Physical Description	Not Available
Mass Composition	Not Available
Melting Point	Not Available
Boiling Point	Not Available
Experimental Water Solubility	Not Available
Experimental logP	Not Available
Experimental pKa	Not Available
Isoelectric point	Not Available
Charge	Not Available
Optical Rotation	Not Available
Spectroscopic UV Data	Not Available
Density	Not Available
Refractive Index	Not Available

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_1_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_10, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_11, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_12, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_13, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_14, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TMS_2_15, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	N-Glycoloylganglioside GM2, TBDMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0006-0000000900-bee4faa9bf515e17d408	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0006-5110034900-2a1a5346081aa4105b58	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0pk9-9146020000-ab530060298036935dbb	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-052f-7000050900-1218e90887b4b8572e2a	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-06r6-9110081500-7652a75532fc12dd16a0	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-052f-9032010000-b4d90ec8bb1244b11d2a	2021-09-22	View Spectrum

NMR

Not Available

External Links

ChemSpider ID

393427

ChEMBL ID

Not Available

KEGG Compound ID

C01808

Pubchem Compound ID

445946

Pubchem Substance ID

Not Available

ChEBI ID

Not Available

Phenol-Explorer ID

Not Available

DrugBank ID

Not Available

HMDB ID

HMDB00770

CRC / DFC (Dictionary of Food Compounds) ID

Not Available

EAFUS ID

Not Available

Dr. Duke ID

Not Available

BIGG ID

Not Available

KNApSAcK ID

Not Available

HET ID

GM2

Food Biomarker Ontology

Not Available

VMH ID

Not Available

Flavornet ID

Not Available

GoodScent ID

Not Available

SuperScent ID

Not Available

Wikipedia ID

Not Available

Phenol-Explorer Metabolite ID

Not Available

Duplicate IDS

Not Available

Old DFC IDS

Not Available

Associated Foods

Food	Content Range	Average	Reference
Food			Reference

Biological Effects and Interactions

Health Effects / Bioactivities

Not Available

Enzymes

Name	Gene Name	UniProt ID
Ganglioside GM2 activator	GM2A	P17900
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase	PIGL	Q9Y2B2
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q	PIGQ	Q9BRB3
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A	PIGA	P37287
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H	PIGH	Q14442
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	PIGP	P57054
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C	PIGC	Q92535
T-cell surface glycoprotein CD1e, membrane-associated	CD1E	P15812
Epididymal secretory protein E1	NPC2	P61916
Antigen-presenting glycoprotein CD1d	CD1D	P15813
GPI mannosyltransferase 1	PIGM	Q9H3S5
Phosphatidylinositol-glycan biosynthesis class W protein	PIGW	Q7Z7B1
Phosphatidylinositol-glycan biosynthesis class X protein	PIGX	Q8TBF5
GPI mannosyltransferase 4	PIGZ	Q86VD9
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase	B3GNT5	Q9BYG0
Beta-1,3-galactosyltransferase 5	B3GALT5	Q9Y2C3
GPI mannosyltransferase 3	PIGB	Q92521
Phosphatidylinositol-glycan biosynthesis class F protein	PIGF	Q07326
GPI ethanolamine phosphate transferase 2	PIGG	Q5H8A4
GPI ethanolamine phosphate transferase 1	PIGN	O95427
GPI ethanolamine phosphate transferase 3	PIGO	Q8TEQ8
GPI transamidase component PIG-S	PIGS	Q96S52
GPI transamidase component PIG-T	PIGT	Q969N2
Phosphatidylinositol glycan anchor biosynthesis class U protein	PIGU	Q9H490
GPI mannosyltransferase 2	PIGV	Q9NUD9
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y	PIGY	Q3MUY2
Non-lysosomal glucosylceramidase	GBA2	Q9HCG7
GPI-anchor transamidase	PIGK	Q92643
Beta-1,4 N-acetylgalactosaminyltransferase 1	B4GALNT1	Q00973
Beta-1,3-galactosyltransferase 4	B3GALT4	O96024
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase	ST8SIA1	Q92185
Lactosylceramide alpha-2,3-sialyltransferase	ST3GAL5	Q9UNP4
Sialidase-3	NEU3	Q9UQ49