1.0 2011-09-21 00:10:47 UTC 2015-07-21 06:57:05 UTC FDB022243 Sapropterin Sapropterin is converted from 7,8-dihydroneopterin triphosphate by 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase. It is essential in the formation of neurotransmitters and for nitric oxide synthase (PMID 16946131). [HMDB] (6R)-5,6,7,8-Tetrahydro-L-biopterin (6R)-5,6,7,8-Tetrahydrobiopterin (6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin (6R)-L-erythro-Tetrahydrobiopterin (6R)-Tetrahydrobiopterin [6R-[6R*(1R*,2S*)]]-2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-Pteridinone 6b-5,6,7,8-Tetrahydro-L-biopterin 6R-BH4 6R-Tetrahydro-L-biopterin L-erythro-5,6,7,8-Tetrahydrobiopterin L-erythro-Tetrahydrobiopterin R-THBP Sapropterin C9H15N5O3 241.2471 241.117489371 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-1,4,5,6,7,8-hexahydropteridin-4-one 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-1H-pteridin-4-one 62989-33-7 C[C@H](O)[C@H](O)C1CNC2=C(N1)C(=O)N=C(N)N2 InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4?,6-/m0/s1 FNKQXYHWGSIFBK-BYAPIUGTSA-N belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland. Biopterins and derivatives Organic compounds Organoheterocyclic compounds Pteridines and derivatives Pterins and derivatives Aromatic heteropolycyclic compounds 1,2-aminoalcohols 1,2-diols 1,3-aminoalcohols Aminopyrimidines and derivatives Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds Primary amines Pyrimidones Secondary alcohols Secondary alkylarylamines Vinylogous amides 1,2-aminoalcohol 1,2-diol 1,3-aminoalcohol Alcohol Amine Aminopyrimidine Aromatic heteropolycyclic compound Azacycle Biopterin Heteroaromatic compound Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary amine Pyrimidine Pyrimidone Secondary alcohol Secondary aliphatic/aromatic amine Secondary amine Vinylogous amide 5,6,7,8-tetrahydrobiopterin Solid logp -1.66 ALOGPS logs -2.04 ALOGPS solubility 2.21e+00 g/l ALOGPS logp -2.7 ChemAxon pka_strongest_acidic 10.01 ChemAxon pka_strongest_basic 3.58 ChemAxon iupac 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-1,4,5,6,7,8-hexahydropteridin-4-one ChemAxon average_mass 241.2471 ChemAxon mono_mass 241.117489371 ChemAxon smiles C[C@H](O)[C@H](O)C1CNC2=C(N1)C(=O)N=C(N)N2 ChemAxon formula C9H15N5O3 ChemAxon inchi InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4?,6-/m0/s1 ChemAxon inchikey FNKQXYHWGSIFBK-BYAPIUGTSA-N ChemAxon polar_surface_area 132 ChemAxon refractivity 68.43 ChemAxon polarizability 23.69 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 8 ChemAxon donor_count 6 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Catecholamine Biosynthesis SMP00012 map00350 Specdb::CMs 23623 Specdb::CMs 37764 Specdb::MsMs 318379 Specdb::MsMs 318380 Specdb::MsMs 318381 Specdb::MsMs 365128 Specdb::MsMs 365129 Specdb::MsMs 365130 HMDB00787 #<Reference:0x000055ac40220ac8> #<Reference:0x000055ac402207d0> #<Reference:0x000055ac40220618> Phenylalanine-4-hydroxylase P00439 PAH Sepiapterin reductase P35270 SPR Tryptophan 5-hydroxylase 1 P17752 TPH1 Tryptophan 5-hydroxylase 2 Q8IWU9 TPH2 Tyrosine 3-monooxygenase P07101 TH