1.0 2011-09-21 00:11:55 UTC 2025-11-19 02:41:23 UTC FDB022310 Tetrahydrocortisone Cortisol is a corticosteroid hormone that is involved in the response to stress; it increases blood pressure and blood sugar levels and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation. -- Wikipedia; As an oral or injectable drug, cortisol is also known as hydrocortisone. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis. -- Wikipedia [HMDB] (3a,5b)-3,17,21-trihydroxy-pregnane-11,20-dione 3,17-dihydroxy-17-hydroxyacetyl-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-11-one 3a,17,21-trihydroxy-5a-pregnane-11,20-dione 3a,17,21-trihydroxy-5b-pregnane-11,20-dione 3alpha,17,21-trihydroxy-5beta-Pregnane-11,20-dione 3alpha,17,21-Trihydroxypregnane-11,20-dione 3b,17,21-trihydroxy-5a-pregnane-11,20-dione 5a-Pregnan-3b,17a,21-triol-11,20-dion Ba 2681 Tetrahydro E tetrahydro-Cortisone Tetrahydrocompound E Tetrahydrocortison Tetrahydrocortisone Urocortisone C21H32O5 364.4758 364.224974134 (1S,2S,5S,7S,10S,11S,14R,15S)-5,14-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-17-one (1S,2S,5S,7S,10S,11S,14R,15S)-5,14-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-17-one 53-05-4 [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](O)CC[C@]12C InChI=1S/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,18,22-23,26H,3-11H2,1-2H3/t12-,13-,14-,15-,18+,19-,20-,21-/m0/s1 SYGWGHVTLUBCEM-SDYDLROXSA-N belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. 21-hydroxysteroids Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids Aliphatic homopolycyclic compounds 11-oxosteroids 17-hydroxysteroids 20-oxosteroids 3-beta-hydroxysteroids Alpha-hydroxy ketones Cyclic alcohols and derivatives Gluco/mineralocorticoids, progestogins and derivatives Hydrocarbon derivatives Organic oxides Primary alcohols Secondary alcohols Tertiary alcohols 11-oxosteroid 17-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-beta-hydroxysteroid 3-hydroxysteroid Alcohol Aliphatic homopolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Tertiary alcohol Solid logp 2.04 ALOGPS logs -3.27 ALOGPS solubility 1.94e-01 g/l ALOGPS logp 1.5 ChemAxon pka_strongest_acidic 12.58 ChemAxon pka_strongest_basic -1.4 ChemAxon iupac (1S,2S,5S,7S,10S,11S,14R,15S)-5,14-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-17-one ChemAxon average_mass 364.4758 ChemAxon mono_mass 364.224974134 ChemAxon smiles [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](O)CC[C@]12C ChemAxon formula C21H32O5 ChemAxon inchi InChI=1S/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,18,22-23,26H,3-11H2,1-2H3/t12-,13-,14-,15-,18+,19-,20-,21-/m0/s1 ChemAxon inchikey SYGWGHVTLUBCEM-SDYDLROXSA-N ChemAxon polar_surface_area 94.83 ChemAxon refractivity 96.68 ChemAxon polarizability 40.47 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Steroidogenesis SMP00130 map00140 Specdb::NmrOneD 1595 Specdb::NmrTwoD 1536 Specdb::CMs 15616 Specdb::CMs 37833 Specdb::CMs 137225 Specdb::CMs 144959 Specdb::CMs 1081193 Specdb::CMs 1081196 Specdb::CMs 1081198 Specdb::CMs 1081200 Specdb::CMs 1081201 Specdb::CMs 1081203 Specdb::CMs 1081206 Specdb::CMs 1081208 Specdb::CMs 1081210 Specdb::CMs 1081212 Specdb::CMs 1081214 Specdb::CMs 1081216 Specdb::CMs 1081218 Specdb::CMs 1081220 Specdb::CMs 1081222 Specdb::CMs 1081224 Specdb::CMs 1081226 Specdb::CMs 1081228 Specdb::CMs 1081230 Specdb::CMs 1081232 Specdb::CMs 1081234 Specdb::MsMs 1283 Specdb::MsMs 1284 Specdb::MsMs 1285 Specdb::MsMs 300601 Specdb::MsMs 300602 Specdb::MsMs 300603 Specdb::MsMs 342913 Specdb::MsMs 342914 Specdb::MsMs 342915 Specdb::MsMs 2731737 Specdb::MsMs 2731738 Specdb::MsMs 2731739 Specdb::MsMs 2977760 Specdb::MsMs 2977761 Specdb::MsMs 2977762 HMDB00903 #<Reference:0x000055ce322c2f58> #<Reference:0x000055ce322c2da0> #<Reference:0x000055ce322c2be8> #<Reference:0x000055ce322c2a30> #<Reference:0x000055ce322c2878> #<Reference:0x000055ce322c26c0> #<Reference:0x000055ce322c2508> #<Reference:0x000055ce322c2350> #<Reference:0x000055ce322c2198> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823