1.0 2011-09-21 00:13:08 UTC 2025-11-19 02:41:34 UTC FDB022381 DHEA sulfate DHEAS or Dehydroepiandrosterone sulfate is the sulfated form of DHEA. This sulfation is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestine. In the blood, most DHEA is found as DHEAS with levels that are about 300 times higher than those of free DHEA. Orally-ingested DHEA is converted to its sulfate when passing through intestines and liver. Whereas DHEA levels naturally reach their peak in the early morning hours, DHEAS levels show no diurnal variation. From a practical point of view, measurement of DHEAS is preferable to DHEA, as levels are more stable. DHEA (from which DHEAS comes from) is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an autocrine mechanism). DHEA is the precursor of androstenedione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol. DHEA is also a potent sigma-1 agonist. DHEAS can serve as a precursor for testosterone; androstenedione; estradiol; and estrone. [HMDB] (3-b)-3-(Sulfooxy)androst-5-en-17-one (3-b)-3-(Sulphooxy)androst-5-en-17-one (3-beta)-3-(Sulfooxy)androst-5-en-17-one (3-beta)-3-(Sulphooxy)androst-5-en-17-one (3-β)-3-(sulfooxy)androst-5-en-17-one (3-β)-3-(sulphooxy)androst-5-en-17-one (3beta)-3-(sulfooxy)-Androst-5-en-17-one 17-Ketoandrost-5-en-3b-yl sulfate 17-Ketoandrost-5-en-3b-yl sulfuric acid 17-Ketoandrost-5-en-3b-yl sulphate 17-Ketoandrost-5-en-3b-yl sulphuric acid 17-Ketoandrost-5-en-3beta-yl sulfate 17-Ketoandrost-5-en-3beta-yl sulfuric acid 17-Ketoandrost-5-en-3beta-yl sulphate 17-Ketoandrost-5-en-3beta-yl sulphuric acid 17-Ketoandrost-5-en-3β-yl sulfate 17-Ketoandrost-5-en-3β-yl sulfuric acid 17-Ketoandrost-5-en-3β-yl sulphate 17-Ketoandrost-5-en-3β-yl sulphuric acid 17-Oxoandrost-5-en-3-yl hydrogen sulfate 17-Oxoandrost-5-en-3-yl hydrogen sulphate 17-oxoandrost-5-en-3b-yl hydrogen sulfate 17-Oxoandrost-5-en-3b-yl hydrogen sulfuric acid 17-Oxoandrost-5-en-3b-yl hydrogen sulphate 17-Oxoandrost-5-en-3b-yl hydrogen sulphuric acid 17-oxoandrost-5-en-3beta-yl hydrogen sulfate 17-Oxoandrost-5-en-3beta-yl hydrogen sulfuric acid 17-Oxoandrost-5-en-3beta-yl hydrogen sulphate 17-Oxoandrost-5-en-3beta-yl hydrogen sulphuric acid 17-Oxoandrost-5-en-3β-yl hydrogen sulfate 17-Oxoandrost-5-en-3β-yl hydrogen sulfuric acid 17-Oxoandrost-5-en-3β-yl hydrogen sulphate 17-Oxoandrost-5-en-3β-yl hydrogen sulphuric acid 3-b-hydroxyandrost-5-en-17-one 3-sulfate 3-b-Hydroxyandrost-5-en-17-one 3-sulphate 3-beta-hydroxyandrost-5-en-17-one 3-sulfate 3-beta-Hydroxyandrost-5-en-17-one 3-sulphate 3-O-Sulfodehydroepiandrosterone 3-O-Sulphodehydroepiandrosterone 3b-hydroxy-Androst-5-en-17-one hydrogen sulfate 3b-Hydroxy-androst-5-en-17-one hydrogen sulphate 3b-hydroxyandrost-5-en-17-one 3-sulfate 3b-Hydroxyandrost-5-en-17-one 3-sulfuric acid 3b-Hydroxyandrost-5-en-17-one 3-sulphate 3b-Hydroxyandrost-5-en-17-one 3-sulphuric acid 3beta-hydroxy-Androst-5-en-17-one hydrogen sulfate 3beta-Hydroxy-androst-5-en-17-one hydrogen sulphate 3beta-hydroxyandrost-5-en-17-one 3-sulfate 3beta-Hydroxyandrost-5-en-17-one 3-sulfuric acid 3beta-Hydroxyandrost-5-en-17-one 3-sulphate 3beta-Hydroxyandrost-5-en-17-one 3-sulphuric acid 3β-hydroxyandrost-5-en-17-one 3-sulfate 3β-hydroxyandrost-5-en-17-one 3-sulfuric acid 3β-hydroxyandrost-5-en-17-one 3-sulphate 3β-hydroxyandrost-5-en-17-one 3-sulphuric acid Androst-5-en-17-on-3b-yl sulfate Androst-5-en-17-on-3b-yl sulfuric acid Androst-5-en-17-on-3b-yl sulphate Androst-5-en-17-on-3b-yl sulphuric acid Androst-5-en-17-on-3beta-yl sulfate Androst-5-en-17-on-3beta-yl sulfuric acid Androst-5-en-17-on-3beta-yl sulphate Androst-5-en-17-on-3beta-yl sulphuric acid Androst-5-en-17-on-3β-yl sulfate Androst-5-en-17-on-3β-yl sulfuric acid Androst-5-en-17-on-3β-yl sulphate Androst-5-en-17-on-3β-yl sulphuric acid Dehydroepiandrosterone 3-sulfate Dehydroepiandrosterone 3-sulfuric acid Dehydroepiandrosterone 3-sulphate Dehydroepiandrosterone 3-sulphuric acid Dehydroepiandrosterone monosulfate Dehydroepiandrosterone monosulfuric acid Dehydroepiandrosterone monosulphate Dehydroepiandrosterone monosulphuric acid Dehydroepiandrosterone sulfate Dehydroepiandrosterone sulfuric acid Dehydroepiandrosterone sulphate Dehydroepiandrosterone sulphuric acid Dehydroepiandrosterone-3-sulfate Dehydroepiandrosterone-3-sulphate Dehydroisoandrosterone sulfate Dehydroisoandrosterone sulfuric acid Dehydroisoandrosterone sulphate Dehydroisoandrosterone sulphuric acid Dehydroisoandrosterone-3-sulfate Dehydroisoandrosterone-3-sulfuric acid Dehydroisoandrosterone-3-sulphate Dehydroisoandrosterone-3-sulphuric acid DHEA sulfuric acid DHEA sulphate DHEA sulphuric acid DHEA-S DHEAS Formylisoglutamic acid Prasterone sulfate Prasterone sulfuric acid Prasterone sulphate Prasterone sulphuric acid Prasterone-3-sulfate Prasterone-3-sulphate C19H28O5S 368.488 368.165744696 [(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]oxidanesulfonic acid [(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]oxidanesulfonic acid 651-48-9 [H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OS(O)(=O)=O InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1 CZWCKYRVOZZJNM-USOAJAOKSA-N belongs to the class of organic compounds known as sulfated steroids. These are sterol lipids containing a sulfate group attached to the steroid skeleton. Sulfated steroids Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Sulfated steroids Aliphatic homopolycyclic compounds 17-oxosteroids Alkyl sulfates Androstane steroids Delta-5-steroids Hydrocarbon derivatives Ketones Organic oxides Sulfuric acid monoesters 17-oxosteroid Aliphatic homopolycyclic compound Alkyl sulfate Androstane-skeleton Carbonyl group Delta-5-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organic sulfuric acid or derivatives Organooxygen compound Oxosteroid Sulfate-ester Sulfated steroid skeleton Sulfuric acid ester Sulfuric acid monoester 17-oxo steroid Androgens C19 steroids (androgens) and derivatives Sulfates steroid sulfate sulfates Solid logp 0.49 ALOGPS logs -4.66 ALOGPS solubility 8.06e-03 g/l ALOGPS logp 3.42 ChemAxon pka_strongest_acidic -1.4 ChemAxon pka_strongest_basic -7.5 ChemAxon iupac [(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]oxidanesulfonic acid ChemAxon average_mass 368.488 ChemAxon mono_mass 368.165744696 ChemAxon smiles [H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OS(O)(=O)=O ChemAxon formula C19H28O5S ChemAxon inchi InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1 ChemAxon inchikey CZWCKYRVOZZJNM-USOAJAOKSA-N ChemAxon polar_surface_area 80.67 ChemAxon refractivity 94.65 ChemAxon polarizability 39.85 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 10424 Specdb::CMs 165793 Specdb::NmrOneD 303331 Specdb::NmrOneD 303332 Specdb::NmrOneD 303333 Specdb::NmrOneD 303334 Specdb::NmrOneD 303335 Specdb::NmrOneD 303336 Specdb::NmrOneD 303337 Specdb::NmrOneD 303338 Specdb::NmrOneD 303339 Specdb::NmrOneD 303340 Specdb::NmrOneD 303341 Specdb::NmrOneD 303342 Specdb::NmrOneD 303343 Specdb::NmrOneD 303344 Specdb::NmrOneD 303345 Specdb::NmrOneD 303346 Specdb::NmrOneD 303347 Specdb::NmrOneD 303348 Specdb::NmrOneD 303349 Specdb::NmrOneD 303350 Specdb::MsMs 78474 Specdb::MsMs 78475 Specdb::MsMs 78476 Specdb::MsMs 138825 Specdb::MsMs 138826 Specdb::MsMs 138827 Specdb::MsMs 2243991 Specdb::MsMs 2246084 Specdb::MsMs 2246184 Specdb::MsMs 2248118 Specdb::MsMs 2358765 Specdb::MsMs 2358766 Specdb::MsMs 2358767 Specdb::MsMs 2603228 Specdb::MsMs 2603229 Specdb::MsMs 2603230 HMDB01032 #<Reference:0x000055ce318fa110> #<Reference:0x000055ce318f9f58> #<Reference:0x000055ce318f9da0> #<Reference:0x000055ce318f9be8> #<Reference:0x000055ce318f9a30> #<Reference:0x000055ce318f9878> #<Reference:0x000055ce318f96c0> #<Reference:0x000055ce318f9508> #<Reference:0x000055ce318f9350> #<Reference:0x000055ce318f9198> #<Reference:0x000055ce318f8fe0> #<Reference:0x000055ce318f8e28> #<Reference:0x000055ce318f8c70> #<Reference:0x000055ce318f8ab8> #<Reference:0x000055ce318f8900> #<Reference:0x000055ce318f8748> #<Reference:0x000055ce318f8590> #<Reference:0x000055ce318f83d8> #<Reference:0x000055ce318f8220> #<Reference:0x000055ce318f8068> #<Reference:0x000055ce318f7e60> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 Sulfotransferase family cytosolic 2B member 1 O00204 SULT2B1