1.02011-09-21 00:13:12 UTC2015-07-21 06:57:10 UTCFDB022385Angiotensin IVAngiotensin IV is one of the N-terminal angiotensin degradation products of angiotensin II. Angiotensin IV (AngIV) mediates important physiologic functions in the central nervous system, including blood flow regulation, processes underlying to learning and memory, and presents anticonvulsant activity. The presence of AngIV-specific binding sites has been identified in various mammalian tissues, including blood vessels, heart, kidney, and brain. Besides the presence of AngIV binding sites in the cardiovascular system, the major AngIV synthesizing enzymes aminopeptidase N (APN) and aminopeptidase B (APB) are also expressed in different cell types of this system. AngIV activates several protein kinases, including phosphatidylinositol 3 kinase, PI-dependent kinase-1, extracellular signal-related kinases (ERK), protein kinase B-α/Akt, and p70 ribosomal S6 kinase. AngIV could contribute to vascular damage, increasing the production of monocyte chemoattractant protein-1, the main chemokine involved in monocyte recruitment, and up-regulates the expression of the adhesion molecule intercellular adhesion molecule-1 that is involved in the attachment and transmigration of circulating cells into the damaged tissue. (PMID: 17210474) [HMDB](3-8)-5-Isoleucine-angiotensin II(Des(Asp1,Arg2)-Ile5)angiotensin II(Ile5)-angiotensin II (3-8)(Isoleucine5)-angiotensin II hexapeptide1-De-asp-2-de-arg-5-ile-angiotensin II3-L-isoleucine-Angiotensin IV5-Isoleucine-angiotensin II 3-8-hexapeptideHuamn angiotensin (3-8)Human angiotensin hexapeptide (3-8)Human angiotensin ivIle3-angiotensin IVNle-angivVal-TYR-ile-his-pro-pheC40H54N8O8774.9056774.406460744(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid12676-15-2CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=OInChI=1S/C40H54N8O8/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56)/t24-,29-,30-,31-,32-,33-,34-/m0/s1QSBGWDDCOJYQGY-KOQODJNWSA-N belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.OligopeptidesOrganic compoundsOrganic acids and derivativesCarboxylic acids and derivativesAmino acids, peptides, and analoguesAromatic heteromonocyclic compounds1-hydroxy-2-unsubstituted benzenoidsAlpha amino acid amidesAmino acidsAmphetamines and derivativesAzacyclic compoundsCarbonyl compoundsCarboxylic acidsHeteroaromatic compoundsHistidine and derivativesHydrocarbon derivativesImidazolyl carboxylic acids and derivativesIsoleucine and derivativesMonoalkylaminesMonocarboxylic acids and derivativesN-acyl aminesN-acyl-L-alpha-amino acidsN-acylpyrrolidinesOrganic oxidesOrganopnictogen compoundsPhenylalanine and derivativesPhenylpropanoic acidsProline and derivativesPyrrolidinecarboxamidesSecondary carboxylic acid amidesTertiary carboxylic acid amidesTyrosine and derivativesValine and derivatives1-hydroxy-2-unsubstituted benzenoid3-phenylpropanoic-acidAlpha-amino acid amideAlpha-amino acid or derivativesAlpha-oligopeptideAmineAmino acidAmino acid or derivativesAmphetamine or derivativesAromatic heteromonocyclic compoundAzacycleAzoleBenzenoidCarbonyl groupCarboxamide groupCarboxylic acidFatty acylFatty amideHeteroaromatic compoundHistidine or derivativesHydrocarbon derivativeImidazoleImidazolyl carboxylic acid derivativeIsoleucine or derivativesMonocarboxylic acid or derivativesMonocyclic benzene moietyN-acyl-alpha amino acid or derivativesN-acyl-alpha-amino acidN-acyl-amineN-acyl-l-alpha-amino acidN-acylpyrrolidineN-substituted-alpha-amino acidOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganoheterocyclic compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPhenolPhenylalanine or derivativesPrimary aliphatic aminePrimary amineProline or derivativesPyrrolidinePyrrolidine carboxylic acid or derivativesPyrrolidine-2-carboxamideSecondary carboxylic acid amideTertiary carboxylic acid amideTyrosine or derivativesValine or derivativesSolidlogp-0.02logs-4.71solubility1.53e-02 g/llogp-0.69pka_strongest_acidic3.6pka_strongest_basic8.21iupac(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acidaverage_mass774.9056mono_mass774.406460744smilesCC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=OformulaC40H54N8O8inchiInChI=1S/C40H54N8O8/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56)/t24-,29-,30-,31-,32-,33-,34-/m0/s1inchikeyQSBGWDDCOJYQGY-KOQODJNWSA-Npolar_surface_area248.94refractivity206.05polarizability81.13rotatable_bond_count19acceptor_count10donor_count8physiological_charge1formal_charge0Specdb::CMs64293Specdb::CMs784377Specdb::CMs784378Specdb::CMs784379Specdb::CMs784380Specdb::CMs784381Specdb::CMs784382Specdb::CMs784383Specdb::CMs784384Specdb::CMs784385Specdb::CMs784386Specdb::CMs784387Specdb::CMs784388Specdb::CMs784389Specdb::CMs784390Specdb::CMs784391Specdb::CMs784392Specdb::NmrOneD8322Specdb::NmrOneD8323Specdb::NmrOneD8324Specdb::NmrOneD8325Specdb::NmrOneD8326Specdb::NmrOneD8327Specdb::NmrOneD8328Specdb::NmrOneD8329Specdb::NmrOneD8330Specdb::NmrOneD8331Specdb::NmrOneD8332Specdb::NmrOneD8333Specdb::NmrOneD8334Specdb::NmrOneD8335Specdb::NmrOneD8336Specdb::NmrOneD8337Specdb::NmrOneD8338Specdb::NmrOneD8339Specdb::NmrOneD8340Specdb::NmrOneD8341Specdb::MsMs288178Specdb::MsMs288179Specdb::MsMs288180Specdb::MsMs327208Specdb::MsMs327209Specdb::MsMs327210Specdb::MsMs2304906Specdb::MsMs2304907Specdb::MsMs2304908Specdb::MsMs2657224Specdb::MsMs2657225Specdb::MsMs2657226HMDB01038#<Reference:0x00005556747dc588>AnatidaeType 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