1.0 2011-09-21 00:13:18 UTC 2025-11-19 02:41:35 UTC FDB022391 Hypochlorite The hypochlorite ion is ClO-. A hypochlorite compound is a chemical compound containing this group. Hypochlorite is a strong oxidant. About 28% of oxygen consumed by phagocytes upon activation participates in its generation. Hypochlorite reacts with H2O2 producing singlet oxygen (1O2) - a strong initiator of Lipid peroxidation. O-sub 2, along with H2O2 can serve as the substrate for myeloperoxidase. When this takes place, Hypochlorite is formed. Hypochlorite is able to modify antioxidants incorporated into lipoproteins such as Alpha-tocopherol, Beta-carotene, lycopene, and ubiquinol-10. It is also able to modify a number of proteins which possess antioxidant functions such as ceruloplasmin, transferrin, superoxide dismutase, and catalase. Active myeloperoxidase is found at sites of atherosclerotic damage to the arterial vessel wall in humans. Lipid peroxidation is known to contribute to the development of pathological processes, among them atherosclerosis. The present hypothesis is that blood lipoproteins modified by Lipid peroxidation play a key role in the pathogenesis of this disease. One of the possible reasons for the appearance of oxidized blood lipoproteins in blood is the interaction of native blood lipoproteins with the reactive oxygen species generated by stimulated neutrophils, monocytes and other cells. The main reaction of Hypochlorite with unsaturated lipid is probably the generation of chlorohydrins. However, this reaction is not accompanied by generation of free radicals and Lipid peroxidation. This reaction is accompanied by the production of free radicals (but not singlet oxygen), probably alkoxyl radicals, which may play a role in the initiation of Hypochlorite-induced Lipid peroxidation. (PMID: 9260000, Biofactors. 1997;6(2):181-90.) [HMDB] [ClO](-) Chlorine oxide (ClO1-) ClO(-) Hypochlorit Hypochlorite anion Hypochlorite ion Hypochlorous acid ion(1-) ClO 51.452 50.963767329 hypochlorite hypochlorite 14380-61-1 [O-]Cl InChI=1S/ClO/c1-2/q-1 WQYVRQLZKVEZGA-UHFFFAOYSA-N belongs to the class of inorganic compounds known as non-metal hypochlorites. These are inorganic non-metallic compounds containing a hypochlorite as its largest oxoanion. Non-metal hypochlorites Inorganic compounds Homogeneous non-metal compounds Non-metal oxoanionic compounds Non-metal hypochlorites Inorganic oxides Inorganic oxide Non-metal hypochlorite an inorganic compound chlorine oxide chlorine oxoanion monovalent inorganic anion logp 0.02 ALOGPS logs 0.74 ALOGPS solubility 3.78e+02 g/l ALOGPS logp 0.32 ChemAxon pka_strongest_acidic 7.93 ChemAxon pka_strongest_basic -5.9 ChemAxon iupac hypochlorite ChemAxon average_mass 51.452 ChemAxon mono_mass 50.963767329 ChemAxon smiles [O-]Cl ChemAxon formula ClO ChemAxon inchi InChI=1S/ClO/c1-2/q-1 ChemAxon inchikey WQYVRQLZKVEZGA-UHFFFAOYSA-N ChemAxon polar_surface_area 23.06 ChemAxon refractivity 7.58 ChemAxon polarizability 3.15 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 1 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge -1 ChemAxon Specdb::MsMs 110010 Specdb::MsMs 110011 Specdb::MsMs 110012 Specdb::MsMs 177582 Specdb::MsMs 177583 Specdb::MsMs 177584 HMDB01050 29222 #<Reference:0x000055ce325e6518> #<Reference:0x000055ce325e6360> #<Reference:0x000055ce325e61a8> #<Reference:0x000055ce325e5ff0> #<Reference:0x000055ce325e5e38> #<Reference:0x000055ce325e5c80> #<Reference:0x000055ce325e5ac8> #<Reference:0x000055ce325e5910> #<Reference:0x000055ce325e5758> #<Reference:0x000055ce325e55a0> #<Reference:0x000055ce325e53e8> #<Reference:0x000055ce325e5230> #<Reference:0x000055ce325e5078> #<Reference:0x000055ce325e4ec0> #<Reference:0x000055ce325e4d08> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823