1.0 2011-09-21 00:15:28 UTC 2025-11-19 02:41:54 UTC FDB022532 2-Aminomuconic acid semialdehyde 2-aminomuconic semialdehyde is an intermediate in the oxidative metabolism of tryptophan in mammals, and takes place via the kynurenine pathway, which is also used for NAD biosynthesis in all eukaryotic organisms. 2-Aminomuconic semialdehyde is reported to be unstable and spontaneously converted to picolinic acid (regarded as metabolically inert and is excreted in the urine as a glycine conjugate), and enzymatically converted to 2-aminomuconic acid through the action of 2-aminomuconic semialdehyde dehydrogenase. (PMID: 10510494, 16267312, 14275129) [HMDB] 2-Aminomuconate 6-semialdehyde 2-aminomuconate semialdehyde 2-Aminomuconic acid 6-semialdehyde 2-aminomuconic semialdehyde C6H7NO3 141.1247 141.042593095 2-amino-6-oxohexa-2,4-dienoic acid 2-aminomuconic semialdehyde 245128-91-0 NC(=CC=CC=O)C(O)=O InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10) QCGTZPZKJPTAEP-UHFFFAOYSA-N belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Alpha amino acids Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aliphatic acyclic compounds Aldehydes Amino acids Amino fatty acids Carboxylic acids Enals Enamines Hydrocarbon derivatives Medium-chain fatty acids Monoalkylamines Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Unsaturated fatty acids Aldehyde Aliphatic acyclic compound Alpha,beta-unsaturated aldehyde Alpha-amino acid Amine Amino acid Amino fatty acid Carbonyl group Carboxylic acid Enal Enamine Fatty acid Fatty acyl Hydrocarbon derivative Medium-chain fatty acid Monocarboxylic acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary aliphatic amine Primary amine Unsaturated fatty acid Solid logp -0.14 ALOGPS logs -1.38 ALOGPS solubility 5.90e+00 g/l ALOGPS logp -3.1 ChemAxon pka_strongest_acidic 2.76 ChemAxon pka_strongest_basic 7.72 ChemAxon iupac 2-amino-6-oxohexa-2,4-dienoic acid ChemAxon average_mass 141.1247 ChemAxon mono_mass 141.042593095 ChemAxon smiles NC(=CC=CC=O)C(O)=O ChemAxon formula C6H7NO3 ChemAxon inchi InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10) ChemAxon inchikey QCGTZPZKJPTAEP-UHFFFAOYSA-N ChemAxon polar_surface_area 80.39 ChemAxon refractivity 37.63 ChemAxon polarizability 13.14 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Tryptophan Metabolism SMP00063 map00380 HMDB01280 #<Reference:0x000055ce331d1a80> #<Reference:0x000055ce331d18c8> #<Reference:0x000055ce331d1710> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase Q8TDX5 ACMSD