1.0 2011-09-21 00:15:46 UTC 2015-07-21 06:57:15 UTC FDB022553 (13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid (13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid is a substrate for Carbonyl reductase 1. Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes) and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signaling pathways. [HMDB] (11a,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oate (11a,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oic acid (11alpha,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oate (11alpha,13E)-11-hydroxy-9,15-dioxoprost-13-en-1-oic acid (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoic acid (13e)-11a-Hydroxy-9,15-dioxoprost-13-en-1-Oate (13e)-11a-Hydroxy-9,15-dioxoprost-13-en-1-Oic acid (13e)-11a-Hydroxy-9,15-dioxoprost-13-enoate (13E)-11alpha-hydroxy-9,15-dioxoprost-13-en-1-oate (13E)-11alpha-hydroxy-9,15-dioxoprost-13-en-1-oic acid (13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate (13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoic acid (13e)-11α-hydroxy-9,15-dioxoprost-13-en-1-Oate (13e)-11α-hydroxy-9,15-dioxoprost-13-en-1-Oic acid (13e)-11α-hydroxy-9,15-dioxoprost-13-enoate (13e)-11α-hydroxy-9,15-dioxoprost-13-enoic acid 1-hydroxy-9,15-dioxo-(11a,13E)-Prost-13-en-1-oate 1-hydroxy-9,15-dioxo-(11a,13E)-Prost-13-en-1-oic acid 15-Keto PGE1 15-Keto-PGE 15-keto-PGE1 15-keto-PGE1-alpha 15-keto-Prostaglandin E1 15-Ketoprostaglandin E 15-Ketoprostaglandin E1 15-Oxo-PGE1 15-Oxoprostaglandin E1 3-hydroxy-5-oxo-2-(3-oxo-1-octenyl)-Cyclopentaneheptanoate 3-hydroxy-5-oxo-2-(3-oxo-1-octenyl)-Cyclopentaneheptanoic acid 9,15-dioxo-11R-hydroxy-13E-prostaenoate 9,15-dioxo-11R-hydroxy-13E-prostaenoic acid C20H32O5 352.4651 352.224974134 7-[(1R,2R,3R)-3-hydroxy-5-oxo-2-[(1E)-3-oxooct-1-en-1-yl]cyclopentyl]heptanoic acid 15-keto-PGE1 22973-19-9 CCCCCC(=O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,16-17,19,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t16-,17-,19-/m1/s1 VXPBDCBTMSKCKZ-XQHNHVHJSA-N belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid. Prostaglandins and related compounds Organic compounds Lipids and lipid-like molecules Fatty Acyls Eicosanoids Aliphatic homomonocyclic compounds Acryloyl compounds Carboxylic acids Cyclic alcohols and derivatives Cyclic ketones Cyclopentanols Enones Hydrocarbon derivatives Hydroxy fatty acids Long-chain fatty acids Monocarboxylic acids and derivatives Organic oxides Acryloyl-group Alcohol Aliphatic homomonocyclic compound Alpha,beta-unsaturated ketone Carbonyl group Carboxylic acid Carboxylic acid derivative Cyclic alcohol Cyclic ketone Cyclopentanol Enone Hydrocarbon derivative Hydroxy fatty acid Ketone Long-chain fatty acid Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Prostaglandin skeleton Secondary alcohol Prostaglandins prostaglandins E Solid logp 3.37 ALOGPS logs -3.84 ALOGPS solubility 5.07e-02 g/l ALOGPS logp 4 ChemAxon pka_strongest_acidic 4.35 ChemAxon pka_strongest_basic -2.9 ChemAxon iupac 7-[(1R,2R,3R)-3-hydroxy-5-oxo-2-[(1E)-3-oxooct-1-en-1-yl]cyclopentyl]heptanoic acid ChemAxon average_mass 352.4651 ChemAxon mono_mass 352.224974134 ChemAxon smiles CCCCCC(=O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O ChemAxon formula C20H32O5 ChemAxon inchi InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,16-17,19,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t16-,17-,19-/m1/s1 ChemAxon inchikey VXPBDCBTMSKCKZ-XQHNHVHJSA-N ChemAxon polar_surface_area 91.67 ChemAxon refractivity 97.42 ChemAxon polarizability 40.82 ChemAxon rotatable_bond_count 13 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 20837 Specdb::CMs 38022 Specdb::CMs 169552 Specdb::MsMs 312409 Specdb::MsMs 312410 Specdb::MsMs 312411 Specdb::MsMs 357664 Specdb::MsMs 357665 Specdb::MsMs 357666 Specdb::MsMs 2374916 Specdb::MsMs 2374917 Specdb::MsMs 2374918 Specdb::MsMs 2560767 Specdb::MsMs 2560768 Specdb::MsMs 2560769 HMDB01320 15548 Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 Carbonyl reductase [NADPH] 1 P16152 CBR1