Record Information
Version1.0
Creation date2011-09-21 00:16:56 UTC
Update date2019-11-26 03:21:04 UTC
Primary IDFDB022617
Secondary Accession NumbersNot Available
Chemical Information
FooDB NamePhosphate
DescriptionPhosphate (Pi) is an essential component of life. In classical endocrine regulation, low serum phosphate induces the renal production of the seco-steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).This active metabolite of vitamin D acts to restore circulating mineral levels by increasing absorption in the intestine, reabsorption in the kidney, and mobilization of calcium and phosphate from bone. Thus, chronic renal failure is associated with hyperparathyroidism, which in turn contributes to osteomalacia. Another complication of chronic renal failure is hyperphosphatemia. Fibroblast growth factor 23 (FGF-23) has recently been recognized as a key mediator of phosphate homeostasis, its most notable effect being promotion of phosphate excretion. FGF-23 was discovered to be involved in diseases such as autosomal dominant hypophosphatemic rickets, X-linked hypophosphatemia, and tumor-induced osteomalacia in which phosphate wasting was coupled to inappropriately low levels of 1,25(OH)2D3. FGF-23 is regulated by dietary phosphate in humans: phosphate restriction decreased FGF-23, and phosphate loading increased FGF-23. Phosphate must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pi transporters carry out this task. Remarkably, the two families transport different Pi species: whereas type II Na+/Pi cotransporters (SCL34) prefer divalent HPO4(2), type III Na+/Pi cotransporters (SLC20) transport monovalent H2PO4. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes of the gut and kidney, they maintain body Pi homeostasis, and in salivary and mammary glands, liver, and testes they play a role in modulating the Pi content of luminal fluids. Hyperphosphatemia is a prevalent condition in the dialysis population and is associated with increased risk of mortality. Hypophosphatemia (hungry bone syndrome) has been associated to postoperative electrolyte aberrations and after parathyroidectomy. (PMID: 17581921, 11169009, 11039261, 9159312, 17625581) [HMDB]. Phosphate is found in many foods, some of which are yellow zucchini, avocado, longan, and garden rhubarb.
CAS Number14265-44-2
Structure
Thumb
Synonyms
SynonymSource
[PO4](3-)ChEBI
OrthophosphateChEBI
PhosphateChEBI
PO4(3-)ChEBI
Orthophosphoric acidGenerator
Phosphoric acidGenerator
Phosphoric acid ionGenerator
Phosphates, inorganicMeSH
PhosphatesMeSH
Inorganic phosphatesMeSH
PHOSPHATE ionChEBI
NFB OrthophosphateHMDB
O-Phosphoric acidHMDB
ortho-PhosphateHMDB
Orthophosphate (PO43-)HMDB
Orthophosphate(3-)HMDB
Phosphate (PO43-)HMDB
Phosphate anion(3-)HMDB
Phosphate ion (PO43-)HMDB
Phosphate ion(3-)HMDB
Phosphate trianionHMDB
Phosphate(3-)HMDB
Phosphoric acid ion(3-)HMDB
PiHMDB
ate (PO43-)HMDB
ate Anion(3-)HMDB
ate Ion (PO43-)HMDB
ate Ion(3-)HMDB
ate TrianionHMDB
ate(3-)HMDB
ic acid IONGenerator
NFB orthoateHMDB
O-Oric acidHMDB
Oric acid ion(3-)HMDB
ortho-ateHMDB
Ortho-phosphatehmdb
orthoate (PO43-)HMDB
orthoate(3-)HMDB
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area86.25 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.29 m³·mol⁻¹ChemAxon
Polarizability4.93 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaO4P
IUPAC namephosphate
InChI IdentifierInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChI KeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
Isomeric SMILES[O-]P([O-])([O-])=O
Average Molecular Weight94.9714
Monoisotopic Molecular Weight94.95342
Classification
Description Belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal phosphates
Direct ParentNon-metal phosphates
Alternative Parents
Substituents
  • Non-metal phosphate
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Ontology
OntologyNo ontology term
Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MSNot Available
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-5fa0319f90e59fa29fd62015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-9000000000-4d04c52017553b8714c82015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000t-9000000000-cb8134bc14f66db5b0bb2015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0006-9000000000-755717f229a32cd2dccf2015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0006-9000000000-003ecbaa2a45f587b9532015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0006-9000000000-d32bf6727c65f9ec0f1d2015-09-15View Spectrum
NMRNot Available
ChemSpider ID1032
ChEMBL IDNot Available
KEGG Compound IDC00009
Pubchem Compound ID1061
Pubchem Substance IDNot Available
ChEBI ID18367
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB01429
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG ID33499
KNApSAcK IDNot Available
HET IDPO4
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDPhosphate
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
Enzymes
NameGene NameUniProt ID
Multiple inositol polyphosphate phosphatase 1MINPP1Q9UNW1
Propionyl-CoA carboxylase beta chain, mitochondrialPCCBP05166
Trifunctional purine biosynthetic protein adenosine-3GARTP22102
Glutathione synthetaseGSSP48637
Glutamate--cysteine ligase catalytic subunitGCLCP48506
Lysosomal acid phosphataseACP2P11117
Testicular acid phosphataseACPTQ9BZG2
Lactase-phlorizin hydrolaseLCTP09848
Beta-galactosidaseGLB1P16278
V-type proton ATPase catalytic subunit AATP6V1AP38606
Receptor-type tyrosine-protein phosphatase SPTPRSQ13332
V-type proton ATPase subunit C 1ATP6V1C1P21283
Prostatic acid phosphataseACPPP15309
Lysophosphatidic acid phosphatase type 6ACP6Q9NPH0
Putative uncharacterized protein ACP1ACP1B5MCC7
Glycogen phosphorylase, liver formPYGLP06737
Glycogen phosphorylase, muscle formPYGMP11217
Glycogen phosphorylase, brain formPYGBP11216
Sialic acid synthaseNANSQ9NR45
ATP-citrate synthaseACLYP53396
S-methyl-5'-thioadenosine phosphorylaseMTAPQ13126
Selenide, water dikinase 2SEPHS2Q99611
Acylphosphatase-2ACYP2P14621
Acylphosphatase-1ACYP1P07311
Phosphoglycolate phosphatasePGPA6NDG6
LaforinEPM2AO95278
Dual specificity protein phosphatase 2DUSP2Q05923
Dual specificity protein phosphatase CDC14ACDC14AQ9UNH5
Dual specificity protein phosphatase CDC14BCDC14BO60729
Cyclin-dependent kinase inhibitor 3CDKN3Q16667
RNA polymerase II subunit A C-terminal domain phosphataseCTDP1Q9Y5B0
Dual specificity protein phosphatase 10DUSP10Q9Y6W6
Dual specificity protein phosphatase 13DUSP13Q9UII6
Dual specificity protein phosphatase 16DUSP16Q9BY84
Dual specificity protein phosphatase 19DUSP19Q8WTR2
Dual specificity protein phosphatase 1DUSP1P28562
Dual specificity protein phosphatase 3DUSP3P51452
Dual specificity protein phosphatase 4DUSP4Q13115
Dual specificity protein phosphatase 5DUSP5Q16690
Dual specificity protein phosphatase 6DUSP6Q16828
Dual specificity protein phosphatase 7DUSP7Q16829
Dual specificity protein phosphatase 8DUSP8Q13202
Dual specificity protein phosphatase 14DUSP14O95147
Dual specificity protein phosphatase 15DUSP15Q9H1R2
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit betaPPP2R3BQ9Y5P8
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1CTDSP1Q9GZU7
Dual specificity protein phosphatase 21DUSP21Q9H596
Putative uncharacterized protein DKFZp686I0955DKFZp686I0955Q5HYC3
Serine/threonine-protein phosphatasePPP2CAB3KUN1
Sodium/potassium-transporting ATPase subunit beta-3ATP1B3P54709
Sodium/potassium-transporting ATPase subunit beta-2ATP1B2P14415
Cytosolic 5'-nucleotidase 3NT5C3Q9H0P0
Potassium-transporting ATPase alpha chain 2ATP12AP54707
Potassium-transporting ATPase subunit betaATP4BP51164
Potassium-transporting ATPase alpha chain 1ATP4AP20648
Delta-1-pyrroline-5-carboxylate synthaseALDH18A1P54886
Ornithine carbamoyltransferase, mitochondrialOTCP00480
Carbamoyl-phosphate synthase [ammonia], mitochondrialCPS1P31327
CTP synthase 2CTPS2Q9NRF8
ENTPD4 proteinENTPD4Q8NE73
Polyribonucleotide nucleotidyltransferase 1, mitochondrialPNPT1Q8TCS8
Thiamine-triphosphataseTHTPAQ9BU02
Glucose-6-phosphataseG6PCP35575
Glucose-6-phosphatase 2G6PC2Q9NQR9
Propionyl-CoA carboxylase alpha chain, mitochondrialPCCAP05165
Glucose-6-phosphatase 3G6PC3Q9BUM1
Folylpolyglutamate synthase, mitochondrialFPGSQ05932
5-oxoprolinaseOPLAHO14841
Multifunctional protein ADE2PAICSP22234
C-1-tetrahydrofolate synthase, cytoplasmicMTHFD1P11586
Monofunctional C1-tetrahydrofolate synthase, mitochondrialMTHFD1LQ6UB35
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolaseMTHFD2Q7Z650
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase AINPP5JQ15735
Inositol polyphosphate 5-phosphatase KINPP5KQ9BT40
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrialMCCC2Q9HCC0
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialMCCC1Q96RQ3
Selenide, water dikinase 1SEPHS1P49903
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3PFKFB3Q16875
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4PFKFB4Q16877
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1PFKFB1P16118
Fructose-1,6-bisphosphatase isozyme 2FBP2O00757
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2PFKFB2O60825
Diphosphomevalonate decarboxylaseMVDP53602
Katanin p60 ATPase-containing subunit A1KATNA1O75449
Bifunctional polynucleotide phosphatase/kinasePNKPQ96T60
Synaptojanin-2SYNJ2O15056
72 kDa inositol polyphosphate 5-phosphataseINPP5EQ9NRR6
Synaptojanin-1SYNJ1O43426
Dolichyldiphosphatase 1DOLPP1Q86YN1
Tyrosine-protein phosphatase non-receptor type 6PTPN6P29350
Receptor-type tyrosine-protein phosphatase CPTPRCP08575
Receptor-type tyrosine-protein phosphatase alphaPTPRAP18433
MyotubularinMTM1Q13496
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2INPPL1O15357
Type II inositol 3,4-bisphosphate 4-phosphataseINPP4BO15327
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1INPP5DQ92835
3-hydroxyisobutyryl-CoA hydrolase, mitochondrialHIBCHQ6NVY1
Type I inositol 3,4-bisphosphate 4-phosphataseINPP4AQ96PE3
Lipid phosphate phosphatase-related protein type 4LPPR4Q7Z2D5
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2TPTE2Q6XPS3
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1PTPMT1Q8WUK0
Putative tyrosine-protein phosphatase auxilinDNAJC6O75061
CTD nuclear envelope phosphatase 1CTDNEP1O95476
Dual specificity phosphatase 28DUSP28Q4G0W2
Dual specificity protein phosphatase 9DUSP9Q99956
Lipid phosphate phosphatase-related protein type 2LPPR2Q96GM1
Lipid phosphate phosphatase-related protein type 3LPPR3Q6T4P5
M-phase inducer phosphatase 1CDC25AP30304
M-phase inducer phosphatase 2CDC25BP30305
M-phase inducer phosphatase 3CDC25CP30307
Protein phosphatase 1HPPM1HQ9ULR3
Protein phosphatase 1JPPM1JQ5JR12
Tyrosine-protein phosphatase non-receptor type 11PTPN11Q06124
Tyrosine-protein phosphatase non-receptor type 12PTPN12Q05209
Tyrosine-protein phosphatase non-receptor type 13PTPN13Q12923
Tyrosine-protein phosphatase non-receptor type 14PTPN14Q15678
Tyrosine-protein phosphatase non-receptor type 18PTPN18Q99952
Tyrosine-protein phosphatase non-receptor type 1PTPN1P18031
Tyrosine-protein phosphatase non-receptor type 21PTPN21Q16825
Tyrosine-protein phosphatase non-receptor type 22PTPN22Q9Y2R2
Tyrosine-protein phosphatase non-receptor type 2PTPN2P17706
Tyrosine-protein phosphatase non-receptor type 3PTPN3P26045
Tyrosine-protein phosphatase non-receptor type 4PTPN4P29074
Tyrosine-protein phosphatase non-receptor type 5PTPN5P54829
Tyrosine-protein phosphatase non-receptor type 9PTPN9P43378
Receptor-type tyrosine-protein phosphatase N2PTPRN2Q92932
Receptor-type tyrosine-protein phosphatase betaPTPRBP23467
Receptor-type tyrosine-protein phosphatase deltaPTPRDP23468
Receptor-type tyrosine-protein phosphatase epsilonPTPREP23469
Receptor-type tyrosine-protein phosphatase FPTPRFP10586
Receptor-type tyrosine-protein phosphatase gammaPTPRGP23470
Receptor-type tyrosine-protein phosphatase etaPTPRJQ12913
Receptor-type tyrosine-protein phosphatase kappaPTPRKQ15262
Receptor-type tyrosine-protein phosphatase muPTPRMP28827
Receptor-type tyrosine-protein phosphatase OPTPROQ16827
Receptor-type tyrosine-protein phosphatase RPTPRRQ15256
Receptor-type tyrosine-protein phosphatase TPTPRTO14522
Receptor-type tyrosine-protein phosphatase UPTPRUQ92729
Receptor-type tyrosine-protein phosphatase zetaPTPRZ1P23471
Protein phosphatase Slingshot homolog 1SSH1Q8WYL5
Protein phosphatase Slingshot homolog 2SSH2Q76I76
Putative tyrosine-protein phosphatase TPTETPTEP56180
Receptor-type tyrosine-protein phosphatase HPTPRHQ9HD43
Tyrosine-protein phosphatase non-receptor type 23PTPN23Q9H3S7
V-type proton ATPase subunit G 3ATP6V1G3Q96LB4
V-type proton ATPase subunit G 1ATP6V1G1O75348
ATP synthase subunit epsilon, mitochondrialATP5EP56381
ATP synthase subunit delta, mitochondrialATP5DP30049
V-type proton ATPase subunit G 2ATP6V1G2O95670
ATP synthase subunit O, mitochondrialATP5OP48047
ATP synthase-coupling factor 6, mitochondrialATP5JP18859
ATP synthase protein 8MT-ATP8P03928
ATP synthase subunit e, mitochondrialATP5IP56385
ATP synthase subunit gamma, mitochondrialATP5C1P36542
V-type proton ATPase subunit d 1ATP6V0D1P61421
V-type proton ATPase subunit B, brain isoformATP6V1B2P21281
ATP synthase subunit b, mitochondrialATP5F1P24539
ATP synthase subunit alpha, mitochondrialATP5A1P25705
Probable phospholipid-transporting ATPase IIBATP9BO43861
V-type proton ATPase 16 kDa proteolipid subunitATP6V0CP27449
V-type proton ATPase subunit e 1ATP6V0E1O15342
ATP synthase subunit d, mitochondrialATP5HO75947
ATP synthase subunit f, mitochondrialATP5J2P56134
V-type proton ATPase 116 kDa subunit a isoform 2ATP6V0A2Q9Y487
ATP synthase lipid-binding protein, mitochondrialATP5G3P48201
V-type proton ATPase subunit HATP6V1HQ9UI12
V-type proton ATPase subunit DATP6V1DQ9Y5K8
V-type proton ATPase subunit d 2ATP6V0D2Q8N8Y2
V-ATPase subunit E 2ATP6V1E2Q96A05
V-type proton ATPase subunit C 2ATP6V1C2Q8NEY4
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3, isoform CRA_c)TCIRG1Q13488
V-type proton ATPase subunit e 2ATP6V0E2Q8NHE4
Putative uncharacterized protein ATP6V1E1ATP6V1E1P36543
ATPase, H+ transporting, lysosomal accessory protein 1 (ATPase, H+ transporting, lysosomal accessory protein 1, isoform CRA_d) (cDNA FLJ78461, highly similar to Homo sapiens ATPase, H+ transporting, lysosomal accessory protein 1 (ATP6AP1), mRNA) (FragmentATP6AP1Q15904
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit FATP6V1FA4D1K0
Protein tyrosine phosphatase domain-containing protein 1PTPDC1A2A3K4
Receptor-type tyrosine-protein phosphatase-like NPTPRNQ16849
Tyrosine-protein kinase LckLCKP06239
Sphingosine 1-phosphate receptor 1S1PR1P21453
Phosphate carrier protein, mitochondrialSLC25A3Q00325
Myotubularin-related protein 14MTMR14Q8NCE2
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
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References
Synthesis ReferenceNot Available
General ReferenceNot Available
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