1.0 2011-09-21 00:17:12 UTC 2015-07-21 06:57:17 UTC FDB022636 Biotin amide The enzyme biotinidase (EC-Number 3.5.1.12 ) is involved in the recycling of the vitamin biotin, cleaving D-biotinylamides and esters, in a reaction including biotin amide and water. (PMID 1719240, 171927) Late-onset multiple carboxylase deficiency (MCD) with biotinidase deficiency is caused by mutation in the biotinidase gene. MCD is an autosomal recessive metabolic disorder characterized primarily by cutaneous and neurologic abnormalities. Symptoms result from the patient's inability to reutilize biotin, a necessary nutrient. (OMIM 253260) [HMDB] biotin amide C10H17N3O2S 243.326 243.104147493 5-[(3aR,4R,6aS)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamide 5-[(3aR,4R,6aS)-2-oxo-hexahydrothieno[3,4-d]imidazolidin-4-yl]pentanamide 6929-42-6 [H][C@@]12CS[C@H](CCCCC(N)=O)[C@]1([H])NC(=O)N2 InChI=1S/C10H17N3O2S/c11-8(14)4-2-1-3-7-9-6(5-16-7)12-10(15)13-9/h6-7,9H,1-5H2,(H2,11,14)(H2,12,13,15)/t6-,7-,9-/m1/s1 XFLVBMBRLSCJAI-ZXFLCMHBSA-N belongs to the class of organic compounds known as biotin and derivatives. These are organic compounds containing a ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. Biotin and derivatives Organic compounds Organoheterocyclic compounds Biotin and derivatives Aliphatic heteropolycyclic compounds Azacyclic compounds Carbonyl compounds Dialkylthioethers Fatty amides Hydrocarbon derivatives Imidazolidinones Organic oxides Organonitrogen compounds Organopnictogen compounds Primary carboxylic acid amides Thienoimidazolidines Thiolanes Thiophenes Ureas Aliphatic heteropolycyclic compound Azacycle Biotin_derivative Carbonic acid derivative Carbonyl group Carboxamide group Carboxylic acid derivative Dialkylthioether Fatty acyl Fatty amide Hydrocarbon derivative Imidazolidine Imidazolidinone Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary carboxylic acid amide Thienoimidazolidine Thioether Thiolane Thiophene Urea Solid logp -0.20 ALOGPS logs -2.13 ALOGPS solubility 1.81e+00 g/l ALOGPS logp -0.49 ChemAxon pka_strongest_acidic 13.6 ChemAxon pka_strongest_basic -0.56 ChemAxon iupac 5-[(3aR,4R,6aS)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamide ChemAxon average_mass 243.326 ChemAxon mono_mass 243.104147493 ChemAxon smiles [H][C@@]12CS[C@H](CCCCC(N)=O)[C@]1([H])NC(=O)N2 ChemAxon formula C10H17N3O2S ChemAxon inchi InChI=1S/C10H17N3O2S/c11-8(14)4-2-1-3-7-9-6(5-16-7)12-10(15)13-9/h6-7,9H,1-5H2,(H2,11,14)(H2,12,13,15)/t6-,7-,9-/m1/s1 ChemAxon inchikey XFLVBMBRLSCJAI-ZXFLCMHBSA-N ChemAxon polar_surface_area 84.22 ChemAxon refractivity 61.87 ChemAxon polarizability 25.4 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 2 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 12837 Specdb::CMs 169592 Specdb::NmrOneD 147800 Specdb::NmrOneD 147801 Specdb::NmrOneD 147802 Specdb::NmrOneD 147803 Specdb::NmrOneD 147804 Specdb::NmrOneD 147805 Specdb::NmrOneD 147806 Specdb::NmrOneD 147807 Specdb::NmrOneD 147808 Specdb::NmrOneD 147809 Specdb::NmrOneD 147810 Specdb::NmrOneD 147811 Specdb::NmrOneD 147812 Specdb::NmrOneD 147813 Specdb::NmrOneD 147814 Specdb::NmrOneD 147815 Specdb::NmrOneD 147816 Specdb::NmrOneD 147817 Specdb::NmrOneD 147818 Specdb::NmrOneD 147819 Specdb::MsMs 294187 Specdb::MsMs 294188 Specdb::MsMs 294189 Specdb::MsMs 334843 Specdb::MsMs 334844 Specdb::MsMs 334845 Specdb::MsMs 2664691 Specdb::MsMs 2664692 Specdb::MsMs 2664693 Specdb::MsMs 3018054 Specdb::MsMs 3018055 Specdb::MsMs 3018056 HMDB01458 16615 #<Reference:0x00005636d21ce148> #<Reference:0x00005636d21cde50> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columba 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 Animal Capra aegagrus hircus 9925 Domestic pig Type 1 Animal Sus scrofa domesticus 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus cuniculus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus hemionus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 Biotinidase P43251 BTD