1.0 2011-09-21 00:18:01 UTC 2025-11-19 02:42:17 UTC FDB022690 1-Methylguanosine 1-Methylguanosine is a methylated nucleoside. It is known that some modified, especially methylated, nucleosides originating from RNA degradation are excreted in abnormal levels in the urine of patients with malignant tumours and they have been proposed as tumour markers. Their measurement could provide a non-invasive diagnostic method, be helpful in the identification of different cancers and in the monitoring of therapeutic effects. PMID: 9129323 [HMDB] 1-methyl-guanosine m1g methylguanosine N1-Methylguanosine trmd protein C11H15N5O5 297.2673 297.107318615 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1H-purin-6-one 1-methylguanosine 2140-65-0 CN1C(N)=NC2=C(N=CN2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1=O InChI=1S/C11H15N5O5/c1-15-9(20)5-8(14-11(15)12)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14)/t4-,6-,7-,10-/m1/s1 UTAIYTHAJQNQDW-KQYNXXCUSA-N belongs to the class of organic compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. Purine nucleosides Organic compounds Nucleosides, nucleotides, and analogues Purine nucleosides Aromatic heteropolycyclic compounds 6-oxopurines Azacyclic compounds Glycosylamines Heteroaromatic compounds Hydrocarbon derivatives Lactams N-substituted imidazoles Organic oxides Organonitrogen compounds Organopnictogen compounds Oxacyclic compounds Pentoses Primary alcohols Pyrimidones Secondary alcohols Tetrahydrofurans Vinylogous amides 6-oxopurine Alcohol Aromatic heteropolycyclic compound Azacycle Azole Glycosyl compound Heteroaromatic compound Hydrocarbon derivative Imidazole Imidazopyrimidine Lactam Monosaccharide N-glycosyl compound N-substituted imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Pentose monosaccharide Primary alcohol Purine Purine nucleoside Purinone Pyrimidine Pyrimidone Secondary alcohol Tetrahydrofuran Vinylogous amide methylguanosine Solid logp -1.81 ALOGPS logs -1.27 ALOGPS solubility 1.61e+01 g/l ALOGPS logp -2.5 ChemAxon pka_strongest_acidic 12.45 ChemAxon pka_strongest_basic 1.43 ChemAxon iupac 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1H-purin-6-one ChemAxon average_mass 297.2673 ChemAxon mono_mass 297.107318615 ChemAxon smiles CN1C(N)=NC2=C(N=CN2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1=O ChemAxon formula C11H15N5O5 ChemAxon inchi InChI=1S/C11H15N5O5/c1-15-9(20)5-8(14-11(15)12)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14)/t4-,6-,7-,10-/m1/s1 ChemAxon inchikey UTAIYTHAJQNQDW-KQYNXXCUSA-N ChemAxon polar_surface_area 146.43 ChemAxon refractivity 69.52 ChemAxon polarizability 28.17 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 8 ChemAxon donor_count 4 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1673 Specdb::CMs 9479 Specdb::CMs 38128 Specdb::CMs 147915 Specdb::MsMs 47718 Specdb::MsMs 47719 Specdb::MsMs 47720 Specdb::MsMs 146667 Specdb::MsMs 146668 Specdb::MsMs 146669 Specdb::MsMs 2229440 Specdb::MsMs 2230016 Specdb::MsMs 2235791 Specdb::MsMs 2237562 Specdb::MsMs 2240014 Specdb::MsMs 2241675 Specdb::MsMs 2242140 Specdb::MsMs 2243751 Specdb::MsMs 2253064 Specdb::MsMs 2253382 Specdb::MsMs 2255171 Specdb::MsMs 2255418 Specdb::MsMs 2257088 Specdb::MsMs 2257488 Specdb::MsMs 2259061 Specdb::MsMs 2259527 Specdb::MsMs 2315015 Specdb::MsMs 2315016 Specdb::MsMs 2315017 Specdb::NmrOneD 1732 Specdb::NmrOneD 96458 Specdb::NmrOneD 96459 Specdb::NmrOneD 96460 Specdb::NmrOneD 96461 Specdb::NmrOneD 96462 Specdb::NmrOneD 96463 Specdb::NmrOneD 96464 Specdb::NmrOneD 96465 Specdb::NmrOneD 96466 Specdb::NmrOneD 96467 Specdb::NmrOneD 96468 Specdb::NmrOneD 96469 Specdb::NmrOneD 96470 Specdb::NmrOneD 96471 Specdb::NmrOneD 96472 Specdb::NmrOneD 96473 Specdb::NmrOneD 96474 Specdb::NmrOneD 96475 Specdb::NmrOneD 96476 Specdb::NmrOneD 96477 Specdb::NmrOneD 166349 Specdb::NmrOneD 166631 HMDB01563 #<Reference:0x000055ce31c201a0> #<Reference:0x000055ce31c1ff98> #<Reference:0x000055ce31c1fde0> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Milk (Cow) Type 2 specific Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823