1.0 2011-09-21 00:18:15 UTC 2015-10-09 22:30:54 UTC FDB022706 Imipramine The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group. -- Pubchem; Imipramine (sold as Antideprin, Janimine, Tofranil) is an antidepressant medication, a tricyclic antidepressant of the dibenzazepine group, mainly used in the treatment of clinical depression and enuresis. -- Wikipedia [HMDB] 10,11-dihydro-N,N-Dimethyl-5H-dibenz[b,F]azepine-5-propanamine 3-(5H-DIBENZO[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine 5-[3-(dimethylamino)Propyl]-10,11-dihydro-5H-dibenz[b,F]azepine Antideprin Berkomine Chimoreptin Declomipramine Dimipressin DPID Dyna-Zina Dynaprin Eupramin Feinalmin Imavate Imidobenzyle Imilanyle Imipramin Imipramine Imipraminum Imizine Irmin Janimine Lofepramine Melipramin Melipramine N-(g-Dimethylaminopropyl)iminodibenzyl N-(gamma-Dimethylaminopropyl)iminodibenzyl N-(γ-dimethylaminopropyl)iminodibenzyl Psychoforin Surmontil Surplix Teperine Timolet Tofranil Tofranil base Tofranil-Pm Trimipramine Maleate C19H24N2 280.4073 280.193948778 (3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)dimethylamine (3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)dimethylamine 50-49-7 CN(C)CCCN1C2=CC=CC=C2CCC2=CC=CC=C12 InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 BCGWQEUPMDMJNV-UHFFFAOYSA-N belongs to the class of organic compounds known as dibenzazepines. Dibenzazepines are compounds with two benzene rings connected by an azepine ring. Azepine is an unsaturated seven-member heterocycle with one nitrogen atom replacing a carbon atom. Dibenzazepines Organic compounds Organoheterocyclic compounds Benzazepines Dibenzazepines Aromatic heteropolycyclic compounds Alkyldiarylamines Azacyclic compounds Azepines Benzenoids Hydrocarbon derivatives Organopnictogen compounds Trialkylamines Alkyldiarylamine Amine Aromatic heteropolycyclic compound Azacycle Azepine Benzenoid Dibenzazepine Hydrocarbon derivative Organic nitrogen compound Organonitrogen compound Organopnictogen compound Tertiary aliphatic amine Tertiary aliphatic/aromatic amine Tertiary amine a small molecule dibenzoazepine Solid logp 4.53 ALOGPS logs -3.63 ALOGPS solubility 6.64e-02 g/l ALOGPS logp 4.28 ChemAxon pka_strongest_basic 9.2 ChemAxon iupac (3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)dimethylamine ChemAxon average_mass 280.4073 ChemAxon mono_mass 280.193948778 ChemAxon smiles CN(C)CCCN1C2=CC=CC=C2CCC2=CC=CC=C12 ChemAxon formula C19H24N2 ChemAxon inchi InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 ChemAxon inchikey BCGWQEUPMDMJNV-UHFFFAOYSA-N ChemAxon polar_surface_area 6.48 ChemAxon refractivity 90.61 ChemAxon polarizability 33.39 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::EiMs 177 Specdb::NmrOneD 1752 Specdb::NmrTwoD 1692 Specdb::CMs 6635 Specdb::CMs 27631 Specdb::CMs 99707 Specdb::CMs 132486 Specdb::CMs 140220 Specdb::MsMs 1705 Specdb::MsMs 1706 Specdb::MsMs 1707 Specdb::MsMs 5465 Specdb::MsMs 248832 Specdb::MsMs 248833 Specdb::MsMs 248834 Specdb::MsMs 268773 Specdb::MsMs 268774 Specdb::MsMs 268775 Specdb::MsMs 441054 Specdb::MsMs 2242305 Specdb::MsMs 2242854 Specdb::MsMs 2243544 Specdb::MsMs 2244427 Specdb::MsMs 2245666 Specdb::MsMs 2246529 Specdb::MsMs 2247768 Specdb::MsMs 2248629 Specdb::MsMs 2249090 Specdb::MsMs 2249308 Specdb::MsMs 2249737 Specdb::MsMs 2250694 Specdb::MsMs 2251720 Specdb::MsMs 2352976 HMDB01848 5881 IXX Adenosine receptor A1 P30542 ADORA1 UDP-glucuronosyltransferase 1-4 P22310 UGT1A4