1.0 2011-09-21 00:18:17 UTC 2015-10-09 22:30:55 UTC FDB022708 Verapamil A calcium channel blocker that is a class IV anti-arrhythmia agent. -- Pubchem; Calcium channel antagonists can be quite toxic. In the management of poisoning, early recognition is critical. Calcium channel antagonists are frequently prescribed, and the potential for serious morbidity and mortality with over dosage is significant. Ingestion of these agents should be suspected in any patient who presents in an overdose situation with unexplained hypotension and conduction abnormalities. The potential for toxicity should be noted in patients with underlying hepatic or renal dysfunction who are receiving therapeutic doses. (PMID 8213877) [HMDB] Akilen Anpec Apo-Verap Arpamyl LP Berkatens Calan Calan SR Calaptin Calaptin 240 SR Calcan Cardiabeltin Cardiagutt Cardibeltin Cardioprotect Caveril Civicor Civicor Retard Coraver Cordilox Cordilox SR Corpamil Covera-Hs D-365 delta-365 Dignover Dilacoran Dilacoran HTA Durasoptin Elthon Falicard Finoptin Flamon Geangin Harteze Hexasoptin Hexasoptin Retard Hormitol Ikacor Ikapress Inselon Iproveratril Isoptin Isoptin Retard Isoptin SR Isoptine Isoptino Isotopin Izoptin Jenapamil Lekoptin Lodixal Magotiron Manidon Manidon Retard Novapamyl LP Novo-Veramil Nu-Verap Ormil Praecicor Quasar Rapam Robatelan Securon Tarka Univer Univex Vasolan Vasomil Vasopten Vera-Sanorania Verabeta Veracaps SR Veracor Verahexal Veraloc Veramex Veramil Verapamil Verapamil Acis Verapamil AL Verapamil Atid Verapamil Basics Verapamil Ebewe Verapamil hcl Verapamil Henning Verapamil Injection Verapamil MSD Verapamil NM Verapamil NM Pharma Verapamil Nordic Verapamil PB Verapamil Riker Verapamil SR Verapamil Verla Verapamil-AbZ Verapamilo Verapamilum Verapin Verapress 240 SR Verasal Verasifar Veratensin Verdilac Verelan Verelan PM Verelan SR Veroptinstada Verpamil Vetrimil Vortac C27H38N2O4 454.6016 454.283157714 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile veraβ 52-53-9 COC1=C(OC)C=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1 InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3 SGTNSNPWRIOYBX-UHFFFAOYSA-N belongs to the class of organic compounds known as phenylbutylamines. Phenylbutylamines are compounds containing a phenylbutylamine moiety, which consists of a phenyl group substituted at the fourth carbon by an butan-1-amine. Phenylbutylamines Organic compounds Benzenoids Benzene and substituted derivatives Phenylbutylamines Aromatic homomonocyclic compounds Alkyl aryl ethers Anisoles Aralkylamines Dimethoxybenzenes Hydrocarbon derivatives Nitriles Organopnictogen compounds Phenethylamines Phenoxy compounds Phenylpropanes Trialkylamines Alkyl aryl ether Amine Anisole Aralkylamine Aromatic homomonocyclic compound Carbonitrile Dimethoxybenzene Ether Hydrocarbon derivative Methoxybenzene Nitrile O-dimethoxybenzene Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenethylamine Phenol ether Phenoxy compound Phenylbutylamine Phenylpropane Tertiary aliphatic amine Tertiary amine aromatic ether nitrile polyether tertiary amino compound Solid logp 5.23 ALOGPS logs -5.06 ALOGPS solubility 3.94e-03 g/l ALOGPS logp 5.04 ChemAxon pka_strongest_basic 9.68 ChemAxon iupac 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile ChemAxon average_mass 454.6016 ChemAxon mono_mass 454.283157714 ChemAxon smiles COC1=C(OC)C=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1 ChemAxon formula C27H38N2O4 ChemAxon inchi InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3 ChemAxon inchikey SGTNSNPWRIOYBX-UHFFFAOYSA-N ChemAxon polar_surface_area 63.95 ChemAxon refractivity 132.65 ChemAxon polarizability 51.7 ChemAxon rotatable_bond_count 13 ChemAxon acceptor_count 6 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1694 Specdb::CMs 25919 Specdb::CMs 122410 Specdb::CMs 126312 Specdb::CMs 133613 Specdb::CMs 141347 Specdb::EiMs 640 Specdb::NmrOneD 1754 Specdb::MsMs 1711 Specdb::MsMs 1712 Specdb::MsMs 1713 Specdb::MsMs 5476 Specdb::MsMs 5477 Specdb::MsMs 5478 Specdb::MsMs 5479 Specdb::MsMs 5480 Specdb::MsMs 5481 Specdb::MsMs 5482 Specdb::MsMs 5483 Specdb::MsMs 5484 Specdb::MsMs 5485 Specdb::MsMs 264744 Specdb::MsMs 264745 Specdb::MsMs 264746 Specdb::MsMs 284673 Specdb::MsMs 284674 Specdb::MsMs 284675 Specdb::MsMs 441374 Specdb::MsMs 441375 Specdb::MsMs 441376 Specdb::MsMs 441377 Specdb::MsMs 441378 Specdb::MsMs 442323 HMDB01850 #<Reference:0x000055ce33334710> #<Reference:0x000055ce33334558> #<Reference:0x000055ce333343a0> #<Reference:0x000055ce333341e8> #<Reference:0x000055ce33334030> #<Reference:0x000055ce33333e28> #<Reference:0x000055ce33333c70> #<Reference:0x000055ce33333ab8> #<Reference:0x000055ce33333900> #<Reference:0x000055ce33333748> #<Reference:0x000055ce33333590> #<Reference:0x000055ce333333d8> #<Reference:0x000055ce33333220> #<Reference:0x000055ce33333068> #<Reference:0x000055ce33332eb0> #<Reference:0x000055ce33332cf8> #<Reference:0x000055ce33332b40> #<Reference:0x000055ce33332988> #<Reference:0x000055ce333327a8> #<Reference:0x000055ce333325f0> #<Reference:0x000055ce33332438> #<Reference:0x000055ce33332280>